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Journal of Iron and Steel Research International 2011年第S1期18卷 350-354页

作者： XU Lei 1,liu Guo-quan 2,NIE yu-zhu 1,wang Xue-hui 1,MA E 1 (1.Hebei Iron and Steel Technology Research Institute,shi Jiazhuang 050021,Hebei,China 2.School of Materials Science and Engineering /State Key Laboratory for Advanced Metals and Materials,University of Science and Technology Beijing,Beijing 100083,China) Hebei Iron & Steel Technol Res Inst Shijiazhuang 050021 Hebei Peoples R China Univ Sci & Technol Beijing Sch Mat Sci & Engn State Key Lab Adv Met & Mat Beijing 100083 Peoples R China

For a V-Ti-N microalloyed steel with 0.34%C-1.54%Mn,intragranular ferrite (IGF) was obtained in both isothermal austenite decomposition processes and thermomechanical processes simulating the industrial seamless tubing manufacture *** show that with decrease of the isothermal temperature in range of 600℃ down to 450℃,not only the morphology of IGF changed from equiaxed to acicular,but also the equiaxed IGF and the acicular IGF were *** importantly,it is found that the amount of equiaxed ferrite increased significantly in the thermomechanical process sample water quenched from 550℃ after 800℃ deformation than that in the isothermally treated sample at 550℃ sample without hot *** implies that appropriate controlled deformation with controlled cooling can significantly promote equiaxed IGF formation,and not solely rely on nucleation mechanisms related with *** deformation of austenite without dynamic and complete static recrystallization causes high energy regions,therefore further promotes the nucleation potency of IGF.

关键词： V-Ti-N microalloyed steel intragranular ferrite (IGF) isothermal treatment thermomechanical processes controlled cooling

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin liu yu shi Haoxue wang Lijie Huang Su Zhang Ruixin Zhang Song wang Guangxu Lu Peifu Tang Zhongyang liu Kai wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

TM9SF1 promotes bladder cancer cell growth and infiltration

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World Journal of Clinical Oncology 2024年第2期15卷 302-316页

作者： Long Wei shi-Shuo wang Zhi-Guang Huang Rong-quan He Jia-yuan Luo Bin Li Ji-Wen Cheng Kun-Jun Wu yu-Hong Zhou shi liu Sheng-Hua Li Gang Chen Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Bladder cancer(BC)is the most common urological *** has a high recur-rence rate,displays tutor heterogeneity,and resists ***,the long-term survival rate of BC patients has remained unchanged for decades,which seriously affects the quality of patient *** improve the survival rate and prognosis of BC patients,it is necessary to explore the molecular mechanisms of BC development and progression and identify targets for treatment and *** 9 superfamily member 1(TM9SF1),also known as MP70 and HMP70,is a member of a family of nine transmembrane superfamily proteins,which was first identified in ***9SF1 can be expressed in BC,but its biological function and mechanism in BC are not *** To investigate the biological function and mechanism of TM9SF1 in *** of TM9SF1 increased the in vitro proliferation,migration,and invasion of BC cells by promoting the entry of BC cells into the G2/M *** of TM9SF1 inhibited in vitro proliferation,migration,and invasion of BC cells and blocked BC cells in the G1 *** TM9SF1 may be an oncogene in BC.

关键词： TM9SF1 Bladder cancer Biological function Cell function assay Oncogene

Digitization of Astronomical Photographic Plates of China and Astrometric Measurement of Single-exposure Plates

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Research in Astronomy and Astrophysics 2024年第5期24卷 103-116页

作者：商正君于涌王亮亮杨美婷杨静沈世银刘敏徐权峰崔辰州樊东卫唐正宏赵建海 Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China Key Lab for Astrophysics Shanghai200234China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Astronomical Data Center Chinese Academy of SciencesBeijing 100101China

