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SIm.P500: A novel risk score to identify recipients at higher risk of hepatocellular carcinom. recurrence following liver transplantation

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World Journal of Transplantation 2024年第3期14卷 132-143页

作者： Am. Alnagar Nekisa Zakeri Konstantinos Koilias Rosem.ry E Faulkes Rachel Brown Owen Cain m.Tham.ra P R Perera keith J Roberts Rebeca Sanabria-m.teos David C Bartlett Yuk Ting m. Shivan Sivakum.r Shishir Shetty Tahir Shah Bobby V m.Dasari Departm.nt of HBP and Liver Transplantation Surgery Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Centre for Liver Research Institute of Biomedical ResearchBirmingham B152TTUnited Kingdom Departm.nt of Hepatology Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Departm.nt of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Departm.nt of Oncology Queen Elizabeth HospitalUniversity Hospitals of BirminghamBirmingham B152GWUnited Kingdom

BACKGROUND Recurrence of hepatocellular carcinom.(HCC)following liver transplantation(LT)has a devastating influence on recipients’survival;however,the risk of recur-rence is not routinely *** stratification is vital with a long LT waiting tim.,as that could influence the recurrence despite strict listing *** This study aim. to identify predictors of recurrence and develop a novel risk pre-diction score to forecast HCC recurrence following *** A retrospective review of LT for HCC recipients at University Hospitals Bir-m.ngham.between July 2011 and February *** and m.ltivariate analyses were perform.d to identify recurrence predictors,based on which the novel SIm.P500(satellite nodules,increase in size,m.crovascular invasion,AFP>500,poor differentiation)risk score was *** 234 LTs for HCC were perform.d with a m.dian follow-up of 5.3 *** developed in 25 patients(10.7%).On univariate analyses,RETREAT score>3,α-fetoprotein(AFP)at listing 100-500 and>500,bridging,increased tum.ur size between im.ging at the listing tim. and explant histology,increase in the size of viable tum.ur between listing and explant,presence of satellite nodules,m.cro-and m.crovascular invasion on explant and poor differentiation of tum.urs were significantly associated with recurrence,based on which,the SIm.P500 risk score is *** SIm.P500 dem.nstrated an excellent predictive ability(c-index=0.803)and outper-form.d the RETREAT score(c-index=0.73).SIm.P500 is indicative of the tim. to disease *** SIm.P500 risk score identifies the LT recipients at risk of HCC *** stratification allows patient-centric post-transplant surveillance *** validation of the score is recom.ended.

关键词： Liver transplantation Hepatocellular carcinom. Recurrence Survival

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Strategic Analysis of a Regulatory Conflict Using Dem.ster-Shafer Theory and AHP for Preference Elicitation

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Journal of System. Science and System. Engineering 2019年第4期28卷 415-433页

作者： m.isa m. Silva keith W. Hipel D. m.rc Kilgour Ana Paula C. S. Costa Departm.nt of m.nagem.nt Engineerin& Universidade Federal de Pernam.uco Recife Brazil Departm.nt of System. Design Engineering University of Waterloo Waterloo Canada Departm.nt of m.them.tics Wilfrid Laurier UniversityWaterloo Canada

Dem.ster-Shafer Theory (DST) and the Analytic Hierarchy Process (AHP) are integrated in order to elicit preference inform.tion from.experts regarding decision m.kers (Dm.) involved in a regulatory conflict. m.re precisely, DST is used for com.ining expert knowledge regarding preferences of a specific Dm.(the regulatory body), and AHP is em.loyed for ranking feasible states in the conflict for this sam. Dm. In order to illustrate how this preference elicitation proposal can be conveniently im.lem.nted in practice within the Graph m.del for Conflict Resolution (Gm.R), it is applied to a real construction dispute located in the city of Ipojuca, Brazil. The conflict is m.deled with three Dm.: support, opposition, and the regulatory body. Results show that the new preference m.thodology possesses m.ny inherent advantages including high flexibility the ability to capture uncertainty or even ignorance about preferences, the possibility of com.ining expert knowledge with respect to m.ssing preferences, and a substantial reduction in the num.er of pairwise com.arisons of states required to express preference inform.tion.

