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Patient-Reported Outcomes of Postoperative NSCLC Patients with or without Staged Chinese Herb Medicine Therapy during Adjuvant Chemotherapy(NALLC 2): A Randomized, Double-Blind, Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第11期30卷 963-973页

作者： zhang Yi-lu jiaO li-jing GONG Ya-bin XU jian-fang NI jian SHEN Xiao-yong zhang Jie ZHOU Di Qian cheng-xin WANG Qin yao jia-lin YANG Wen-xiao SU ling-zi WANG li-yu li jia-qi yao Yi-qin zhang Yuan-hui WANG Yi-chao chen Zhi-wei XU ling Oncology Department Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Institute of Traditional Chinese Medicine Oncology Shanghai University of Traditional Chinese Medicine Oncology Department Shanghai Pulmonary Hospital Shanghai Tongji University Thoracic Surgery Department Huadong Hospital Shanghai Fudan University Thoracic Surgery Department Shanghai Cancer Hospital Shanghai Fudan University Oncology Department Shanghai Chest Hospital Shanghai Jiao Tong University

Objective:To investigate whether the combination of chemotherapy with staged Chinese herbal medicine(CHM) therapy could enhance health-related quality of life(QoL) in non-small-cell lung cancer(NSCLC)patients and prolong the time before deterioration of lung cancer symptoms,in comparison to chemotherapy ***:A prospective,double-blind,randomized,controlled trial was conducted from December 14,2017 to August 28,2020.A total of 180 patients with stage ⅠB-ⅢA NSCLC from 5 hospitals in Shanghai were randomly divided into chemotherapy combined with CHM(chemo+CHM) group(120 cases) or chemotherapy combined with placebo(chemo+placebo) group(60 cases) using stratified blocking *** European Organization for Research and Treatment of Cancer(EORTC) Quality-of-life-Core 30 Scale(QLQ-C30) was used to evaluate the patient-reported outcomes(PROs) during postoperative adjuvant chemotherapy in patients with early-stage *** events(AEs) were assessed in the safety ***:Out of the total 180 patients,173 patients(116in the chemo+CHM group and 57 in the chemo+placebo group) were included in the PRO *** initial mean QLQ-C30 Global Health Status(GHS)/QoL scores at baseline were 57.16±1.64 and 57.67±2.25 for the two respective groups(P>0.05).Compared with baseline,the chemo+CHM group had an improvement in QLQ-C30GHS/QoL score at week 18 [least squares mean(LSM) change 17.83,95% confidence interval(CI) 14.29 to 21.38].Conversely,the chemo+placebo group had a decrease in the score(LSM change-13.67,95% CI-22.70 to-4.63).A significant between-group difference in the LSM GHS/QoL score was observed,amounting to 31.63 points(95% CI25.61 to 37.64,P1).The similar trends were observed in physical functioning,fatigue and appetite *** week 18,patients in the chemo+CHM group had a higher proportion of improvement or stabilization in GHS/QoL functional and symptom scores compared to chemo+placebo group(P1).The median time to deterioration

关键词： Chinese herbal medicine adjuvant chemotherapy health-related quality of life non-small-cell lung cancer patient-reported outcome

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Direct measurement of the break-out ^(19)F(p,γ)^(20)Ne reaction in the China Jinping underground laboratory(CJPL)

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Nuclear Science and Techniques 2024年第8期35卷 142-152页

作者： Yin‑Ji chen Hao zhang li‑Yong zhang jian‑Jun He Richard James deBoer Michael Wiescher Alexander Heger David Kahl Jun Su Daniel Odell xin‑Yue li jian‑Guo Wang Long zhang Fu‑Qiang Cao Zhi‑cheng zhang xin‑Zhi jiang Luo‑Huan Wang Zi‑Ming li Lu‑Yang Song Liang‑Ting Sun Qi Wu jia‑Qing li Bao‑Qun Cui li‑Hua chen rui‑Gang Ma Er‑Tao li Gang Lian yao‑De Sheng Zhi‑Hong li Bing Guo wei‑Ping liu Key Laboratory of Beam Technology of the Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Department of Physics and Astronomy The Joint Institute for Nuclear AstrophysicsUniversity of Notre DameNotre DameIN 46556USA School of Physics and Astronomy Monash UniversityClaytonVIC 3800Australia Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI 48824USA Institute of Nuclear and Particle Physics and Department of Physics and Astronomy Ohio UniversityAthensOH 45701USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China China Institute of Atomic Energy Beijing 102413China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China College of Science Southern University of Science and TechnologyShenzhen 518055China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Mathematics and Physics Handan UniversityHandan 056005China

