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世界地震译丛 1993年第6期24卷 68-69页

作者： л.,em 郑嘉炯

Shape of the geometrically active atomic states of carbon

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Chinese Physics B 2010年第2期19卷 219-224页

作者：熊庄 Bacalis n.C. AMS Research Center Southeast University Theoretical and Physical Chemistry Institute National Hellenic Research FoundationVasileos Constantinou 48AthensGreece 11635

We have developed a computer code for {／em ab initio} the variational configuration interaction calculation of the electronic structure of atoms via variationally optimized Lagurre type orbitals, treating the orbital effective charges as variational parameters. Excited states of the same symmetry, in order to avoid the inherent restrictions of the standard method of Hylleraas--Unheim and MacDonald, are computed variationally by minimizing the recently developed minimization functionals for excited states. By computing, at the minimum, the one-electron density and the probability distribution of the two-electron angle, and the most probable two-electron angle, we investigate the atomic states of the carbon atom. We show that, without resorting to the （admittedly unproven） concept of hybridization, as an intrinsic property of the atomic wave function, the most probable value of the two-electron angle is around the known angles of carbon bonding, i.e. either 109^／circ or 120^／circ or 180^／circ, depending on each low-lying state of the bare carbon atom.

关键词： carbon hybridization excited states variational principle

Oxidative stress in n88S seipinopathy:novel insights into the mechanisms of neurodegeneration and therapeutic avenues

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neural Regeneration Research 2023年第8期18卷 1719-1720页

作者： vítor Costa vitor Teixeira i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoPortoPortugal Yeast Signalling networks IBMC-Instituto de Biologia Molecular e CelularUniversidade do PortoPortoPortugal ICBAS Instituto de Ciências Biomédicas Abel SalazarUniversidade do PortoPortoPortugal

Lipid droplets (LDs) are ubiquitous cellular orga nelles that perform functions mostly dedicated to energy homeostasis and lipid *** neutral lipid depots (triacylglycerol,sterol esters),they can be rapidly mobilized through lipase-mediated hydrolysis (lipolysis) or via lipophagy,a specific form of autophagy devoted to consumption of LDs inside the lysosome.

关键词： hydrolysis insight devoted

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英国食源性疾病的流行病学

国外医学（卫生学分册） 1992年第2期19卷 87-89页

作者： Cooke em 刘本先

在英国引起食源性疾病的病原微生物主要有三种,其中沙门氏菌尤为重要。家禽和蛋类易被肠炎沙门氏菌噬菌体4型(PT_4)污染,而PT_4是英格兰和威尔士男性中较常见的血清型,但由于所致疾病症状轻微且散在发生,因此易被忽视。另一种病原体是... 详细信息

在英国引起食源性疾病的病原微生物主要有三种,其中沙门氏菌尤为重要。家禽和蛋类易被肠炎沙门氏菌噬菌体4型(PT_4)污染,而PT_4是英格兰和威尔士男性中较常见的血清型,但由于所致疾病症状轻微且散在发生,因此易被忽视。另一种病原体是弯曲菌,已诊断明确的食源性疾病多由该菌所致。李斯特菌病并不常见,但由于所致病情严重、胎儿和新生儿易被感染且死亡率较高,因此也是一种重要的病原体。

关键词：食源性病细菌性流行病学英国

Body awareness therapy: A new strategy for relief of symptoms in irritable bowel syndrome patients

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World Journal of Gastroenterology 2007年第23期13卷 3206-3214页

作者： em Eriksson IE Mller RH Sderberg HT Eriksson GK Kurlberg Departments of Surgery Sahlgrenska University Hospital/stra Gteborg Sweden Departments of Medicine Sahlgrenska University Hospital/stra Gteborg Sweden

