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5-Hydroxydecanoate inhibits proliferation of hypoxic human pulmonary artery smooth muscle cells by blocking mitochondrial KATP channels

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Acta Pharmacologica Sinica 2007年第10期28卷 1531-1540页

作者： Tao WANG~2,Zhen-xiang ZHANG~(2,4),Yong-jian XU~2,Qing-hua HU~3~2 Department of Respiratory Medicine,Tongji Hospital,Tongji Medical college,Huazhong university of science and technology,Wuhan430030,china ~3 Key Laboratory of Pulmonary Diseases of the Ministry of Health of china and Department of Pathophysiology,TongjiMedical college,Huazhong university of science and technology Wuhan 430030,china Department of Respiratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Key Laboratory of Pulmonary Diseases of the Ministry of Health of china and Department of Pathophysiology Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:To study the effect of 5-hydroxydecanoate （5-HD） on the proliferation of 24h hypoxic human pulmonary artery smooth muscle cells （HPASMC） and to explorethe pharmacological mechanisms of 5-HD as an inhibitor of mitochondrial mem-brane ATP-sensitive potassium channel ***:Normoxic or hy-poxic HPASMC in culture were stimulated by either diazoxide or 5-HD for 24 *** proliferation of HPASMC was examined by 3-（4,5-dimethyl-2-thiazol-yl）-2,5-diphenyl-2H-tetrazolium bromide （MTT） assay and proliferating cell nuclear anti-gen （PCNA） immunohistochemistry *** apoptosis of HPASMC wasassessed by terminal deoxynucleotidyl transferase-mediated dUTP nick end la-beling （TUNEL） assayand flow cytometric *** relative changes inmitochondrial membrane potential （ΔΨm） were measured using the rhodamine fluo-rescence （R-123） ***:Both hypoxia and diazoxide stimulationincreased ΔΨmvalue measured by the absorbance of MTT,PCNA-positive stain-ing and decreased TUNEL-positive staining and apoptotic cells in *** and the concomitant stimulation of diazoxide obviously enhanced theeffects of hypoxia or diazoxide alone.5-HD significantly attenuated the effects ineach of the above ***,5-HD partially inhibited the effect ofhypoxia on R-123 fluorescence intensity in ***:5-HD caninhibit the proliferation of hypoxic HPASMC by blocking mitochondrial KATPchannels.

关键词： pulmonary artery smooth muscle cell hypoxia 5-hydroxydecanoate mitochondrial membrane ATP-sensitive potassium channel

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Photoluminescence Characterization of NASICON Material

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稀有金属材料与工程 2006年第S3期 535-537页

作者： Yuehua He~1 Baofu Quan~1 Ying Wang~2 Chuanhui Cheng~1 Fengmin Liu~1 Biao Wang (1.college of Electronic science and Engineering,Jilin university,Changchun 130012,china) (2.School of Materials science and Engineering,dalian Jiaotong university,dalian 116028,china)

Besides gas sensitivity,NASICON （Na super ion conductor） material has luminescence *** this paper,the photoluminescence properties of NASICON and doped-NASICON material are *** NASICON material was synthesized by conventional sol-gel process,and doped with Er2O3,Tm2O3,Dy2O3,CsCl by 1%,3%,5% （mass ratio）,*** ultraviolet light （325 nm,He-Cd laser） excited luminescent emissions of the resulted powders are recorded *** in the 330 nm to 650 nm *** main peak of the pure NASICON is found at the wavelength of 474 nm （blue light）,the transition energy is 2.616 *** luminescent intensity is weakened obviously after doping with Er2O3and Tm2O3,but is increased after doping with Dy2O3and 3% CsCl.

关键词： photoluminescence NASICON luminescent intensity wavelength

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Knockdown of CD146 reduces the migration and proliferation of human endothelial cells

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Cell Research 2006年第3期16卷 313-318页

作者： Yanyong Kang~(1,3) Fengcai Wang~(1,2) Jing Feng~1 Dongling Yang~1 Xu Yang~3 Xiyun Yan~11 National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of science Beijing 100101,china 2 Chemistry Department,Anyang teacher's college,Anyang 455000,china 3 college of life science,Central china Normal university,Wuhan 430079,china National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Science Beijing China college of life science Central China Normal University Wuhan China Chemistry Department Anyang teacher's College Anyang China

Our previous study has demonstrated that CD 146 molecule is a biomarker on vascular endothelium,which is involvedin angiogenesis and tumor *** the mechanism behind is not *** we have for the first time devel-oped a novel CD146 blockade system using CD146 siRNA to study its function on endothelial *** data showedthat CD146 siRNA specifically blocked the expression of CD146 on both mRNA and protein levels,leading to thesignificant suppression of HUVEC proliferation,adhesion and *** results demonstrate that CD146 playsa key role in vascular endothelial cell activity and angiogenesis,and CD146 siRNA can be used as a new inhibitor foranti-angiogenesis therapy.

关键词： small interfering RNA adhesion molecule CD 146 vascular endothelial cell

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Heterosis and allotriploid advantage between Crassostrea hongkongensis and C. gigas

Heterosis and allotriploid advantage between Crassostrea hon...

