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Gastroschisis at the Leon University Hospital, Nicaragua

Reproductive and Developmental Medicine 2022年第2期6卷 86-91页

作者： Dania Maria Pastora Bucardo paula Andrea Pimienta Ramirez Department of Pediatrics Faculty of MedicineNational Autonomous University of Nicaragua UNAN-LeonLeonNicaragua Center for Precision Environmental Health Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonTexasUSA

Objective::The prevalence of midline birth defects, such as gastroschisis, has increased worldwide, over the last few decades. This study aims to explore the prevalence, maternal epidemiological characteristics, and natural history of neonates affected by gastroschisis at the University Hospital of Leon city, ***:Data were collected from the birth defect surveillance system of the Hospital Oscar Danilo Rosales (HEODRA). The analysis included all pregnancies that had gastroschisis complications between January 1 and December 31, 2020. The prevalence of gastroschisis was calculated according to maternal age. The mothers were interviewed, and the clinical records of the newborns were ***::Among the 4,460 deliveries included in this study, four cases of gastroschisis were identified, including three live births and one stillbirth. The gastroschisis rate was 8.9 per 10,000 live births (95% confidence interval [CI]: 0.18-17.8). The prevalence among mothers younger than 20 years and those older than 20 years was 26.4 (95% CI: -3.43 to 56.25) and 3.01 (95% CI: 2.89-8.90)/10,000 births, respectively. Mothers of gastroschisis-affected fetuses were of rural origin ( n = 3), had normal body mass indexes ( n = 3), were exposed to tobacco and wood smoke ( n = 2), and one was exposed to pesticides during the periconceptional period. Primary closure of the gastroschisis was performed on one patient, and complex gastroschisis for intestinal perforation was observed in another patient. The mean hospitalization duration was 33 days, and two patients were discharged alive. Conclusions::Gastroschisis was a significant birth defect among children delivered at HEODRA in 2020. Its prevalence in Nicaragua was higher than that in other countries in the region. All complicated pregnancies were young women with unplanned pregnancies, from rural areas, with exposure to secondhand smoke, and without vitamin supplements before or during the first trimester of pregnancy.

关键词： Environmental exposures Gastroschisis Preterm deliveries

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Is there a need for new kitchen design?Assessing the adaptative capacity of space to enable circularity in multiresidential buildings

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Frontiers of Architectural Research 2022年第5期11卷 891-916页

作者： Anita Ollár Kaj Granath paula Femenías Ulrike Rahe Department of Architecture and Civil Engineering Chalmers University of TechnologySE-41296GothenburgSweden

This paper aims to contribute to the development of spatial criteria for adaptive capacity,which is identified as one important factor for the transition towards more circular housing *** paper focuses on the kitchen,as an important function of the home which is connected to large resource flows and is exposed to frequent renovations and *** paper identifies spatial characteristics of the kitchen and evaluates their potential to accommodate circular solutions focusing on adaptive *** a first step,previous literature on the spatial characteristics of kitchens and indicators that support adaptability is *** are then used to develop an analytical framework to assess the adaptive capacity and circularity potential of 3624 kitchens in contemporary Swedish apartments.A qualitative approach in combination with quantitative methods is employed to analyse the selected *** main contributions of this paper include its spatial analytical framework,its descriptive presentation of contemporary kitchen and apartment designs,and its adaptive capacity assessment of the studied *** results point out that although the overcapacity of the floor area of kitchens and apartments can have significance for adaptability,it is not the only determinative spatial *** windows’location and distribution,the number of door openings and traffic zones,the shafts’location and accessibility from multiple rooms,the room typology and the kitchen typology can improve the adaptive capacity and circularity potential of kitchens and *** findings show that in contemporary floorplans advantageous design solutions connected to the identified spatial characteristics are not applied in a systematic *** research is necessary to define the exact measures of the individual spatial characteristics and their combined application in multiresidential floorplan design.

关键词： Adaptive capacity Spatial criteria Circular design Kitchen design Apartment floorplans Multiresidential

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CECRE:Supervision and Control of Spanish renewable Energies in the Last 15 years

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 269-276页

作者： Gema Garcia Platero Mayte Garcia Casado Marta Perez Garcia paula Junco Madero David Alvira Baeza the Red Electrica de Espafia MaridSpain

From its commissioning in 2006 to the present,the Spanish Control Centre for renewable Energies(CECRE)has been a worldwide pioneer and reference centre in the integration of renewable energies in the electrical *** the last 15 years,CECRE has allowed a high penetration of renewable energies in Spanish electrical system by means of the supervision and control of renewable facilities,while ensuring the power supply *** paper defines the bases of renewable en-ergy operation in CECRE and introduces forecasting systems for renewable ***,this paper describes the participation of renewable energies in balancing services and congestion ***,new challenges for Spanish transmission system operator(TSO)are presented for the integration of renewable energies along with the energy transition and decarbonization.