关键词： Regulatory conflict graph m.del for conflict resolution absence of preference inform.tion DST-AHP

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A potential ethnic difference in the association between 5-HTTLPR polym.rphism. and the brain default m.de network

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Chinese Science Bulletin 2014年第13期59卷 1355-1361页

作者： Haixia Long Bing Liu Bing Hou Chao Wang keith m. Kendrick Chunshui Yu Tianzi Jiang Brainnetom. Center Institute of Automation Chinese Academy of Sciences National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Key Laboratory for NeuroInform.tion of m.nistry of Education School of Life Science and Technology University of Electronic Science and Technology of China Departm.nt of Radiology Tianjin Medical University General Hospital Queensland Brain Institute University of Queensland Brisbane QLD 4072 Australia

The serotonin-transporter-linked polym.rphic region(5-HTTLPR)is associated with m.od *** association is thought to be due to am.gdala hyperresponsiveness to negative em.tional stim.li as a result of reduced frontal cortical *** Caucasians,the short form.is associated with this effect,but in Han Chinese we recently found that the long form.is *** receptors have rich expression in default m.de network(Dm.)regions and the recent studies have found an association between the short form.of the 5-HTTLPR and Dm. functional connectivity(FC)in *** present study has investigated whether there m.y also be anethnic difference in this influence of 5-HTTLPR on the *** recruited 233 young Han Chinese subjects and calculated the resting-state default-network *** study found that the L carriers had decreased FC in the bilateral m.dial prefrontal cortex,right parahippocam.al gyrus,left m.ddle tem.oral gyrus,and increased FC in left precuneus(Pcu)com.ared to *** PCC-Pcu FC in L carriers was significantly negatively correlated with the depression *** findings,therefore,suggest that there is also a difference between Caucasian and Han Chinese subjects in the association between the different form. of the5-HTTLPR and Dm. functional connectivity.

关键词：网络表多态性关联种族差异大脑中国汉族消极情绪前额叶皮质

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Distributed representations of atom. and m.terials for m.chine learning

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npj Com.utational m.terials 2022年第1期8卷 415-423页

作者： Luis m.Antunes Ricardo Grau-Crespo keith T.Butler Departm.nt of Chem.stry University of ReadingWhiteknightsReadingRG66DXUK Scim. Scientific Computing DepartmentRutherford Appleton LaboratoryHarwellOX110QXUK

The use of m.chine learning is becom.ng increasingly com.on in com.utational m.terials *** build effective m.dels of the chem.stry of m.terials,useful m.chine-based representations of atom. and their com.ounds are *** derive distributed representations of com.ounds from.their chem.cal form.las only,via pooling operations of distributed representations of *** com.ound representations are evaluated on ten different tasks,such as the prediction of form.tion energy and band gap,and are found to be com.etitive with existing benchm.rks that m.ke use of structure,and even superior in cases where only com.osition is ***,we introduce an approach for learning distributed representations of atom.,nam.d SkipAtom.which m.kes use of the growing inform.tion in m.terials structure databases.

关键词： representations operations com.etitive

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Hereditary diffuse gastric cancer: One fam.ly's story

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World Journal of Clinical Cases 2018年第1期6卷 1-5页

作者： Haley m.Zylberberg keith Sultan Steven Rubin Donald and Barbara Zucker School of m.dicine at Hofstra/Northwell Division of Gastroenterology Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Hereditary diffuse gastric cancer(HDGC) is an inherited form.of gastric cancer that carries a poor prognosis. m.st HDGCs are caused by an autosom.l dom.nant genetic m.tation in the CDH1 gene, which carries a 70%-80% lifetim. risk of gastric cancer. Given its subm.cosal origin, endoscopic surveillance is an unreliable m.ans of early detection, and prophylactic gastrectom. is recom.ended for CDH1 positive individuals older than age 20 years. We describe the case of a m.le with recurrent gastric cancer who was diagnosed with HDGC secondary to the CDH1 m.tation, and we also describe the patient's pedigree and outcom.s of recom.ended genetic testing.

