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Holmes-Adie syndrome, autoimmune hepatitis and celiac disease: A case report

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World Journal of Gastroenterology 2006年第9期12卷 1485-1487页

作者： Timea Csak Aniko Folhoffer Andrea Horvath Judit halász Csaba Diczházi Zsuzsa Schaff Ferenc szalay Department of Medicine Semmelweis University BudapestHungary Department of Pathology Semmelweis University BudapestHungary

A 35-year-old female patient presented with the following symptoms of Holmes-Adie syndrome： photophobia, enlargement of the left pupil unresponsive to light, Achilles areflexia. The pilocarpine test was positive. No tumor or other neurological abnormality was found. She had a 19-year history of autoimmune hepatitis. Flares up were observed following each 3 deliveries. At age of 31 she presented with diarrhea and weight loss. Abdominal tumor was detected by ultrasound. The surgically removed tumor was histologically a benign mesenteric multicystic lymphangioma. Simultaneously, celiac disease was diagnosed. Gluten-free diet resulted in a significant improvement of celiac disease, but not of autoimmune hepatitis. Autonomic neuropathy was proven by standard cardiovascular tests. The patient was a homozygous carrier for HLA DQ2 antigen characteristic for celiac disease and heterozygous for HLA DR3 B8 frequent in autoimmune liver diseases. Our novel observation on association of Holmes-Adie syndrome with autoimmune hepatitis and celiac disease is suggestive for a common immunological background for all three entities present in a patient with mesenteric multicystic lymphangioma.

关键词： Holmes-Adie syndrome Autoimmune hepatitis Celiac disease Mesenteric lymphangioma Autonomic neuropathy

vanishing torsion of parametric curves

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 593-595页

作者： JUHsz Imre Department of Descriptive Geometry University of MiskolcMiskolc-Egyetemváros H-3515Hungary

We consider the class of parametric curves that can be represented by combination of control points and basis func- tions. A control point is let vary while the rest is held fixed. It’s shown that the locus of the moving control point that yields points of zero torsion is the osculating plane of the corresponding discriminant curve at its point of the same parameter value. The special case is studied when the basis functions sum to one.

关键词： Parametric curve Torsion Discriminant curve

火花源光发射光谱法分析中测量不确定度的表述及原材料规格一致性概率的计算

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冶金分析 2012年第1期32卷 19-22页

作者： Edmund halász J-M Bhlen 赛默飞世尔科技有限公司

根据ISO 17025,每年有越来越多的实验室开始使用光发射光谱仪(OES)。ISO17025的遵守提升了评估和报道测量不确定度的重要性。《测量不确定度表示指南》(GUM)提供了不确定度分析的指导方法。不过,这些指导方针的实施是一项艰巨的任务,尤... 详细信息

根据ISO 17025,每年有越来越多的实验室开始使用光发射光谱仪(OES)。ISO17025的遵守提升了评估和报道测量不确定度的重要性。《测量不确定度表示指南》(GUM)提供了不确定度分析的指导方法。不过,这些指导方针的实施是一项艰巨的任务,尤其是不熟悉必要的数学和统计学概念时。因此,试验和校准人员必须经常寻找现成的工具以满足分析需求。本文报道了赛默飞世尔科技有限公司实施的分析软件,用于测量不确定度的计算。此外,还描述了基于不确定度知识的应用,以用于计算产品一致性的概率。

关键词：火花源光发射光谱测量不确定度置信区间一致性测试风险分析

CDH1 germline mutation in hereditary gastric carcinoma

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World Journal of Gastroenterology 2004年第21期10卷 3088-3093页

作者： hal-DanWang JunRen LianZhang CenterofClinicalOncolugyandInternationalCollaborativeGrouponHereditaryGastricCarcinoma XijingHospitaltheFourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChina PekingUniversitySchoolofOncology Beijing100036China

This paper provides a bird's-eye view both in preclinical and clinical aspects of E-cadherin germline gene (CDH1) in gastric cancer patients and their families. E-cadherin, a product of CDH1 gene, belonging to the functionally related trans-membrane glycoprotein family, is responsible for the Ca^2+-dependent cell-cell adhesion mechanism and contributes to dissociation followed by acquisition of cell motility, which usually occurs in the first step of cancer irwasion and metastasis. CDH1 gene germline mutation is common in many types of carcinoma, and occurs very frequent in hereditary gastric carcinoma (HGC) patients and their families. Recently, more and more researches support that E-cadherin plays an important role in the differentiation, growth and invasion of HGC. So it is of great value to clarify its mechanisms both for understanding HGC pathogenesis and for clinical therapy, especially in China, where there are a high risk population of gastric cancer and a high HGC incidence rate. In this paper, recent researches on CDH1 gene mutation, especially its role in tumor genesis and progress of HGC, are reviewed, and advances in evaluation of its mutation status for HGC diagnosis, therapy and prognosis, are also discussed briefly.

