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Potential preservative mechanisms of cardiac rehabilitation pathways on endothelial function in coronary heart disease

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Science China Life Sciences 2024年

作者： Wen-Tao Sun Jian-Yong Du Jia Wang Yi-Long Wang er-Dan Dong Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital)School of Health and Life SciencesUniversity of Health and Rehabilitation Sciences Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalThe Institute of Cardiovascular SciencesPeking UniversityState Key Laboratory of Vascular Homeostasis and RemodelingPeking University

Cardiac rehabilitation, a comprehensive exercise-based lifestyle and medical management, is effective in decreasing morbidity and improving life quality in patients with coronary heart disease. Endothelial function, an irreplaceable indicator in coronary heart disease progression, is measured by various methods in traditional cardiac rehabilitation pathways, including medicinal treatment, aerobic training, and smoking cessation. Nevertheless, studies on the effect of some emerging cardiac rehabilitation programs on endothelial function are limited. This article briefly reviewed the endothelium-beneficial effects of different cardiac rehabilitation pathways, including exercise training, lifestyle modification and psychological intervention in patients with coronary heart disease, and related experimental models, and summarized both uncovered and potential cellular and molecular mechanisms of the beneficial roles of various cardiac rehabilitation pathways on endothelial function. In exercise training and some lifestyle interventions, the enhanced bioavailability of nitric oxide, increased circulating endothelial progenitor cells(EPCs), and decreased oxidative stress are major contributors to preventing endothelial dysfunction in coronary heart disease. Moreover, the preservation of endothelial-dependent hyperpolarizing factors and inflammatory suppression play roles. On the one hand, to develop more endothelium-protective rehabilitation methods in coronary heart disease, adequately designed and sized randomized multicenter clinical trials should be advanced using standardized cardiac rehabilitation programs and existing assessment methods. On the other hand, additional studies using suitable experimental models are warranted to elucidate the relationship between some new interventions and endothelial protection in both macro-and microvasculature.

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从《一千零一夜》开始

当代文坛 2024年第1期 52-60页

作者：李洱北京大学文学讲习所

1.《一千零一夜》,博尔赫斯认为,这是世界上最好的书名。“一千夜”就是“永远”,“一千零一夜”就是“比永远还要远”,就是“永恒”。所以,英文里表达“永恒”用的就是“forever and a day”(永远零一天)。在写作意义上,“一千零一夜... 详细信息

1.《一千零一夜》,博尔赫斯认为,这是世界上最好的书名。“一千夜”就是“永远”,“一千零一夜”就是“比永远还要远”,就是“永恒”。所以,英文里表达“永恒”用的就是“forever and a day”(永远零一天)。在写作意义上,“一千零一夜”让整体变成个体,让模糊变得具体,让整体与个体相融,让模糊与具体交织。“一千零一夜”也让每一个夜晚变成“这一个”夜晚,让每一个故事变成“这一个”故事。

关键词：一千零一夜写作意义博尔赫斯《一千零一夜》整体与个体书名故事

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寻找细节丰茂之地

扬子江文学评论 2024年第3期 10-14,F0002页

作者：田耳广西大学艺术学院

一前不久看一篇评论家综论,提及“70后”的创作,认为这一代作家执念于细节的营造,同时也因过于拘泥细节,而未获取足够开阔的视野,也未抵达更为幽深的人性观照。我读罢这一段,脑子迅速扫描我熟悉的一些“70后”作家及创作。作为一个群体... 详细信息

一前不久看一篇评论家综论,提及“70后”的创作,认为这一代作家执念于细节的营造,同时也因过于拘泥细节,而未获取足够开阔的视野,也未抵达更为幽深的人性观照。我读罢这一段,脑子迅速扫描我熟悉的一些“70后”作家及创作。作为一个群体,我们起初似乎都排斥“70后”这样笼统粗率的命名,但随着写作的推进,这一代人整体步入中年,“70后”的指称也一直未有更好的替代,慢慢我们开始接受、认领。毕竟我们不能否认,我们就是一代人。起初感觉这样的命名什么也没说,慢慢觉得它把什么都说了,甚至具有某种预言性质:你们只是整体清晰而个体贫弱的一代人。所以,“70后”老早又被冠名为“夹缝的一代”。相对于晚一点的“80后”,“70后”的个人面孔相对模糊,而“80后”个人仿佛自带一种横空出世的禀赋,比如早一点的韩寒,稍晚的双雪涛,近几年的班宇。

