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Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis

World Journal of Gastroenterology 2016年第45期22卷 10064-10070页

作者： Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez Javier Ampuero Francisco Javier Cubero Luis Chi-Cervera Silvia L Ríos-Torres Andrés Duarte-Rojo ángeles espinosa-cuevas Manuel Romero-Gómez Aldo Torre Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán14080 México City México Department of Internal Medicine Ⅲ University Hospital RWTH Aachen52074 Aachen Germany Unit for the Clinical Management of Digestive Diseases Virgen del Rocio-Virgen Macarena University Hospital41009 Sevilla Spain Department of Immunology Complutense University School of Medicine28040 Madrid Spain University of Arkansas for Medical Sciences Little Rock AR 72205 United States Department of Nephrology and Mineral Merabolism Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán México City 14080 México

AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic *** This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic *** Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis.

关键词： Malnutrition Hepatic encephalopathy Phase angle Cachexia Prognosis

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Tumor invasion front in oral squamous cell carcinoma

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World Journal of Clinical Cases 2022年第28期10卷 10387-10390页

作者： Juan Carlos cuevas-González Maria Veronica cuevas-González Leon Francisco espinosa-Cristobal Alejandro Donohue Cornejo Institute of Biomedical Sciences Universidad Autonoma de Ciudad JuarezJuarez 32320ChihuahuaMexico Faculty of Health Sciences Valle de las Palmas Universidad Autonoma de Baja CaliforniaTijuana 21480Baja CaliforniaMexico

Oral squamous cell carcinoma is a neoplasm that originates from the epithelial *** is usually more frequent between the fifth and sixth decades of life,and more than 90% of carcinomas of the oral cavity are squamous cell *** is an invasive neoplasia with a significant recurrence rate;40% of patients present with metastases in the cervical lymph nodes at the time of *** tumor invasion front is a characteristic of tumor growth,which can be infiltrative or *** histopathological parameters examined include the number of mitoses,depth of the tumor,invasion pattern,degree of keratinization,and nuclear *** the pathologist,these parameters are routinely evaluated but are not reported to the treating physician in all cases,which we consider to be useful information when determining the therapeutic route.

关键词： Oral squamous cell carcinoma Invasive neoplasia Therapeutic route Life Tumor growth Pleomorphism

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Soil and Vegetation Seasonal Changes in the Grazing Andean Mountain Grasslands

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Journal of Mountain Science 2014年第5期11卷 1123-1137页

作者： MU?OZ María ángeles FAZ ángel Sustainable Use Management and Reclamation Soil and Water Research Group Agriculture and Science Technology Department Technical University of Cartagena

Andean grasslands ecosystems are fragile environments with rigorous climatologic conditions and low and variable food for the grazing. The Apolobamba area is located in the Bolivian Andean Mountains. Its high grasslands provide a natural habitat for wild and domestic camelids such as vicuna(Vicugna vicugna) and alpaca(Lama pacos). The botanical diversity plays an essential role in maintaining vital ecosystem functions. The objectives of this research were to determine the seasonal changes in soil properties, to study the vegetation changes during the wet and dry seasons and the influence of soil properties and camelid densities on the vegetation in the Apolobamba grasslands. Four zones with different vicuna populations were selected to be studied. The following soil parameters were determined: total organic carbon, total nitrogen, available phosphorous, cation exchange capacity, exchangeable cations, pH and texture. The vegetation season changes were studied through botanical identification, above-ground biomass, plant cover and species richness. Results showed that some soil properties such as C/N ratio, CEC, silt and clay percentages kept stable against the seasonal changes. Generally, soil nutrients were relatively higher during the dry season in the surface and subsurface. The results did not point out the predominant vegetation growth during the wet season. The seasonal vegetation growth depended on each species. Thegood soil fertility corresponded to the highest plant cover. Soil fertility presented no influence on the above-ground biomass of the collected species. The negative influence of camelid grazing on soil properties could not be assessed. However, overgrazing could affect some plant species. Therefore, protection is needed in order to preserve the biodiversity in the Andean mountain grasslands.

