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琼东南盆地陵水北坡LS13-2区勘探思路与突破方向

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石油与天然气地质 2024年第3期45卷 673-683页

作者：周荔青江东辉杨鹏程张如凤董鑫桑亚迪中国石化上海海洋油气分公司上海200120

琼东南盆地陵水凹陷南坡已发现了中央峡谷千亿方级气田,证实了陵水凹陷为富生烃凹陷。而陵水凹陷北坡LS13-2区的岩性圈闭勘探虽然也取得了“点”上的突破,但“见气不见田”,勘探效果不佳。为了明确该地区的油气富集规律和有利区带,以含... 详细信息

琼东南盆地陵水凹陷南坡已发现了中央峡谷千亿方级气田,证实了陵水凹陷为富生烃凹陷。而陵水凹陷北坡LS13-2区的岩性圈闭勘探虽然也取得了“点”上的突破,但“见气不见田”,勘探效果不佳。为了明确该地区的油气富集规律和有利区带,以含油气盆地分析为基础,聚焦关键成藏要素,提出了新的勘探思路,并明确了有利成藏区带。研究结果表明:工区成藏条件整体有利,具备“充足烃源、规模储层、高效输导、整体保存”的大-中型油气田形成基础,但对于中新统岩性圈闭勘探来讲,也存在“烃源岩主排烃期早于圈闭定型期,断层垂向输导能力低”的不利因素,据此建立了“早期成藏、岩性圈闭、断-砂输导”三元勘探评价要素,并评价认为探区西部断坡海底扇带具备“原生油气藏、规模岩性圈闭、断-砂高效输导”的有利成藏条件,为最有利成藏区带。

关键词：富集规律成藏条件有利区带梅山组陵水凹陷琼东南盆地

M2-specific reduction of CD1d switches NKT cell-mediated immune responses and triggers metaflammation in adipose tissue

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Cellular & Molecular Immunology 2018年第5期15卷 506-517页

作者： Huimin Zhang rufeng Xue Shasha Zhu Sicheng Fu Zuolong Chen Rongbin zhou Zhigang Tian li Bai CAS Key Laboratory of Innate Immunity and Chronic Disease CAS Center for Excellence in Molecular Cell ScienceSchool of Life Sciences and Medical CenterUniversity of Science and Technology of ChinaHefei 230027China Innovation Center for Cell Signaling Network Hefei National Laboratory for Physical Sciences at MicroscaleHefei 230027China

Metaflammation is responsible for several metabolic syndromes,such as type 2 ***,the mechanisms by which metabolic disorders trigger metaflammation remain *** identified a cell type-specific downregulation of CD1d expression in M2 macrophages during the progression of obesity prior to the onset of inflammation in visceral adipose tissues.A reduction in CD1d expression influenced the ability of M2 macrophages to present antigens and caused a change in antigen-presenting cells from M2 macrophages to M1 *** CD1d conditional knockout(KO)mice,we further demonstrated that natural killer T(NKT)cell activation by M2 macrophages inhibited metaflammation and insulin resistance by promoting Th2 responses and M2 polarization in visceral adipose tissues of obese mice,whereas NKT cell activation by M1 macrophages exacerbated metaflammation and insulin resistance by promoting Th1 responses and inhibiting M2 *** results suggest that an M2-specific reduction of CD1d is an initiating event that switches NKT cell-mediated immune responses and disrupts the immune balance in visceral adipose tissues in obese mice.

关键词： CD1d macrophage metaflammation NKT cells

Structural mechanism of a dual-functional enzyme Dgp A/B/C as both a C-glycoside cleaving enzyme and an O-to C-glycoside isomerase

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Acta Pharmaceutica Sinica B 2023年第1期13卷 246-255页

作者： Pengfei He Sha Wang Sen li Siqi liu Shuqi zhou Jing Wang Jiayue Tao Dongdong Wang rufeng Wang Wenfu Ma School of life Science Beijing University of Chinese MedicineBeijing 102488China DP Technology Bejing 100080China

The C-glycosidic bond that connects the sugar moiety with aglycone is difficult to be broken or made due to its inert *** knowledge of C-glycoside breakdown and synthesis is very ***,the enzyme Dgp A/B/C cascade from a human intestinal bacterium PUE was identified to specifically cleave the C-glycosidic bond of puerarin(daidzein-8-C-glucoside).Here we investigated how puerarin is recognized and oxidized by Dgp A based on crystal structures of Dgp A with or without substrate and biochemical *** strikingly,we found that apart from being a C-glycoside cleaving enzyme,Dgp A/B/C is capable of efficiently converting O-to C-glycoside showing the activity as a structure isomerase.A possible mechanistic model was proposed dependently of the simulated complex structure of Dgp B/C with 3’’-oxo-daidzin and structure-based *** findings not only shed light on understanding the enzyme-mediated C-glycosidic bond breakage and formation,but also may help to facilitate stereospecific C-glycoside synthesis in pharmaceutical industry.

