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Pancreatic endometrial cyst mimics mucinous cystic neoplasm of the pancreas

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World journal of Gastroenterology 2017年第6期23卷 1113-1118页

作者： Michael A Mederos Nicole villafane Sadhna Dhingra Carlos Farinas Amy Mc Elhany William E Fisher George Van Buren II Department of General Surgery Baylor College of Medicine Department of Pathology Baylor College of Medicine Department of Radiology Baylor College of Medicine

Pancreatic cysts include a variety of benign, premalignant, and malignant lesions. Endometrial cysts in the pancreas are exceedingly rare lesions that are difficult to diagnose pre-operatively. This report describes the findings in a 43-year-old patient with a recent episode of acute pancreatitis who presented with a large cyst in the tail of the pancreas. Imaging demonstrated a loculated pancreatic cyst, and cyst fluid aspiration revealed an elevated amylase and carcinoembryonic antigen. The patient experienced an interval worsening of abdominal pain, fatigue, diarrhea, and a 15-pound weight loss 3 mo after the initial episode of pancreatitis. With concern for a possible pre-malignant lesion, the patient underwent a laparoscopic distal pancreatectomy with splenectomy, which revealed a 16cm×12cm×4cm lesion. Final histopathology was consistent with an intra-pancreatic endometrial cyst. here we discuss the overlapping imaging and laboratory features of pancreatic endometrial cysts and mucinous cystic neoplasms of the pancreas.

关键词： Pancreatic cyst Pancreatic endometrial cyst Endometriosis Mucinous cystic neoplasm of the pancreas Distal pancreatectomy

Non-Stem Amino Acids Are Involved in the Phage P22 TSP NTD Stability

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Advances in Microbiology 2014年第9期4卷 521-526页

作者： Karthikeya Venkatesan jeremie Williams Robert villafane Department of Biological Sciences and Program in Microbiology Alabama State University Montgomery Alabama USA Department of Biological Sciences and Program in Microbiology Alabama State University Montgomery Alabama USA

The P22 phage system is an intensely studied model system. Studies have ranged from biochemical analysis of basic life processes to the use of this phage for phage therapy. The phage tailspike protein (TSP) has itself been the subject of intensive studies over the past fifty years. The P22 TSP is essential for initiation of the infection process and instrumental as the last protein assembled onto the phage particle structure to complete its assembly. It has also been the subject for many structural studies including cryoelectron microscopic analysis and photophysical studies. It has been a model for in vivo and in vitro protein folding including analysis using P22 TSP temperature-sensitive for folding mutations (tsf). Recently the structure and function of the N-terminal domain (NTD), including some aspects of the structural stability of the P22 TSP NTD (aa1-aa108), are being genetically dissected. This report strongly supports the notion that two amino acids, not localized to the internal NTD dome stem, are important in the structural stability of the P22 TSP NTD.

关键词： N-Terminal Domain (NTD) P22 Phage Tailspike Protein (TSP) Mutagenesis Structural Stability

Modeling the Structure of Yeast MAT<i>α</i>1: An hMG-Box Motif with a C-Terminal helical Extension

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Open journal of Biophysics 2013年第1期3卷 1-12页

作者： Doba jackson Tarnisha Lawson Robert villafane Lisa Gary Department of Chemistry and Biochemistry Huntingdon College Montgomery USA Department of Microbiology Alabama State University Montgomery USA School of Public health University of Alabama Birmingham Birmingham USA