关键词： Balancing services controllability forecasting system observability Control Centre for renewable Energies(CECRE) renewable energy photovoltaic(PV) wind.

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Bacillus licheniformis PF9 improves barrier function and alleviates inflammatory responses against enterotoxigenic Escherichia coli F4 infection in the porcine intestinal epithelial cells

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Journal of Animal Science and Biotechnology 2022年第5期13卷 1413-1427页

作者： Qiao Li Linyan Li Yanhong Chen Changning Yu paula Azevedo Joshua Gong Chengbo Yang College of Veterinary Medicine Nanjing Agricultural UniversityNanjing 210095China Department of Animal Science University of ManitobaWinnipegManitoba R3T 2N2Canada Guelph Research and Development Centre Agriculture Agri-Food CanadaGuelphOntario N1G 5C9Canada State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047China

Background:Enterotoxigenic Escherichia coli(ETEC)F4 commonly colonizes the small intestine and releases enterotoxins that impair the intestinal barrier function and trigger inflammatory *** Bacillus licheniformis(***)has been reported to enhance intestinal health,it remains to be seen whether there is a functional role of *** in intestinal inflammatory response in intestinal porcine epithelial cell line(IPEC-J2)when stimulated with ETEC ***:In the present study,the effects of *** PF9 on the release of pro-inflammation cytokines,cell integrity and nuclear factor-κB(NF-κB)activation were evaluated in ETEC F4-induced IPEC-J2 ***:*** PF9 treatment was capable of remarkably attenuating the expression levels of inflammation cytokines tumor necrosis factor-α(TNF-α),interleukin(IL)-8,and IL-6 during ETEC F4 ***,the gene expression of Toll-like receptor 4(TLR4)-mediated upstream related genes of NF-κB signaling pathway has been significantly *** changes were accompanied by significantly decreased phosphorylation of p65 NF-κB during ETEC F4 infection with *** PF9 *** immunofluorescence and western blotting analysis revealed that *** PF9 increased the expression levels of zona occludens 1(ZO-1)and occludin(OCLN)in ETEC F4-infected IPEC-J2 ***,the *** PF9 could alleviate the injury of epithelial barrier function assessed by the trans-epithelial electrical resistance(TEER)and cell permeability ***,*** PF9 protect IPEC-J2 cells against ETEC F4 infection by decreasing the gene expressions of virulence-related factors(including luxS,estA,estB,and elt)in ETEC ***:Collectively,our results suggest that *** PF9 might reduce inflammation-related cytokines through blocking the NF-κB signaling ***,*** PF9 displayed a significant role in the enhancem

关键词： Bacillus licheniformis PF9 Barrier function ETEC F4 Inflammatory response IPEC-J2

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Bull spermatozoa selected by thermotaxis exhibit high DNA integrity,specific head morphometry,and improve ICSI outcome

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1001-1011页

作者： Sara Ruiz-Diaz Rosane Mazzarella paula Navarrete-Lopez Raul Fernandez-Gonzalez Celia de Frutos Maria Maroto Claudia Cucala paula Beltran-Brena Marta Lombo Dimitrios Rizos Alfonso Gutierrez-Adan Department of Animal Reproduction INIA-CSIC28040 MadridSpain Mistral Fertility Clinics S.L Clinica TambreCalle Tambre828002 MadridSpain

Background Sperm migration by thermotaxis is a guidance mechanism that operates along the oviduct and it has proved to be a valid method for selecting spermatozoa with low DNA fragmentation(SDF)in mice,humans,and *** study aimed to analyse if bull spermatozoa could be selected by thermotaxis and to assess their quality in terms of SDF as well as determine the presence of a specific sperm subpopulation based on sperm morphometry and assess their fertilizing capacity by *** We used frozen-thawed sperm from 6 bulls and sperm selection by thermotaxis was performed with TALP medium supplemented with 25 mmol/L of HEPES and 5 mmol/L of *** these conditions,sperm selection was achieved,obtaining a net thermotaxis of 3.6%.Subsequently,we analysed the SDF of the migrated and not-migrated spermatozoa using the neutral COMET assay,and we evaluated the size of the sperm head using Hemacolor■ staining with Motic Images Plus 3 ***,migrated and not-migrated spermatozoa by thermotaxis were used to fertilize bovine in vitro matured(IVM)oocytes by ICSI,a very inefficient procedure in cattle that is only successful when the oocyte is artificially *** The results showed lower SDF(χ^(2),P<0.001,13.3%reduction,n=8)and lower head size parameters(length and width,P<0.01;and perimeter and area,P<0.001;n=4)in those spermatozoa migrated in comparison to those *** distribution of sperm subpopulations structure varied between groups,highlighting cluster 2,characterized by spermatozoa with small head size,and high ellipticity and elongated heads,as the most abundant in the thermotaxis migrated *** performed ICSI(without oocyte artificial activation)with the thermotactic sperm,the blastocyst rate was 32.2%±9.3%in the group microinjected with the thermotactic spermatozoa vs.8.3%±7.8%in the group of not-migrated sperm(χ^(2),P<0.05).Conclusion Our results showed that bull sperm selection by thermotaxis has a much higher D

