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Science China Chemistry 2013年第8期56卷 1029-1039页

作者： ROMERO Gabriela MURRAY Richard A. QIU Yuan SANZ David moya Sergio E. Biosurfaces Department CIC biomaGUNE Department of Polymer Science and Engineering Zhejiang University

Recent work regarding the Layer by Layer (LbL) engineering of poly(lactide-co-glycolide) nanoparticles (PLGA NPs) is reviewed *** LbL engineering of PLGA NPs is applied as a means of generating advanced drug delivery devices with tailored recognition,protection,cargo and release *** in combination with covalent chemistry is used to attach PEG and folic acid to control cell uptake and direct it towards cancer *** coatings composed of chitosan and alginate show low protein interactions and can be used as an alternative to *** assembly on top of LbL coatings of lipid layers composed of variable percentages of 1,2-dioleoyl-sn-glycero-3-choline (DOPC) and 1,2-dioleoyl-sn-glycero-3-phosphoL-serine (DOPS) increases NP uptake and directs the NPs towards the endoplasmic *** antibody anti-TNF-α is encapsulated forming a complex with alginate that is assembled LbL on top of PLGA *** antibody is released in cell culture following first order *** release kinetics of encapsulated molecules inside PLGA NPs are studied when the PLGA NPs are coated via LbL with different *** intracellular release of encapsulated Doxorubicin is studied in the HepG2 cell line by means of Fluorescence Lifetime Imaging.

关键词：纳米工程乙醇酸靶向给药乳酸表面层纳米层多功能蛋白质相互作用

Evaluation of three sets of advanced backcrosses of eggplant with wild relatives from different gene pools under low N fertilization conditions

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Horticulture Research 2023年第8期10卷 295-309页

作者： Gloria Villanueva Mariola Plazas Pietro Gramazio Reyes D.moya Jaime Prohens Santiago Vilanova Instituto de Conservación y Mejora de la Agrodiversidad Valenciana Universitat Politècnica de ValènciaCamino de Vera 1446022ValenciaSpain

The development of new cultivars with improved nitrogen use efficiency(NUE)is key for implementing sustainable agriculture *** wild relatives(CWRs)provide valuable genetic resources for breeding programs aimed at achieving this *** this study,three eggplant(Solanum melongena)accessions together with their advanced backcrosses(ABs;BC3 to BC5 generations)were evaluated for 22 morpho-agronomic,physiological,and NUE traits under low nitrogen(LN)fertilization *** ABs were developed with introgressions from the wild relatives Solanum insanum,Solanum dasyphyllum,and Solanum *** AB population comprised a total of 25,59,and 59 genotypes,respectively,with overall donor wild relative genome coverage percentages of 58.8%,46.3%,and 99.2%.The three *** recurrent parents were also evaluated under control(normal)N *** of N fertilization in the parents resulted in decreased chlorophyll content-related traits,aerial biomass,stem diameter,and yield and increased NUE,nitrogen uptake efficiency(NUpE),and nitrogen utilization efficiency(NUtE).However,the decrease in yield was moderate,ranging between 62.6%and 72.6%.A high phenotypic variation was observed within each of the three sets of ABs under LN conditions,with some individuals displaying improved transgressive characteristics over the recurrent *** the single primer enrichment technology 5 k probes platform for high-throughput genotyping,we observed a variable but high degree of recurrent parent genome recovery in the ABs attributable to the lines recombination,allowing the successful identification of 16 quantitative trait loci(QTL).Different allelic effects were observed for the introgressed QTL *** candidate genes were identified in the QTL regions associated with plant growth,yield,fruit size,and NUE-related *** results show that eggplant materials with introgressions from CWRs can result in a dramatic impact in eggplant breedi

关键词： breeding cultivar fertilization

Development of heartwood,sapwood,bark,pith and specific gravity of teak(Tectona grandis)in fast-growing plantations in Costa Rica

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Journal of Forestry Research 2020年第2期31卷 667-676页

作者： Alexander Berrocal Johana Gaitan-Alvarez Roger moya David Fernandez-Solis Edgar Ortiz-Malavassi Instituto Tecnologico de Costa Rica Escuela de Ingenieria ForestalCartago Apartado 159-7050Costa Rica

To elucidate the development of heartwood,bark,sapwood,pith and specific gravity of wood in fastgrowing teak(Tectona grandis)plantations in Costa Rica,we sampled three trees in each of 55 plantations and modelled each variable with age,site and different tree *** and stand density of plantations were significant correlated with stem diameter at breast height and total height of the *** of heartwood was initiated at the age of 4-year-old and increased in direct proportion with *** age of plantation had a significant relationship with stem diameter at breast height,heartwood percentage,sapwood thickness,sapwood percentage,percentage of bark,pith diameter and percentage,and specify *** model for these tree parameters was model with these parameters as dependent variable and in relation to age as independent variable.

