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Central depressant effects of Piper tuberculatum Jacq essential oil in mice

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Food Bioscience 2022年第4期48卷 620-629页

作者： Valterlúcio dos Santos Sales Francisco Romero Cabral Emmily Petícia do Nascimento Sales Tatyelle Bezerra carvalho Maria Haiele Nogueira Costa Victor Afonso Pereira de Oliveira Cristina Kelly de Souza Rodrigues Francisco Rodolpho Sobreira Dantas Nobrega de Figueiredo daniel Souza Bezerra Gyllyandeson de Araújo delmondes Henrique Douglas Melo Coutinho Jose Galberto Martins da Costa Irwin Rose Alencar de Menezes Cícero Francisco Bezerra Felipe Marta Regina Kerntopf Universidade Regional do Cariri Departamento de Química Biol´ogicaCratoCear´aBrazil Universidade Federal de S˜ao Paulo-departamento de Fisiologia S˜ao PauloSPBrazil Faculdade de Ciˆencias M´edicas da Santa Casa de S˜ao Paulo S˜ao PauloSPBrazil Universidade Federal da Paraíba Departamento de Biologia MolecularJo˜ao PessoaParaíbaBrazil

This study aims to investigate the toxicity and possible effects and mechanism of action of the essential oil obtained from the Piper tuberculatum Jacq.‘s fruit(EOPT)on the central nervous system(CNS)of *** the Hippocratic test,it was observed ambulation reduction,sedation,piloerection and mortality of 25%at the dose of 1000 mg/kg and 50%at the dose of 5000 mg/*** results found demonstrate that the EOPT is endowed with a possible depressant effect,and is characterized by a likely sedative(open field test),anxiolytic-like(elevated plus maze test),anticonvulsant(pentylenetetrazole-induced seizure test)and hypnotic action(pentobarbital-induced sleeping time).These effects may possibly occur due to the interaction between the monoterpenes,present in its essential oil,and the GABAergic pathway confirmed by reversion of the effects by ***,these results demonstrate the therapeutic potential and the validation of the ethnopharmacological use of this species in the treatment of disorders affecting the central nervous system.

关键词： Piper tuberculatum Jacq. Essential oil Sedative Anxiolytic Hypnotic

Lumbar Synovial Cyst, Literature Review: Challenges of the Surgical Management, the Role of Minimal Invasive Techniques and Endoscopy

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Surgical Science 2023年第11期14卷 681-693页

作者： Marcel Sincari Alfredo carvalho André Nunes Mark daniel Sincari Neurosurgery department Centro Hospitalar Tondela-Viseu Viseu Portugal Orthopedy department Centro Universitário Cova de Beira Covilh&#227 Portugal Neurosurgery department Hospital Prenda Luanda Angola Faculty of Medicine University of Coimbra Coimbra Portugal

The management of symptomatic lumbar synovial cysts is still a challenge and a matter of debate with no existing strong consensus. There are different treatment techniques and strategies, the most debated matter is to fuse or not to fuse, efficiency of less invasive techniques. One of our purposes was to provide an updated review of a literature about treatment of juxta facet synovial cysts and as standard surgical strategies are inconsistent, we present a small series of patients treated using different approaches, most of them were treated with MISS techniques, endoscopy, providing good results.

关键词： Lumbar Synovial Cyst Lumbar decompression Facet Joint

Large primary hepatic gastrinoma in young patient treated with trisegmentectomy: A case report and review of the literature

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World Journal of Hepatology 2018年第7期10卷 517-522页

作者： Leonardo Zumerkorn Pipek Yuri Justi Jardim Gustavo Heluani Antunes de Mesquita Fernanda Nii Kayo Augusto de Almeida Medeiros Bárbara Justo carvalho Diego Ramos Martines Leandro Ryuchi Iuamoto daniel Reis Waisberg Luiz Augusto Carneiro D'Albuquerque Alberto Meyer Wellington Andraus Faculdade de Medicina FMUSP Universidade de Sa?o Paulo Program in Global Surgery and Social Change Department of Global Health and Social Medicine Harvard Medical School departamento de Gastroenterologia Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo

Primary hepatic gastrinoma is a rare disease, with fewer than 40 cases reported in the medical literature. Because it is located in an organ in which metastases are common, its diagnosis is difficult. We report a case of a 19 years old male patient with a history of gastric ulcers since the age of nine. Following gastric surgery, an antrectomy and a vagotomy, there was some alleviation of symptoms. Subsequently, the patient reported various intermittent episodes of diarrhea, diffuse abdominal pain, and vomiting. The patient underwent tomography, which revealed the presence of a hepatic mass measuring 19.5 cm × 12.5 cm × 17 cm. Primary hepatic gastrinoma was diagnosed based on laboratory examinations that indicated hypergastrinemia and a positron emission tomography/magnetic resonance study with somatostatin analogue that confirmed the liver as the primary site. After hepatic trisegmentectomy(Ⅱ, Ⅲ, Ⅳ, Ⅴ, Ⅷ), the patient's symptoms improved. The case is notable for the presence of a rare tumor with uncommon dimensions.

