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Estrogen influences the differentiation, maturation and function of dendritic cells in rats with experimental autoimmune encephalomyelitis

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Acta Pharmacologica Sinica 2004年第4期25卷 110-115页

作者： Qing-hong ZHANG2, Yu-zhen HU, Jun CAO3, Yan-qing ZHONG,Yu-feng ZHAO, Qi-bing MEI4 department of physiology, department ofOrthodontics, 3 4department of Pharmacology, The Fourth Military medical university, Xi’an 710032, china department of physiology The Fourth Military Medical University Xi'an 710032 China

AIM: To examine if estrogen can affect the immune response at the dendritic cells (DCs) level in rats with experi- mental autoimmune encephalomyelitis (EAE). METHODS: Lewis rats were immunized with inoculum containing MBP68-86. DCs were derived from spleen monocytes of EAE rats with IL-4 and GM-CSF in presence of 17β- estradiol (E2). Nitric oxide (NO) was detected by Griess reagent. The surface markers and cytokines production of DCs were shown by flow cytometry. DCs were cocultured with MBP-specific T cells, [3H]-TdR incoportation was used to reveal the antigen presentability, the supernatant of the coculture were collected to examine the cytokines secretion by ELISA. RESULTS: E2 activated DCs by accelerating the maturation process characterized by upregulation of MHC II and costimulating molecule B7-1, B7-2, drastic high expression of CD40. IFN-γ–produc- ing DCs were also elevated without any alteration of IL-10. Estradiol-treated DCs (E2-DCs) secreted more NO in the culture supernatant. By contrast, E2-DCs showed decreased antigen presentation ability with reduced secretion of IFN-γ but no alteration of IL-10 in the coculture with T cells. CONCLUSION: Estrogen can affect the differentiation, maturation and function of DCs from EAE rats, which may be attributed to its protection against EAE and the remission of multiple sclerosis patients in pregnancy.

关键词： multiple sclerosis experimental autoimmune encephalomyelitis dendritic cells estrogens nitric oxide

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Exact Controllability and Stabilization of Networkswith an Interior Point Mass

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Systems Science and Systems Engineering 1998年第4期8卷 462-473页

作者： WANG Yaoting LI Shengjia(department of Mathematics, shanxi university, taiyuan 030006 P. R. china)

In this paper we consider the problems of exact controllability and stabilization forone-dimensional wave equation with an interior point mass. Using equivalent norms, we prove that thesystem is energy dissipative. The exact controllability is proven by the "Hilbert Uniform Method"[3].The energy may decay uniformly exponentially and the only equilibrium state is zero one if stabilizers areinstalled at both ends. This result correct the main work of [1]. Several related results for singularitiesare also given.

关键词： vibrating network wave equation boundary control exponential stability

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A new ordered phase forming during ageing in Cu-Ti alloys

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Chinese Science Bulletin 1997年第19期42卷 1671-1672页

作者： WEI Yinghui and WANG Xiaotian1. department of Materials Science, taiyuan university of Technology, taiyuan 030024, china 2. College of Materials Science, Xi’an Jiaotong university, Xi’an 710049, china Ion Beam Laboratory Shanghai Institute of Metallurgy Chinese Academy of Sciences Shanghai 200050 China

AGE-hardened Cu-Ti has been an important alloy of investigation in the field of continuousphase transformation due to its complicated transformation processes which involve short rangeordering (SRO), spinodal decomposition (SD), long range ordering (LRO), etc. So far, ithas been a controversial topic whether each process exists, and in what sequence they pro-ceed.

关键词： Ti Cu A new ordered phase forming during ageing in Cu-Ti alloys

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“有效降低全社会物流成本”研讨会专家观点综述

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中国流通经济 2024年第5期38卷 3-17页

作者：本刊编辑部《中国流通经济》编辑部

2024年2月24日,习近平总书记主持召开中央财经委员会第四次会议,指出物流是实体经济的“筋络”,强调必须有效降低全社会物流成本,增强产业核心竞争力,提高经济运行效率。基于此,2024年4月24日,北京物资学院党委宣传部、杂志社、科研处... 详细信息

2024年2月24日,习近平总书记主持召开中央财经委员会第四次会议,指出物流是实体经济的“筋络”,强调必须有效降低全社会物流成本,增强产业核心竞争力,提高经济运行效率。基于此,2024年4月24日,北京物资学院党委宣传部、杂志社、科研处联合主办了“有效降低全社会物流成本”研讨会。本次研讨会邀请我国流通物流领域的专家学者,围绕物流服务实体经济和人民群众、物流成本构成、交通运输体系改革、统一高效物流市场构建和现代商贸流通体系完善等问题,发表观点,为探索有效降低全社会物流成本可行路径,构建现代流通体系提供理论支持和实践指导。本刊编辑部对专家阐述的主要观点进行了归纳整理,以飨读者。