关键词： C-Glycoside O-Glycoside C-Glycoside cleaving enzyme Isomerase Gut microbiota Flavonoid Puerarin and oxidoreductase

Safety and efficacy of the SeparGateTM balloon-guiding catheter in neurointerventional surgery:A prospective,multicenter,single-arm clinical trial

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Journal of Interventional Medicine 2022年第3期5卷 143-147页

作者： Huan liu rufeng Jia Yanyan He Tengfei zhou liangfu Zhu Yonghong Ding Juha Antero Hernesniemi Tianxiao li Yingkun He Department of Cerebrovascular Disease Zhengzhou University People's HospitalHenan University People's HospitalHenan Provincial People's HospitalHenan Provincial Neurointerventional Engineering Research CenterHenan International Joint Laboratory of Cerebrovascular Disease and Henan Engineering Research Center of CerebrovascularInterventionZhengzhou450003China Department of Radiology Mayo CliniRochesterMNUS “Juha Hernesniemi”International Center for Neurosurgery Henan Provincial People s HospitalZhengzhouChina

Objective:To evaluate the safety and efficacy of the SeparGateballoon-guiding catheter(BGC)for blocking flow and delivering devices in neurointerventional ***:This prospective multicenter single-arm trial enrolled patients who received BGC adjuvant therapy to provide temporary blood flow arrest of the supra-aortic arch arteries and their branch vessels in interventional *** primary endpoint was immediate procedural success rate in flow arrest,device delivery,and *** efficacy endpoints were intraoperative product performance,including rigidity,smoothness,fracture resistance of the catheter wall,catheter push performance,compatibility and radiopaque display,integrity,adhesion thrombus after withdrawal and balloon *** safety endpoints were adverse and serious adverse events associated with the test device and serious adverse events resulting in death or serious health ***:A total of 129 patients were included;of them,128 were analyzed in the full analysis set(FAS)and per protocol set(PPS).Immediate procedural success was achieved in 97.7%of patients with FAS and *** lower bound of the 95%confidence interval was 94.6%,higher than the preset efficacy margin of 94%.Device-related adverse events occurred in 2(1.6%)*** was mild adverse event of vasospasm,which resolved *** other was serious adverse event of dissection aggravation,which was treated with stenting *** device defects were ***:In neurointerventional surgery,the SeparGateBGC can be used to temporarily block the flow of the supra-aortic arch arteries and their branch vessels and guide the interventional device to the target vascular position.

关键词： SeparGateTM balloon guiding catheter Safety and efficacy Neurointerventional surgery

新型股骨锁定钢板联合钛缆内固定治疗Vancouver B1型股骨假体周围骨折的疗效分析

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中国骨与关节损伤杂志 2024年第8期39卷 790-793页

作者：荚龙吴晓天周凯华何小健陈铭吉高如峰复旦大学附属中山医院青浦分院骨科上海201700

目的观察新型股骨锁定钢板联合钛缆捆扎内固定治疗Vancouver B1型股骨假体周围骨折的临床疗效。方法本研究回顾性分析自2019-06—2022-06于笔者所在医院采用带有大粗隆钩形爪结构的新型股骨钢板联合钛缆捆扎内固定治疗10例Vancouver B1... 详细信息