关键词： Gastrinoma Primary hepatic gastrinoma Zollinger-Ellison syndrome Hepatic trisegmentectomy Gastric surgery

Lymphedema in the Mastectomy Postoperative Period:An Integrative Literature Review

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Advances in Breast Cancer Research 2013年第4期2卷 154-160页

作者： Ana Fátima carvalho Fernandes Glécya Oliveira Vidal Camila Brasil Moreira Tiago barreto de Castro e Silva Paula Natasha Rodrigues Valentim Míria Conceicao Lavinas Santos department of Nursing Federal University of CearáFortalezaBrazil

Aims and Objectives: To analyze the evidence available in the literature on the stages during which upper limb lymphedema after mastectomy occurs. Background: Among the adverse effects of breast cancer treatment, lymphedema is the most prevalent. design: Integrative literature review. Methods: The Latin American and Caribbean Literature on Health Sciences (Literatura Latino-Americana e do Caribe em Ciências da Saúde—LILACS), PubMed, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases were used to select the pertinent studies. The identification data for these studies were summarized, and their methodological features and results were extracted. Results: Regarding the time elapsed since surgery, the highest prevalence of lymphedema corresponded to the late postoperative period, and regarding its severity, mild lymphedema was the most prevalent form. The prevalence was also the highest among the women who were subjected to radical mastectomy and radiotherapy. Conclusions: Many women who are undergoing treatment for breast cancer use strategies for the prevention and control of lymphedema of the upper limb following mastectomy. Relevance to Clinical Practice: The findings of the present study might inform future studies aiming to assess strategies that can be started in the immediate and late postoperative stages to detect lymphedema early and prevent the increase of its prevalence during the late postoperative period after mastectomy.

关键词： Breast Cancer Post-Operative Care Nursing

Technical Evaluation of Hybrid Clones of Corymbia spp. to Produce Market Pulp

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Paper And Biomaterials 2022年第3期7卷 1-6页

作者： Marcelo Moreira da Costa Ricardo de carvalho Bittencourt Thales Augusto Pinto Coelho Nogueira Larissa Soares Silva Weslley Henrique Martins da Silva Sebastião Renato Valverde Gleison Augusto Dos Santos daniel Alexander Fernandes Coelho Claudilene Aparecida Alves Pena department of Forest Sciences Federal University of VicosaVicosaMinas Gerais36570900Brazil Aperam BioEnergia Co. CapelinhaMinas Gerais39680000Brazil

This study presents hybrid clones of Corymbia *** by Aperam BioEnergia as potential substitutes for Eucalyptus wood in the pulp *** biomass of Eucalyptus *** compared with that of Corymbia *** performing modified kraft pulping and basic density *** were made by analyzing their respective mean annual increments of cellulose(MAI_(cel))and specific wood consumption(SWC),estimated using a kappa number of(19±1).The results showed that one of the hybrid clones(Corymbia citriodora×Corymbia torelliana,ID 4)had higher basic wood density,higher screened yield,better MAI_(cel#k19),and lower SWC than the other samples,reaching values of 0.608 t/m^(3),54.1%,24.6 ADt/ha/year(i.e.,air dry ton/hectare/year),and 2.74 m^(3)/ADt,***,clone ID 4 had the highest MAI_(cel)/SWC ratio score(8.98).Given its high forest productivity and low industrial cost compared with other samples,as well as its advantages over Eucalyptus ***,we concluded that clone ID 4 has great potential as an alternative biomass for pulp production.