关键词： Teak Growth Tree morphology parameters Morphology Tree development

Bilateral Carotid Aneurysms Secondary to Catastrophic Antiphospholipid Syndrome in a Patient with Differential Diagnosis of Polyarteritis Nodosa

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World Journal of Cardiovascular Diseases 2022年第1期12卷 30-37页

作者： Alexandre Sacchetti Bezerra Fernanda Gonçalves moya Idalecio Souto Fonseca Filho Alexandre Cesar Fioretti Instituto de Infectologia Emilio Ribas S&atilde o Paulo Brazil Universidade de Sao Paulo S&atilde o Paulo Brazil Faculdade de Medicina do ABC S&atilde o Paulo Brazil

Background: Extracranial Carotid Artery Aneurysm is considered a therapeutic and diagnostic challenge. In an unprecedented way in the literature, we describe an aneurysm originating from the Catastrophic Antiphospholipid Syndrome. Case Presentation: A 25-year-old male patient came to the Emergency Room of the ABC University Hospital in Sao Bernardo do Campo referring to bilateral neck pain for 1 month, associated with carotid aneurysms. Due to the severity and urgency of the clinical condition, immediate surgical therapy was performed without a definitive etiological diagnosis. The initial morphological analysis of the carotid artery suggested a diagnosis of Polyarteritis Nodosa. After anamnesis, physical examination, the use of a specific primary vasculitis algorithm, and a review of the pathological anatomy was requested, which showed bilateral carotid aneurysms secondary to catastrophic antiphosp

关键词： Aneurism Anticardiolipin Antibodies Antiphospholipid Syndrome Carotid Artery Thrombosis

Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion

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Science China Chemistry 2018年第1期61卷 54-63页

作者： Haolan Zhang Danyu Wang Xue Lin Nikolaos Politakos Jimena S. Tuninetti Sergio Enrique moya Changyou Gao Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Department of Polymer Science and Engineering Zhej iang University Hangzhou 310027 China Centre for Cooperative Research in Biomaterials San Sebastian 20009 Gipuzkoa Spain Dr. Li Dak Sum & Iqp Chin Center for Stem Cell and Regenerative Medicine Zhejiang University Hangzhou 310058 China

Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer(LbL) self-assembly are much attractive due to their advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate(PA) was synthesized, and was copolymerized with acrylic acid(AA) to obtain the amphiphilic and photodegradable P(PA-co-AA)polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride(PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549, HepG2 and endothelial cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected significantly until 5 d.

关键词： biomaterials multilayers surfaces photo-responsive cell adhesion

Study of wind towers with different funnels attached to in crease natural ventilation in an underground building

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Frontiers of Architectural Research 2020年第4期9卷 925-939页

作者： C.A.Varela-Boydo S.L.moya R.Watkins Tecnologico Nocional de Mexico Centro Nacional de Investisacion y Desorrollo TecnoldsicoInterior Internado Palmira s/nColonia PalmiraCuernavaca62490 MorelosMexico Kent School of Architecture&Planning University of KentUK

Finding ways to cool buildings by natural,passive techniques is crucial in the context of global *** centuries,wind towers(traditi onal win dcatchers)have been used in the Middle East for cooling *** this study,the use of funnels at the openings of wind towers for wind ingress and egress is proposed primarily to increase the mass flow captured by the wind *** use of funnels in the wind in gress openings in creases the inlet area,improving the capture of *** parallel,the use of funnels in the egress openings modifies the wake of the tower,which aims to ease the exit of the flow from inside the *** design configurations are presented,where the length and width of the funnels are changed and tested separately by computational fluid dynamics(CFD).Results of over 120 CFD simulations are presented and *** volumetric flow entering the wind towers in creases by 10.7% in several *** results in dicate that adding funnels to wind towers could positively in fluence their *** the dimensions of the funnels affects their efficacy and can increase or decrease the airflow entering the tower.

关键词： Wind towers Passive cooling Natural ventilation Funnels CFD Wind catchers

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VITÁPOLIS老年公寓

当代建筑 2022年第10期 108-117页

作者：无 Ángel Segura(摄影) Romero&Vallejo建筑事务所不详

本项目是Romero&Vallejo建筑事务所为老年人量身定制的住宅综合体,旨在服务于老龄社会,关注老年人的福祉。除了35套完全无障碍的独立公寓外,本项目还涵盖了占地面积1500 m2的社区服务空间,包括体育馆、工作室、餐厅、会议室、休息室、... 详细信息

本项目是Romero&Vallejo建筑事务所为老年人量身定制的住宅综合体,旨在服务于老龄社会,关注老年人的福祉。除了35套完全无障碍的独立公寓外,本项目还涵盖了占地面积1500 m2的社区服务空间,包括体育馆、工作室、餐厅、会议室、休息室、花园、游泳池等体育及休闲设施。换言之,VITÁPOLIS老年公寓的设计已经超越了对建筑单体的思考,而是旨在以一种适宜的方式迎合老年人的生理和情感需求。

