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Basin-scale exposure risk of psychiatric pharmaceuticals and illicit drugs in tap water in Eastern China

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Emerging Contaminants 2024年第3期10卷 40-45页

作者： Wei Wang Zeyuan Wang Feng {3. Fangxing Yang zhejiang Institute of Hydraulics&Estuary(zhejiang Institute of Marine Planni{2. and Design) Hangzhou310008China Key Laboratory of Marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou310012China Key Laboratory of Environment remediation and Ecological Health Ministry of EducationCollege of Natural Resources and Environmental ScienceZhejiang University310058HangzhouChina Hangzhou Ecological and Environmental Monitoring Center of {3. Province 310058HangzhouChina Innovation Center of Yangtze river Delta Zhejiang University314100JiashanChina

A total of twenty-three psychiatric pharmaceuticals and illicit drugs were analyzed in tap water covering seven basins in Eastern *** residual concentrations of these substances were detected up to 2..4 ng L^(-1).Among the substances,benzodiazepines were more often detected with higher median concentrations than those of illicit ***,the higher residual levels of psychoactive substances were detected in the upstream of the basins compared with the *** example,the concentrations of diazepam,temazepam,and oxazepam in the downstream were much higher than those in the upstream in *** the basins,YH was the most polluted *** assessment indicated the median exposure doses of diazepam and temazepam were from 85 to 99 and 3.5e4.1 pg kg^(-1) bw d^(-1) in the basins,*** quotient for the nine detected substances was calculated in each basin with the range from 0.0001 to 0.03.9,indicating low risk in the tap water for human health under current concentrations.

关键词： Psychiatric pharmaceuticals Illicit drugs Psychoactive substances Tap water risk assessment

Simultaneous Determination of Indandione rodenticides in Human Serum by Liquid Chromatography-Electrospray Ionization Ion Trap Mass Spectrometry

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Simultaneous Determination of Indandione Rodenticides in Hum...

稻谷开发利用——早籼米在啤酒酿造中的应用研究

第四届上海国际分析化学研讨会

作者： Mi-cong Jin~(1*) Xiao-hong {2.~1 Mei-qiang Cai~2.1 dep.r.ment of Chemistry,Xixi Campus,{2. university,Hangzhou 3.002.,China, 2.College of Environmental science and {13.,{2. Gongshang university,Hangzhou 3.003.,China.

Measurement of indandione rodenticides is crucial in the diagnosis and treatment of the rodenticides *** assays lack effective measurements for simultaneous analysis the indandiones,especially the *** target of this study was to establish a novel and selective method for simultaneous determination of indandione-type rodenticides(diphacinone, chlorophacinone,pindone and valone)in human serum by liquid chromatography-electrospray ionization ion trap mass spectrometry(LC-MS/MS).After addition of internal standard,the sample was extracted with 10% methanol in acetonitrile and was cleaned by solid-phase extraction(SPE).The analytes were separated on a rapid column and were infused into an ion trap mass spectrometer in the negative electrospray ionization *** limits of detection and quantification,recovery,linearity,precision,and stability were *** multiple-reaction monitori{3. ion pairs were m/z 3.9→167 for diphacinone,m/z 3.3.2.1 for chlorophacinone, m/z 2.9→172.for pindone and m/z 2.9→145 for *** were between 93.and 108%, the limits of detection were 0.1～0.7 {3./mL,and the limits of quantification were 0.3.to 2.0 {3./mL for the ***-and inter-day relative standard deviations(rSDs)were less than 7.8 and 11.5%,*** assay was linear in the ra{3.e of 2.0～2.0.0 {3./mL with coefficients of determination(r>0.99)for all *** proposed method enables the unambiguous identification and quantification of the indandiones in both clinical and forensic *** method combines a new,rapid SPE procedure with an extremely fast chromatographic analysis,which is especially advantageous for clinical laboratories.

关键词： LC-MS/MS Indandione rodenticides Human serum Multiresidue analysis

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食品科技 2003年第3期28卷 72-74页

作者：陈廷登何国庆胡勤严中华浙江工业大学杭州310032 浙江大学杭州310029 浙江常山万德富酒业有限公司常山324200

研究了以47%早籼米作为啤酒酿造辅助原料,通过添加耐高温α-淀粉酶,采用二次煮出法和圆筒锥形罐啤酒发酵的新工艺,不仅使所酿造的成品啤酒的各项指标符合GB/T492.-91标准,色浅,口味纯正、淡爽,泡沫洁白细腻,持久挂杯,而且具有较明显的... 详细信息

研究了以47%早籼米作为啤酒酿造辅助原料,通过添加耐高温α-淀粉酶,采用二次煮出法和圆筒锥形罐啤酒发酵的新工艺,不仅使所酿造的成品啤酒的各项指标符合GB/T492.-91标准,色浅,口味纯正、淡爽,泡沫洁白细腻,持久挂杯,而且具有较明显的经济和社会效益。