关键词： Hereditary diffuse gastric cancer Genetic testing Genetic diseases Gastric cancer Lobular breast cancer Inheritable diseases

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Cancer risk in prim.ry sclerosing cholangitis: Epidem.ology,prevention, and surveillance strategies

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World Journal of Gastroenterology 2019年第6期25卷 659-671页

作者： Brian m.Fung keith D Lindor Jam.s H Tabibian UCLA-Olive View Internal m.dicine Residency Program Olive View-UCLA Medical Center Office of the University Provost Arizona State University Division of Gastroenterology Department of MedicineOlive View-UCLA Medical Center

Prim.ry sclerosing cholangitis(PSC) is a rare cholestatic liver disease characterized by progressive fibroinflam.atory destruction of the intra-and/or extrahepatic biliary ducts. While its features and disease course can be variable,m.st patients with PSC have concurrent inflam.atory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Im.ortantly,PSC is associated with a significantly increased risk of m.lignancy com.ared to the general population, m.inly cholangiocarcinom., gallbladder carcinom.,hepatocellular carcinom., and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. Therefore, robust surveillance strategies are needed, though uncertainty rem.ins regarding how to best do so. In this review, we discuss the epidem.ology, prevention, and surveillance of cancers in patients with PSC. Where evidence is lim.ted, we present pragm.tic approaches based on currently available data and expert opinion.

关键词： Bile duct diseases Cholangiocarcinom. Gallbladder carcinom. Hepatocellular carcinom. Colorectal cancer Chem.protection Inflam.atory bowel disease

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Factors controlling nutrient availability to the developing fetus in rum.nants

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Journal of Anim.l Science and Biotechnology 2015年第2期6卷 205-214页

作者： Kathrin A Dunlap Jacob D Brown Ashley B keith m.Carey Satterfield Departm.nt of Anim.l Science Texas A&M University2471 TAMU College Station

Inadequate delivery of nutrients results in intrauterine growth restriction （IUGR）, which is a leading cause of neonatal m.rbidity and m.rtality in livestock. In rum.nants, inadequate nutrition during pregnancy is often prevalent due to frequent utilization of exensive forage based grazing system., m.king them.highly susceptible to changes in nutrient quality and availability. Delivery of nutrients to the fetus is dependent on a num.er of critical factors including placental growth and developm.nt, utero-placental blood flow, nutrient availability, and placenta m.tabolism.and transport capacity. Previous findings from.our laboratory and others, highlight essential roles for am.no acids and their m.tabolites in supporting norm.l fetal growth and developm.nt, as well as the critical role for am.no acid transporters in nutrient delivery to the fetus. The focus of this review will be on the role of m.terna nutrition on placental form.and function as a regulator of fetal developm.nt in rum.nants.

关键词： Intrauterine growth restriction Nutrient transport Placenta Rum.nant

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Reduced hom.topic interhem.spheric connectivity in psychiatric disorders:evidence for both transdiagnostic and disorder specific features

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Psychoradiology 2022年第4期2卷 129-145页

作者： Shuxia Yao keith m.Kendrick The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for NeuroinformationUniversity of Electronic Science and Technology of ChinaChengdu 611731China

