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The Dream of Little Tuk

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英语画刊（初三版） 2011年第9期 1-4页

作者： hans christian.Andersen

《小杜克》是丹麦著名童话作家安徒生的作品。安徒生1805年出生于丹麦欧登塞的贫民区，父亲是个鞋匠，母亲是洗衣妇。安徒生在他的《童话全椠》的手记中写道：“这篇故事中有些情节牵涉到我儿时的记忆。”

关键词：英语学习中学英语课外读物英语阅读

Front line defenders of the ecological niche!Screening the structural diversity of peptaibiotics from saprotrophic and fungicolous Trichoderma/Hypocrea species

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Fungal Diversity 2014年第6期69卷 117-146页

作者： christian.R.Rohrich Walter M.Jaklitsch Hermann Voglmayr Anita Iversen Andreas Vilcinskas Kristian Fog Nielsen Ulf Thrane hans von Dohren hans Bruckner Thomas Degenkolb Bioresources Project Group Fraunhofer Institute for Molecular Biology and Applied Ecology(IME)Winchesterstrasse 235394 GiessenGermany Department of Systematic and Evolutionary Botany Faculty Centre of BiodiversityUniversity of ViennaRennweg 141030 ViennaAustria Department of Systems Biology Technical University of DenmarkSoltofts PladsBuilding 2212800 Kgs.LyngbyDenmark Interdisciplinary Research Centre for BioSystems Land Use and Nutrition(IFZ)Department of Applied EntomologyInstitute of Phytopathology and Applied Zoology(IPAZ)University of GiessenHeinrich-Buff-Ring 26-3235392 GiessenGermany Biochemistry and Molecular Biology OE 2 Institute of ChemistryTechnical University of BerlinFranklinstrasse 2910587 BerlinGermany Interdisciplinary Research Centre for BioSystems Land Use and Nutrition(IFZ)Department of Food SciencesInstitute ofNutritional ScienceUniversity of GiessenHeinrich-Buff-Ring 26-3235392 GiessenGermany AB SCIEXGermany GmbH Landwehrstrasse 5464293 DarmstadtGermany Danish Emergency Management Agency Universitetsparken 22100 CopenhagenDenmark

Approximately 950 individual sequences of nonribosomally biosynthesised peptides are produced by the genus Trichoderma/Hypocreathat belong to a perpetually growing class of mostly linear antibiotic oligopeptides,which are rich in the non-proteinogenic α-aminoisobutyric acid(Aib).Thus,they are comprehensively named ***,peptaibiotics represent ca.80% of the total inventory of secondarymetabolites currently known from Trichoderma/*** unique membrane-modifying bioactivity results from amphipathicity and helicity,thus making them ideal candidates in assisting both colonisation and defence of the natural habitats by their fungal *** this,reports on the in vivo-detection of peptaibiotics have scarcely been published in the *** order to evaluate the significance of peptaibiotic production for a broader range of potential producers,we screened nine specimens belonging to seven hitherto uninvestigated fungicolous or saprotrophic Trichoderma/Hypocrea species by liquid chromatography coupled to electrospray high resolution mass *** of peptaibiotics found were independently confirmed by analysing the peptaibiome of pure agar cultures obtained by single-ascospore isolation from the *** the nine species examined,five were screened positive for peptaibiotics.A total of 78 peptaibiotics were sequenced,56(=72%)of which are ***,dihydroxyphenylalaninol and O-prenylated tyrosinol,two C-terminal residues,which have not been reported for peptaibiotics before,were found as well as new and recurrent sequences carrying the recently described tyrosinol residue at their *** majority of peptaibiotics sequenced are 18-or 19-residue *** homologies with‘classical representatives’of subfamily 1(SF1)-peptaibiotics argue for the formation of transmembrane ion channels,which are prone to facilitate the producer capture and defence of its substratum.

