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Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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World Journal of Otorhinolaryngology-Head and Neck surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III Jeremy l.Barth Rodney J.schlosser Thomas.s.Edwards Timothy l.smith Zachary m.soler Department of Otolaryngology-Head and Neck surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRs)has focused on patients with polyps and sugges.s that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this.study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dys.smic CRs patients without polyps(CRssNP).methods:Tissue sam.les were obtained from the superior turbinates of patients with CRssNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analys.s to investigate biological pathways associated with differentially expressed genes between dys.smic(n=7)and normosmic(n=4)***:Differential gene expression analys.s comparing dys.smic and normosmic CRssNP patients.showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for m.ltiple comparisons,one upregulated gene(Immediate Early Response 3[IER3])had an false discovery rate(FDR)correction adjustedP value considered statistically significant(Pld change 2.69).Reactome functional analys.s revealed eight biological pathways.significantly different between dys.smic and normosmic patients(Pluding Il-4 and Il-13 signaling,Il-10 signaling,and rhodopsin-like ***:RNA sequencing of the superior turbinates in patients with CRssNP can provide valuable information regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of Il-10,rhodopsin-like receptors,andIER3 in the pathogenes.s of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing

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长江中下游典型污水系统提质增效案例研究

城市道桥与防洪 2024年第4期 140-144,I0010页

作者：伍亮上海市政工程设计研究总院(集团)有限公司上海市200092 上海市政工程设计科学研究所有限公司上海市200092

以长江中下游某城市南部污水系统为例,对污水系统外水入侵、高水位运行、进厂水质浓度低等问题进行分析,针对性的提出分片、分区、分阶段提质增效的思路,并给出降水位排查污水管网、市政管网系统整治、排水单元整治、污水管网优化运行... 详细信息

以长江中下游某城市南部污水系统为例,对污水系统外水入侵、高水位运行、进厂水质浓度低等问题进行分析,针对性的提出分片、分区、分阶段提质增效的思路,并给出降水位排查污水管网、市政管网系统整治、排水单元整治、污水管网优化运行等技术措施.先期实施的1#泵站片区通过上述措施,已挤出外水量约为12 708 m3/d,污水厂进水BOD5浓度由69.6 mg/l提升至78.3 mg/l,较整治前提升12.5%,城市污水集中收集率由61.6%提升至69.3%,基本实现了提质增效的阶段目标.

关键词：外水入侵高水位运行进水BOD5浓度污水提质增效

前言:青藏高原及其周边综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 911-914页

作者：沈树忠丁林朱茂炎王向东邓涛南京大学地球科学与工程学院关键地球物质循环前沿科学中心内生金属成矿机制研究国家重点实验室南京210023 中国科学院青藏高原研究所青藏高原地球系统全国重点实验室北京100101 中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 中国科学院大学地球与行星科学学院北京100049 中国科学院古脊椎动物与古人类研究所中国科学院脊椎动物演化与人类起源重点实验室北京100044

青藏高原研究对揭示地史时期全球构造、古地理、生物与环境等的演化都具有举足轻重的作用.文章介绍了“青藏高原及其周边综合地层、生物群与古地理演化”专辑的组织背景、主要内容和期望目标,同时总结了本专辑成果相比第一次青藏高原科... 详细信息

青藏高原研究对揭示地史时期全球构造、古地理、生物与环境等的演化都具有举足轻重的作用.文章介绍了“青藏高原及其周边综合地层、生物群与古地理演化”专辑的组织背景、主要内容和期望目标,同时总结了本专辑成果相比第一次青藏高原科考报告的显著进展.

关键词：期望目标生物群全球构造生物与环境青藏高原周边

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碳纳米管对PDC热稳定性及力学性能的影响

稀有金属材料与工程 2024年第8期53卷 2321-2330页

作者：高中堂段迪彭腊梅丰德友王斌奇高志明西安科技大学机械工程学院陕西太合智能钻探有限公司

由于现代石油、煤田开采的环境愈加复杂，对钻头的耐热性与抗冲击韧性提出了更高的要求。而聚晶金刚石复合片(polycrystalline diamond compact,PDC)作为钻头工作的核心零部件，会直接影响钻头的使用寿命。在实际的工况中，PDC往往会以... 详细信息