关键词：全社会社会物流成本新质生产力流通体系降本增效

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Protein transduction domain of membrane penetrating peptide can efficiently deliver DNA and protein into mouse liver for gene therapy

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 90-93页

作者： Jun Xie, Bao-Feng Yu, Jun Xu, Yue-Hong Zhang, Niu-Liang Cheng, Bo Niu, Xiao-Nian Hu, Qian Xiang and Zheng-Guo Zhang taiyuan, china department of Biochemistry and Molecular Biology, shanxi medical university, taiyuan 030001 , china Peking Union medical College, Chi- nese Academy of medical Sciences, Beijing 100005, china department of Biochemistry and Molecular Biology Shanxi Medical University Taiyuan 030001 China. xiejunty@***

BACKGROUND: The development of a harmless and effi- cient nonviral gene delivery system that can facilitate the penetration of nucleic acids through the plasma membrane is a key to successful gene therapy. The aim of this study was to test a nonviral gene transferring vector's function of delivering DNA into liver cells to provide an important clue for gene transfer in liver gene therapy. METHODS: The complex of DNA and DNA delivering protein was injected into mice through their tail veins. Then the mice were killed and their liver tissue was sec- tioned. The gene transferring results were detected using a confocal laser scanning microscope. RESULTS: Fluorescence analysis indicated that both DNA- membrane penetrating peptide (MPP) complex and DNA- hepatocyte specific receptor binding domain ( HSRBD) - MPP complex could go into liver cells. The fluorescence value of liver cells in the DNA-HSRBD-MPP group was higher than that in the DNA-MPP group. CONCLUSIONS; MPP can successfully deliver DNA and protein into cells, and MPP with a HSRBD can specifically deliver DNA into liver cells. These have laid a foundation for further study on the nonviral liver cell gene delivering system.

关键词： membrane penetrating peptide gene therapy gene delivering

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Density functional study on enantioselective reduction of keto oxime ether with borane catalyzed by oxazaborolidine

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Science china Chemistry 2006年第4期49卷 296-307页

作者： LI Ming1, ZHENG Wenxu2 & TIAN Anmin2 1. department of Chemistry, Southwest-china Normal university, Chongqing 400715, china 2. department of Chemistry, Sichuan university, Chengdu 610064, china 1. department of Chemistry Southwest-China Normal University Chongqing 400715 China 2. department of Chemistry Sichuan University Chengdu 610064 China

The enantioselective reduction of keto oxime ether with borane catalyzed by oxazaborolidine is discussed by the density functional theory (DFT) method. The main intermediates and transition states for this reaction are optimized completely at the B3LYP/6-31g(d) level, and the transition states are verified by vibrational modes. As shown, the chirality-controlled steps for this re- action are the hydride transfer from borane to carbonyl carbon and oxime carbon of keto oxime ether, and the chirality for the reduced products is determined in these two reaction steps. In all examined reaction paths, the first hydride is transferred via a six-membered ring and the second hydride via a five-membered ring or a four-membered ring.

关键词： keto oxime ether, oxazaborolidine, enantioselective reduction, DFT.

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Binding of PLCδ1PH-GFP to Ptdlns(4,5)P2 prevents inhibition of phospholipase C-mediated hydrolysis of Ptdlns(4,5)P2 by neomycin

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Acta Pharmacologica Sinica 2005年第12期26卷 1485-1491页

作者： Chuan WANG Xiao-na DU Qing-zhong JIA Hai-lin ZHANG~2 department of Pharmacology Hebei medical university,Shijiazhuang 050017,china department of Pharmacology Hebei Medical University Shijiazhuang China

Aim:To investigate the effects of the pleckstrin homology(PH)domain of phos-pholipase Cδ1(PLCδ1PH)on inhibition of phospholipase C(PLC)-mediated hy-drolysis of phosphatidylinositol 4,5-bisphosphate[PtdIns(4,5)P2]by ***:A fusion construct of green fluorescent protein(GFP)and PLCδ1PH(PLCδ1PH-GFP),which is known to bind PtdIns(4,5)P2specifically,together withlaser-scanning confocal microscopy,was used to trace PtdIns(4,5)***:Stimulation of the type 1 muscarinic receptor and the bradykinin 2 recep-tor induced a reversible PLCδ1PH-GFP translocation from the membrane to thecytosol in COS-7 *** inhibitor U73122 blocked the ***,a known PtdIns kinase inhibitor,did not affect the translocationinduced by ACh,but blocked recovery after translocation,indicating thatPtdIns(4,5)P2hydrolysis occurs through receptor-mediated PLC ***,a commonly used phospholipase C blocker,failed to block the recep-tor-induced PLCδ1PH-GFP translocation,indicating that neomycin is unable toblock PLC-mediated Ptdlns(4,5)Pe ***,in the absence of PLCδ1PH-GFP expression,neomycin abolished the receptor-induced hydrolysis ofPtdIns(4,5)P2 by ***:Although PLCδ1PH and neomycin bind toPtdIns(4,5)P2 in a similar way,they have distinct effects on receptor-mediatedactivation of PLC and PtdIns(4,5)P2 hydrolysis.

