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Effects of coffee and caffeine on bladder dysfunction in streptozotocininduced diabetic rats

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Acta Pharmacologica Sinica 2006年第8期27卷 1037-1043页

作者： Chao-ran YI~(2,5) Zhong-qing WEI~2 Xiang-lei DENG~4 Ze-yu SUN~2 Xing-rong LI~4 Cheng-gong TIAN~3 ~2Department of Urology,~3Department of Endocrinology,the Affiliated Drum Tower Hospital,Nanjing university Medical School,Nanjing 210008,china ~4Department of Biochemisto,and Molecular Biology,Medieal college of Southeast university,Nanjing 210009,china Department of Urology the Affiliated Drum Tower Hospital Nanjing University Medical School Nanjing 210008 Chin

Aim:To explore the effects and mechanisms of caffeine and coffee on bladderdysfunction in streptozotocin-induced diabetic ***:Sprague-Dawleymale rats were divided randomly into 4 groups:control,diabetes mellitus(DM),DM with coffee treatment,and DM with caffeine *** diabetic rat wasinduced by intraperitoneal injection of streptozotocin(60 mg/kg).After 7 weeks oftreatment with coffee and caffeine,cystometrogram,contractile responses to elec-trical field stimulation(EFS)and acetylcholine(ACh),and cyclic AMP(cAMP)concentration of the bladder body and base were ***:The bladderweight,volume threshold for micturition and post-void residual volume(PVR)inthe diabetic rats were significantly higher compared to those in the control *** or caffeine treatment significantly reduced the bladder weight,bladdercapacity and PVR in the diabetic *** caused significant decreases in cAMPconcentration of the bladder and coffee and caffeine caused upregulation of cAMPcontent in the diabetic *** addition,coffee and caffeine tended to normal-ize the altered detrusor contractile responses to EFS and ACh in the diabetic ***:These results indicate that caffeine and coffee may have beneficialeffects on bladder dysfunction in the early stage of diabetes by increasing cAMPcontent in the lower urinary tract,recovering the micturition reflex and improvingthe detrusor contractility.

关键词： caffeine diabetic mellitus bladder urodynamics muscle contraction cyclic AMP

Study on Bending Fatigue life test and FEA Analysis of the Steel Wheel

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Study on Bending Fatigue life test and FEA Analysis of the S...

2009中国控制与决策会议

作者： Wang Guofeng~(1,2),Sun Huixue~1,Li Jian~1,Wang Yixiang~1 1.college of Mechanical Engineering,Yanshan university,Qin Huangdao,china,066004 2.college of Information Technology,jilin Normal university,Si Ping,china,136000

＜正＞Based on the steel wheel bending fatigue bench test,the bending fatigue life FEA model for the wheel was *** wheel fatigue regions got in FEA analyses matched the actual test results *** works established a foundation for further study on wheel fatigue use FEA and provided a basis for the steel wheel’s design and manufacture, which also can enhance the products reliability and improve the products competitiveness in the market.

关键词： Wheel Bench Test Bending fatigue Fatigue life

An Empirical Study of the Relationship between the Capability of IT and BPR in Equipment manufacturer in Guizhou Province

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An Empirical Study of the Relationship between the Capabilit...

第17届工业工程与工程管理国际学术会议(IE&EM2010)

作者： Ting WANG~(1,2),Lin YANG~2,Jin ZHAO~2, 1 college of Management Engineering,Guizhou university,Guiyang,P.R.china 2 college of Mechanical Engineering,Guizhou university,Guiyang,P.R.china

In order to explore effective ways to improve the performance and ensure the success of BPR,the paper puts forward a conceptual model and 4 hypotheses describing the relationship between the capability of IT (information Technology) and *** Analysis, Correlation Analysis,Multiple Linear Regression,Canonical Correlation Analysis and One-Way ANOVA are as well as the SPSS13.0 statistical software is used to test the *** relationship between BPR and the capability of IT is concretely revealed;it preliminarily explored how contextual factors(for example,the size of the enterprise) influence role which the capability of IT plays in *** result showed that four factors of the capability of IT play positive roles in the success of BPR,various factors influence BPR differently,and there wasn't a significant difference in the depth of implementing BPR among enterprises in different size.

关键词： Business Process Reengineering(BPR) corporate culture organizational and background factors BPR success degree implementing BPR degree

A NEW CONTINUUM TRAFFIC MODEL WITH THE EFFECT OF VISCOSITY

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Journal of Hydrodynamics 2011年第2期23卷 164-169页

作者： SONG Tao LI Xing-li KUANG Hua DONG Li-yun Shanghai Institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai University Shanghai 200072 China School of Applied Science Taiyuan University of Science and Technology Taiyuan 030024 China college of Physics and Technology Guangxi Normal University Guilin 541004 China

Through considering the connection between microscopic car-following model and macroscopic continuum model, a new viscous vehicular flow model is proposed, in which the viscosity coefficient is determined by a more realistic constitutive relationship between averaged reaction time of drivers and the car density. Further analysis indicates that two traffic sound speeds in this viscous model may determine the existence and the stability of traveling wave solutions with an analytical method.

关键词： viscosity continuum traffic model reaction time traffic sound speed traveling wave

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Oxidative Coupling:chemistry between Two "Nucleophiles"

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Oxidative Coupling:Chemistry between Two "Nucleophiles"

中国化学会第十届全国有机合成化学学术研讨会

作者： Aiwen Lei college of chemistry and Molecular Sciences,Wuhan university,Hubei,P.R.china,430072

Our research focuses on developing novel and efficient bond-formation methods catalyzed by transition ***,we are interested in the oxidative coupling,which avoids difficult oxidative addition step and makes bonds between two *** an important character of our research,in-depth understanding toward the reactions is the other ***,we revealed a second transmetallation reaction,which could occur in the Pd-catalyzed coupling reaction as a fundamental *** addition, kinetic studies in our laboratory quantitatively disclosed the rate ofreductive elimination of Csp-Ni-Csp.