关键词：早籼米啤酒酿造应用研究高辅料质量成本

Effect of suction change on water content and total volume of an expansive clay

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Journal of zhejiang university-{2. A(Applied Physics & {3.) 2007年第5期8卷 699-706页

作者： ZHAN Liang-tong {2. Ping ng C.W.W. ~ dep.r.ment of Civil engineer.ng Zhejiang University Hangzhou 310027 China dep.r.ment of Civil engineer.ng Zhejiang Sci- Tech University Hangzhou 310018 China dep.r.ment of Civil engineer.ng Hong Kong University of Science and Technology Hong Kong China

A laboratory study was carried out on both natural and compacted specimens to investigate the complex soil-water interaction in an unsaturated expansive clay. The laboratory study includes the measurement of soil-water characteristic curves, 1D free swelling tests, measurement of swelling pressure and shrinkage tests. The test results revealed that the air-entry value of the natural specimen was quite low due to cracks and fissures present. The hydraulic hysteresis of the natural specimen was relatively insignificant as compared with the compacted specimen. Within a suction range 0 to 500 kPa, a bilinear relationship between free swelling strain (or swelling pressure) and initial soil suction was observed for both the natural and compacted specimens. As a result of over-consolidation and secondary structures such as cementation and cracks, the natural specimens exhibited significant lower swelling (or swelling pressure) than the compacted specimen. The change of matric suction exerts a more significant effect on the water phase than on the soil skeleton for this expansive clay.

关键词： Expansive soil Water content Suction Swelling Shrinkage

Facilitating effect of histamine on spatial memory deficits induced by dizocilpine as evaluated by 8-arm radial maze in SD rats

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Acta Pharmacologica Sinica 2003年第12期24卷 96-102页

作者： HUAng Yu-Wen, chen Zhong~{3. HU Wei-Wei, ZHAng Li-San, WU Wei, YIng Li-Yang, WEI Er-Qing dep.r.ment of Neurobiology and Pharmacology, School of Medicine, {2. university, Hangzhou 3.003., China dep.r.ment of Neurobiology and Pharmacology School of Medicine Zhejiang University

AIM: To investigate whether or not histamine is involved in spatial memory deficits induced by dizocilpine (MK-801) as evaluated by 8-arm radial maze of rats. METHODS: 8-Arm (4-arm baited) radial maze was used to measure spatial memory in rats. rESULTS: Bilaterally intrahippocampal (ih) injection of MK-801 (0.3.μg/site) impaired working memory and reference memory in rats. Both histamine (50, 100 ng/site, ih) and intraperitoneal (ip) injection of histidine (100, 2.0 mg/kg) markedly improved the spatial memory deficits induced by MK-801. On the other hand, the ameliorating effect of histidine (100 mg/kg, ip) was completely antagonized by α-fluoromethylhistidine (α-FMH, 5 μg/site, ih), a potent and selective histidine decarboxylase (HDC) inhibitor, and H1-antagonist pyrilamine (1 μg/site, ih), but not by H2.antagonist cimetidine, even at a high dose (2.5 μg/site, ih). CONCLUSION: The hippocampal histamine plays an important role in the ameliorating effect on MK-801-induced spatial memory deficits,

关键词： histamine maze learning dizocilpine memory disorders

Absorbed Bioactive Compounds replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min LIU Hao SU Meng-qing LI Lan YU Ai-ling {3. Ken HUAng Yun-ke ZHAO Qiu-long HUAng Wen-ya HUAng Xi Institute of Traditional Chinese Medicine related Comorbid depression Nanjing University of Chinese MedicineNanjing 210029China dep.r.ment of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(3. g/kg)were detected using ultra-performance liquid chromatography-mass *** 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(3. g/kg)and FTA(5,2. and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were *** 12.h of exposure to blank medium or 0.5 mmol/L H_(2.O_(2.,endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,3.0μL PGSDS per 1 m L of culture medium)or FTA(2.7,153.,and 1510 mg/m L)for 10 min as control,H_(2.O_(2.,PGSDS and FTA *** oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3.kinase(p-PI3.),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,Protective(lower VEGF,ET-1,Preases in aortic relaxation,endothelial NO levels and phosphorylated PI3./Akt/e NOS protein induced by FTA/PGSDS were markedly abolished by ng-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3./AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats

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Acta Pharmacologica Sinica 2005年第12期26卷 1448-1453页

作者： Li-sha XU Li-xia YAng Wei-wei HU Xiao YU Li MA Lu-ying LIU Er-qing WEI Zhong chen~2.dep.r.ment of Pharmacology School of Medicine,{2. university,Hangzhou 3.003.,China dep.r.mentofPharmacology SchoolofMedicineZhejiangUniversityHangzhou310031China