From the mid-19th century to the end of the 20th century, photographic plates served as the primary detectors for astronomical observations. Astronomical photographic observations in China began in 1901, and over a century, a total of approximately 30,000 astronomical photographic plates were captured. These historical plates play an irreplaceable role in conducting long-term, time-domain astronomical research. To preserve and explore these valuable original astronomical observational data, Shanghai Astronomical Observatory has organized the transportation of plates, taken during nighttime observations from various stations across the country, to the Sheshan Plate Archive for centralized preservation. For the first time, plate information statistics were calculated. On this basis, the plates were cleaned and digitally scanned, and finally digitized images were acquired for 29,314 plates. In this study, using Gaia DR2 as the reference star catalog, astrometric processing was carried out successfully on 15,696 single-exposure plates, including object extraction, stellar identification,and plate model computation. As a result, for long focal length telescopes, such as the 40 cm double-tube refractor telescope, the 1.56 m reflector telescope at Shanghai Astronomical Observatory, and the 1m reflecting telescope at yunnan Astronomical Observatory, the astrometric accuracy obtained for their plates is approximately 0."1–0."3. The distribution of astrometric accuracy for medium and short focal length telescopes ranges from 0."3 to 1."0. The relevant data of this batch of plates, including digitized images and a stellar catalog of the plates, are archived and released by the National Astronomical Data Center. Users can access and download plate data based on keywords such as station, telescope, observation year, and observed celestial coordinates.

关键词： methods data analysis-techniques image processing-astronomical databases miscellaneous-astrometry

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蛋白质组学推动慢性鼻窦炎异质性图谱构建

中华耳鼻咽喉头颈外科杂志 2024年第6期59卷 636-643页

作者：叶方舟王丽李光耀史俊峰刘全余洪猛复旦大学附属眼耳鼻喉科医院耳鼻咽喉科上海200031 中国医学科学院内镜下鼻颅底肿瘤外科治疗技术创新单元(2018RU003) 上海200031

慢性鼻窦炎(CRS)是一类累及鼻和鼻窦的慢性炎性疾病,患病率高,显著影响人群生活质量。而CRS异质性强,临床诊疗策略却趋于同质,其治疗策略亟待个体化、精准化发展。近年,生物大数据蓬勃发展,高通量测序技术更是推动着组学研究不断深入,... 详细信息

慢性鼻窦炎(CRS)是一类累及鼻和鼻窦的慢性炎性疾病,患病率高,显著影响人群生活质量。而CRS异质性强,临床诊疗策略却趋于同质,其治疗策略亟待个体化、精准化发展。近年,生物大数据蓬勃发展,高通量测序技术更是推动着组学研究不断深入,其中蛋白质组学在探索疾病异质性方面已初露头角,是研究CRS病因机制、表型特征、疗效预测的良好工具。随着蛋白质组学技术不断进展,以此为依托的CRS研究也将逐步深入。本文将针对近年CRS相关蛋白质组学研究展开综述,阐明蛋白质组学技术在推动构建CRS异质性图谱中的潜在优势及未来前景。

关键词：慢性鼻窦炎病因机制蛋白质组学诊疗策略疗效预测治疗策略高通量测序技术未来前景

NON-LCL AND TRACER TEST FOR GROUNDWATER FLOW IN A SINGLE FRACTURE

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Journal of Hydrodynamics 2006年第1期18卷 104-108页

作者： qian Jia-zhong liu Yong wang jian-hua GUAN Hou-chun CHEN shi-jun wang Jia-quan School of Resources and Environmental Engineering Hefei University of Technology Hefei 230009China School of Biotechnology and Food Engineering Hefei University of Technology Hefei 230009 China

The validity of Local Cubic Law （LCL） is an important issue to study groundwater flow and transport in fractured media. According to laboratory simulaion tests, the average velocity with a lower gradient in a single fracture is calculated by the LCL, which is compared with the measured average velocity. Then dye tracer test is designed and completed. The evidence for non-LCL, is drawn from the results of the simulation tests and the dye tracer tests. Then the Reynolds number of groundwater is calculated, the critical value of Re for laminar flow is discussed in a single fracture under different conditions. The motion types for groundwater flow have been discussed.

