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Altered Endothelial Modulation of Vasoconstriction to Alphal Adrenoceptor Autoantibodies in Spontaneously Hypertensive Rats:a Potential Mechanism for Primary Hypertension Development

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Altered Endothelial Modulation of Vasoconstriction to Alphal...

Confocal microscopic evaluation of cornea after AquaLase liquefaction cataract extraction

第八届海峡两岸心血管科学研讨会

作者： Li YAN~1,Yun-hui DU~2,Zhong-mei HE~3,Hui-rong LIU~(2,3),Ji-min CAO~1 (1.department of physiology and Pathophysiology,Institute of Basic medical Sciences Chinese Academy of medical Sciences,School of Basic medical Sciences Peking Union medical College,Beijing 100005,china 2.department of Pathophysiology,School of Basic medical Sciences, Capital medical university,Beijing 100069,china. 3.department of physiology, shanxi medical university,taiyuan 030001,china)

Objective Primary or secondary activation of immune mechanisms has been implicated in the pathogenesis of ***,hypertensive patients have been found to have high levels of the autoantibody against the second extracellular loop of alphal - adrenoceptor(α- AR autoantibody,α- AA), which exertα - AR agonist - like vasoconstrictive ***,whether the vasoconstrictive effect ofα - AA is enhanced in hypertension with concomitantly decreased endothelial function is *** The present study utilized isolated aortic rings from spontaneously hypertensive rats(SHRs) and control normotensive Wistar - Kyoto(WKY) rats to perform vascular reactivity *** nitrotyrosine content was measured by *** Aortic contractile responses to phenylephrine(1 nM - 100 mM) andα - AA (1 nM - 100 mM) were greater in SHRs than in *** endothelium denudation and non - selective NOS inhibitor L- NAME(100μM) further increased phenylephrine - andα- AA - induced vasoconstriction in both SHRs and ***,the selective iNOS inhibitor 1400W(10 mM) enhancedα - AA -induced aortic constriction in control,but not *** aortic nitrotyrosine content was significantly increased compared to *** These results demonstrate that decreased endothelial vasodilatory function and decreased NO bioavailability contribute to the increased SHR arterial contractile responsiveness toα - AA,suggestive of a potential mechanism for hypertension development in patients harboring highα -AA levels.

关键词： alphal-adrenoceptor Inos α1-AA

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 293-297页

作者： Jiang-Yue Zhao 1,Ming-Wu Wang 2,Qi Sun 1,Jin-Song Zhang 1 1 Eye Hospital of china medical university department of Ophthalmology,the Fourth Affiliated Hospital of china medical university Provincial Key Laboratory of Lens Research,Liaoning,china 2 department of Ophthalmology and Vision Science,the university of Arizona,Tucson,Arizona,USA Eye Hospital of china medical university department of Ophthalmology the Fourth Affiliated Hospital of China Medical University Provincial Key Laboratory of Lens Research Liaoning China department of Ophthalmology and Vision Science the University of Arizona Tucson Arizona USA

AIM: The most recent and innovative AquaLase liquefaction technology has offered an alternative to lens extraction. Many studies have investigated its functions and advantages. This article focuses on evaluating the vivo microscopic cornea changes after AquaLase liquefaction by using a laser confocal microscope. METHODS: In this perspective, randomized case study, 37 eyes of 35 patients submitted to cataract surgery were chosen to undergo AquaLase liquefaction cataract extraction. Each patient was assessed before the operation, on the 1(st), 7(th), and 30(th) postoperative days, and 6 months after the cataract extraction. The morphologies and quantitative comparisons of corneal cells and corneal nerves layer by layer were evaluated in vivo with the Heidelberg Retina Tomograph III-Rostock Cornea Module (HRT-III RCM) confocal microscope. ANOVA and Post-Hoc Bonferroni test were carried out to compare the results pre- and post-operation. RESULTS: ANOVA results indicated no post-operation changes for epithelium and anterior stroma cells. Irregular segments of sub-basal nerve fiber were most pronounced seven days post-operation. In the mid and posterior stroma, keratocytes were obvious compared with the preoperative condition. Corneal endothelium cells became obviously swollen in cytoplasm and nucleus. The mid and posterior stroma cell density decreased from the 1(st) to 7(th) postoperative days (P < 0.05). The corneal endothelium cell density decreased (P < 0.05) and did not revert to the preoperative level after six months (P < 0.05). CONCLUSION: Slight microstructural abnormalities were identified in the corneal recovery process after AquaLase liquefaction. AquaLase liquefaction cataract extraction is safe for cornea.