Aim:To investigate the role of histamine in memory deficits induced by MK-801infusion into the ventral hippocampus in ***:An 8-arm radial maze(4arms baited)was used to assess spatial ***:Bilateral ventralintrahippocampal(ih)infusion of MK-801(0.3.μg/site),an N-methyl-D-aspartate(NMDA)antagonist,impaired the retrieval process in both working memory andreference *** injection of histamine(2. or 50 ng/site)orintraperitoneal(ip)injection of histidine(2.,50 or 100 mg/kg)markedly amelio-rated the spatial memory deficits induced by *** the histamine H1an-tagonist pyrilamine(0.5 or 1.0 μg/site,ih)and the H2.antagonist cimetidine(2.5 μg/site,ih)abolished the ameliorating effect of histidine( 100 mg/kg,ip)on reference memorydeficits,but not that on working memory deficits induced by ***:The results indicate that histamine in the ventral hippocampus can ameliorateMK-801-induced spatial memory deficits,and that histamine’s effect on referencememory is mediated by postsynaptic histamine H1and H2.eceptors.

关键词： histamine: maze learning MK-801 working memory reference memory ventral hippocampus histamine H1 receptor

Key progresses of MOE key laboratory of macromolecular synthesis and functionalization in 2.2.

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Chinese Chemical Letters 2024年第3期35卷 114-126页

作者： Xumeng Deng Kaihao {2. Kai Pang Xiaoting Liu Minsong Gao Jie ren Guanwen Yang Guangpeng Wu {2.gjian Zhang Xufeng Ni Peng Zhang Jian Ji Jianzhao Liu Zhengwei Mao Ziliang Wu Zhen Xu Haoke Zhang Hanying Li MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X PolymersDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

In 2.2.,The MOE Key Laboratory of Macromolecular Synthesis and Functionalization in zhejiang {3. had achieved several important ***,a series of well-defined dinuclear organoboron catalysts were developed to pre... 详细信息

In 2022,The MOE Key Laboratory of Macromolecular Synthesis and Functionalization in zhejiang university had achieved several important ***,a series of well-defined dinuclear organoboron catalysts were developed to precisely control the enchain{2. of ether and carbonate seg{2.s during the copolymerization of CO_(2)and ***,polyester had been synthesized through cationic copolymerization of cyclic ***,ring-opening polymerization of carbon dioxide based valerolactone had been achieved,revealing the prospect of 3.ethylidene-6-vinyltetrahydro-2H-pyran-2-one(EVL)in utilizing CO_(2)and synthesizing functional ***,machine learning methods have been applied to biomaterial research,enabling high-throughput screening of functional biomaterial surfaces for implantable devices,and searching for potent antimicrobial peptides in whole combinatorial peptide ***,methods of characterization of biomacromolecule rNA transcription and manipulation of nucleoside modification were ***,artificial enzymes-armed Bifidobacterium Longum probiotics were established to tune down gut ***,three-dimensional(3.)printing technologies were used to engineer tough supramolecular ***,hydroplastic foaming graphene frameworks for acoustic and conductive polymer composites were provided for ***,aggregate photophysics about the nature of through-space interactions(TSIs)and manipulating their strength in small molecules with non-conjugated structure had been ***,the forming mechanism of a newfound nested texture in poly(L-lactic acid)(PLLA)spherulitic films had been ***,the isotropically dyeing mechanism of KDP single crystals grown from hydrogels have been *** related works are reviewed in this paper.

关键词： Polymer Catalyst Biomaterial research mrNA Hydrogel Graphene Crystal

应用胶体金免疫层析法检测饲料中恩拉霉素残留的方法建立

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生物工程学报 2024年第7期40卷 2346-2356页

作者：王康余璞陈孔陈敏蔡永辉王冰清浙江工商大学食品与生物工程学院浙江杭州310018

为了实现饲料中恩拉霉素的快速检测,本研究开发了基于抗恩拉霉素A单克隆抗体(anti-enramycin A monoclonal antibody,anti-Er.A-m Ab)的竞争抑制胶体金免疫层析试纸条。以实验室制备的高纯度抗恩拉霉素A单克隆抗体制备胶体金探针,并考... 详细信息

为了实现饲料中恩拉霉素的快速检测,本研究开发了基于抗恩拉霉素A单克隆抗体(anti-enramycin A monoclonal antibody,anti-Er.A-m Ab)的竞争抑制胶体金免疫层析试纸条。以实验室制备的高纯度抗恩拉霉素A单克隆抗体制备胶体金探针,并考察了标记p H、抗体标记量、检测线浓度对恩拉霉素胶体金免疫层析试纸条的影响。在碳酸钾添加量为8μL、抗体标记量为4μg/m L、检测线划膜浓度为1.0 mg/m L、金标抗体使用量为3.L的条件下制备得到的胶体金试纸条特异性好、检出限低。经胶体金读数仪测定,恩拉霉素A检出限为2. ng/m L、线性范围为2.-3.0 ng/m L。选用畜禽饲料进行阳性样本添加实验,结果显示检测结果重复性好,比高效液相色谱法更为灵敏,适合大批量饲料样本的恩拉霉素快速检测。

关键词：恩拉霉素胶体金技术单克隆抗体竞争抑制法