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中国动物学会·中国海洋湖沼学会贝类学分会第九次会员代表大会暨第十五次学术讨论会

作者： Yuehuan Zhang~(1,2) Zhaoping Wang~(1,*a) Xiwu Yan~2 Hui Zhang~2 Ruihai Yu~1 1.Ocean university of china,fisheries college,Qingdao 266003 2.college of fisheries and life science,dalian Ocean university,dalian 116023

In theory,the allotritriploids are expected to sterile more so than diploids because of the added burden of gametogenesis in hybrids,which may also have combine desirable traits of to two parental species,increase growth rate,increase environmental tolerances,and increase overall hardiness in culture ***,artificial introduction of allotriploid in *** and *** is potentially required to improve their phenotypic *** replicates were introduced on July 2011 at dalian(Liaoning Province),and each one was consist of two intraspecific families GG (***♀×gigas♂) and HH(***♀×***♂),an interspecific hybridization family HG(***♀×***♂),and an allotriploid family HHG(2n ***♀×In ***♂) by the hypotonic treatment *** and allotriploid advantage of experimental groups were studied for traits such as fertilization and hatching success, survival,larval and juvenile *** egg cleavage rate of HHG group is similar to HG group, and they were significantly smaller than two intraspeicifc *** D larval rate of HHG group was the smallest in these experimental *** heterosis of hybrids was always positive,but no growth heterosis was observed because of genome incompatibility in the whole stage. Allotriploid advantage of survival and growth were both negative in larval stage and positive in juvenile *** analysis confirmed that the HG spat were true hybrids,and that the flow cytometry further to revealed that the HHG cross was all triploids in D larval *** finding suggested that the phenotypic character of the allotriploid HHG with obvious alltriploid advantage was superior to HH and HG,but inferior to GG.

关键词： Crassotrea gigas C.hongkongensis heterosis allotriploid

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Sufficient and necessary conditions for Lyapunov stability of Lorenz system and their application

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science china(Information sciences) 2010年第8期53卷 1574-1583页

作者： LUO Qi 1 , LIAO XiaoXin 2 & ZENG ZhiGang 2 1 college of Information and Control, Nanjing university of Information science and technology, Nanjing 210044, china 2 Department of Control science and Engineering, Huazhong university of science and technology, Image Processing and Intelligent Control Key Laboratory of Education Ministry of china, Wuhan 430074, china college of Information and Control Nanjing University of Information Science and Technology Nanjing China Department of Control science and Engineering Huazhong University of Science and Technology Image Processing and Intelligent Control Key Laboratory of Education Ministry of China Wuhan China

The sufficient and necessary conditions for Lyapunov stability of the zero equilibrium point of Lorenz system are discussed, and some brief criteria are presented for globally exponential stability, globally asymptotical stability and instability. Furthermore, the behavior of the non-zero equilibrium point of Lorenz system is also investigated, and several sufficient and necessary conditions are provided for locally exponential stability and instability. The established theorems in this paper develop and extend the existing achievements on Lyapunov stability of Lorenz system. In conclusion, by applying the obtained results, some less conservative feedback-control laws are derived to guarantee the globally exponential stability of the chaos control of Chen system, Lu¨ system, Yang-Chen system and Yu-Xia Li system.

关键词： Lorenz system Lyapunov stability sufficient and necessary condition bifurcation values globally exponential synchronization

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Series-based approximate approach of optimal tracking control for nonlinear systems with time-delay

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Progress in Natural science:Materials International 2008年第12期18卷 1571-1576页

作者： Gongyou Tang~a Mingqu Fan~(a,b) a college of Information science and Engineering,Ocean university of china,Qingdao 266100,china b college of Information and Engineering,Shandong university of science and technology,Jinan 250031,china college of Information science and Engineering Ocean University of China Qingdao 266100 China college of Information and Engineering Shandong University of Science and Technology Jinan 250031 China

The optimal output tracking control (OTC) problem for nonlinear systems with time-delay is *** a series-based approx- imate approach,the original OTC problem is transformed into iteration solving linear two-point boundary value problems without time- *** OTC law obtained consists of analytical linear feedback and feedforward terms and a nonlinear compensation term with an infinite series of the adjoint *** truncating a finite sum of the adjoint vector series,an approximate optimal tracking control law is obtained.A reduced-order reference input observer is constructed to make the feedforward term physically *** exam- ples are used to test the validity of the series-based approximate approach.