关键词： aquaLase liquefaction cataract cornea changes

The cloning of 3'-truncated preS/S gene from HBV genomic DNA and its expression in transgenic mice

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World Journal of Gastroenterology 2000年第5期6卷 734-737页

作者： Yi Ping Hu~1 Yu Cheng Yao~1 Jian Xiu Li~1 Xin Min Wang~1 Hong Li~2 Zhong Hua Wang~1 Zhang Heng Lei~3 1 department of Cell Biology,Second Military medical university,Shanghai 200433,china 2 department of Biology,department of Basic Medicine,West-china university of medical Sciences,Chengdu 610041,china 3 department of Biology,North Sichuan medical College,Nanchong 637007,china 第二军医大学上海华西医科大学四川成都川北医学院四川

INTRODUCTIONHepatitis B virus (HBV) is regarded as one of themain etiologic factors involved in the developmentof human hepatocellular carcinoma (HCC).The open reading frame (orf)of X gene of HBVencoded a transactivating factor is the evidence thatstrongly supported the notion that the X gene ofHBV DNA integrated in HCC genomic DNA couldcontribute to the carcinogenesis of liver cells byactivation of some related cellular genes

关键词： hepatitis B virus gene expression mice transgene polymerase chain reaction DNA recombinant hepatoma

Glutamate activated spinal astrocytes are involved in the thermal hyperalgesia

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Glutamate activated spinal astrocytes are involved in the th...

Microwave peak absorption frequency of liquid

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Rui-Hong SHI,Xin ZHAO,Ce ZHANG~* department of physiology National Key Disciplines,Key Laboratory for Cellular physiology of Ministry of Education,shanxi medical university,taiyuan 030001,china

＜正＞Objective Numerous evidence suggests that spinal astrocytes play an important role in chronic pain through release of neuroactive substances,such as interleukin and *** produces marked effects in initiation and transmission of nociceptive ***,there is a lack of direct evidence that how glutamate activate astrocytes and what’s effects of activated astrocytes by glutamate on pain *** study therefore explored the direct effects of glutamate activation of spinal *** Primary culture of spinal astrocytes were administered with *** levels of protein and mRNA expression of IL-6,which reflect astrocyte activation, were determined by ELISA assay and real-time *** spinal astrocytes activated by glutamate were injected into the lumber enlargement of adult Wistar rats,and paw withdrawal latency（PWL） was *** Administration of glutamate（1 000 uM） activated astrocytes from 6 h after intrathecal injection and reached the maximal level at 24 h（the last time point we explored）.Besides,glutamate（1 000 uM） enhanced the release of IL-6 by astrocytes. Intrathecal injection of cultured spinal astrocytes,which were stimulated by glutamate,induced a substantial decrease of PWL,indicating the development of thermal *** Our results suggest that activated astrocytes by glutamate is sufficient to produce thermal hyperalgesia in rats by releasing IL-6.

关键词： glutamate spinal astrocyte thermal hyperalgesia IL-6

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Science china(Physics,Mechanics & Astronomy) 2008年第9期51卷 1254-1263页

作者： HAN GuangZe1 & CHEN MingDong2 1 department of Physics,South china university of Technology,Guangzhou 510640,china 2 Guangzhou Auto College,South china university of Technology,Guangzhou 510800,china 1. department of Physics South China University of Technology Guangzhou 510640 China 2. Guangzhou Auto College South China University of Technology Guangzhou 510800 China

Microwave-assisted extraction is a new effective method which has practical ap-plications in many fields. Microwave heating is one of its physical mechanisms,and it also has the characteristic of selectivity. When the applied microwave fre-quency equals a certain absorption frequency of the material (or specific compo-nent),the material will intensively absorb microwave energy. This is also known as resonant absorption,and the frequency is called the peak absorption frequency which depends on the physical structure of the material. In this work,dynamic hy-drogen bond energy was included in molecular activation energy; with the liquid cell model,the expression of interaction energy between dipolar molecules was derived. The rotational relaxation time was gotten from the Eyring viscosity formula. Then based on the relationship between dielectric dissipation coefficient and re-laxation time,the expression of microwave peak absorption frequency as a func-tion of the material physical structure,rotational inertia and electrical dipole mo-ment of molecules was established. These theoretical formulas were applied to water and benzene,and the calculated results agree fairly well with the experi-mental data. This work can not only deepen the study of the interaction between microwave and material,but also provide a possible guide for the experiment of microwave-assisted extraction.

