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Chip 2024年第3期3卷 36-42页

作者： bo Li Jinpei lin linfei Gao Zhengweng Ma Huakai Yang Zhihao Wu Hsien-Chin Chiu Hao-Chung Kuo Chunfu Zhang Zhihong Liu Shuangwu Huang Wei He Xinke Liu College of Materials Science and Engineering College of Electronics and Information EngineeringInstitute of Microelectronics(IME)Guangdong Research Center for Interfacial Engineering of Functional MaterialsState Key Laboratory of Radio Frequency Heterogeneous IntegrationShenzhen UniversityShenzhen 518060China Department of Electronic Engineering Chang Gung UniversityTaoyuan 333TaiwanChina Department of Photonics and the Institute of Electro-Optical Engineering and with Foxconn Semiconductor Research InstituteNational Chiao Tung UniversityHsinchu 300TaiwanChina Xidian University School of MicroelectronicsXi’an710071China

In this study,a galliumnitride(GaN)substrate and its 15μmepitaxial layer were entirely grown by adopting the hydride vapor phase epitaxy(HVPE)*** enhance the breakdown voltage(VBR)of vertical GaN-on-GaN Schottky barrier diodes(SBDs),a dual ion coimplantation of carbon and heliumwas employed to create the edge *** resulting devices exhibited a low turn-on voltage of 0.55 V,a high Ion/Ioff ratio of approximately 109,and a lowspecific onresistance of 1.93.mU cm^(2).When the ion implantation edge was terminated,the maximumVBR of the devices reached 1575 V,with an average improvement of 126%.These devices demonstrated a high figure of merit(FOM)of 1.28 GW cm^(-2) and showed excellent reliability during pulse stress testing.

关键词： Vertical GaN SBD HVPE Dual ion co-implantation Leakage mechanism Device reliability

Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1361-1373页

作者： Wen-Feng Luo Yu-Ting Jiao Xiao-ling lin Ying Zhao Sheng-bo Wang Jian Shen Jie Deng Yu-Feng Ye Ze-Ping Han Fang-Mei Xie Jin-Hua He Yu Wan Central Laboratory of Panyu Central Hospital Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Digestive Disease Center Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Shunde Vocational and Technical College Foshan 528300Guangdong ProvinceChina Medical Imaging Institute of Panyu Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies ***-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool and serum ***(CRC)is among the most prevalent and life-threatening malignancies ***2 testing has emerged as a widely used biomarker for early detection of CRC in stool and serum *** To validate the effectiveness of fecal DNA mSDC2 testing in the detection of CRC among a high-risk Chinese population to provide evidence-based data for the development of diagnostic and/or screening guidelines for CRC in *** A high-risk Chinese cohort consisting of 113. individuals aged 40-79 years was selected for evaluation via fecal mSDC2 *** and specificity for CRC,advanced adenoma(AA)and advanced colorectal neoplasia(ACN)were ***-risk factors for the incidence of colorectal lesions were determined and a logistic regression model was constructed to reflect the efficacy of the *** A total of 103. high-risk individuals were included in this study according to established *** them,16 suffered from CRC(1.55%),65 from AA(6.28%)and 189 from non-AAs(18.26%);150 patients were diagnosed with polyps(14.49%).Diagnoses were established based upon colonoscopic and pathological *** of the mSDC2 test for CRC and AA were 87.50%and 40.00%,respectively;specificities were 95.61%for other *** predictive values of the mSDC2 test for CRC,AA and ACN were 16.09%,29.89%and 45.98%,respectively;the negative predictive value for CRC was 99.79%.After adjusting for other high-risk covariates,mSDC2 test positivity was found to be a significant risk factor for the occurrence of ACN(P<0.001).CONCLUSION Our findings confirmed that offering fecal mSDC2 testing and colonoscopy in combination for CRC screening is effective for earlier detection of malignant colorectal lesions in a high

关键词： Colorectal cancer Syndecan-2 DNA methylation Chinese population

Risk factors for esophagogastric variceal-related poor outcomes in primary biliary cholangitis:A prospective cohort study

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iLIVER 2024年第1期3卷 30-37页

作者： lin Han Huan Xie Xue-Mei Ma Xiao-Long Lu Jun Zhao Qing-Sheng Liang Zheng-Sheng Zou Jing-Feng Bi bo Jin Ying Sun Senior Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China Senior Department of Infectious Diseases Medicine The Fifth Medical Center of PLA General HospitalBeijing 100039China Graduate School Medical School of Chinese PLABeijing 100039China

Background and aims:Esophagogastric varices(EGV)are common complications of primary biliary cholangitis(PBC).We examined the risk factors for variceal bleeding-related liver transplantation(LT)or ***:This prospective observational cohort study involved PBC in our hospital from 1 January 2005 to 1 January *** clinical endpoints were variceal bleeding-related LT and *** analysis was performed using the Kaplan-Meier estimate,cox regression analysis was performed to investigate risk ***:PBC with EGV had significantly shorter survival than those without(p?0.002).Endoscopic prophylaxis significantly improved poor outcomes in PBC with EGV(plinesterase(CHE)of1.2ULN at baseline,total bilirubin of>1.2ULN,aspartate aminotransferase(AST)of>2.3.ULN after 1 year of ursodeoxycholic acid(UDCA)treatment,non-biochemical responders according to the Paris criteria,and no history of endoscopic *** PBC without EGV,risk factors included AST of>2.3.ULN,INR of>1.2ULN at baseline,CHE of***:This study provides evidence that AST,INR and CHE are major risk factors for variceal bleedingrelated poor outcomes in *** PBC with EGV,a good biochemical response to UDCA and endoscopic prophylaxis may improve *** findings can aid for guiding initial PBC risk stratification and screening endoscopy in patients without EGV.