关键词： Nonlinear systems Time-delay Tracking control Optimal control Observer

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Clustering-based hyperspectral band selection using sparse nonnegative matrix factorization

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Journal of Zhejiang university-science C(Computers and Electronics) 2011年第7期12卷 542-549页

作者： Ji-ming LI 1,2,Yun-tao QIAN 1 (1 School of Computer science and technology,Zhejiang university,Hangzhou 310027,china) (2 Zhejiang Police college,Hangzhou 310053,china) School of Computer science and technology Zhejiang University Hangzhou China Zhejiang Police college Hangzhou China

Hyperspectral imagery generally contains a very large amount of data due to hundreds of spectral *** selection is often applied firstly to reduce computational cost and facilitate subsequent tasks such as land-cover classification and higher level image *** this paper,we propose a new band selection algorithm using sparse nonnegative matrix factorization (sparse NMF).Though acting as a clustering method for band selection,sparse NMF need not consider the distance metric between different spectral bands,which is often the key step for most common clustering-based band selection *** imposing sparsity on the coefficient matrix,the bands' clustering assignments can be easily indicated through the largest entry in each column of the *** results showed that sparse NMF provides considerable insight into the clustering-based band selection problem and the selected bands are good for land-cover classification.

关键词： Hyperspectral Band selection Clustering Sparse nonnegative matrix factorization

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SYNTHESIS AND CHARACTERIZATION OF PHTHALAZINONE POLY(ARYL ETHER SULFONE KETONE)WITH CARBONYL GROUP

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Chinese Journal of Polymer science 2002年第3期20卷 225-229页

作者： Ying-nan Xuan Yan Gao Yong Huang Xi-gao Jian Laboratory of Cellulose and Lignocellulosics Chemistry Guangzhou Institute of Chemistry Chinese Academy of sciences, Guangzhou 510650 china Institute of Chemistry Chinese Academy of sciences, Beijing 100080 china Department of Polymer science, college of Chemical Engineering dalian university of technology, dalian 116012, china 中科院广州化学所 Laboratory of Cellulose and Lignocellulosics Chemistry CAS Guangzhou 510650 Department of Polymer science College of Chemical Engineering Dalian University of Technology Dalian 116012

A kind of novel heat-resistant, high performance engineering thermoplastic phthalazinone poly(aryl ether sulfone ketone) (PPESK) containing a carboxyl group in its side chain was prepared by the nucleophilic displacement reaction of 4-(4-hydroxylphenyl)- 1 (2H)-phthalazinone with di(4-chlorophenyl) sulfone, 4,4'-difluoro-benzophenone and phenolphthalin in sulfolane in the presence of K2CO3 to produce high molecular weight polymers which can be dissolved in some polar solvents such as chloroform and nitrobenzene at room temperature and can be easily cast into flexible, yellowish and transparent films. PPESK is an amorphous polymer having a decomposition temperature above 400degreesC, which indicates that it has high thermal stability. At the same time, the thermal properties of PPESKs with dicyandiamide (DICY) as curing agent indicated that the heat-resistance properties of the PPESKs are improved after curing. The apparent activation energy (A-E) of the cross-linking reaction and the reaction order (n) of PPESK/DICY were found to be 52.2 kJ/mol and ca. 1.0, respectively. Therefore, the cross-linking reaction is approximately a first order reaction.

关键词： poly(aryl ether sulfone ketone) synthesis active pendant group

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Development of a high-throughput assay for the HIV-1 integrase disintegration reaction

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science china(life sciences) 2010年第2期53卷 241-247页

作者： HE HongQiu,LIU Bin,ZHANG XiaoYi,CHEN WeiZu & WANG CunXin college of life science and Bioengineering,Beijing university of technology,Beijing 100124,china college of life science and Bioengineering Beijing University of Technology Beijing China

Both HIV-1 integrase (IN) and the central catalytic domain of IN (IN-CCD) catalyze the disintegration reaction in *** this study,IN and IN-CCD proteins were expressed and purified,and a high-throughput format enzyme-linked immunosorbent assay (ELISA) was developed for the disintegration *** exhibited a marked preference for Mn2+ over Mg2+ as the divalent cation cofactor in ***,a known IN inhibitor,was found to be an IN-CCD *** assay is sensitive and specific for the study of disintegration reaction as well as for the in vitro identification of antiviral drugs targeting IN,especially targeting IN-CCD.

关键词： HIV-1 integrase IN-CCD disintegration high-throughput assay

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Modelling Immune System:Principles,Models,Analysis and Perspectives

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Journal of Bionic Engineering 2009年第1期6卷 77-85页

作者： Xiang-hua Li~1, Zheng-xuan Wang~1, Tian-yang Lu~2, Xiang-jiu Che~11. college of Computer science and technology, Jilin university, Changchun 130012, P. R. china2. college of Computer science and technology, Harbin Engineering university, Harbin 150001, P. R. china college of Computer science and technology Jilin University Changchun P. R. China college of Computer science and technology Harbin Engineering University Harbin P. R. China

The biological immune system is a complex adaptive *** are lots of benefits for building the model of the immune *** biological researchers,they can test some hypotheses about the infection process or simulate the responses of some *** computer researchers,they can build distributed,robust and fault tolerant networks inspired by the functions of the immune *** paper provides a comprehensive survey of the literatures on modelling the immune *** the methodology perspective,the paper compares and analyzes the existing approaches and models,and also demonstrates the focusing research effort on the future immune models in the next few years.

关键词： immune system modelling agent-based simulation complex adaptive system (CAS) HIV

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