目的观察新型股骨锁定钢板联合钛缆捆扎内固定治疗Vancouver B1型股骨假体周围骨折的临床疗效。方法本研究回顾性分析自2019-06—2022-06于笔者所在医院采用带有大粗隆钩形爪结构的新型股骨钢板联合钛缆捆扎内固定治疗10例Vancouver B1型股骨假体周围骨折。骨折复位后选择合适长度带有大粗隆钩形结构的股骨锁定钢板置于股骨外侧,近端钩形装置钩住大粗隆,采用专用的弧形导向器于大粗隆下方用1根钛缆经钢板线缆通道斜向穿过小粗隆下方,收紧后将股骨与钢板固定在一起,在股骨近端用另外1根钛缆经线缆通道将股骨干与钢板固定在一起,近端因假体存在使用平头锁定螺钉单皮质固定,远端可通过微创小切口经皮置入锁定螺钉实现双皮质固定。结果所有患者均获得随访,随访时间12~27个月,平均17.8月,无切口感染、内固定及假体松动、断裂等并发症。所有患者手术均顺利完成,1例术前下肢静脉B超提示深静脉血栓,血管外科会诊后放置下肢静脉滤器后完成手术。本组手术时间110~160 min,平均128.0 min;术中出血量100~500 mL,平均370.0 mL。本组中8例术中进行输血,其中7例输2 U红细胞悬液+200 mL血浆,1例输4 U红细胞悬液+200 mL血浆;4例术后因贫血进行输血,其中3例输2 U红细胞悬液+200 mL血浆,1例输2 U红细胞悬液。本组住院时间12~20 d,平均16.0 d;骨折愈合时间4~6个月,平均4.8个月。末次随访患者髋关节功能Harris评分72~92分,平均82.2分。结论带有大粗隆钩形爪结构的新型股骨锁定钢板联合钛揽捆扎内固定治疗Vancouver B1型股骨假体周围骨折可获得骨折断端的坚强固定,加速患者早期康复,近期疗效较好。

关键词：股骨假体周围骨折锁定钢板钛缆内固定

文昌B凹陷差异伸展-走滑机制及控藏作用研究

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地质学报 2020年第8期94卷 2422-2432页

作者：江汝锋周家雄杨希冰游君君李珊珊陈林张霞中海石油(中国)有限公司湛江分公司广东湛江524057

为查明文昌B凹陷油气富集差异性的原因,基于断裂展布和形成期次、构造样式组合、构造演化和断层活动的差异等标志,建立了差异伸展-走滑机制,识别出19洼为伸展-强走滑、14洼为伸展-中等走滑、30洼为伸展-弱走滑。差异伸展-走滑作用控制... 详细信息

为查明文昌B凹陷油气富集差异性的原因,基于断裂展布和形成期次、构造样式组合、构造演化和断层活动的差异等标志,建立了差异伸展-走滑机制,识别出19洼为伸展-强走滑、14洼为伸展-中等走滑、30洼为伸展-弱走滑。差异伸展-走滑作用控制了优质烃源岩的展布和供烃方向,控制输导体系类型和运移动力,提供物源通道和改造储层,还控制了圈闭类型和力学性质。进一步深化了走滑增压理论,基于先存断裂形态、伸展应力场右旋演化和应变差异,建立了走滑增压圈闭识别方法,识别出S型增压、右行左阶增压、斜交型增压3种走滑增压构造。研究表明,文昌B凹陷的油气富集受伸展-走滑构造背景、源-运时空配置关系所控制,强—中等走滑变形、发育优质中深湖源岩的文昌19洼和14洼是油气富集区。该研究成果成功推动了文昌凹陷近期的多个勘探发现。

关键词：差异伸展-走滑控藏作用走滑增压文昌凹陷珠三坳陷珠江口盆地西部

基于CMT的钛合金电弧增材制造技术研究现状与展望

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中国表面工程 2021年第3期34卷 1-15页

作者：伊浩黄如峰曹华军刘蒙霖周进重庆大学机械与运载工程学院重庆400030 重庆大学机械传动国家重点实验室重庆400044

钛合金高强度、高耐热的特性决定了其在航空航天、船舶制造等领域的广泛应用,但由于钛合金的难加工性,使得传统锻造+机加的方式模具损耗严重、制造周期长。增材制造作为一种制造成本低、成形效率高的绿色化制造工艺,凭借其无需模具、直... 详细信息

钛合金高强度、高耐热的特性决定了其在航空航天、船舶制造等领域的广泛应用,但由于钛合金的难加工性,使得传统锻造+机加的方式模具损耗严重、制造周期长。增材制造作为一种制造成本低、成形效率高的绿色化制造工艺,凭借其无需模具、直接成形的优势在钛合金制造领域受到国内外学者的广泛关注。电弧增材制造技术相较于其他增材工艺(如激光增材制造、电子束增材制造等)沉积效率更高,不受零件尺寸的限制,在大型和超大型结构件的制造中具有突出优势,其中基于冷金属过渡(Cold metal transfer,CMT)的电弧增材制造技术由于沉积过程更稳定、热输入量更低,已逐渐成为钛合金增材制造领域的研究热点。文中对基于冷金属过渡的钛合金电弧增材制造技术的研究现状进行综述,介绍钛合金打印件的微观组织和力学性能特征,总结分析了成形参数对打印件微观组织与力学性能的影响规律,并概述了形核条件调控、轧制和超声冲击等辅助技术对打印件微观组织与力学性能的影响机制,最后展望了钛合金CMT电弧增材制造的未来发展趋势。