Calcium production and the stellar evolution of first-generation stars remain fascinating mysteries in *** one possible nucleosynthesis scenario,break-out from the hot carbon–nitrogen–oxygen(HCNO)cycle was thought to be the source of the calcium observed in these oldest ***,according to the stellar modeling,a nearly tenfold increase in the thermonuclear rate ratio of the break-out ^(19)F(p,γ)^(20) Ne reaction with respect to the competing ^(19)F(p,α)^(16) O back-processing reaction is required to reproduce the observed calcium *** performed a direct measurement of this break-out reaction at the China Jinping underground *** measurement was performed down to the low-energy limit of E_(c.m.)=186 keV in the center-of-mass *** key resonance was observed at 225.2 keV for the first *** a temperature of approximately 0.1 GK,this new resonance enhanced the thermonuclear ^(19)F(p,γ)^(20) Ne rate by up to a factor of≈7.4,compared with the previously recommended NACRE *** is of particular interest to the study of the evolution of the first stars and implies a stronger breakdown in their“warm”CNO cycle through the ^(19)F(p,γ)^(20) Ne reaction than previously *** break-out resulted in the production of the calcium observed in the oldest stars,enhancing our understanding of the evolution of the first stars.

关键词： Nuclear astrophysics First stars Abundance of calcium Reaction cross section Reaction rate China Jinping underground laboratory(CJPL) JUNA

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A new species of Leptocycas (Zamiaceae) from the Upper Triassic sediments of liaoning Province,China

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Journal of Systematics and Evolution 2010年第4期48卷 286-301页

作者： 1,2.3jian-wei zhang 2.ian-xin yao 1jia-rui chen 1cheng-sen li 1(State Key Laboratory of Systematic and Evolutionary Botany,Institute of Botany,Chinese Academy of Sciences,Beijing 100093,China) 2(State Key Laboratory of Stratigraphy and Paleontology,Institute of Geology,Chinese Academy of Geological Sciences,Beijing 100037,China) 3(Graduate University,Chinese Academy of Sciences,Beijing 100049,China) (State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences Beijing 100093 China) (State Key Laboratory of Stratigraphy and Paleontology Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China) (Graduate University Chinese Academy of Sciences Beijing 100049 China)

A new cycad,Leptocycas yangcaogouensis ***.,was found in sediments from the Late Triassic in western liaoning,*** pinnately compound leaves(Pseudoctenis type)are screwed in a crown on the stem *** leaflets are linear,with parallel veins and decurrent bases on the *** leaf bases are *** cataphylls intermix with the *** female cone is ovoid in *** characteristics of the new plant are more similar to those of Leptocycas gracilis,a Triassic cycad from North America,but the new species differs from *** in the size of its stem(7–8 vs.3–5 cm in diameter,respectively),leaves(length×width 100×16 vs.30×7 cm,respectively)and leaf density along the stem(4–6 vs.1–2 bases/1 cm length,respectively).Both *** and ***,having leaves of the Pseudoctenis type,show a closer relationship to the extant Dioon of *** present study provides evidence for the origin of the genus Dioon,which may have come from Leptocycas plants of the *** would be assumed that the extent cycads in Zamiaceae originate from the pteridosperms in the Late Paleozoic and have evolved through the stage of *** and *** in Late Triassic,and reaching the extant Dioon.