关键词： Corymbia hybrids modified kraft pulping mean annual increments of cellulose(MAIcel) specific wood consumption(SWC)

How Do I Care for My Patients with...？

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Journal of Health Science 2015年第4期3卷 141-147页

作者： Thomas Kuehlein Ana carvalho Catarina Viegas Dias David Rodrigues daniel Pinto Allgemeinmedizinisches Institut Universitasklinikum Erlangen Universitatsstraβe 29 Erlangen 91054 Germany Unidade de Saude Familiar (USF) Loure Saudavel Loures 2670-487 Portugal Dafundo Family Medicine Unit Dafundo 1495-713 Portugal Family Medicine Unit NOVA Medical School/FacuMade de Ciencias Medicas Universidade Nova de Lisboa Lisboa 169-056Portugal

Introduction： Physicians want to know how they care for their patients. However, it can be challenging to describe the quality of their work. A basic question to ask would be： How do I care for my patients with a certain health condition？ The authors wanted to find out whether they can answer this question for their patients suffering from osteoporosis with the support of their EHR （electronic health record）. Materials and methods： Postmenopausal women having experienced a fracture were identified from the EHR. At the same time, criteria to assess the quality of care were defined following current guidelines. As it emerged that the EHR was unsuitable to fulfill the authors＇ purpose, the free software package ＂Epi Info 7＂ was used to create a template for data entry and analysis. Results： Of the 41 female patients identified with possible osteoporotic fractures, as many as 90% （37 patients） did not have any bone-density measurements recorded despite 39% （16 patients） had been given a diagnosis of osteoporosis. Of the 16 patients with recorded osteoporosis, only two were prescribed antiosteoporotic medication. The EHR was largely inadequate to answer the question. Conclusion：＂How do I care for mypatients with...？＂ is a difficult question to answer when relying on conventional EHR. The resulting answer is worrying and opens up a lot of room for improvement on behalf of the EHR and the quality of care provided.

关键词： Quality of care electronic health record clinical governance family practice.

Cecum Dieulafoy＇s Lesion Presenting with Recurrent Lower Gastrointestinal Bleeding： Case Report

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Journal of Pharmacy and Pharmacology 2018年第3期6卷 254-258页

作者： Ludmila Resende Guedes Silas Castro de carvalho Vitor Nunes Arantes Arthur Manoel Braga de Albuquerque Gomes daniel Antonio de Albuquerque Terra Nathalia da Silva Braga Nicoly Eudes da Silva Dias Endoscopy Unit of Alfa Institute of Gastroenterology at Hospital das Clinicas da Universidade Federal de Minas Gerais (UFMG) Belo Horizonte MG 30130100 Brazil

Introduction： Gastrointestinal Dieulafoy＇s lesion is a rare entity, of unknown etiology, and corresponds to an arterial malformation at the submucosal space that can be a source of life-threatening hemorrhage. We report a case of a Cecum Dieulafoy＇s bleeding lesion that was managed endoscopically with a favorable outcome. Case report： Female, 70-year-old, diagnosed with type 2 diabetes, hypothyroidism, and chronic heart failure associated with rheumatic mitral stenosis, submitted to biological valve replacement in 2006 and with permanent atrial fibrillation using vitamin K antagonist anticoagulant for thrombosis prophylaxis. Her background includes a stroke in 2004 without any permanent disability. In 2016, the patient experienced voluptuous and painless lower gastrointestinal bleeding with severe acute anemia, requiring hospital admission, fluid resuscitation and blood transfusion. Urgent colonoscopy revealed a small reddish vascular malformation at the cecum with oozing active bleeding, about 3 mm in size. Initially argon plasma coagulation was performed with satisfactory and immediate hemostasis. One week later, she recurred with hematochezia. The lesion at the cecum was reassessed and it was possible to notice a large caliber vessel surrounded by a normal appearance mucosa, compatible with Dieulafoy＇s lesion and it was treated with an endoscopic clip placement with a good long-term response. Conclusion： Endoscopy is the method of choice for diagnosis of Dieulafuy＇s lesion and may provide efficient treatment with mechanical hemostasis such as endoclip placement with a high success rate.

关键词： Dieulafoy's lesion lower gastrointestinal bleeding endoscopy endoscopic clip

Disentangling spatial,environmental and historical effects on tropical forest tree species turnover

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Journal of Plant Ecology 2021年第4期14卷 717-729页

作者： Alisson Borges Miranda Santos Vinicius Andrade Maia Cleber Rodrigo de Souza Nathalle Cristine Alencar Fagundes Fernanda Moreira Gianasi Aurelio de Jesus Rodrigues Pais Natalia de Aguiar-Campos Gabriela Gomes Pires Diego Teixeira Girardelli Jean daniel Morel Mariana Caroline Moreira Morelli Felipe de carvalho Araujo Rubens Manoel dos Santos department of Forestry Sciences Federal University of LavrasUniversity CampusLavrasBrazil Biological Sciences University of the State of Minas GeraisItuiutaba UnitItuiutabaBrazil department of Biology Federal University of LavrasUniversity CampusLavrasBrazil Faculty of Environmental Engineering and Natural Resources Zambeze UniversityChimoioMozambique