关键词：这一代人人性观照冠名韩寒 80后细节

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东汉兰台“文”的实践——以“刘秀起家”“建武革命”和“万夷宾服”为中心

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文学遗产 2024年第2期 85-98页

作者：王尔中国人民大学历史学院

东汉前期新设兰台,皇帝征召兰台之官。兰台文雄会聚,成为一个职能清晰的官方文艺机构。兰台文人用史、赋、颂、传记述东汉获得天命、功致太平的历程,由此形成一系列“文”的实践活动。班固等在兰台撰著《世祖本纪》,编织光武帝事迹,彰... 详细信息

东汉前期新设兰台,皇帝征召兰台之官。兰台文雄会聚,成为一个职能清晰的官方文艺机构。兰台文人用史、赋、颂、传记述东汉获得天命、功致太平的历程,由此形成一系列“文”的实践活动。班固等在兰台撰著《世祖本纪》,编织光武帝事迹,彰显其创业之功,确立开国史叙述;兰台文人撰著多篇“都赋”,以迁都洛阳隐喻东汉受命,批评西汉之承秦,凸显“汉历中绝”,建构“建武革命”的观念;文人创作《哀牢传》《神雀颂》等,染“万夷宾服”,暗喻东汉的统治区域达到前所未有之广阔。文人作“汉颂”,比拟《周颂》,传达古今同况、功成德洽之义。这一系列文章实践是明、章时代一场重要的政治文化工程,是东汉王朝重建合法性的自我表达。

关键词：兰台文《世祖本纪》都赋汉颂

CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3k-Akt pathway

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1029-1045页

作者： Wen-Qian Ma Ming-Chang Miao Ping-An Ding Bi-Bo Tan Wen-Bo Liu Shuo Guo Li-Mian er Zhi-Dong Zhang Qun Zhao Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Hebei key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer Shijiazhuang 050011Hebei ProvinceChina Department of Radiotherapy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Third Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACkGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors,including gastric cancer(GC),and is associated with tumor progression and immune infiltration;however,the roles and mechanisms of CALD1 in epithe-lial-mesenchymal transition(EMT)in GC are *** To investigate the role and mechanism of CALD1 in GC progression,invasion,and *** In this study,the relationship between CALD1 and GC,as well as the possible network regulatory mechanisms of CALD1,was investigated by bioinformatics and validated by ***1-siRNA was synthesized and used to trans-fect GC *** activity was measured using the CCk-8 method,cell migration and invasive ability were measured using wound healing assay and Transwell assay,and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot.A GC cell xenograft model RESULTS Bioinformatics results showed that CALD1 was highly expressed in GC tissues,and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of *** prognosis of patients with high expression of CALD1 was worse than that of patients with low expression,and a prognostic model was constructed and *** experimental results were consistent with the results of the bioinformatics *** expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1,with the strongest expression found in AGS and MkN45 *** activity was significantly reduced after CALD1-siRNA trans-fection of AGS and MkN45 *** ability of AGS and MkN45 cells to migrate and invade was reduced after CALD1-siRNA transfection,and the related mRNA and protein expression was *** to bioinfor-matics findings in GC samples,the CALD1 gene was significantly associated with the expression of members of the PI3k-AkT-mTOR signaling pathway as well as the EMT signaling pathway,and was closely rel

关键词： Gastric tumor CALD1 Epithelial-mesenchymal transition Gene disruption Invasion Migration Bioinformatics

Harm of Hail to Crops and Countermeasures of Artificial Hail Suppression in Ulanqab City

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Meteorological and Environmental Research 2024年第2期15卷 62-63,70页

作者： Pei WANG Tengge'er WU Jinhua LIU Ulanqab Meteorological Bureau Ulanqab 012000China Huade Meteorological Bureau Huade 013350China

Hail is one of meteorological disasters affecting crop growth in Ulanqab *** happens frequently from May to September,and this period is also the main growing season of *** this period,hail will cause damage to crops,make farmland soil harden,and bring varying degrees of harm to agricultural *** hail suppression is an important scientific and technological means for disaster prevention and *** is necessary to strengthen the monitoring,analysis and forecast of severe convection weather,intensify the release of early warning information of hail weather,provide accurate and reliable real-time information for the implementation of artificial hail suppression operations,strengthen the implementation of artificial weather modification,effectively carry out artificial hail suppression operations,and avoid and reduce the impact of hail disaster.