关键词： non-Local Cubic Law (LCL) tracer test,groundwater flow in a single fracture

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-Hong Zhou Wei-Hong jiang Yan jiang Jing-Wu Sun Qin-Tai Yang Xue-Zhong Li Ya-Nan Sun Li shi Min wang Xi-Cheng Song Fu-quan Chen Xiao-Shu Zhang Hong-quan Wei Shao-Qing yu Dong-Dong Zhu Luo Ba Zhi-Wei Cao Xu-Ping Xiao Xin Wei Zhi-Hong Lin Feng-Hong Chen Chun-Guang Shan Guang-Ke wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-Lin wang Hua-Bin Li Feng liu Xiao-Bo Cui Sheng-Nan Ye Zheng liu yu Xu Xiao Cai Wei Huang Ru-Xin Zhang yu-Lin Zhao Guo-Dong yu Guang-Gang shi Mei-Ping Lu Yang Shen yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang yu Ye-Hai liu Shao-Wei Gu yu-Cheng Yang Lei Cheng jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

Quafu-Qcover:Explore combinatorial optimization problems on cloud-based quantum computers

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Chinese Physics B 2024年第5期33卷 104-115页

作者：许宏泽庄伟峰王正安黄凯旋时运豪马卫国李天铭陈驰通许凯冯玉龙刘培陈墨李尚书杨智鹏钱辰靳羽欣马运恒肖骁钱鹏顾炎武柴绪丹普亚南张翼鹏魏世杰增进峰李行龙桂鲁金贻荣于海峰范桁刘东胡孟军 Beijing Academy of quantum Information Sciences Beijing 100193China State Key Laboratory of Low Dimensional quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China Institute of Physics Chinese Academy of SciencesBeijing 100190China Frontier Science Center for quantum Information Beijing 100184China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological quantum Computation UCASBeijing 100190China

We introduce Quafu-Qcover,an open-source cloud-based software package developed for solving combinatorial optimization problems using quantum simulators and hardware ***-Qcover provides a standardized and comprehensive workflow that utilizes the quantum approximate optimization algorithm(QAOA).It facilitates the automatic conversion of the original problem into a quadratic unconstrained binary optimization(QUBO)model and its corresponding Ising model,which can be subsequently transformed into a weight *** core of Qcover relies on a graph decomposition-based classical algorithm,which efficiently derives the optimal parameters for the shallow QAOA ***-Qcover incorporates a dedicated compiler capable of translating QAOA circuits into physical quantum circuits that can be executed on Quafu cloud quantum *** to a general-purpose compiler,our compiler demonstrates the ability to generate shorter circuit depths,while also exhibiting superior speed ***,the Qcover compiler has the capability to dynamically create a library of qubits coupling substructures in real-time,utilizing the most recent calibration data from the superconducting quantum *** ensures that computational tasks can be assigned to connected physical qubits with the highest *** Quafu-Qcover allows us to retrieve quantum computing sampling results using a task ID at any time,enabling asynchronous ***,it incorporates modules for results preprocessing and visualization,facilitating an intuitive display of solutions for combinatorial optimization *** hope that Quafu-Qcover can serve as an instructive illustration for how to explore application problems on the Quafu cloud quantum computers.

关键词： quantum cloud platform combinatorial optimization problems quantum software

Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS)

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中华神经外科杂志(英文) 2024年第3期10卷 1-9页

作者： Ge Peicong Yin Zihan Tao Chuming Zeng Chaofan yu Xiaofan Lei shixiong Li Junsheng Zhai yuanren Ma Long He Qiheng liu Chenglong liu Wei Zhang Bojian Zheng Zhiyao Mou Siqi Zhao Zhikang wang Shuang Sun Wei Guo Min Zheng Shuai Zhang Jia Deng Xiaofeng liu Xingju Ye Xun Zhang qian wang Rong Zhang Yan Zhang Shaosen wang Chengjun Yang Ziwen Zhang Nijia Wu Mingxing Sun jian Zhou yujia shi Zhiyong Ma Yonggang Zhou jianpo yu Shaochen Li Jiaxi Lu Junli Gao Faliang wang Wenjing Chen Yanming Zhu Xingen Zhang Dong Zhao Jizong Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China China National Clinical Research Center for Neurological Diseases Beijing China Department of Neurosurgery Beijing Hospital National Center of Gerontology Beijing China Department of Radiology Beijing Tiantan Hospital Beijing China Department of Ultrasound Beijing Tiantan Hospital Capital Medical University Beijing China Department of Neurology Beijing Tiantan Hospital Beijing China Department of Neurosurgery Beijing Friendship Hospital Capital Medical University Beijing China Department of Neurosurgery Beijing Chaoyang Hospital Capital Medical University Beijing China Department of Neurosurgery Beijing Childrens Hospital Capital Medical University Beijing China Department of Neurosurgery The Affiliated Children’s Hospital Capital Institute of Pediatrics Beijing China Department of Neurosurgery Beijing Changping District Hospital Beijing China Department of Neurosurgery Dongfang Hospital Beijing University of Chinese Medicine Beijing China Department of Neurosurgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China Department of NeuroInterventional Surgery Binzhou Medical University Hospital Binzhou Shandong China Department of Neurosurgery Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Neurosurgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Neurosurgery The First Affiliated Hospital of Xi’an Jiaotong University Shaanxi Xi’an China Department of Neurosurgery West China Hospital Sichuan University Chengdu China Department of Neurosurgery Center for Rehabilitation Medicine Zhejiang Provincial Peoples Hospital Affiliated Peoples Hospital Hangzhou Medical College Hangzhou Zhejiang China Beijing Institute of Hepatology Beijing YouAn Hospital Capital Medical University Beijing China Department of Neu

Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of the internal carotid arteries and the formation of compensatory collateral vessels. The etiology of MMD remains enigmatic, making diagnosis and management challenging. The MOYAOMICS project was initiated to investigate the molecular underpinnings of MMD and explore potential diagnostic and therapeutic *** The MOYAOMICS project employs a multidisciplinary approach, integrating various omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, to comprehensively examine the molecular signatures associated with MMD pathogenesis. Additionally, we will investigate the potential influence of gut microbiota and brain-gut peptides on MMD development, assessing their suitability as targets for therapeutic strategies and dietary interventions. Radiomics, a specialized field in medical imaging, is utilized to analyze neuroimaging data for early detection and characterization of MMD-related brain changes. Deep learning algorithms are employed to differentiate MMD from other conditions, automating the diagnostic process. We also employ single-cellomics and mass cytometry to precisely study cellular heterogeneity in peripheral blood samples from MMD *** The MOYAOMICS project represents a significant step toward comprehending MMD’s molecular underpinnings. This multidisciplinary approach has the potential to revolutionize early diagnosis, patient stratification, and the development of targeted therapies for MMD. The identification of blood-based biomarkers and the integration of multiple omics data are critical for improving the clinical management of MMD and enhancing patient outcomes for this complex disease.

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超微虾壳粉对草鱼鱼糜凝胶品质的影响

中国调味品 2024年第8期49卷 1-6,11页

作者：粟燕吴伟伦石柳于巍汪兰乔宇黄云康峻吴茜湖北工业大学生命科学与健康工程学院武汉430068 农业农村部农产品冷链物流技术重点实验室/湖北省农业科学院农产品加工与核农技术研究所武汉430064 湖北省农业科技创新中心农产品加工研究分中心武汉430080 湖北华醇食品有限公司湖北荆门420800 湖北潜网生态小龙虾产业园集团有限公司湖北潜江433115

为提高草鱼鱼糜的凝胶特性,改善其品质,以鲜活草鱼为试验原料,添加虾壳粉,探究不同添加量的虾壳粉(0.25%、0.5%、0.75%、1%、1.25%)对草鱼鱼糜凝胶质构特性、凝胶特性、流变性等的影响。结果表明,与对照组相比,添加虾壳粉会显著降低草... 详细信息

为提高草鱼鱼糜的凝胶特性,改善其品质,以鲜活草鱼为试验原料,添加虾壳粉,探究不同添加量的虾壳粉(0.25%、0.5%、0.75%、1%、1.25%)对草鱼鱼糜凝胶质构特性、凝胶特性、流变性等的影响。结果表明,与对照组相比,添加虾壳粉会显著降低草鱼鱼糜凝胶的白度和色泽评分(P<0.05),但其质构特性显著增大(P<0.05),持水性显著升高(P<0.05),结合水含量显著增加(P<0.05)。感官评价和电子鼻分析结果表明,当虾壳粉在最适添加量0.5%时,可以显著改善鱼糜凝胶的风味和品质。因此,添加适量虾壳粉能增强鱼糜凝胶的网络结构和持水能力,得到具有较好风味和品质的鱼糜制品,研究结果可为生产高品质的鱼糜产品提供理论依据。

关键词：虾壳粉草鱼鱼糜凝胶凝胶特性流变性