关键词： microwave-assisted extraction microwave heating relaxation time liquid viscosity peak absorption fre-quency

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Different-Periodic Travelling Wave Solutions for Nonlinear Equations

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Communications in Theoretical Physics 2004年第4期41卷 481-486页

作者： YE Li-Jun~1 LIN Ji~(1,2)1 department of Physics,Zhejiang Normal university,Jinhua 321004,china2 Physics department,Shanghai Jiao Tong university,Shanghai 200030,china Physics department Shanghai Jiao Tong University Shanghai 200030 China

Using Jacobi elliptic function linear superposition approach for the(1+1)-dimensional Caudrey-Dodd-Gibbon-Sawada-Kotera(CDGSK)equation and the(2+1)-dimensional Nizhnik-Novikov-Veselov(NNV)equation,many new periodic travelling wave solutions with different periods and velocities are obtained based on the knownperiodic *** procedure is crucially dependent on a sequence of cyclic identities involving Jacobi ellipticfunctions sn(ξ,m),cn(ξ,m),and dn(ξ,m).

关键词： linear superposition nonlinear equation travelling wave solution

Research advance on interstitial lung disease be complicated by connective tissue disease

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Research advance on interstitial lung disease be complicated...

A mutation in signal peptide of rat resistin gene inhibits differentiation of 3T3-L1 preadipocytes

The 8th International Congress on SLE

作者： Gao Hui-ying Li Xiao-feng department of Rheumatology the Second Hospital shanxi medical university taiyuan 030001 china

＜正＞Connective Tissue Disease（CTD）includes many diseases. For instance,Lupus Erythematosus,Scleroderma, Rheumatoid Arthritis,Sjogren Syndrome,Dermatomyositis/ Multiple Myositis and *** Lung Disease can always be d...

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Acta Pharmacologica Sinica 2004年第12期25卷 139-145页

作者： Xi-rong GUO2,3, Hai-xia GONG2, Yan-qin GAO4, Li FEI, Yu-hui NI, Rong-hua CHEN department of Pediatrics, Center of Human Functional Genomics, Nanjing medical university, Nanjing 210029, china 4department of Pediatrics, the Third Affiliated Hospital of Nanjing medical university, Yizheng 211900, china department of Pediatrics Center of Human Functional Genomics Nanjing Medical University department of Pediatrics the Third Affiliated Hospital of Nanjing Medical University

AIM: To detect the resistin expression of white adipose tissue in diet-induced obese (DIO) versus diet-resistant (DR)rats, andto investigatethe relationshipof mutatedresistin and 3T3-L1 preadipocytes differentiation. METHODS: RT-PCR and Western Blot were used to detect gene /protein expression. 3T3-L1 cells were cultured, transfected, and induced to differentiation using 0.5 mmol/L 3-isobutyl-1-methyxanthine (MIX), 1 mg/L insulin, and 1 μmol/L dexamethasone. Oil red O staining was applied to detect the degree of preadipocytes differentiation. RESULTS: Expression of resistin mRNA was upregulated in DIO rats and downregulated in DR rats. However, the expression levels varied greatly within the groups. Sequencing of the resistin genes from DIO and DR rats revealed a Leu9Val (C25G) missense mutation within the signal peptide in one DR rat. The mutant resistin inhibited preadipocyte differentiation. Local experiments and Western blotting with tagged resistin fusion proteins identified both mutant and wild type proteins in the cytoplasm and secreted into the culture medium. Computer predictions using the Proscan and Subloc programs revealed four putative phosphorylation sites and a possible leucine zipper motif within the rat resistin protein. CONCLUSION: Resistin-increased differentiation may be inhibited by the mutation- containing precursor protein, or by the mutant non-secretory resistin isoform.

关键词： resistin mutation adipocyte differentiation obesity

Asymptotic Behavior of Slender Flying Vehicle with a Finite Controller

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Systems Science and Systems Engineering 1996年第2期6卷 246-249页

作者： LI Shengjia(department of Mathematics, shanxi university, taiyuan, china, 030006)YU Jiangyuan(Istitute of information and Control, Beijing , china, 100037)

In this paper, it is proved that there exists a finite controller such that the aymptoticbehavior of a slender space vehicle with the effect of aerodynamic power exponentially stablizes to atable state.

关键词： beam equation finite control exponential stability.

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