关键词： HPLC/QTOF-ESI-HRMS Metabolite profiling Peptaibiotics Peptaibols Aib peptides Trichoderma Hypocrea

Solvent Interactions with Polymeric Heat Transfer Surfaces

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材料科学与工程（中英文A版） 2013年第9期3卷 591-600页

作者： christian.Dreiser hans-Joeg Bart Chair of Separation Science and Technology University of Kaiserslautern Kaiserslautern D-67653 Germany

Little Tiny or Thumbelina （III）

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考试与评价（英语高二专刊） 2017年第6期 44-45,38页

作者： hans christian.Andersen 曹硕不详吉林长春

Little Tiny or Thumbelina （I）

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考试与评价（英语高二专刊） 2017年第4期 44-46,39页

作者： hans christian.Andersen 曹硕不详吉林长春

世界上有一些书是可以从小读到老的，丹麦作家安徒生的童话就具有这种独特魅力。人们如此隆重地纪念一位童话作家，是因为他的童话作品已成为一代又一代读者心目中的经典，而经典的魅力是不会随时间的流逝而改变的。本期向你讲述其中的... 详细信息

世界上有一些书是可以从小读到老的，丹麦作家安徒生的童话就具有这种独特魅力。人们如此隆重地纪念一位童话作家，是因为他的童话作品已成为一代又一代读者心目中的经典，而经典的魅力是不会随时间的流逝而改变的。本期向你讲述其中的一个故事——拇指姑娘。

关键词：中等教育英语阅读理解

Associations of cerebrospinal fluid amyloidogenic nanoplaques with cytokines in Alzheimer’s disease

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Translational Neurodegeneration 2021年第2期10卷 230-239页

作者： Mari Aksnes hans christian.DAass Ann Tiiman Trine Holt Edwin Lars Terenius Nenad Bogdanovic Vladana Vukojevic Anne-Brita Knapskog Department of Geriatric Medicine Institute of Clinical MedicineFaculty of MedicineUniversity of OsloOsloNorway Department of Medical Biochemistry Oslo University HospitalOsloNorway Department of Clinical Neurosciences(CNS) Center for Molecular Medicine CMM L8:01Karolinska InstitutetStockholmSweden Department of Geriatric Medicine The Memory ClinicOslo University HospitalOsloNorway Institute of Health and Society Faculty of MedicineUniversity of OsloOsloNorway Norwegian National Advisory Unit on Ageing and Health Vestfold Hospital TrustTonsbergNorway Department of Neurobiology Care Science and Society(NVS)Division of Clinical GeriatricsKarolinska InstitutetHuddingeSweden

Background:The aggregation of amyloidβ(Aβ)is central in the pathogenesis of Alzheimer’s disease(AD).Recently it has been shown that specifically,larger,Thioflavin T-binding Aβaggregates are associated with increased neuroinflammation and cytokine *** study was aimed to quantify fibrillary amyloid aggregates,so-called nanoplaques,and investigate their relationship with cytokines in the cerebrospinal fluid(CSF).Methods:CSF was collected from 111 patients assessed for cognitive complaints at the Oslo University Hospital Memory *** patients were grouped based on their amyloid *** CSF nanoplaque concentration was quantified with the Thioflavin T-fluorescence correlation spectroscopy(ThT-FCS)*** levels of nine cytokines(eotaxin-1,granulocyte stimulating factor,interleukin[IL]-6,IL-7,IL-8,monocyte chemoattractant protein-1,gammainduced protein 10,macrophage inflammatory protein[MIP]-1α,and MIP-1β)were quantified with a magnetic bead-based multiplex assay and read on a Luminex IS 200 ***:There were 49 amyloid-negative and 62 amyloid-positive patients in the cohort;none of the cytokines differed significantly between the amyloid *** increased nanoplaque levels were associated with levels of MIP-1βbelow the lower limit of quantification,and with decreased levels of MIP-1αand *** associations remained significant when adjusted for age,sex,cognitive function,apolipoproteinε4 status and CSF core biomarker ***:The cytokine levels were not associated with amyloid status in this *** nanoplaque levels were negatively associated with MIP-1β,MIP-1αand IL-8,which is in line with recent findings suggesting that the upregulation of some cytokine markers has a protective role and is negatively associated with AD progression.

关键词： Alzheimer's disease Amyloid Amyloid beta peptides Amyloidogenic proteins Biomarkers Cerebrospinal fluid Cytokines Inflammation Fluorescence correlation spectroscopy Thioflavin T

Benzyl Amino Purine and Gibberellic Acid Coupled to Nitrogen-Limited Stress Induce Fatty Acids,Biomass Accumulation,and Gene Expression in Scenedesmus Obliquus