关键词：老年公寓建筑事务所建筑单体休闲设施游泳池无障碍体育馆占地面积

Cellular targets in diabetic retinopathy therapy

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World Journal of Diabetes 2021年第9期12卷 1442-1462页

作者： María Lucía Rodríguez Iván Millán Ángel Luis Ortega Department of Physiology Faculty of PharmacyUniversity of ValenciaBurjassot 46100ValenciaSpain Neonatal Research Group Health Research Institute La FeValencia 46026ValenciaSpain

Despite the existence of treatment for diabetes,inadequate metabolic control triggers the appearance of chronic complications such as diabetic *** retinopathy is considered a multifactorial disease of complex etiology in which oxidative stress and low chronic inflammation play essential *** exposure to hyperglycemia triggers a loss of redox balance that is critical for the appearance of neuronal and vascular damage during the development and progression of the *** therapies for the treatment of diabetic retinopathy are used in advanced stages of the disease and are unable to reverse the retinal damage induced by *** lack of effective therapies without side effects means there is an urgent need to identify an early action capable of preventing the development of the disease and its pathophysiological consequences in order to avoid loss of vision associated with diabetic ***,in this review we propose different therapeutic targets related to the modulation of the redox and inflammatory status that,potentially,can prevent the development and progression of the disease.

关键词： Diabetic retinopathy Oxidative stress Inflammation Cellular target Diabetic macular edema

Effects of loadinge-unloading and wettinge-drying cycles on geomechanical behaviors of mudrocks in the Colombian Andes

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Journal of Rock Mechanics and Geotechnical Engineering 2014年第3期6卷 257-268页

作者： Mario Camilo Torres-Suarez Adolfo Alarcon-Guzman Rafael Berdugo-De moya National University of Colombia North University Barranquilla Colombia

The mudrocks in the Colombian Andes, particularly those exhibiting low cementation （bonding）, are susceptible to degradation when the environmental conditions change, which are challenging issues for engineering works. In this paper, the changes in physico-mechanical properties of mudrocks were moni- tored in laboratory, and some influential factors on the mechanical competence of geomaterials were studied. The geotechnical characteristics and experimental designs were developed from physical, chem- ical, mechanical and compositional points of view. In the tests, the techniques such as vapor equilibrium technique （VET） were employed to apply wetting-drying cycles and to control relative humidity （suction- controlled） and loading-unloading cycles through ultrasonic wave velocities technique. The results show that the main failure mechanisms for the laminated mudrocks start on the microscopic scale by fissures coalescence, exhibiting physico-chemical degradation as well; the global geomechanical behavior presents a state between a ductile, like rock, and a fragile, like soil. The obtained results can provide engineering values according to monitoring laboratory set, when compared with in situ conditions.

关键词： MudrocksDegradation processesSuction changesStress-strain behaviorVapor equilibrium technique (VET)

Initial floristic composition of rehabilitated gullies through bioengineering in the Mixteca Region, Sierra Madre del Sur, Mexico

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Journal of Mountain Science 2018年第10期15卷 2120-2135页

作者： Verónica Guadalupe LIRA-CABALLERO Mario Roberto MARTíNEZ-MENEZ Angélica ROMERO-MANZANARES Edmundo GARCíA-moya Department of Hydrosciences Colegio de Postgraduados Department of Botany Colegio de Postgraduados

Re-vegetation plays a fundamental role for erosion control and plant recovery in lands affected by gully erosion. Bioengineered practices facilitate the gullies rehabilitation. Objectives of the research were: 1) Identify taxonomically the pioneer vegetation on each gully section; 2) Characterize vegetation distribution preferences and 3) Assess structural/functional traits to recognize erosion control key species. Bioengineering was applied in a watershed belonging to Sierra Madre del Sur, at Oaxaca, Mexico, on eight gullies, with local support and minimal investment. "La Mixteca" is a poor ecological and socio-economic region, comparable to other regions of the world. The Initial Floristic Composition(IFC) inventory is the baseline of the successional process. The transect method was used to determine the colonization of species. Cover abundance of registered species was estimated using the semi-quantitative scale of Braun-Blanquet. This procedure was repeated in five different positions(floor, hillslopes and tops), in the cross section of the gully. Throughcorrespondence analysis and clustering, the distribution of species was analyzed. Adequate responses were obtained in soil retention(quantity) and plant cover(existence and diversity); as measurable indicators of the bioengeneering works efficiency. Occupation of soil by native species from the Tropical Deciduous Forest was favored using live barriers. We detected species guilds with spatial distribution preferences in the gullies cross section. Plant cover characterization includes: native colonizer species, herbaceous, shrubby and trees of the forest community bordering the gully area, with cover abundance and structural/functional traits, useful to protect degraded areas. This spatial occupation process of plants responds to a secondary succession in gullies, where the proposed IFC model is correctly represented through bioengineering. Natural establishment of plants was successful by traits of species such

关键词：生物工程学 del 墨西哥植物恢复侵蚀控制社会经济工作效率行业协会