关键词： China Cycadales Leptocycas Upper Triassic Zamiaceae

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Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao zhang Wen Huang Fu-Jie Yu Qi Zhao xin-Dong Zhu Tao Feng yao jiang Xiao-Ming li Xue-Fei Miao He Zhu Si Lan Xue-Qian Wang Bao-Long Shen Zhe jia Feng-Qi zhang wei Wang Qi liu Yang Ren Xun-li Wang Xiao-Ya Cui Xiao-Yang Wang Ya-Nan chen Bing-Bing Fan Meng-Ru li Qi-Long Gao jia-Ming Guo Zeng-Bao jiao Zhi-Min Guo Yu-Ping Zhao Qian Yu rui Huang ling-Kun zhang Yi-Ping Lu Xu-Bo li Huai-Jun lin Yan Ma wei-Ming Yang Zhi-Hua Shen Hai-Yan He Yong-Gang Sun Yong-jiang Huang De-Zhuang Wang Qing-Feng liu Fei-Yang Wang Hui liu Hong-Hui Wu li-Qiang Wang Yang Lu Nan Wang Tian-li Wang wei-Bing liao Yi-Han Wang Yuan Wu Yu-Zhen Yin Jie Pan Yi zhang Qing Wang jian-Yang zhang Tao Yang Yasir Sohail Jin-Yu zhang Hua Ji Qiang li wei-Di liu Zhi-Gang chen Xiong-Jun liu Wen Ma Liang Mao Zhen-Duo Wu School of Materials Science and Engineering Nanjing University of Science and Technology jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Department of Physics City University of Hong Kong School of Materials Science and Engineering Tianjin University School of Physics and Microelectronics Zhengzhou University Department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation Technology (liaoning Province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical Sciences Great Bay University School of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing Department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University Department of Materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen Guoming chen Hua-xing chen Huirun chen Jinhui chen Ji-Yuan chen Kai chen Mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen wei chen Xiang chen Xiaoyu chen xin chen Xun chen Xurong chen Ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

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Deciphering the degradation discrepancy in Ni-rich cathodes with a diverse proportion of[003]crystallographic textures

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Carbon Energy 2023年第7期5卷 15-26页

作者： Lang Qiu Mengke zhang Yang Song Zhenguo Wu Yan-Fang Zhu Jun zhang Dong Wang Hai-Yan Hu Hong-wei li Hang-rui liu xin-Bei jia jian Peng Shuangqiang chen Zuguang Yang yao Xiao Xiaodong Guo Department of Chemical Engineering College of Chemical EngineeringSichuan UniversityChengduChina Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhouZhejiangChina Ruyuan Dongyang Guangcixing Material Limited CompanyShaoguanGuangdongChina Department of Chemical Engineering School of Environmental and Chemical EngineeringShanghai UniversityShanghaiChina Department of Aerospace Engineering College of Aerospace EngineeringChongqing UniversityChongqingChina State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi'an Jiaotong UniversityXi'anShaanxiChina

The crystal plane plays a very important role in the properties of Ni-rich cathodes.[003]crystallographic texture regulation has been proven to improve structural stability,and yet,the discrepancy of particles with different exposed ratios of[003]in structural attenuation has not been ***,we have unraveled comprehensively the structural decay difference for Ni-rich cathodes’primary particles with the different percentages of exposed[003]by regulating the precursor coprecipitation *** findings based on structural characterization,first-principles calculations,finite element analysis,and electrochemical test reveal that the length and width of particles represent[110]and[003]directions,respectively,and show that cathode particles with a higher[110]/[003]ratio can effectively inhibit structure degradation and intergranular/intragranular crack formation owing to the low oxygen vacancy formation energy on(003)planes and the small local stress on secondary/primary *** study may provide guidance for the structural design of layered cathodes.

关键词： cracks crystal plane Ni-rich cathodes oxygen vacancy structure degradation

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术前口服布洛芬对种植体植入术后疼痛影响的随机对照研究

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中华口腔医学杂志 2024年第8期59卷 777-783页

作者：郜康魏雪竺赵彬刘之光杜聪林王新王瑶刘长营唐德争张琪吴瑞卿欧明明李威程茜谢亦林马攀李钧王昊王左敏陈溯张伟周建首都医科大学口腔医学院特诊特需科北京100050 首都医科大学口腔医学院急诊综合诊疗中心北京100050 中国医学科学院、北京协和医学院、北京协和医院药剂科北京100730 首都医科大学附属北京安贞医院药理基地统计部北京100011 首都医科大学口腔健康北京实验室北京100069 首都医科大学口腔医学院种植中心北京100050 首都医科大学附属北京天坛医院口腔科北京100070 首都医科大学附属北京朝阳医院口腔科北京100020 北京大学口腔医学院·口腔医院口腔颌面外科、国家口腔医学中心、国家口腔疾病临床医学研究中心、口腔生物材料和数字诊疗装备、国家工程研究中心、口腔数字医学北京市重点实验室北京100081

目的评价术前口服布洛芬的超前镇痛方案对单枚后牙种植体植入术后疼痛的影响。方法采用多中心、随机、双盲、安慰剂平行对照的试验设计。按照纳排标准收集2022年4月至2024年4月于首都医科大学口腔医学院(40例)、首都医科大学附属北京天... 详细信息