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 515-531页

作者： hans christian.Correa-Aguado Gloria Viviana Cerrillo-Rojas Alejandro Rocha-Uribe Ruth Elena Soria-Guerra JoséFrancisco Morales-Domínguez Departamento de Química Centro de Ciencias BásicasUniversidad Autónoma de AguascalientesAguascalientes20131México Facultad de Ciencias Químicas Universidad Autónoma de San Luis PotosíSan Luis Potosí78210México Instituto Politécnico Nacional Unidad Profesional Interdisciplinaria de Ingeniería Campus ZacatecasBlvd.del Bote 202Cerro del Gato Ejido La EscondidaCol.Ciudad AdministrativaZacatecasZAC 98160Mexico

The need for renewable energy sources makes microalgae an essential feedstock for biofuels *** molecular aspects and the response to nitrogen(N)-limited conditions with a phytohormone stimulus in microalgae have been slightly *** this work,Scenedesmus obliquus was used as a study model to analyze the effect of benzyl amino purine(BAP)and gibberellic acid(GA)coupled to nitrogen limitation on cell growth,biomass and fatty *** selected 10^(-5)M BAP increased the biomass by 1.44-fold,and 10^(-6)M GA by *** total lipids also increased by 2.8 and 1.11-fold,*** 10^(-5)M BAP and 10^(-6)M GA addition to *** cultures at different initial nitrogen percentages(N-0,N-25,and N-50)showed a significant increase in cell growth and biomass productivity compared to the unstimulated *** N-0 and GA N-0 produced the highest lipid yields with 55%and 50%,*** lipid profile analysis revealed an increase,particularly in C18:1 and C16:0 fatty *** expression analysis showed an over-expression of acyl carrying protein(ACP),stearoyl-ACP desaturase(SAD),fatty acid acyl-ACP thioesterase(FATA),and diacylglycerol acyltransferase(DGAT)genes,which were mainly induced by nitrogen ***,BAP and GA produced a significant over-expression on these genes in the N-replete *** study shows that BAP and GA,coupled to N limitation stress,can be used to increase the biomass and lipid production in *** for sustainable biofuels.

关键词： Biodiesel gene expression lipids microalgae nitrogen deficiency phytohormones

Host and viral factors contributing to CD8+ T cell failure in hepatitis C virus infection

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World Journal of Gastroenterology 2007年第36期13卷 4839-4847页

作者： Christoph Neumann-Haefelin hans christian.Spangenberg Hubert E Blum Robert Thimme Department of Medicine Ⅱ University Hospital Freiburg Germany

Virus-specific CD8+ T cells are thought to be the major anti-viral effector cells in hepatitis C virus (HCV) infection. Indeed, viral clearance is associated with vigorous CD8+ T cell responses targeting multiple epitopes. In the chronic phase of infection, HCV-specific CD8+ T cell responses are usually weak, narrowly focused and display often functional defects regarding cytotoxicity, cytokine production, and proliferative capacity. In the last few years, different mechanisms which might contribute to the failure of HCV-specific CD8+ T cells in chronic infection have been identified, including insufficient CD4+ help, deficient CD8+ T cell differentiation, viral escape mutations, suppression by viral factors, inhibitory cytokines, inhibitory ligands, and regulatory T cells. In addition, host genetic factors such as the host’s human leukocyte antigen (HLA) background may play an important role in the efficiency of the HCV- specific CD8+ T cell response and thus outcome of infection. The growing understanding of the mechanisms contributing to T cell failure and persistence of HCV infection will contribute to the development of successful immunotherapeutical and -prophylactical strategies.

关键词： Hepatitis C virus CD8+ T cells T cell failure Viral escape Programmed death 1 Regulatory T cells T cell maturation Human leukocyte antigen

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雪花莲

疯狂英语（初中天地） 2006年第2期 24-28页

作者： hans christian.Andersen 叶林

你见过雪花莲吗?如果没有,那就读一读安徒生的这个故事吧。看这个故事之前,小编可真是从没见过这种美丽的花。乍一看,以为这只是一个讲述雪花莲曲折经历的故事,但在最后,我们就会发现作者是借雪花莲赞扬丹麦的一位诗人。我们可能没听说... 详细信息

你见过雪花莲吗?如果没有,那就读一读安徒生的这个故事吧。看这个故事之前,小编可真是从没见过这种美丽的花。乍一看,以为这只是一个讲述雪花莲曲折经历的故事,但在最后,我们就会发现作者是借雪花莲赞扬丹麦的一位诗人。我们可能没听说过这位诗人,但故事歌颂的那些思想进步的人则存在于我们周围。隆冬之际,你可有留意身边开放的雪花莲?

关键词：雪花莲一朵花