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溶胶-凝胶法合成稀土铁氧体过程中的相变与形成机制

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中国稀土学报 2001年第3期19卷 278-280页

作者：甘树才洪广言张军车平唐娟长春科技大学化学系吉林长春130026 中国科学院长春应用化学研究所稀土化学与物理开放研究室吉林长春130022

利用元素相态分析、X射线衍射分析和红外光谱分析等多种测试技术对溶胶凝胶法合成稀土六方铁氧体过程中的相态变化进行剖析 ,并对掺加La后稀土铁氧体的形成机制作初步探讨。干凝胶在焙烧过程中 ,由金属柠檬酸配合物发生碳酸铁、Fe2 O... 详细信息

利用元素相态分析、X射线衍射分析和红外光谱分析等多种测试技术对溶胶凝胶法合成稀土六方铁氧体过程中的相态变化进行剖析 ,并对掺加La后稀土铁氧体的形成机制作初步探讨。干凝胶在焙烧过程中 ,由金属柠檬酸配合物发生碳酸铁、Fe2 O3与铁酸钡、六方铁氧体和γ Fe2 O3等相变反应。La3+取代Ba2 +晶格位置的同时 ,通过缺陷结构发生电荷转移 ,使Fe3+还原成Fe2 + 。

关键词：溶胶-凝胶法稀土六方铁氧体相变合成形成机制

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Integrated Intelligent Fault Diagnosis Approach to TE Process

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Integrated Intelligent Fault Diagnosis Approach to TE Proces...

第二十九届中国控制会议

作者： YANG Qing 1,2,TIAN Feng 2,WU Dongsheng 1,2,WANG Dazhi 1,3 1.college of Optical and Electronical Information,changchun university of Science and Technology,changchun 130022,P.R.china2.School of Information Science and Engineering,Shenyang Ligong university,Shenyang 110159,P.R.china 3.college of Information Science and Engineering,Northeast university,Shenyang 110004,P.R.china

An integrated algorithm based on lifting wavelets and probabilistic neural network（LWPNN）for classifying the industrial system faults was presented in this *** the data were preprocessed to remove noise by lifting scheme wavelets,which were faster than first generation wavelets,and then PNN was used to diagnose *** validate the performance and effectiveness of the proposed scheme,LWPNN was applied to diagnose the faults in TE *** studies showed that the proposed algorithm not only provided an accepted degree of accuracy in fault classification under different fault conditions,but also was reliable,fast and computationally efficient tool.

关键词： Fault Detection and Diagnosis LWPNN Lifting wavelets Intelligent Fault Diagnosis TE process

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基于改进移动极限常数的变密度拓扑优化方法

科学技术创新 2024年第2期 5-8页

作者：刘强郑吉霖西安石油大学机械工程学院陕西西安

为提高基于变密度法的拓扑优化模型的迭代速度,将模型中的极限移动常数,改进为随单元密度变动的变量。结果表明:改进后,在目标函数变动微小的情况下,极大地提高了模型的迭代速率。可见此种方法,有效地改进了拓扑优化模型,具有可行性。

关键词：变密度法拓扑优化移动极限常数变量

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Inhibitory effect of dendroaspis natriuretic peptide on spontaneous contraction in gastric antral circular smooth muscles of guinea pigs

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Acta Pharmacologica Sinica 2007年第11期28卷 1797-1802页

作者： Hui-shu GUO~(2,5),Zheng-xu CAI~3,Tai-hua WU~2,Jing XU~3,Yang QIU~2,Wen-xie XU~4~2 Centralab and ~3 Department of Neurology,The Fist Affiliated Hospital of Dalian Medical university,Dalian 116011,china ~4 Department ofPhysiology Shanghai Jiao Tong university Medical college,Shanghai 200240,china lab and Department of Neurology The Fist Affiliated Hospital of Dalian Medical University Dalian 116011 China. guohuishu1@***.

Aim:To determine whether the natriuretic peptide receptor (NPR) is present in thestomach of guinea pigs and to investigate the effect of dendroaspis natriureticpeptide (DNP) on the gastric motility of guinea pigs and its ***:The distribution of the NPR was analyzed by *** spon-taneous contraction of gastric antral circular muscles of guinea pigs was recordedby a 4-channel *** whole cell patch-clamp technique was intro-duced to record calcium-activated potassium currents in the gastric myocytesisolated by ***:The NPR existed in the gastric fundus,gastricbody,and gastric antrum of guinea pigs,and its density was largest in the *** inhibited spontaneous contraction and exhibited a *** DNP-induced inhibition was diminished by LY83583 (a guanylatecyclase inhibitor) and was potentiated by zaprinast (a cGMP-sensitivephosphoesterase inhibitor).The inhibitory effect of DNP on spontaneous con-traction was also inhibited by tetraethylammonium (a non-selective potassiumchannel blocker);10 nmol/L DNP increased the calcium-activated potassium cur-rents in the gastric circular myocytes of guinea ***:The NPR ismost common in the gastric antrum of guinea *** significantly inhibitsgastric motility in the gastric antrum of guinea *** inhibitory effect occursvia a cGMP-dependent pathway,and a calcium-activated potassium channel maybe also involved in the relaxation induced by DNP in gastric antral circular smoothmuscles.

关键词： dendroaspis natriuretic peptide motility natriuretic peptide receptor spontaneous contraction