关键词： Biodiversity Camelid grazing High grasslands Plant communities Soil properties

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Follow-up and multimodal imaging in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1730-1732页

作者： Glenda espinosa-Barberi Sara Miranda Fernández Michel Ernesto Valdés Martín María ángeles Betancor Perdomo Carmen Julissa Aguilar Rosales Ophthalmology Department Doctor Negrín University Hospital Las Palmas de Gran Canaria School of Doctoral and Postgraduate University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Hospiten Clinic Group Endoluminal/Vascular Department Santa Cruz de Tenerife Neurophysiology Department Doctor Negrín University Hospital Las Palmas de Gran Canaria

Dear Editor, The deficit of 3-hydroxyacyl-CoA dehydrogenase （LCHAD）is a disease whose incidence is approximately 3 cases/100 000 births, with autosomal recessive inheritance.

关键词： Follow-up 3-hydroxyacyl-CoA dehydrogenase deficiency

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In Situ Tests of Multiwalled Carbon Nanotubes with Strength Close to Theoretical Predictions

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Chinese Physics Letters 2009年第1期26卷 194-197页

作者：彭倍 Horacio D. espinosa Center for Micro and Nano Electromechanical Systems University of Electronic Science and Technology of China Chengdu 610054 Micro and Nano Mechanics Laboratory Northwestern University Illinois 60208 USA

Using MEMS technology and transmission electron microscopy we show experimentally multiwalled carbon nanotubes with a mean fracture strength of larger than 100 GPa, which exceeds the earlier observations by a factor of approximately 3. These results are in excellent agreement with quantum-mechanical estimations. This performance is made possible by omitting chemical treatments from the sample preparation process, thus avoiding the formation of defects. High-resolution imaging is used to directly determine the number of fractured shells and the ehirality of the outer shell. Electron irradiation at 200keV for 10, 100 and 1800s lead to improvements of the maximum sustainable loads by factors of 2.4, 7.9 and 11.6 compared with non-irradiated samples of similar diameter. This effect is attributed to crosslinking between the shells. This procedure is a cost effective way of customizing the properties of multiwall nanotubes for many applications of interest ranging from nanocomposites to nanodevices.

关键词： field emission molybdenum dioxide enhancement factor

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Stem cells as an option for the treatment of COVID-19

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World Journal of Clinical Cases 2022年第18期10卷 6338-6340页

作者： Maria Veronica cuevas-González Juan Carlos cuevas-González Institute of Biomedical Sciences Universidad Autonoma de Ciudad JuarezJuarez 32310ChihuahuaMexico Institute of Biomedical Sciences Autonomous University of Ciudad JuárezCiudad Juarez 32310ChihuahuaMexico

The application of stem cells is among the many strategies currently available for the treatment of multiple *** cells are characterized as undifferentiated cells that have the ability to differentiate towards multiple lineages and selfrenewal,among other *** the first umbilical cord stem cell transplant for the treatment of Fanconi anemia,the use of stem cells for the treatment of multiple diseases,including coronavirus disease 2019,has increased,showing promising results that require evaluation through research studies that include a longer follow-up ***,the main objective of this Letter is to provide an update on the use of stem cells in the treatment of severe acute respiratory syndrome coronavirus 2,as well as identify the main challenges and limitations presented by this type of therapy.

关键词： COVID-19 Stem cells Multiple diseases Undifferentiated cells Appropriate treatment Cytokines granulocyte-macrophage colony-stimulating factor

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Study of the Potassium Content in Amaranth Protein Using the Gamma Spectrometry Technique

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材料科学与工程（中英文B版） 2019年第2期9卷 50-55页

作者： Carmenángeles Galloso Laura Vargas-Ulloa Guillermo espinosa-García Manuel Soriano-García Physics Institute National Autonomous University of Mexico(UNAM)Mexico City 04520Mexico Chemistry Institute National Autonomous University of Mexico(UNAM)Mexico City 04510Mexico

Amaranthus is a dicotyledonous pseudocereal and one of the new world’s oldest crops,having originated from Meso-America and was a major food crop of the *** in the cultivation and consumption of Amaranthus seed in the modern era began in the mid-1970s with the rediscovery and promotion of amaranth due to its superior nutritional attributes as compared to cereal *** plant has a high-quality protein,carbohydrates,unsaturated oil,squalene,dietary fiber,tocopherols,phenolic compounds,flavonoids,vitamins and *** amaranth’s grain was collected at San Martin Pahuacan,Estado de Mexico,*** used methodology is gamma spectrometry with Hyperpure Germanium detector(HPGe)and Multichannel Analyzer(MCA)with Maestro *** result shows a unique concentration of radioactive potassium content in the amaranth protein isolated from amaranth grains is 424.1 mg/100 g of amaranth *** is an excellent agreement between the amount of potassium determined by atomic absorption spectroscopy in our laboratory and the value obtained in this work using the Gamma Spectrometry Technique.