AIM: To compare irritable bowel syndrome (IBS) pa- tients with apparently healthy persons and to evaluate body awareness therapy, which is a physiotherapeutic remedy focusing on normalising tensions in the body, for the treatment of IBS with the hypothesis that altered body tension is associated with the syndrome. METHODS: Twenty-one IBS patients received body awareness therapy two hours weekly for 24 wk. At base- line as well as after 12 and 24 wk, they underwent ex- aminations including resource oriented body examination in combination with body awareness scale evaluation and f illed in gastrointestinal and psychological symptom questionnaires. Saliva cortisol was analysed. A group of 21 apparently healthy persons underwent the same ex- aminations once. RESULTS: Compared to the apparently healthy group, IBS patients scored higher at baseline for gastrointestinal and psychological symptoms. They showed more often alterations in normal body tension patterns, as well as deviating cortisol slopes in saliva. After 24 wk of body awareness therapy, their gastrointestinal and psychologi- cal symptoms were reduced overall. Somatic symptoms decreased in parallel with depressive symptoms. Whole body pain score decreased, coping ability as well as bio- chemical stress markers improved. COnCLUSIOn: IBS patients scored higher for gastroin- testinal and psychological symptoms, and presented with altered biochemical stress markers. Their body tension deviated compared to healthy controls. Furthermore,body awareness therapy gave relief of both somatic com- plaints, psychological symptoms and normalised body tension. These findings indicate that distorted tension constitutes an important part of the symptoms in IBS.

关键词： Irritable bowel syndrome Pain Cortisol Physiotherapy Body awareness therapy Psychosomatics Gastrointestinal tract Stress

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柬埔寨政府利用世界银行信贷的绩效研究

柬埔寨政府利用世界银行信贷的绩效研究

作者： em Rina（李永庆）云南大学

学位级别：硕士

回顾柬埔寨与世界银行合作的20年,正是柬埔寨进入到新知识经济时期(90年代中期至今),处于经济腾飞的阶段,这期间世界银行的信贷援助对于刚刚渡过经济恶化时期的柬埔寨来说,发挥了重要的作用。本文在梳理国际援助的相关文献后发现,柬埔... 详细信息

回顾柬埔寨与世界银行合作的20年,正是柬埔寨进入到新知识经济时期(90年代中期至今),处于经济腾飞的阶段,这期间世界银行的信贷援助对于刚刚渡过经济恶化时期的柬埔寨来说,发挥了重要的作用。本文在梳理国际援助的相关文献后发现,柬埔寨关于这方面的研究比较少,而且仅有的文献也是从国际政治视角或发展经济学方面来考虑的,缺乏相应的实证研究。世界银行对柬埔寨信贷援助绩效问题的研究是前所未有的,这是对以前缺乏的文献的补充,也是为以后如何更有效的利用世界银行信贷政策提供一种借鉴。本文拟从世界银行的信贷政策作为出发点,在现有的信贷政策理论的基础之上,对世界银行现行的信贷政策进行研究,然后通过计量模型等统计方法反映和说明现行的信贷政策对柬埔寨产生的积极的作用,同时结合实际情况深入分析当前存在的问题并提出相应的解决问题的建议。其中,介绍了信贷政策的演变过程和未来的发展方向,以及对现有的信贷政策的评析,同时还结合信贷政策的最前沿的理论,阐述了当前学者对信用贷款的方式、手段以及积极的作用等方面的理论成果;同时,相关学者还针对相应的数据显示,结合理论提出了世界银行提供信贷业务对发展中国家所带来的积极的影响,主要包括了为发展中国家提供了充沛的资金、良好的环境以及先进的技术为发展国内经济提供基础;信贷政策存在的问题主要指受援国外债规模、具体情况和推行的政治理念等问题。其次是针对柬埔寨利用世界银行信贷的现状和效果进行实证分析,主要介绍了柬埔寨接受世行信贷援助的现状及取得的成果,并利用正确的国际前沿的援助分类模型,来保证合理有效的模型数据采集依据;然后将柬埔寨国内的受援部门包括农业、政府管理、环境、卫生和教育作为自变量,利用Eviews7.2软件对模型进行回归分析以及相关变量和总体的显著性检验,结果发现该模型以绝对数值通过了t检验和F检验,不但保证了该模型是准确的,还证明了其的合理性;最后对回归模型中各个受援部门进行经济性分析,得出世行的信贷援助对柬埔寨的总体发展具有显著性的作用的结论,并提出部分受援部门出现负效应的实证结论,并进一步分析出现负效应的各方面原因。文中最后通过绩效分析的方法全面剖析了世行在柬埔寨的信贷援助效果并反映出其存在的信贷水平、贷款管理系统、投入分配和市场机制等问题,提出相应的政策建议,包括降低信贷风险、建立有效的贷款管理系统、优化受援产业结构和积极参与国际合作等方面。文中在进行绩效分析的基础上,不仅提到世行对柬埔寨经济增长的巨大贡献,还分析了柬埔寨利用世行信贷政策存在的问题的各方面原因,以及提出如何更有效利用世行贷款的四点建议。