目的评价术前口服布洛芬的超前镇痛方案对单枚后牙种植体植入术后疼痛的影响。方法采用多中心、随机、双盲、安慰剂平行对照的试验设计。按照纳排标准收集2022年4月至2024年4月于首都医科大学口腔医学院(40例)、首都医科大学附属北京天坛医院(22例)及首都医科大学附属北京朝阳医院(20例)就诊的要求植入种植体的患者。采用简单随机方法将患者按照1∶1的比例分配至布洛芬组和对照组,每组41例。布洛芬组与对照组分别于术前15 min口服300 mg布洛芬缓释胶囊和安慰剂,并在术后3 d内接受相同的镇痛方案。通过数字评定量表(NRS)统计患者术后30 min和4、6、8、24、48、72 h的疼痛评分,并记录术后4~6 d额外镇痛药使用量。结果研究共入组82例患者,失访脱落7例(对照组4例、布洛芬组3例),共计75例(对照组37例、布洛芬组38例)患者完成试验,患者均未发生恶心、呕吐等不良事件。布洛芬组患者术后4、6、8 h的疼痛评分[分别为1.0(0.0,2.0)、1.0(0.0,2.0)、1.5(0.0,3.0)分]均显著低于对照组[分别为2.0(1.0,3.0)、3.0(1.5,4.0)、2.0(1.0,4.0)分](Z=-1.99,P=0.047;Z=-3.01,P=0.003;Z=-2.10,P=0.036)。布洛芬组与对照组分别有18.4%(7/38)和27.0%(10/37)的患者于术后4~6 d额外服用镇痛药,两者额外服用镇痛药的患者比例差异无统计学意义(χ^(2)=0.79,P=0.373);对照组与布洛芬组术后额外用药量分别为[0.0(0.0,1.0)粒]与[0.0(0.0,0.0)粒],差异无统计学意义(Z=-0.78,P=0.439)。结论布洛芬超前镇痛可有效降低患者种植体植入术后疼痛程度,是一种安全有效的围手术期疼痛管理方案。

关键词：镇痛疼痛超前镇痛疼痛管理布洛芬种植体植入

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Long-term outcome of patients with atrial myxoma after surgical intervention: analysis of 403 cases

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Journal of Geriatric Cardiology 2019年第4期16卷 338-343页

作者： chen-Xi jianG jian-Gang WANG rui-Dong QI wei WANG li-jian GAO Jing-Hua ZHAO Chun-Xiao zhang Meng-chen ZHOU xin TU Mei-Sheng SHANG Yan yao Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Cardiovascular Surgery Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Center for Coronary Heart Disease Department of CardiologyCardiovascular Institute & Fuwai HospitalCAMS & PUMCNational Center for Heart DiseaseBeijingChina College of life Science and Technology Huazhong University of Science and TechnologyWuhanChina

Objective To assess long-term survival and late cardiovascular events in patients with atrial myxoma after surgical intervention. Methods Retrospective analysis of 403 patients undergoing resection of atrial myxoma from January 2002 to December 2016 was conducted with a median follow-up period of 4.5 (range: 0.5?15) years. Results The cross-clamp time and cardiopulmonary bypass times were 41.1 ± 21.4 and 65.2 ± 27.3 min,respectively. A diagnosis of myxoma was histopathologically confirmed in all cases. The early in-hospital mortality rate was 0.7%(n = 3). During the follow-up period,tumor recurrence occurred in six patients and cerebral infarction in nine. There were 48 (11.9%) patients with late onset atrial fibrillation (AF). By multivariate analysis,age (HR = 1.05,95% CI: 1.02–1.09,P 1),left atrial diameter (HR = 1.23,95% CI: 1.08–1.36,P = 0.012),and mitral valve surgery (HR = 1.17,95% CI: 1.05–1.29,P = 0.027) were independent predictors of late onset AF. Twenty-one (5.2%) patients died during the follow-up period. Advanced age (HR = 1.07,95% CI: 1.04–1.10,P = 0.003) and multiple surgical procedures (HR = 1.18,95% CI: 1.06–1.29,P = 0.012) were significantly associated with overall mortality. Conclusions Atrial myxoma can be resected with good long-term survival. Late onset AF is common after surgery in patients with atrial myxoma. Advanced age,left atrial diameter,and mitral valve surgery were independent predictors of outcomes.

