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scRNA-seq transcriptomic profiling of irradiated mouse skin reveals altered cell types,pathways,and cell-cell interactions

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Radiation Medicine and Protection 2024年第3期5卷 185-193页

作者： Zhisen Zhang Yinyin Shu Shuangshuang Lu Kai Kang Mintao Ji Peng Zhang lei Chang State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionCollaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsMedical College of Soochow UniversitySuzhou 215123China Pasteurien college Medical College of Soochow UniversitySuzhou 215123China Department of Orthopaedics The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China

Objective:To investigate the substantial changes in cell types,pathways,and cell-cell interactions occurring in the irradiation-induced alopecia and dermatitis(IRIAD)mouse model and to identify potential targets for patients experiencing skin adverse reactions to ***:Mice were irradiated at 15 Gy,targeting the head and neck *** a 14-day interval,living cells were extracted from both wild-type(WT)mice and irradiated mice for single-cell RNA sequencing(scRNA-seq).The scRNA-seq data,retrieved from the GEO database(GSE201447),underwent stringent quality control using the Seurat(v4.3.0)R *** type annotation relied on previously reported typical markers and CellMarker *** expressed genes were calculated to perform gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)***-cell interactions were evaluated using the Cellchat R ***:The application of single-cell RNA sequencing(scRNA-seq)enabled a comprehensive characterization of the intricate cellular composition of both wild-type(WT)and irradiated mice ***,cells within irradiated mice skin exhibited a significant alteration in the intensity of cell-cell interactions compared to their wild-type *** change in interaction intensity was observed across various cell types,including fibroblast cells,endothelial cells,and dendritic ***,these"interacting cells"shared common signaling pathways,notably the upregulation of the IL-17 pathway following ***:The modification of intercellular communication induced by irradiation primarily involves fibroblast cells,endothelial cells,and various types of immune *** investigation provides a novel perspective on potential targets and holds promise for enhancing the clinical management of IRIAD.

关键词： scRNA-seq IRIAD cell-cell interaction IL-17

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双碳目标下煤氢协同发展路径分析

现代化工 2024年第1期44卷 8-12,17页

作者：李雷聂荟扬陕西科技大学经济与管理学院陕西西安710021

通过分析煤炭产业与氢能产业协同发展的现实意义与发展现状,厘清二者的协同发展关系,探讨协同发展路径:以煤促氢,即通过示范与推广煤炭制氢结合CCS实现煤炭制氢的低碳发展;以氢促煤,即促进绿氢生产与煤化工的结合,以降低化工产品生产过... 详细信息

通过分析煤炭产业与氢能产业协同发展的现实意义与发展现状,厘清二者的协同发展关系,探讨协同发展路径:以煤促氢,即通过示范与推广煤炭制氢结合CCS实现煤炭制氢的低碳发展;以氢促煤,即促进绿氢生产与煤化工的结合,以降低化工产品生产过程中的碳排放,提高产品的环保性能;探讨煤炭气化联合循环制氢技术､煤浆电解制氢技术､煤炭超临界水气化制氢技术以及地下煤炭气化制氢技术等其他有潜力的煤氢协同发展路径。最后提出了促进煤氢产业发展政策建议,以助力实现双碳目标。

关键词：氢能煤炭协同发展路径研究碳捕捉与储存技术

Impact Factors of Energy Productivity in China: An Empirical Analysis

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Chinese Journal of Population,Resources and Environment 2007年第2期5卷 28-33页

作者： Wei Chu1,2, Shen Manhong2 1. college of economics and management, Zhejiang Sci-Tech University, Hangzhou Zhejiang 310018, China 2. college of economics, Zhejiang University, Hangzhou Zhejiang 310017, China college of economics and management Zhejiang Sci-Tech University Zhejiang 310018 Hangzhou China college of economics Zhejiang University Zhejiang 310017 Hangzhou China

This article developed a decomposition model of energy productivity on the basis of the economic growth model. Four factors were considered which may influence China’s energy productivity according to this model: technology improvement, resource allocation structure, industrial structure and institute arrangement. Then, an econometric model was employed to test the four factors empirically on the basis of China’s statistical data from 1978 to 2004. Results indicated that capital deepening con- tributes the most (207%) to energy efficiency improvement, and impact from labor forces (13%) is the weakest one in resource factor; industrial structure (7%) and institute innovation (9.5%) positively improve the energy productivity.