关键词： CDH1 种系基因突变遗传性胃癌肿瘤 HGC 发病机理

mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan

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World Journal of Gastroenterology 2015年第25期21卷 7814-7823页

作者： Tünde halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai Second Department of Pathology Semmelweis University Department of Pathology Military Hospital Hepatology Center of Buda 1111 BudapestHungary First Department of Medicine University of Pécs Second Department of Internal Medicine Semmelweis University MTA-SE Tumor Progression Research Group Semmelweis University

AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis ***: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) ***: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P values(all P values(P values in the samples of autoimmune live

关键词： Expression FibroScan Liver fibrosis METAVIR microRNA miR-122

Prediction of HLA-A2-restricted CTL epitope specific to HCC by SYFPEITHI combined with polynomial method

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World Journal of Gastroenterology 2005年第2期11卷 208-211页

作者： hal-LongDong Yan-FangSui Departmentofpathology FourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChina Departmentofpathology FourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChina

AIM: To predict the HLA-A2-restricted CTL epitopes of tumor antigens associated with hepatocellular carcinoma (HCC).METHODS: MAGE-1, MAGE-3, MAGE-8, P53 and AFP were selected as objective antigens in this study for the close association with HCC. The HLA-A*0201 restricted CTL epitopes of objective tumor antigens were predicted by SYFPEITHI prediction method combined with the polynomial quantitative motifs method. The threshold of polynomial scores was set to -***: The SYFPEITHI prediction values of all possible nonamers of a given protein sequence were added together and the ten high-scoring peptides of each protein were chosen for further analysis in primary prediction. Thirtyfive candidates of CTL epitopes (nonamers) derived from the primary prediction results were selected by analyzing with the polynomial method and compared with reported CTL ***: The combination of SYFPEITHI prediction method and polynomial method can improve the prediction efficiency and accuracy. These nonamers may be useful in the design of therapeutic peptide vaccine for HCC and as immunotherapeutic strategies against HCC after identified by immunology experiment.

关键词： Hepatocellular carcinoma HLA-A*0201 Cytotoxic T Lymphocyte Epitope

A reflection on the contrast between the Cooper pairing in iron-based and conventional superconductors

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Frontiers of physics 2011年第4期6卷 350-356页

作者： Fa Wang Dung-hal Lee Department of Physics Massachusetts Institute of Technology Cambridge MA 02139 USA Department of Physics University of California at Berkeley Berkeley CA 94720 USA Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA

In this Perspective article we review retrospectively the streamline of our work on iron-based superconductors, and reflect on the mechanism of Cooper pairing in conventional and unconventional, such as iron-based sup... 详细信息

关键词： Cooper pairing iron-based superconductors effective interaction renormalizationgroup

On the Bifurcations of a Hamiltonian Having Three Homoclinic Loops under Z_3 Invariant Quintic Perturbations

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Acta Mathematica Sinica,English Series 2007年第5期23卷 869-878页

作者： Yu hal WU Mao An HAN Department of Mathematics Jiang Su University Zhenjiang 212013 P. R. China Department of Mathematics Shanghai Normal University Shanghai 200234 P. R. China

A cubic system having three homoclinic loops perturbed by Z3 invariant quintic polynomials is considered. By applying the qualitative method of differential equations and the numeric computing method, the Hopf bifurcation, homoclinic loop bifurcation and heteroclinic loop bifurcation of the above perturbed system are studied. It is found that the above system has at least 12 limit cycles and the distributions of limit cycles are also given.

关键词： homoclinic loop bifurcation heteroclinic loop bifurcation Hopf bifurcation stability limit cycles

Prediction to the Efficiency of Soft Clay Sample Preparation with vacuum Loading

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China Ocean Engineering 1998年第2期13卷 243-251页

作者： Yan, SW Fang, sz Tianjin Univ Dept Hydraul Engn Tianjin 300072 Peoples R China

vacuum loading has been examined as a way of preparing uniformly consolidated soft clay samples. The facility and loading procedure are described in this paper. An analytical solution to the three dimensional consolidation equation is derived for estimating the degree of consolidation of the soil sample with vacuum loading. The given example shows that the predicted degree of consolidation of a soft clay bulk with vacuum loading is close to that measured in the consolidation process.

关键词： reconstituted clay vacuum loading sample preparation 3D consolidation analytical solution