由于现代石油、煤田开采的环境愈加复杂，对钻头的耐热性与抗冲击韧性提出了更高的要求。而聚晶金刚石复合片(polycrystalline diamond compact,PDC)作为钻头工作的核心零部件，会直接影响钻头的使用寿命。在实际的工况中，PDC往往会以断裂和耐热性差的形式失效。碳纳米管具有优异的力学性能、化学稳定性和热稳定性，将碳纳米管引入PDC层中，可以解决PDC中抗冲击韧性差、热稳定性差的问题。本研究采用碳纳米管作为PDC的增强相，在高压和高温(5.5 GPa和1300℃)的条件下制备PDC复合材料，烧结时间为90 s。对PDC复合材料的微观结构、元素分布、相组成进行了表征，分析了碳纳米管对复合材料力学性能和热稳定性的影响。结果表明，碳纳米管添加量为1.4%(质量分数)的PDC抗冲击韧性从400 J提升到550 J，比原始PDC的抗冲击韧性高37.5%,PDC复合材料抗冲击韧性的提高归因于碳纳米管在裂纹偏转过程中的拔出和桥接。碳纳米管添加量为1.6%的PDC耐热性从原始的704℃提高至813℃，摩擦系数从0.064降低到了0.048，磨耗比达到159.69×10～4，比原始PDC提高了59.64×10～4。

关键词：聚晶金刚石复合片碳纳米管抗冲击韧性热稳定性摩擦系数

Radioisotope production using lasers:From basic science to applications

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matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： m.R.D.Rodrigues A.Bonasera m.scisciò J.A.Pérez-Hernández m.Ehret F.Filippi P.l.Andreoli m.Huault H.larreur D.singappuli D.m.lloy D.Raffestin m.Alonzo G.G.Rapisarda D.lattuada G.l.Guardo C.Verona Fe.Consoli G.Petringa A.mcNamee m.la Cognata s.Palmerini T.Carriere m.Cipriani G.Di Giorgio G.Cristofari R.De Angelis G.A.P.Cirrone D.margarone l.Giuffrida D.Batani P.Nicolai K.Batani R.lera l.Volpe D.Giulietti s.Agarwal m.Krupka s.singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA laboratori Nazionali del sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de láseres Pulsados(clpu) VillamayorSpain Universidad de salamanca SalamancaSpain Centre lasers Intens.s et Applications(CElIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia school of mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartimento di Fisica e Astronomia“E.majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ElI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETsIA Universidad Politécnica de MadridMadridSpain Dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of sciences PragueCzech Republic

The discovery of chirped pulse am.lification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of meV can be accelerated using,for instance,target norm.l sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes.suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,sect.A 637,164–170(2011)].

关键词： purity estimates backward

The secondary injury cascade after spinal cord injury: an analys.s of local cytokine/chemokine regulation

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Neural Regeneration Research 2024年第6期19卷 1308-1317页

作者： Daniel J.Hellenbrand Charles m.Quinn Zachariah J.Piper Ryan T.Elder Raveena R.mishra Taylor l.marti Phoebe m.Omuro Rylie m.Roddick Jae sung lee William.l.murphy Amgad s.Hanna Department of Neurosurgery University of Wisconsin-Madison School of Medicine and Public Health Department of Biomedical Engineering University of Wisconsin-Madison Department of Orthopedics and Rehabilitation University of Wisconsin-Madison Department of materials.science and Engineering University of Wisconsin-Madison Forward BIO Institute University of Wisconsin-Madison

After spinal cord injury, there is an extensive infiltration of immune cells, which exacerbates the injury and leads to further neural degeneration. Therefore, a major aim of current research involves targeting the immune response as a treatment for spinal cord injury. Although much research has been performed analyzing the com.lex inflammatory process following spinal cord injury, there remain major discrepancies within previous literature regarding the tim.line of local cytokine regulation. The objectives of this.study were to establish an overview of the tim.line of cytokine regulation for 2 weeks after spinal cord injury, identify sexual dimorphis.s in terms of cytokine levels, and determine local cytokines that significantly change based on the severity of spinal cord injury. Rats were inflicted with either a m.ld contusion, moderate contusion, severe contusion, or com.lete transection, 7 mm of spinal cord centered on the injury was harvested at varying times post-injury, and tissue homogenates were analyzed with a Cytokine/Chemokine 27-Plex assay. Results demonstrated pro-inflammatory cytokines including tumor necros.s factor α, interleukin-1β, and interleukin-6 were all upregulated after spinal cord injury, but returned to uninjured levels within approximately 24 hours post-injury, while chemokines including monocyte chemoattractant protein-1 remained upregulated for days post-injury. In contrast, several anti-inflammatory cytokines and growth factors including interleukin-10 and vascular endothelial growth factor were downregulated by 7 days post-injury. After spinal cord injury, tissue inhibitor of metalloproteinase-1, which specifically affects astrocytes involved in glial scar development, increased more than all other cytokines tested, reaching 26.9-fold higher than uninjured rats. After a m.ld injury, 11 cytokines demonstrated sexual dimorphis.s; however, after a severe contusion only leptin levels were different between fem.le and m.le rats. In conclus

关键词： astrocytes chemokines cytokines inflammation macrophages microglia secondary damage spinal cord injury

2020年古冶m_(s)5.1地震序列微震检测及活动性研究

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地球物理学报 2024年第4期67卷 1501-1514页

作者：王同利张盛中崔博闻武敏捷马泽宇葛慧颖北京市地震局北京100081 中国地质大学(北京)信息网络与数据中心北京100083 中国地质大学(北京)地球物理与信息技术学院北京100083