关键词： Atrial fibrillation Atrial myxoma Embolism Survival

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First proof-of-principle experiment with the post-accelerated isotope separator on-line beam at BRIF:measurement of the angular distribution of ^(23)Na+^(40)Ca elastic scattering

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Nuclear Science and Techniques 2021年第5期32卷 101-106页

作者： wei Nan Bing Guo cheng-jian lin Lei Yang Dong-Xi Wang Yang-Ping Shen Bing Tang Bao-Qun Cui Tao Ge Yin-Long Lyu Hui-Ming jia Yun-Ju li chen chen li-Hua chen Qi-Wen Fan xin-Yue li Gang Lian jian-cheng liu Tian-Peng Luo Nan-Ru Ma rui-Gang Ma Xie Ma Ying-Jun Ma wei-Ke Nan Dan-Yang Pang You-Bao Wang Pei-wei Wen Feng Yang Yong-Jin yao Sheng Zeng Hao zhang Fu-Peng Zhong Shan-Hao Zhong Zhi-Hong li Tian-Jue zhang wei-Ping liu BRIF Collaboration China Institute of Atomic Energy(CIAE) P.O.Box 275(10)Beijing 102413China Department of Physics Guangxi Normal UniversityGuilin 541004China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China School of Physics Beihang UniversityBeijing 100191China Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China

The reaction dynamics of exotic nuclei near the drip line is one of the main research topics of current *** scattering is a useful probe for investigating the size and surface diffuseness of exotic *** development of rare isotope accelerators offers opportunities for such *** date,many relevant measurements have been performed at accelerators using the projectile fragmentation technique,while the measurements at accelerators using isotope separator on-line(ISOL)systems are still quite *** this work,we present the first proof-of-principle experiment with a post-accelerated ISOL beam at the Beijing Radioactive Ion Beam Facility(BRIF)by measuring the angular distribution of elastic scattering for the stable nucleus^(23)Na from the doubly magic nucleus^(40)Ca at energies above the Coulomb *** angular distribution measured by a silicon strip detector array in a scattering chamber using the ISOL beam at BRIF is in good agreement with that measured by the high-precision Q3 D magnetic spectrograph using the nonISOL beam at nearly the same *** work provides useful background for making BRIF a powerful tool for the investigation of the reaction dynamics of exotic nuclei.

关键词： BRIF Exotic nuclei Elastic scattering Angular distribution

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Exposure Effects of Terahertz Waves on Primary Neurons and Neuron-like Cells Under Nonthermal Conditions

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Biomedical and Environmental Sciences 2019年第10期32卷 739-754页

作者： TAN Sheng Zhi TAN Peng cheng LUO Lan Qing CHI Yun Liang YANG Zi Long ZHAO Xue Long ZHAO li DONG Ji zhang Jing yao Bin wei XU xin Ping Tian Guang chen jian Kui WANG Hui PENG rui Yun Beijing Institute of Radiation Medicine Beijing 100850China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Inner Mongolia University for the Nationalities Yakeshi 022150Inner MongoliaChina General Hospital of Northern Theater Command Shenyang 110000LiaoningChina State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Fifth Medical Center Chinese People's Liberation Army General HospitalBeijing 100071China

Objective This study aimed to explore the potential effects of terahertz(THz) waves on primary cultured neurons from 4 rat brain regions(hippocampus, cerebral cortex, cerebellum, and brainstem)and 3 kinds of neuron-like cells(MN9 D, PC12, and HT22 cells) under nonthermal *** THz waves with an output power of 50(0.16 THz) and 10(0.17 THz) m W with exposure times of 6 and 60 min were used in this study. Analysis of temperature change, neurite growth, cell membrane roughness, micromorphology, neurotransmitters and synaptic-related proteins(SYN and PSD95) was used to evaluate the potential *** Temperature increase caused by the THz wave was negligible. THz waves induced significant neurotransmitter changes in primary hippocampal, cerebellar, and brainstem neurons and in MN9 D and PC12 cells. THz wave downregulated SYN expression in primary hippocampal neurons and downregulated PSD95 expression in primary cortical *** Different types of cells responded differently after THz wave exposure, and primary hippocampal and cortical neurons and MN9 D cells were relatively sensitive to the THz waves. The biological effects were positively correlated with the exposure time of the THz waves.

关键词： Neuron brainstem cortex

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