关键词： ART Bovine Sperm morphometry Sperm selection Thermotaxis

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Differential diagnosis between autism spectrum disorder and other developmental disorders with emphasis on the preschool period

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世界儿科杂志:英文版 2023年第8期19卷 715-726页

作者： Taynara Amancio de Lima Patricia Aparecida Zuanetti Marina Estima Neiva Nunes Ana paula Andrade Hamad Department of Neurosciences and Behavioral Sciences Ribeirão Preto Medical SchoolUniversity of São PauloAv.Bandeirantes3900Monte AlegreRibeirão PretoSP14049-900Brazil University Hospital Ribeirão Preto Medical SchoolUniversity of São Paulo(HCFMRP-USP)Ribeirão PretoSPBrazil

Background Neurodevelopmental disorders are a heterogeneous group of conditions that manifest as delays or deviations in the acquisition of expected developmental milestones and behavioral *** spectrum disorder(ASD)is a neurodevelopmental disorder characterized by deficits in communication and social interaction and by repetitive and restricted patterns of behavior,interests and *** aim of this review is to discuss the clinical features of the differential diagnoses of ASD that are prevalent among preschoolers,focusing on their similarities and *** sources The international medical literature search was conducted using PubMed and was revised regarding the subject using single and/or combined keywords as follows:differential diagnosis,preschoolers,diagnostic challenge,attention deficit hyperactivity disorder,intellectual disability,high abilities/giftedness,childhood apraxia of speech,social communication disorder,Landau–Kleffner syndrome,stereotyped movement disorder and excessive screen *** We describe conditions commonly found in clinical practice,taking ASD as a *** addressed converging and divergent aspects of behavior,cognition,communication,language,speech,socialization,and stereotypes for the diagnosis of ASD and other disorders identified as potential differential or comorbid *** The ranking and characterization of symptoms appear to be essential for better understanding the underlying common ground between children with developmental disorders and children with ASD,thus properly diagnosing and directing social,professional,or medication *** detailed discussion adds to the literature since,although ASD differential diagnoses are frequently mentioned and discussed in textbooks and journal articles,they rarely occupy a prominent place as we aimed herein.

关键词： Autism spectrum disorder Clinical features Differential diagnosis Neurodevelopmental disorders Preschool

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The best of both worlds:mastering nerve regeneration combining biological and nanotechnological tools

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Neural Regeneration Research 2023年第3期18卷 556-557页

作者： paula A.Soto Marcela B.Fernández van Raap C.Patricia Setton-Avruj Departamento de Química Biológica Cátedra de Química Biológica PatológicaUniversidad de Buenos AiresFacultad de Farmacia y BioquímicaInstituto de Química y Fisicoquímica Biológicas(IQUIFIB)Universidad de Buenos AiresBuenos AiresArgentina Departamento de Física Universidad Nacional de La Plata(UNLP)Facultad de Ciencias ExactasLa PlataArgentinaLaboratorio de BiotecnologíaUniversidad ORT UruguayMontevideoUruguay

Over the last decade,remarkable developments in nanotechnology have powered medical research,unveiling new approaches for the solution of public health issues such as the treatment of traumatic peripheral neuropathies.

关键词： traumatic technological treatment

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Abiotic stress on seed germination and plant growth of Zeyheria tuberculosa

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林业研究:英文版 2023年第5期34卷 1511-1522页

作者： Robson Luis Silva de Medeiros Rinaldo Cesar de paula Joao Vitor Oliveira de Souza Joao Pedro Peixoto Fernandes Department of Agricultural Sciences School of Agricultural and Veterinarian SciencesSao Paulo State University(Unesp)14884-900JaboticabalSao PauloBrazil