关键词：柬埔寨世界银行信贷政策绩效分析存在的问题

The Self-Demagnetization Factor of Bonded Magnets

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The Self-Demagnetization Factor of Bonded Magnets

A comparative review of petrogenetic processes beneath the Cameroon volcanic Line: Geochemical constraints

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作者： n.v.vUOng n.v.KHAnH M.M.TAn Institute of Materials Science NCST of Vietnam Institute of Materials Science NCST of Vietnam Institute of Materials Science NCST of Vietnam

＜正＞ The self-demagnetization effect in bonded magnets （BM）, which are compacted from ferromagnetic particles em-bedded in a binder medium, was investigated by means of the numerical computation. It is shown that the self-demag-netization factor is dependent not only on the shape but also the granular structure of magnets. The calculated factorsn as functions of the magnet shape, mass density and particle orientation have been presented. The influence of theself-demagnetization effect on the characterization of BMs is also discussed.

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Geoscience Frontiers 2015年第4期6卷 557-570页

作者： Asobo n.E.Asaah Tetsuya Yokoyama Festus T.Aka Tomohiro Usui Mengnjo J.Wirmvem Boris Chako Tchamabe Takeshi Ohba Gregory Tanyileke J.v.Hell Department of Earth & Planetary Sciences Tokyo Institute of Technology2-12-1 Ookayama Meguro-ku Tokyo 152-8551 Japan Department of Mines Ministry of Mines Industry and Technological Development Yaoundé Cameroon Institute of Mining & Geological Research P.O. Box 4110 Yaoundé Cameroon Department of Chemistry School of Science Tokai UniversityHiratsuka 259-1211 Japan

The origin and petrogenesis of the Cameroon volcanic Line （CvL）, composed of volcanoes that form on both the ocean floor and the continental crust, are difficult to understand because of the diversity, het- erogeneity, and nature of available data. Major and trace elements, and Sr-nd-Pb isotope data of volcanic rocks of the CvL spanning four decades have been compiled to reinterpret their origin and petrogenesis. volcanic rocks range from nephelinite, basanite and alkali basalts to phonolite, trachyte and rhyolite with the presence of a compositional gap between Si02 58-64 wt.%. Similarities in geochemical characteristics, modeled results for two component mixing, and the existence of mantle xenoliths in most mafic rocks argue against significant crustal contamination. Major and trace element evidences indicate that the melting of mantle rocks to generate the CvL magma occurred dominantly in the garnet lherzolite stability feld. Melting models suggest small degree （〈3%） partial melting of mantle bearing （6-10%） garnet for Mr. Etinde, the ngaoundere Plateau and the Biu Plateau, and 〈5% of garnet for the oceanic sector of the CvL, Mr. Cameroon, Mt. Bambouto, Mt. Manengouba and the Oku volcanic Group. The Sr-nd-Pb isotope sys- tematics suggest that mixing in various proportions of Depleted MORB Mantle （DMM） with enriched mantle 1 and 2 （em1 and em2） could account for the complex isotopic characteristics of the CvL lavas. Low Mg number （Mg# - 100 x MgO/（MgO ＋FeO）） and ni, Cr and Co contents of the CvL mafic lavas reveal their crystallization from fractionated melts. The absence of systematic variation in nbJTa and Zr/Hf ratios, and Sr-nd isotope compositions between the mafic and felsic lavas indicates progressive evolution of magmas by fractional crystallization. Trace element ratios and their plots corroborate mantle het- erogeneity and reveal distinct geochemical signatures for individual the CvL volcanoes.

