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INTRASPINAL CONNECTIONS OF DORSAL COLUMN POSTSYNAPTIC NEURONS IN THE CAT——A PHYSIOLOGICAL ANALYSIS

Science China Chemistry 1985年第9期28卷 972-978页

作者：吕国蔚,gary j.bennett,nozomu nishikawa,marvin j.hoffert,ronald dubner Department of Neurophysiology Beijing Second Medical College China Neurobiology and Anesthesiology Branch National Institute of Dental Research National Institutes of Health USA Neurobiology and Anesthesiology Branch National Institute of Dental Research National Institutes of Health USA Department of Anesthesiology Shiga University of Medical Seience Shiga japan Neurobiology and Anesthesiology Branch National Institute of Dental Research National Institutes of Health USA Department of Neurology Univeraity of Wisenonsin Medieal School Madison Wisconsin 53792 U.S.A Neurobiology and Anesthesiology Branch National Institute of Dental Research National Institutes of Health USA

Dorsal column postsynaptic (DCPS) neurons in the dorsal horn of the spinal cord have been identified by antidromic stimulation and intracellularly recorded in anesthetized cats. In about one-half of the cells, the antidromic stimulus evokes only an antidromic potential. This potential sometimes has an atypical shape due to penetration-induced depolarization. Atypieal potentials arc converted into typical antidromic spike potentials after intracellular injection of hyperpolarizing current. In the other one-half, the antidromic potentials are followed by postsynaptic activity. Intracellular analysis indicates that this postsynaptic activity is generated largely by activation of the intraspinal collaterals of A-beta primary afferents that are ascending the dorsal columns. Part of this postsynaptic activity has been produced monosynaptically. Polysynaptic responses are also evident; these are thought to be initiated by A-beta axons, desending axons from neurons in the dorsal column nuclei, or the local coll

关键词： A PHYSIOLOGICAL ANALYSIS

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猫背索突触后神经元的脊髓内联系——生理学分析

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中国科学:化学 1985年第1期 52-56页

作者：吕国蔚,G.j.bennett,N.nishikawa,M.j.hoffert,R.dubner 北京第二医学院针麻脑学研究室美国国立卫生研究院神经生物学和麻醉学研究室美国国立卫生研究院神经生物学和麻醉学研究室美国国立卫生研究院神经生物学和麻醉学研究室美国国立卫生研究院神经生物学和麻醉学研究室日本滋贺大学医学院麻醉学教研室美国威斯康辛大学医学院神经病学系

在麻醉猫上用逆向刺激和细胞内记录鉴定和记录了背索突触后（DCPS）神经元。约半数细胞,逆向刺激只引起一个逆向电位。由于微电极穿刺引起的去极化,逆向电位有时呈不典型形状,但在细胞内注射超极化电流后转变成典型的逆向锋电位。其余... 详细信息

在麻醉猫上用逆向刺激和细胞内记录鉴定和记录了背索突触后（DCPS）神经元。约半数细胞,逆向刺激只引起一个逆向电位。由于微电极穿刺引起的去极化,逆向电位有时呈不典型形状,但在细胞内注射超极化电流后转变成典型的逆向锋电位。其余半数细胞的逆向电位后还出现突触后活动。细胞内分析提示,这种突触后活动主要是由于经背索上行的Aβ初级传入的脊髓内侧支受到激动而产生的。部分突触后活动通过单突触引起。另一部分显然是多突触反应,据信它们是由Aβ轴突、背索核（DCN）下行轴突或DCPS神经元轴突本身的局部侧支引起的。上述结果表明,DCPS系统具有非丘系性质,可参与Aβ传入激动的疼痛调制系统。

关键词：神经元传导速度锋电位细胞内 DCN 侧支神经组织突触联系反应

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