关键词： Potassium amaranth(Amaranthus hypochondriacus) gamma spectrometry K-40 HPGe

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On the fractional doubly parabolic Keller-Segel system modelling chemotaxis

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Science China Mathematics 2022年第9期65卷 1827-1874页

作者： Mario Bezerra Claudio cuevas Clessius Silva Herme Soto Department of Mathematics Federal University of PernambucoRecife 50540-740Brazil Department of Mathematics Rural Federal University of PernambucoRecife 52171-900Brazil Department of Mathematics and Statistics University of La FronteraTemucoCasilla 54-DChile

This work is concerned with the time-fractional doubly parabolic Keller-Segel system in R^(N)(N≥1),and we derive some refined results on the large time behavior of solutions which are presupposed to enjoy some uniform boundedness ***,the well-posedness and the asymptotic stability of solutions in Marcinkiewicz spaces are *** results are achieved by means of an appropriate estimation of the system nonlinearity in the course of an analysis based on Duhamel-type representation formulae and the Kato-Fujita framework which consists in constructing a fixed-point argument by using a suitable time-dependent space.

关键词： chemotaxis aggregation Keller-Segel model decay properties asymptotic profiles global solutions

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Soluble interleukin 23 receptor gene therapy with adeno-associated vectors for the treatment of multiple sclerosis

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Neural Regeneration Research 2017年第10期12卷 1605-1606页

作者： ángel Edo Juan Francisco espinosa-Parrilla Gene Therapy for Central Nervous System Group Vall d'Hebron Institut de Recerca Hospital Universitari Vall d'HebronBarcelonaSpain

Gene therapy as strategy against autoimmune diseases： In the last century, human societies have witnessed remarkable improvements in wellness and life expectancy, thanks to the consolidation of mod- ern science and medicine. But, while some infectious and other dis- eases, have been almost fully controlled, pathologies associated with intrinsic factors and longevity have increased in incidence.

关键词：基因治疗多发性硬化白细胞介素腺相关病毒自身免疫性疾病可溶性受体人类社会

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Hyalinizing clear cell carcinoma-a rare entity in the oral cavity: A case report

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World Journal of Clinical Cases 2020年第1期8卷 133-139页

作者： Alejandro Donohue-Cornejo Oslei Paes de Almeida Celeste Sánchez-Romero León Francisco espinosa-Cristóbal Simón Yobanny Reyes-López Juan Carlos cuevas-González Stomatology Department Biomedical Sciences InstituteAutonomous University of Ciudad JuárezChihuahua 32310México Diagnosis Department Oral Pathology SectionDentistry Faculty of PiracicabaState University of CampinasSão Paulo 13414-903Brazil

BACKGROUND Hyalinizing clear cell carcinoma(HCCC)is an uncommon tumor that originates in the salivary *** neoplasia constitutes less than 1%of minor salivary gland *** SUMMARY A 67-year-old female visited the maxillofacial surgery department owing to a smooth,slightly yellowish protruding mass on the left side of the floor of the mouth,at the level of the molars;the tumor mass had a soft consistency on palpation and did not adhere to deep *** microscopical analysis of the excisional biopsy showed that the lesion was composed of sheets and cords of clear cells separated by thick eosinophilic bands of hyaline *** glandular tissue was absent,periodic acid-Schiff with and without diastase stains,and immunohistochemical reactions were performed to confirm the *** is the second case reported in the literature of HCCC arising in the floor of the *** HCCC is a rare salivary gland tumor that has not been studied *** diagnosis is usually challenging,because clinically,it can be confused with a benign neoplasm.

关键词： Hyalinizing clear cell carcinoma Salivary gland tumor Immunohistochemical reactions Case report

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