Aims We aimed at disentangling the effects of spatial distance,current and past environmental dissimilarity,and their combinations on tree community taxonomic and phylogenetic turnover by addressing the following questions:(i)Is tree community taxonomic and phylogenetic turnover related to the indirect effects of spatial distance via environmental dissimilarity?(ii)Does tree community taxonomic and phylogenetic turnover respond to paleoclimate(Last Glacial Maximum and Mid-Holocene)?Methods The study was carried out in 14 Atlantic rainforest sites in Brazil(20.4 ha sampled)containing 615 tree species from 83 plant *** obtained plot-level geographic coordinates and soil variables and site-level bioclimatic variables in the current,Mid-Holocene and Last Glacial *** used structural equation models with a distance-based approach to(i)test the direct effects of spatial distance and environmental dissimilarity and(ii)test the indirect effects of spatial distance via environmental dissimilarity on taxonomic(Bray–Curtis distance)and phylogenetic turnover(Comdist and Comdistnt distances).Important Findings Our results suggest a weak indirect effect of spatial distance via environmental dissimilarity on taxonomic and phylogenetic *** community turnover was driven by the direct effects of neutral,niche-based and historical ***,we inferred that the paleoclimate(historical processes)promoted the selection of the clades that gave rise to the current flora,while spatial distances(neutral processes)limited the dispersal range of species from the regional pool and environmental conditions(niche-based processes)locally selected the taxa that are able to persist.

关键词： assembly processes phylogenetic communities environmental filtering neutral communities phylogenetic turnover ecological niche paleoclimate effects

Trace metal dynamics in an industrialized Brazilian river:A combined application of Zn isotopes,geochemical partitioning,and multivariate statistics

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Journal of Environmental Sciences 2021年第3期33卷 313-325页

作者： Myller S.Tonhá daniel F.Araújo Rafael Araújo Bruno C.A.Cunha Wilson Machado Joelma F.Portela João PR Souza Hikari K.carvalho Elton L.Dantas Henrique L.Roig Patrick Seyler Jeremie Garnier Universidade de Brasília Instituto de GeociênciasCampus Darcy RibeiroL2Asa Norte70910900 BrasíliaDistrito FederalBrazil Laboratoire de Biogéochimie des Contaminants Métalliques IfremerCentre AtlantiqueF44311 Nantes Cedex 3France Institute of Geosciences University of São PauloRua do Lago562São Paulo 05508-080Brazil Universidade Federal Fluminense Programa de GeoquímicaCampus do ValonguinhoNiteróiRio de JaneiroBrazil Analytical and Environmental Chemistry Laboratory Instituto de QuímicaUniversity of BrasiliaBrasiliaFederal District 70919-970Brazil Laboratoire Mixte International“Observatoire des Changements Environnementaux”(LMI OCE) Institut de Recherche pour le Développement/University of BrasiliaCampus Darcy RibeiroBrasiliaBrazil Hydrosciences Montpellier Universitéde MontpellierInstitut de Recherche pour le développementCentre National de la Recherche ScientifiqueMontpellierFrance

The Paraiba do Sul(PSR)and Guandu Rivers(GR)water diversion system(120 km long)is located in the main industrial pole of Brazil and supplies drinking water for 9.4 million people in the metropolitan region of Rio de *** study aims to discern the trace metals dynamics in this complex aquatic *** used a combined approach of geochemical tools such as geochemical partitioning,Zn isotopes signatures,and multivariate *** and Pb concentrations in Suspended Particulate Matter(SPM)and sediments were considerably higher in some *** sediment partition of As,Cr,and Cu revealed the residual fraction(F4)as the main fraction for these elements,indicating low *** and Pb were mostly associated with the exchangeable/carbonate(F1)and the reducible(F2)fractions,respectively,implying a higher susceptibility of these elements to being released from *** isotopic compositions of sediments and SPM fell in a binary mixing source process between lithogenic(δ^(66/64)Zn_(JMC)≈+0.30‰)and anthropogenic(δ^(66/64)Zn_(JMC)≈+0.15‰)end *** lighterδ^(66/64)Zn_(JMC)values accompanied by high Zn concentrations in exchangeable/carbonate fraction(ZnF1)enable the tracking of Zn anthropogenic sources in the studied ***,the results indicated that Hg,Pb,and Zn had a dominant anthropogenic origin linked to the industrial activities,while As,Cr,and Cu were mainly associated with lithogenic *** work demonstrates how integrating geochemical tools is valuable for assessing geochemical processes and mixing source effects in anthropized river watersheds.

关键词： Metal pollution Isotope tracer Sequential extraction Anthropogenic activity