Zeyheria tuberculosa(Vell.)Bureau ex *** among the Brazilian flora threatened with *** has high-quality wood and can be used to recover herbicidecontaminated ***,abiotic stresses can harm seed germination and seedling development under adverse conditions and need to be understood to improve autochthonous or indigenous biodiversity conservation and strengthen reforestation *** study evaluated the effects of temperature,water and saline stress on *** seed germination and water stress on seedling *** laboratory experiments evaluated germination under:(1)different temperatures(20,25,30,35 and 40℃);(2)different water potentials simulated with polyethylene glycol(PEG6000)at 25 and 30℃;and,(3)different osmotic potentials simulated with NaCl at 25 and 30℃.In addition,a greenhouse experiment subjected seedlings to five water regimes(20%,35%,50%,65%and 80%of maximum substrate water holding capacity).In the laboratory,seedling biometry and germination were evaluated,while physiological and morphological parameters were assessed in the *** potential of seeds increased at 25 and 30℃.Germination and vigor decreased as water and saline stresses *** tolerance thresholds for water and salt stresses were-0.6 and-0.4 MPa,*** the greenhouse,the most restrictive water regimes reduced seedling physiological and morphological *** development was compromised at moisture levels below50%field capacity.

关键词： Bignoniaceae Climate change Ipê-felpudo Ipê-preto Water stress

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Fecal microbiota transplantation for the maintenance of remission in patients with ulcerative colitis:A randomized controlled trial

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World Journal of Gastroenterology 2023年第17期29卷 2666-2678页

作者： Perttu Lahtinen Jonna Jalanka Eero Mattila Jyrki Tillonen paula Bergman Reetta Satokari Perttu Arkkila Department of Gastroenterology Päijät-Häme Central HospitalLahti 15610Finland Department of Medicine University of HelsinkiHelsinki 00014Finland Human Microbiome Research Program Faculty of MedicineUniversity of HelsinkiHelsinki 00014Finland Department of Infectious Diseases Helsinki University HospitalHelsinki 00029UusimaaFinland Department of Bioinformatics Helsinki University HospitalHelsinki 00014Finland Department of Gastroenterology University HelsinkiCenter HospitalHelsinki 00029UusimaaFinland

BACKGROUND Fecal microbial transplantation(FMT)is a promising new method for treating active ulcerative colitis(UC),but knowledge regarding FMT for quiescent UC is *** To investigate FMT for the maintenance of remission in UC *** Forty-eight UC patients were randomized to receive a single-dose FMT or autologous transplant via *** primary endpoint was set to the maintenance of remission,a fecal calprotectin level below 200μg/g,and a clinical Mayo score below three throughout the 12-mo *** secondary endpoints,we recorded the patient’s quality of life,fecal calprotectin,blood chemistry,and endoscopic findings at 12 *** The main endpoint was achieved by 13 out of 24(54%)patients in the FMT group and by 10 out of 24(41%)patients in the placebo group(log-rank test,P=0.660).Four months after FMT,the quality-of-life scores decreased in the FMT group compared to the placebo group(P=0.017).In addition,the disease-specific quality of life measure was higher in the placebo group than in the FMT group at the same time point(P=0.003).There were no differences in blood chemistry,fecal calprotectin,or endoscopic findings among the study groups at 12 *** adverse events were infrequent,mild,and distributed equally between the *** There were no differences in the number of relapses between the study groups at the 12-mo ***,our results do not support the use of a single-dose FMT for the maintenance of remission in UC.

关键词： Fecal microbial transplantation Ulcerative colitis Quality of life Maintenance of remission Inflammatory bowel disease Fecal calprotectin

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Metabolic determinants of stemness in medulloblastoma

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World Journal of Stem Cells 2022年第8期14卷 587-598页

作者： paula Martín-Rubio Pilar Espiau-Romera Alba Royo-García Laia Caja Patricia Sancho Hospital Universitario Miguel Servet IIS AragónZaragoza 50009Spain Department of Medical Biochemistry and Microbiology Biomedical CenterUppsala UniversityUppsala SE-751Sweden

Medulloblastomas(MBs)are the most prevalent brain tumours in *** are classified as grade IV,the highest in malignancy,with about 30%metastatic tumours at the time of *** stem cells(CSCs)are a small subset of tumour cells that can initiate and support tumour *** MB,CSCs contribute to tumour initiation,metastasis,and therapy *** differences among the different MB groups have started to *** hedgehog tumours show enriched lipid and nucleic acid metabolism pathways,whereas Group 3 MBs upregulate glycolysis,gluconeogenesis,glutamine anabolism,and glutathione-mediated anti-oxidant *** differences impact the clinical behaviour of MB tumours and can be exploited *** this review,we summarise the existing knowledge about metabolic rewiring in MB,with a particular focus on ***,we highlight some of the emerging metabolism-based therapeutic strategies for MB.

关键词： Medulloblastoma Cancer stem cells Stemness Metabolism Glycolysis Lipids

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