The yeast MATα1 is required for the activation of α-specific genes in Saccharomyces cerevisiae and thus confers the α-cell identity of the yeast. MATα1 contains a domain called the α-domain which has significant sequence identity to the hMG-box family of proteins. A multiple sequence alignment of several α-domains and various structurally determined hMG-box domains has revealed that both domains possess very similar structural and functional residues. We found that the basic amino acids of the N-terminal loop, the intercalating hydrophobic residues of the first helix, and the hydrophobic residues required for interactions within the core of the protein are remarkably conserved in α-domains and hMG-box proteins. Our generated molecular models suggest that the first and third helix will be shorter and that the hMG-box core is not an isolated domain. The region beyond the conserved hMG-box motif contains an extended helical region for about 20 - 30 amino acids. Structural models generated by comparative modeling and ab initio modeling reveal that this region will add two or more additional α-helices and will make significant contacts to helix III, II and I of the hMG-box core. We were able to illustrate how the extended α-domain would bind to DNA by merging of the α-domain and the LEF-1/DNA complex. The models we are reporting will be helpful in understanding how MATα1 binds to DNA with its partner MCM1 and activates transcription of α-specific genes. These models will also aid in future biophysical studies of MATα1 including the crystallization and structure determination.

关键词： MATα1 MATα2 Gene Regulation Mating-Type Yeast α-Domain Combinatorial Control of Transcription

Photosynthetic responses of Emiliania huxleyi to UV radiation and elevated temperature Roles of calcified coccoliths

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Photosynthetic responses of Emiliania huxleyi to UV radiatio...

Short-term photosynthetic responses of the diatom phaeodactylum tricornutum to multiple stressors:effects of temperature,UVR and CO2 concentration

中国藻类学会第八次会员大会暨第十六次学术讨论会

作者： E.Walter helbling Virginia E.villafane Estacion de Fotobiologia Playa Union and Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET) Casilla de Correos N°15(9103) Rawson ChubutArgentina

Changes in calcification of coccolithophores may affect their photosynthetic responses to both,ultravioletradiation(UVR,280-400nm) and *** operated semi-continuous cultures of Emiliania huxleyi(strain CS-369) at reduc...

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Short-term photosynthetic responses of the diatom phaeodacty...

Combined effects of ocean acidification and nitrogen limitation on diatom Phaeodactylum tricornutum with special reference to UV radiation

中国藻类学会第八次会员大会暨第十六次学术讨论会

The increases in atmospheric CO concentrations accompanied by lower ph in the surface oceans,substantial shifts in temperature and enhanced in ultraviolet radiation (UVR) are all predicted as a result of anthropogenic...

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Combined effects of ocean acidification and nitrogen limitat...

In Vitro Evaluation of Polyurethane-Chitosan Scaffolds for Tissue Engineering

中国藻类学会第八次会员大会暨第十六次学术讨论会

作者： Virginia E.villafane E.Water helbling Estacion de Fotobiologia Playa Union and Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET) Casilla de Correos N°15(9103) Rawson ChubutArgentina

To study the physiological performance of phytoplankton in copping with multi-factors of ocean acidification,nitrogen limitation and UV radiation,Phaeodactylum tricornutum,a model diatom,cultured in two CO(high CO:100...

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journal of Biomaterials and Nanobiotechnology 2012年第4期3卷 440-445页

作者： Imelda Olivas-Armendariz Perla Garcia-Casillas Adriana Martel Estrada Alberto Martinez-villafane Laura A.A.de la Rosa Carlos A.Martinez-Perez Institute of Engineering and Technology Autonnomous University of the City of JuarezCiudad JuarezMexico Department of Physics of Materials Research Center of Advanced MaterialsChihuahuaMexico Institute of Biomedical Science Autonomous University of the City of JuarezCiudad JuarezMexico

In this work the use of Polyurethane (PU)-Chitosan(Ch) scaffolds prepared by thermal induced phase separation (TIPS) for osteoblast proliferation and bone mineralization is described. Primary rat calvaria osteoblasts were seeded in the scaffolds and it was shown that supported cell adhesion and growth. The behavior osteoblast cells growing in the scaffold in function of the different ratio of PU and Ch is presented. The results showed that TIPS is an appropriate technique for the production of PU-Ch scaffolds with high potential for application as cell scaffolds in bone tissue engineering.

关键词： Biomaterials Composite