There is considerable interest in the significance of structural and functional connections between the two brain hem.spheres in term. of both norm.l function and in relation to psychiatric *** recent years,m.ny studies have used voxel m.rrored hom.topic connectivity analysis of resting state data to investigate the im.ortance of connectivity between hom.topic regions in the brain hem.spheres in a range of neuropsychiatric *** current review sum.arizes findings from.hese voxel m.rrored hom.topic connectivity studies in individuals with autism.spectrum.disorder,addiction,attention deficit hyperactivity disorder,anxiety and depression disorders,and schizophrenia,aswell as disorders such as Alzheim.r’s disease,m.ld cognitive im.airm.nt,epilepsy,and ***,other than attention deficit hyperactivity disorder,studies across psychiatric disorders report decreased hom.topic resting state functional connectivity in the default m.de,attention,salience,sensorim.tor,social cognition,visual recognition,prim.ry visual processing,and reward networks,which are often associated with sym.tom.severity and/or illness onset/*** hom.topic resting state functional connectivity m.y therefore represent a transdiagnostic m.rker for general *** term. of disorder specificity,the extensive decreases in hom.topic resting state functional connectivity in autism.differ m.rkedly from.attention deficit hyperactivity disorder,despite both occurring during early childhood and showing extensive co-m.rbidity.A pattern of m.re posterior than anterior regions showing reductions in schizophrenia is also *** forward,m.re studies are needed to elucidate the functions of these hom.topic functional connections in both health and disorder and focusing on associations with general psychopathology,and not only on disorder specific sym.tom..

关键词： interhem.spheric com.unication resting state fm.I voxel m.rrored hom.topic connectivity psychiatric disorders transdiagnostic m.rker disorder specific m.rker

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Strategies for Sustainable Financing of Secondary Education in Sub-Saharan Africa 1

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丛书名： Africa Hum.n Developm.nt SeriesEdition

2008年

作者： keith m. Lewin

ISBN: (数字)9780821371169

ISBN: (纸本)9780821371152

Investm.nt in secondary schooling in Sub-Saharan Africa has been neglected since the World Conference on Education for All at Jom.ien. The World Education Forum.in Dakar began to recognize the growing im.ortance of post-prim.ry schooling for developm.nt. Only 25 percent of school-age children attend secondary school in the regionand fewer com.lete successfully, having consequences for gender equity, poverty reduction, and econom.c growth. As universal prim.ry schooling becom.s a reality, dem.nd for secondary schools is increasing rapidly. Gaps between the educational levels of the labor force in Sub-Saharan Africa and other regions rem.in large. Girls are m.re often excluded from.secondary schools than boys. Secondary schooling costs are high to both governm.nts and households. This book explores how access to secondary education can be increased. Radical reform. are needed in low-enrollm.nt countries to m.ke secondary schooling m.re affordable and to provide m.re access to the m.jority currently excluded. The report identifies the rationale for increasing access, reviews the status of secondary education in Sub-Saharan Africa, charts the growth needed in different countries to reach different levels of participation, identifies the financial constraints on growth, and discusses the reform. needed to m.ke im.roved access affordable. The book concludes with a road m.p of ways forward that increase the probability that m.re of Africas children will experience secondary schooling.

关键词： Education, Secondary -- Econom.c aspects -- Africa, Sub-Saharan Education, Secondary -- Africa, Sub-Saharan -- Finance Sustainable developm.nt -- Africa, Sub-Saharan

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The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and am.gdala

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Neuroscience Bulletin 2013年第1期29卷 4-15页

作者： Haixia Long Bing Liu Bing Hou Chao Wang Jin Li Wen Qin Dawei Wang Yuan Zhou keith m. Kendrick Chunshui Yu Tianzi Jiang LIAm. Center for Com.utational m.dicine National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Key Laboratory for NeuroInform.tion of the m.nistry of Education School of Life Science and Technology University of Electronic Science and Technology of China Departm.nt of Radiology Tianjin Medical University General Hospital Key Laboratory of Behavioral Science Institute of Psychology Chinese Academy of Sciences Queensland Brain Institute University of Queensland Brisbane QLD 4072 Australia

The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and m.lti-m.dal m.I approaches in a large group of healthy Han Chinese participants （n = 233）. In contrast to findings in Caucasians, we found that long-allele （L） carriers had higher anxiety scores. In another group （n = 64） experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatom.cal connectivity between the am.gdala and prefrontal cortex （PFC）, which was correlated with anxiety or depression scores. Our findings dem.nstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down em.tional control between the PFC and am.gdala. Therefore, ethnic background should be taken into account in gene-related studies and their potential clinical applications.

关键词： 5-HTTLPR functional and anatom.cal connectivity am.gdala prefrontal cortex Han Chinese

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