2020年7月12日河北省古冶(39.78°N,118.44°E)发生m_(s)5.1地震,震源深度10 km.本文通过对其周边500 km范围内的84个固定台站连续观测地震数据,采用基于图形处理器的模板匹配定位识别技术(GPU-m.l)对地震前后(2020年6月1日至2020年8月3... 详细信息

2020年7月12日河北省古冶(39.78°N,118.44°E)发生m_(s)5.1地震,震源深度10 km.本文通过对其周边500 km范围内的84个固定台站连续观测地震数据,采用基于图形处理器的模板匹配定位识别技术(GPU-m.l)对地震前后(2020年6月1日至2020年8月31日)共三个月的连续数据进行了微震检测和地震活动性分析.我们首先从台网目录的362个古冶地震序列事件中挑选了信噪比较高的118个地震作为模板,通过模板扫描和检测,获得共1017个地震,约为台网目录的2.8倍,然后运用双差定位方法(hypoDD)对669个地震事件进行了重定位.最后我们对古冶地震的事件序列进行时空分布、震源机制解以及b值空间分布等分析.结果显示古冶m_(s)5.1地震前,震中区周边地震活动性显著,地震前后地震序列分布优势方向为NE向,震源深度方向近直立分布;发震断裂为唐山—古冶断裂或其延伸部分,与1976年唐山m_(s)7.8地震同为唐山断裂带,发震断层走向基本一致.据此,我们推测古冶m_(s)5.1地震是1976年唐山m_(s)7.8地震后余震区应力调整所触发.

关键词：古冶地震微震检测模板匹配完备震级地震活动性

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科创板股权激励与企业创新绩效传导机制研究

会计之友 2024年第2期 53-61页

作者：张继德张馨予王昊北京工商大学商学院/国有资产管理协同中心新疆维吾尔自治区人民政府研究室经济发展研究处

科创板股权激励制度的完善促进了企业创新水平提高,衡量科创板企业核心竞争力的创新绩效关乎企业健康可持续发展。要提升企业整体创新绩效,就必须利用好新模式下股权激励制度,厘清股权激励与创新绩效的传导关系,探明两者之间的传导机制... 详细信息

科创板股权激励制度的完善促进了企业创新水平提高,衡量科创板企业核心竞争力的创新绩效关乎企业健康可持续发展。要提升企业整体创新绩效,就必须利用好新模式下股权激励制度,厘清股权激励与创新绩效的传导关系,探明两者之间的传导机制。文章选取科创板首次推出新模式股权激励计划的乐鑫科技为案例,基于实体企业数据从制度环境、公司战略以及治理需求等方面分析其股权激励动因,探究“m-s-m”三路径的创新传导及协同机制,并从监管部门、公司以及科创板等维度提出了优化股权激励的措施。研究为监管部门制定科创板股权激励监管政策、企业进行股权激励实践提供了经验证据和数据支持,有利于提升企业创新绩效,推动企业高质量发展,加快融入新发展格局。

关键词：乐鑫科技股权激励创新绩效传导机制

硫氧基团修饰以增强NiFe-s/NF电极在碱性海水OER稳定性

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复合材料学报 2024年

作者：蔡家阳曲德智苏萍萍何雄广西科技大学生物与化学工程学院广西糖资源绿色加工重点实验室

直接电解海水是一种更绿色、可持续性更高的氢能生产源途径。然而海水电解需要面临海水中有害离子的毒害，特别是海水中高浓度Cl-引发的析氯反应（CER），会对阳极析氧反应（OER）产生干扰。因此采用有效的Cl-屏蔽策略来提高催化剂的OE... 详细信息

直接电解海水是一种更绿色、可持续性更高的氢能生产源途径。然而海水电解需要面临海水中有害离子的毒害，特别是海水中高浓度Cl-引发的析氯反应（CER），会对阳极析氧反应（OER）产生干扰。因此采用有效的Cl-屏蔽策略来提高催化剂的OER性能和长期电解寿命，是大范围开发海水制氢关键所在。本文采用一步水热硫化法在泡沫镍（NF）基底上成功制备可用于海水电解的NiFe-s/NF电催化剂。值得注意的是，NiFe-s/NF在碱性淡水（1 m.l/l KOH +超纯水）和海水（1 m.l/l KOH +海水）中分别需要237和248 mV便可轻松达到100 mA/cm2，并具有超过100 h的海水电解耐久度(100 mA/cm2)。这得益于硫化物中的硫在OER过程中氧化为硫氧阴离子，这些阴离子会吸附在电极表面，一方面加速电催化剂的OER过程，另一方面通过静电斥力形成Cl-排斥层，从而提升催化剂性能和寿命。本研究为高效、经济开发海水制氢提供了可行性较高的策略。

关键词： OER,海水电解,硫化物,重建阴离子屏蔽