关键词：钛合金冷金属过渡电弧增材制造微观组织力学性能

BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes

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Journal of Molecular Cell Biology 2023年第5期15卷 21-37页

作者： rufeng Xu Kaiyuan Wang Zhengjian Yao Yan Zhang li Jin Jing Pang Yuncai zhou Kai Wang Dechen liu Yaqin Zhang Peng Sun Fuqiang Wang Xiaoai Chang Tengli liu Shusen Wang Yalin Zhang Shuyong lin Cheng Hu Yunxia Zhu Xiao Han Key Laboratory of Human Functional Genomics of Jiangsu Province Nanjing Medical UniversityNanjing 211166China Institute for Metabolic Disease Fengxian Central Hospital Affiliated to Southern Medical UniversityShanghai 201499China Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes MellitusShanghai Clinical Center for DiabetesShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China Analysis Center Nanjing Medical UniversityNanjing 210029China Organ Transplant Center Tianjin First Central HospitalNankai UniversityTianjin 300192China State Key Laboratory for Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen 361102China

Brain-specific serine/threonine-protein kinase 2(BRSK2)plays critical roles in insulin secretion andβ-cell ***,whether BRSK2 is associated with human type 2 diabetes mellitus(T2DM)has not been ***,we report that BRSK2 genetic variants are closely related to worsening glucose metabolism due to hyperinsulinemia and insulin resistance in the Chinese ***2 protein levels are significantly elevated inβcells from T2DM patients and high-fat diet(HFD)-fed mice due to enhanced protein *** with inducibleβ-cell-specific Brsk2 knockout(βKO)exhibit normal metabolism with a high potential for insulin secretion under chow-diet ***,βKO mice are protected from HFD-induced hyperinsulinemia,obesity,insulin resistance,and glucose ***,gain-of-function BRSK2 in matureβcells reversibly triggers hyperglycemia due toβ-cell hypersecretion-coupled insulin ***,BRSK2 senses lipid signals and induces basal insulin secretion in a kinase-dependent *** enhanced basal insulin secretion drives insulin resistance andβ-cell exhaustion and thus the onset of T2DM in mice fed an HFD or with gain-of-function BRSK2 inβ*** findings reveal that BRSK2 links hyperinsulinemia to systematic insulin resistance via interplay betweenβcells and insulin-sensitive tissues in the populations carrying human genetic variants or under nutrient-overload conditions.

关键词： type 2 diabetes mellitus genetic variant BRSK2 β-cell hypersecretion hyperinsulinemia insulin resistance

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琼东南盆地深水区宝岛凹陷3D输导体系评价

西南石油大学学报（自然科学版） 2018年第2期40卷 57-66页

作者：江汝锋郭明刚朱继田周杰向远高中海石油(中国)有限公司湛江分公司广东湛江524057

为查明宝岛凹陷优势运移通道和运移方向,以钻井和地震资料为基础,采用地震解释、古构造恢复、油气运聚模拟、3D地质建模等技术手段,在宝岛凹陷识别出了4级4组断裂、4套骨架砂体和4条主构造脊,建立了宝岛凹陷烃源岩—输导体系—储层—圈... 详细信息

为查明宝岛凹陷优势运移通道和运移方向,以钻井和地震资料为基础,采用地震解释、古构造恢复、油气运聚模拟、3D地质建模等技术手段,在宝岛凹陷识别出了4级4组断裂、4套骨架砂体和4条主构造脊,建立了宝岛凹陷烃源岩—输导体系—储层—圈闭空间格架,划分了T型、阶梯型、受限网毯型3种输导体系,南部断阶带和东北断阶带为阶梯型输导体系,松南低凸起和北部斜坡带为受限网毯型输导体系。运移模拟表明南部断阶带、东北断阶带、松南低凸起前排构造带都是优势的运移方向,垂向+侧向运移为主。区带优选表明南部断阶带为最有利区带,具有"近源、断—砂—脊阶梯型输导、海底扇和扇三角洲储集、断块-岩性圈闭"配置特征。

关键词：地质建模输导体系宝岛凹陷深水区琼东南盆地南海西部