关键词： Petrogenesis Cameroon volcanic line Depleted MORB mantle Enriched mantle Mantle heterogeneity

The spectrum of building block conformers sustains the biophysical properties of clinically-oriented self-assembling protein nanoparticles

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Science China Materials 2022年第6期65卷 1662-1670页

作者： Eric voltà-Durán Julieta M Sánchez Hèctor-López-Laguna Eloi Parladé Laura Sánchez-García Alejandro Sánchez-Chardi Ario de Marco Ugutz Unzueta Esther vázquez Antonio villaverde Institut de Biotecnologia i de Biomedicina Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Genètica i de Microbiologia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain CIBER de Bioingeniería Biomateriales y nanomedicina(CIBER-BBn) Bellaterra 08193BarcelonaSpain Instituto de Investigaciones Biológicas y Tecnológicas(IIBYT)(COnICET-Universidad nacional de Córdoba) ICTA&Cátedra de Química BiológicaDepartamento de QuímicaFCEFyNUNC.Av.Velez Sarsfield 1611X 5016GCA CórdobaArgentina Servei de Microscòpia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Biologia Evolutiva Ecologia i Ciències AmbientalsFacultat de BiologiaUniversitat de Barcelona08028 BarcelonaSpain Laboratory for Environmental and Life Sciences University of Nova GoricaNova Gorica 5000Slovenia Biomedical Research Institute Sant Pau(IIB Sant Pau) Sant Antoni Ma Claret 16708025 BarcelonaSpain

Histidine-rich peptides confer self-assembling properties to recombinant proteins through the supramolecular coordination with divalent *** fact allows the cost-effective,large-scale generation of microscopic and macroscopic protein materials with intriguing biomedical *** such materials,resulting from the simple bioproduction of protein building blocks,homomeric nanoparticles are of special value as multivalent interactors and drug ***,we have here identified that the assembly of a given His-tagged protein might render distinguishable categories of self-assembling protein *** fact has been scrutinized through the nanobody-containing fusion proteins em1-GFP-H6 and A3C8-GFP-H6,whose biosynthesis results in two distinguishable populations of building *** one of them,the assembling and disassembling is controllable by ***,a second population immediately self-assembles upon purification through a non-regulatable pathway,rendering larger nanoparticles with specific biological *** structural analyses of both model proteins and nanoparticles revealed important conformational variability in the building *** fact renders different structural and functional categories of the final soft materials resulting from the participation of energetically unstable intermediates in the oligomerization *** data illustrate the complexity of the Hismediated protein assembling in recombinant proteins but they also offer clues for a better design and refinement of protein-based nanomedicines,which,resulting from biological fabrication,show an architectonic flexibility unusual among biomaterials.

关键词： recombinant proteins self-assembling protein materials nanoparticles biomaterials

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抗病毒敏感试验:恰逢其时

国外医学（微生物学分册） 1992年第4期15卷 181-182页

作者： Swierkosz em 余传霖

多数抗病毒制剂为核苷类似物目前使用的制剂为核苷类似物,对病毒复制有选择性作用。如阿糖腺苷为一嘌吟核苷,首先用于单纯疱疹病毒(HSv)脑炎及新生儿疱疹感染,能有效地降低死亡率及神经后遗症。阿糖腺苷为细胞激酶磷酸化后成为三磷酸盐... 详细信息

多数抗病毒制剂为核苷类似物目前使用的制剂为核苷类似物,对病毒复制有选择性作用。如阿糖腺苷为一嘌吟核苷,首先用于单纯疱疹病毒(HSv)脑炎及新生儿疱疹感染,能有效地降低死亡率及神经后遗症。阿糖腺苷为细胞激酶磷酸化后成为三磷酸盐,为病毒DnA多聚酶的抑制物。在实验室内虽可产生耐药病毒株,但在临床上问题不大。 Acyclovir[9-(2-羟二氧)甲基鸟嘌呤]为一鸟苷类似物,临床上对HSv和水痘-带状疱疹病毒(vZv)有效,因其相对无毒性作用。

关键词：抗病毒利剂抗病毒敏感性