关键词： Hail Crops Harm Artificial hail suppression Ulanqab City

Super P and MoO2/MoS2 co-doped gradient nanofiber membrane as multi-functional separator for lithium–sulfur batteries

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Rare Metals 2024年第9期43卷 4263-4273页

作者： Xin Liang Dong-Qing Zhao Qian-Qian Huang Sheng Liang Li-Li Wang Lei Hu Ling-Li Liu kun-Hong Hu Chong-Hai Deng Sheng Cheng er-Tao Zhu Hua-Xia Deng School of Energy Materials and Chemical Engineering LIB Technology Center of Anhui ProvinceHefei University Instrumental Analysis Centre Hefei University of Technology Hefei Youngy Energy Materials Co. Ltd. Department of Modern Mechanics University of Science and Technology of China

Lithium-sulfur battery is one of the most promising battery systems for industrialization due to its high theoretical specific capacity and high energy ***,the??shuttle effect??has restrained the advancement of lithium-sulfur *** this work,a gradient-structured nanofiber membrane with pure gelatin on one side and Super P-MoO2/MoS2-gelatin on the other side was created using a multi-step electrostatic spinning technique,which was applied for multi-functional separator for lithium-sulfur *** pure gelatin layer facing the anode side primarily homogenizes the lithium flux,whereas the Super P-MoO2/MoS2-gelatin layer facing the cathode side primarily adsorbs polysulfides by physical and chemical adsorption and enhancing polysulfide conversion *** findings demonstrate that even after 150 cycles at 0.2C,the lithium-sulfur battery can still sustain a discharge-specific capacity of 572.3 mAh·*** used with Li||Li symmetric batteries,it has a cycle life of more than 1200 *** commercialization of lithium-sulfur batteries is given a fresh idea by this straightforward preparation technique.

关键词： Li–S battery Membrane MoO2/MoS2 Nanofiber

Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal Bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer Robert Ringseis klaus Eder karsten krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

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Endometrial carcinoma with cervical stromal invasion:Three case reports

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World Journal of Clinical Cases 2024年第24期12卷 5583-5588页

作者： Ming-Ming Liu Yu-Ting Liang er-Hu Jin Department of Radiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Radiology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijing 100006China

BACkGROUND Endometrial cancer is a kind of well-known tumors of female genitourinary *** stromal invasion is an adverse factor for poor prognosis of endometrial *** is still controversy regarding the use of magnetic resonance imaging(MRI)in the diagnosis of cervical stromal invasion of endometrial *** diagnosis of cervical stromal invasion varies significantly between different observers and *** present a limited case series of the particular pattern of endometrial cancer,which infiltrates the cervical stroma and is often *** SUMMARY We present three cases of endometrial carcinoma with cervical stromal invasion with cancer-free uterine *** patient,a reproductive-aged woman,exhibited irregular menstruation and was diagnosed with endometrial polyps by hysteroscopy and segmental curettage.A MRI scan revealed polypoid nodules within the internal cervical *** other two cases were postmenopausal women who presented with abnormal vaginal *** and segmental curettage suggested atypical hyperplasia of the *** scans did not detect any malignant signs in the *** one case,a nonthickened endometrium was observed,while in another,hyperplasia of the endometrium was ***,none of these patients had malignant tumors identified in the uterine cavity via MRI ***,postoperative pathological results following hysterectomy consistently indicated cervical stromal *** Cervical stromal invasion is easily missed if no cancer is found in the uterine body on *** of endoscopic curettage specimens should be conducted to avoid underestimation of the disease.

关键词： Endometrial carcinoma Cervical stromal invasion Atypical hyperplasia of the endometrium Magnetic resonance imaging Case report