关键词： phosphatidylinositol 4,5-bisphosphate neomycin phospholipase C pleckstrin homology domains competitive binding acetylcholine green fluorescent proteins

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Sharpness on the Lower Bound of the Lifespan of Solutions to Nonlinear Wave Equations

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Chinese Annals of Mathematics,Series B 2011年第4期32卷 521-526页

作者： Yi ZHOU 1 Wei HAN 2 1 Nonlinear Mathematical Modeling and Methods Laboratory Shanghai Key Laboratory for Contem- porary Applied Mathematics School of Mathematical Sciences, Fudan university, Shanghai 200433, china. 2 School of Mathematical Sciences, Fudan university, Shanghai 200433, china department of Mathematics, North university of china, taiyuan 030051, china. Nonlinear Mathematical Modeling and Methods Laboratory Shanghai Key Laboratory for Contemporary Applied Mathematics School of Mathematical Sciences Fudan University Shanghai 200433 China

This paper is devoted to proving the sharpness on the lower bound of the lifespan of classical solutions to general nonlinear wave equations with small initial data in the case n = 2 and cubic nonlinearity （see the results of T. T. Li and Y. M. Chen in 1992）. For this purpose, the authors consider the following Cauchy problem： { where □=δt^2-∑i=1n δx^^2 is the wave operator, g（x）（≡/） 0 is a smooth non-negative function with compact support, and ε 〉 0 is a small parameter. It is shown that the solution blows up in a finite time, and the lifespan T（ε） of solutions has an upper bound T（ε） ≤ exp（Aε-2） with a positive constant A independent of ε, which belongs to the same kind of the lower bound of the lifespan.

关键词： Nonlinear wave equation Cauchy problem Lifespan

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On the Cayley-Bacharach property and the construction of vector bundles

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Science china Mathematics 2011年第9期54卷 1891-1898页

作者： SUN Hao 1,2 1 department of Mathematics and Statistics,Huazhong Normal university,Wuhan 430079,china 2 department of Mathematics,East china Normal university,Shanghai 200241,china 1. department of Mathematics and Statistics Huazhong Normal University Wuhan 430079 China2. Department of Mathematics East China Normal University Shanghai 200241 China

We study the Cayley-Bacharach property on complex projective smooth varieties of dimension n≥2 for zero dimensional subscheme defined by the zero set of the wedge of r-n + 1 global sections of a rank r≥n vector bund... 详细信息

关键词： Cayley-Bacharach property vector bundle reflexive sheaf k-very ample

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Robustness and breakup of the spiral wave in a two-dimensional lattice network of neurons

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Science china(Physics,Mechanics & Astronomy) 2010年第4期53卷 672-679页

作者： MA Jun 1,2, TANG Jun 2 , ZHANG AiHua 3 & JIA Ya 2 1 department of Physics, Lanzhou university of Technology, Lanzhou 730050, china 2 department of Physics, Central china Normal university, Wuhan 430079, china 3 College of Electrical and Information Engineering, Lanzhou university of Technology, Lanzhou 730050, china 1. department of Physics Lanzhou University of Technology Lanzhou 730050 China2. Department of Physics Central China Normal University Wuhan 430079 China3. College of Electrical and Information Engineering Lanzhou University of Technology Lanzhou 730050 China

The robustness and breakup of spiral wave in a two-dimensional lattice networks of neurons are investigated. The effect of small- world type connection is often simplified with local regular connection and the long-range connection with certain probability. The network effect on the development of spiral wave can be better described by local regular connection and changeable long-range connection probability than fixed long-range connection probability because the long-range probability could be changeable in realistic biological system. The effect from the changeable probability for long-range connection is simplified by multiplicative noise. At first, a stable rotating spiral wave is developed by using appropriate initial values, parameters and no-flux boundary conditions, and then the effect of networks is investigated. Extensive numerical studies show that spiral wave keeps its alive and robust when the intensity of multiplicative noise is below a certain threshold, otherwise, the breakup of spiral wave occurs. A statistical factor of synchronization in two-dimensional array is defined to study the phase transition of spiral wave by checking the membrane potentials of all neurons corresponding to the critical parameters(the intensity of noise or forcing current)in the curve for factor of synchronization. The Hindmarsh-Rose model is investigated, the Hodgkin-Huxley neuron model in the presence of the channel noise is also studied to check the model independence of our conclusions. And it is found that breakup of spiral wave is easier to be induced by the multiplicative noise in presence of channel noise.

关键词： spiral wave factor of synchronization breakup multiplicative noise robustness

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