关键词： energy productivity impact factor economic growth China

Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling

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Journal of Integrative Medicine 2024年第1期22卷 83-92页

作者： Lu-lu Han Xin Zhang Hui Zhang Ting Li Yi-chen Zhao Ming-hui Tian Feng-lei Sun Bo Feng Department of Neurology Three The Fifth People’s Hospital of JinanJinan 250013Shandong ProvinceChina Department of Gastroenterology Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina The First Clinical Medical college Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of Geriatrics the First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital)Jinan 250014Shandong ProvinceChina Chinese Medicine Culture and Literature Research Institute Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of General Medicine Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of Traditional Chinese Medicine the Second People’s Hospital of Haibei PrefectureZangzu Autonomous Prefecture of Haibei810300Qinghai ProvinceChina

Objective Obesity is a global health concern with management strategies encompassing bariatric surgery and anti-obesity drugs;however,concerns regarding complexities and side effects persist,driving research for more effective,low-risk *** promotion of white adipose tissue(WAT)browning has emerged as a promising ***,alisol B 23-acetate(AB23A)has demonstrated efficacy in addressing metabolic disorders,suggesting its potential as a therapeutic agent in obesity ***,in this study,we aimed to investigate the therapeutic potential of AB23A for mitigating obesity by regulating metabolic phenotypes and lipid distribution in mice fed a high-fat diet(HFD).Methods An obesity mouse model was established by administration of an *** and insulin metabolism were assessed via glucose and insulin tolerance *** size was determined using hematoxylin and eosin *** expression of browning markers in WAT was evaluated using Western blotting and quantitative real-time polymerase chain *** cage monitoring involved the assessment of various parameters,including food and water intake,energy metabolism,respiratory exchange rates,and physical ***,oil red O staining was used to evaluate intracellular lipid accumulation.A bioinformatic analysis tool for identifying the molecular mechanisms of traditional Chinese medicine was used to examine AB23A targets and associated signaling *** AB23A administration significantly reduced the weight of obese mice,decreased the mass of inguinal WAT,epididymal WAT,and perirenal adipose tissue,improved glucose and insulin metabolism,and reduced adipocyte ***,treatment with AB23A promoted the expression of browning markers in WAT,enhanced overall energy metabolism in mice,and had no discernible effect on food intake,water consumption,or physical *** 3T3-L1 cells,AB23A inhibited lipid accumulation,and both AB23A and rapamycin inhibited t

关键词： Obesity Alisol B 23-acetate Adipose tissue mTOR-SREBP1 High-fat diet

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对数法在幂指形函数极限中的推广与应用

高等数学研究 2024年第5期27卷 16-18页

作者：杨磊大连财经学院公共教学部辽宁大连116000

本文以幂指函数为雏形进行推广,用对数法的思想,化简三种类型的“幂指形”函数,求极限方法简单,通用性强.

关键词：极限对数法幂指函数

Exploring the complex trade-offs and synergies of global ecosystem services

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Environmental Science and Ecotechnology 2024年第5期21卷 141-148页

作者： Jinnan Wang Wenjun Wu Meng yang Yueming Gao Jiacheng Shao Weishan yang Guoxia Ma Fang Yu Nan Yao Hongqiang Jiang State Environmental Protection Key Laboratory of Environmental Planning and Policy Simulation Chinese Academy of Environmental PlanningBeijing100041China The Center for Eco-Environmental Accounting Chinese Academy of Environmental PlanningBeijing100041China The Innovation Center for Eco-environment-Oriented Development Chinese Academy of Environmental PlanningBeijing100041China School of Environment Beijing Normal UniversityBeijing100875China college of Environmental&Resource Sciences Zhejiang UniversityHangzhou310058China college of economics&management Northwest A&F UniversityYangling712100China

The trade-off and synergy relationship of ecosystem services is an important topic in the current *** value of each service provided by the ecosystem is substantially affected by human activities,and conversely,its changes will also affect the relevant human *** to varying tradeoffs among ecosystem services and synergies between them that can either increase or decrease,it is difficult to optimize multiple ecosystem services simultaneously,making it a huge challenge for ecosystem *** study firstly develops a global Gross Ecosystem Product(GEP)accounting *** uses remote sensing data with a spatial resolution of 1 km to estimate the ecosystem services of forests,wetlands,grasslands,deserts,and farmlands in 179 major countries in *** results show that the range of global GEP values is USD 112e197 trillion,with an average value of USD 155 trillion(the constant price),and the ratio of GEP to gross domestic product(GDP)is *** tradeoffs and the synergies among different ecosystem services in each continent and income group have been further *** found a correspondence between the income levels and the synergy among ecosystem services within each *** specific ecosystem services,there are strong synergies between oxygen release,climate regulation,and carbon sequestration services.A trade-off relationship has been observed between flood regulation and other services,such as water conservation and soil retention services in low-income *** results will help clarify the roles and the feedback mechanisms between different stakeholders and provide a scientific basis for optimizing ecosystem management and implementing ecological compensation schemes to enhance human well-being.

关键词： Ecosystem services Biophysical quantity Monetary value Trade-off Synergy

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基于BP神经网络的学术论文评价模型研究

现代情报 2024年第2期44卷 170-177页

作者：韩雷浙江理工大学经济管理学院浙江杭州310018

[目的/意义]学术论文是学者科研水平与学术贡献的重要佐证和标志。构建科学的学术论文评价模型,对人才评价、科研经费分配、评奖评优、晋升及招聘等都具有重要指导意义。[方法/过程]文章选择Web of Science数据库中“Information Scienc... 详细信息

[目的/意义]学术论文是学者科研水平与学术贡献的重要佐证和标志。构建科学的学术论文评价模型,对人才评价、科研经费分配、评奖评优、晋升及招聘等都具有重要指导意义。[方法/过程]文章选择Web of Science数据库中“Information Science and Library Science”学科类别下发表于2010年的论文作为研究对象。首先,基于论文多方面的关联特征构建模型特征空间;然后,采用机器学习中被广泛用于预测任务的有监督学习算法——BP神经网络训练模型,并进行十折交叉验证确保模型稳定性;最后,通过计算模型的校正决定系数(R_(adjusted)^(2))和均方根误差(RMSE),选择出最优模型。[结果/结论]本研究构建的最优BP神经网络模型的校正决定系数(R_(adjusted)^(2))达0.91,均方根误差(RMSE)约19.8,评价性能较好。

关键词：学术论文评价模型 BP神经网络科学价值

Interactive group decision making procedure based on uncertain multiplicative linguistic preference relations

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Journal of Systems Engineering and Electronics 2010年第3期21卷 408-415页

作者： Zeshui Xu1,2,1.college of economics and management,Southeast University,Nanjing 210096,P.R.China 2.Institute of Sciences,University of Science and Technology of the PLA,Nanjing 210007,P.R.China college of economics and management Southeast UniversityNanjing 210096P.R.China Institute of Sciences University of Science and Technology of the PLANanjing 210007P.R.China

Group decision making problems are investigated with uncertain multiplicative linguistic preference *** unbalanced multiplicative linguistic label set is introduced,which can be used by the experts to express their linguistic preference information over *** uncertain linguistic weighted geometric mean operator is utilized to aggregate all the individual uncertain multiplicative linguistic preference relations into a collective one,and then a simple approach is developed to determine the experts＇ weights by utilizing the consensus degrees among the individual uncertain multiplicative linguistic preference relations and the collective uncertain multiplicative linguistic preference ***,a practical interactive procedure for group decision making is proposed based on uncertain multiplicative linguistic preference relations,in which a possibility degree formula and a complementary matrix are used to rank the given ***,the proposed procedure is applied to solve the group decision making problem of a manufacturing company searching the best global supplier for one of its most critical parts used in assembling process.

关键词： group decision making uncertain multiplicative linguistic preference relations unbalanced multiplicative linguistic label set consensus degree interaction.

Studies on the Sustainable Developmint of Forestry in China

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Forest Ecosystems 1994年第1期 61-71页

作者： Zhang Caihong college of economics and management,Bejing Forestry University

ＳｔｕｄｉｅｓｏｎｔｈｅＳｕｓｔａｉｎａｂｌｅＤｅｖｅｌｏｐｍｅｎｔｏｆＦｏｒｅｓｔｒｙｉｎＣｈｉｎａＺｈａｎｇＣａｉｈｏｎｇＣｏｌｌｅｇｅｏｆＥｃｏｎｏｍｉｃｓａｎｄＭａｎａｇｅｍｅｎｔ，ＢｅｊｉｎｇＦｏｒｅｓｔｒ... 详细信息

ＳｔｕｄｉｅｓｏｎｔｈｅＳｕｓｔａｉｎａｂｌｅＤｅｖｅｌｏｐｍｅｎｔｏｆＦｏｒｅｓｔｒｙｉｎＣｈｉｎａＺｈａｎｇＣａｉｈｏｎｇＣｏｌｌｅｇｅｏｆＥｃｏｎｏｍｉｃｓａｎｄＭａｎａｇｅｍｅｎｔ，ＢｅｊｉｎｇＦｏｒｅｓｔｒｙＵｎｉｖｅｒｓｉｔｙＳｔｕｄｉｅ...

关键词： sustainable development of forestry factor potentialities dynamic model simu-lation prediction policy supporting system