关键词： Primary biliary cholangitis Esophagogastric varices Ursodeoxycholic acid Liver transplant-free survival Endoscopic therapy Risk factors

Revealing proton-coupled exchange mechanism in aqueous ion-exchange synthesis of nickel-rich layered cathodes for lithium-ion batteries

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eScience 2024年第4期4卷 103-109页

作者： Yu-Hong Luo Qing-lin Pan Han-Xin Wei Ying-De Huang Pei-Yao Li lin-bo Tang Zhen-Yu Wang Cheng Yan Jing Mao Ke-Hua Dai Qing Wu Xia-Hui Zhang Jun-Chao Zheng School of Materials Science and Engineering Central South UniversityChangsha 410083China School of Metallurgy and Environment Central South UniversityChangsha 410083China Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083China School of Mechanical Medical and Process EngineeringQueensland University of TechnologyBrisbane 4001Australia School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China College of Chemistry Tianjin Normal UniversityTianjin 300387China School of Information and Network Center Central South University Changsha 410083China

Ion exchange is a promising synthetic method for alleviating severe cation mixing in traditional layered oxide materials for lithium-ion batteries,leading to enhanced structural ***,the underlying mechanisms of ion exchange are still not fully *** a fundamental study of the ion-exchange mechanism is needed for achieving the controllable synthesis of layered oxides with a stable ***,we thoroughly unearth the underlying mechanism that triggers the ion exchange of Ni-rich materials in aqueous solutions by examining time-resolved structural evolution combined with theoretical *** results reveal that the reaction pathway of ion exchange can be divided into two steps:protonation and *** proton is the key to achieving charge balance in the ion exchange process,as revealed by X-ray adsorption spectroscopy and inductive coupled plasma *** addition,the intermediate product shows high lattice distortion during ion exchange,but it ends up with a most stable product with high lattice *** apparent discrepancies in lattice energy between materials before and after ion exchange emphasize the importance of synthetic design in structural *** work provides new insights into the ion-exchange synthesis of Ni-rich oxide materials,which advances the development of cathode materials for high-performance lithium-ion batteries.

关键词： Ion exchange Reaction mechanisms Proton-coupledNi-rich oxides Protonation Lithiation Lithium-ion batteries

Silicone oil as a corneal lubricant to reduce corneal edema and improve visualization during

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 92-96页

作者： Dan-Yang Che Zhu-lin Chan Ji-bo Zhou Dong-Qing Zhu Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Health Science and Technology Shanghai Jiao Tong University School of MedicineShanghai 200011China The PLA Navy Anqing Hospital Anqing 246004Anhui ProvinceChina

AIM:To evaluate the efficacy and safety of silicone oil(SO)as a corneal lubricant to improve visualization during ***:Patients who underwent vitreoretinal surgery were divided into two *** 1 was operated on with initial SO(Oxane 5700)as a corneal *** 2 was operated on with initial lactated ringer’s solution(LRS)and then replaced with SO as *** clarity was scored during the *** staining was performed to determine the damage to corneal ***:Totally 114 eyes of 114 patients were *** SO use maintained a clear cornea and provided excellent visualization of surgical *** group 1,the fundus clarity was grade 3.in 41/45 eyes and grade 2 in 4/45 *** group 2,corneal edema frequently occurred after initial LRS *** fundus clarity was grade 3.in 19/69 eyes,2 in 3./69 eyes and 1 in 13.69 eyes(P0.05).CONCLUSION:The use of SO as a corneal lubricant is effective and safe for preserving and improving corneal clarity and providing clear surgical field during vitrectomy.

关键词： silicone oil corneal lubricant corneal edema vitrectomy

Quantitative Applications of Weather Satellite Data for Nowcasting:Progress and Challenges

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Journal of Meteorological Research 2024年第3期38卷 399-413页

作者： Jun LI Jing ZHENG bo LI Min MIN Yanan LIU Chian-Yi LIU Zhenglong LI WPaul MENZEL Timothy J.SCHMIT John L.CINTINEO Scott linDSTROM Scott BACHMEIER Yunheng XUE Yayu MA Di DI Han lin Innovation Centre for Fengyun Meteorological Satellite(FYSIC) National Satellite Meteorological CentreChina Meteorological AdministrationBeijing100081China School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen University and Southern Laboratory of Ocean Science and EngineeringZhuhai519082China Key Laboratory of Geographic Information Science(Ministry of Education) East China Normal UniversityShanghai200241China Research Center for Environmental Changes Academia SinicaTaipei11529China Cooperative Institute for Meteorological Satellite Studies University of Wisconsin-MadisonMadisonWI53706USA Sensors and Calibration Branch STAR/NESDISMadisonWI53706USA Wuxi University Wuxi214105China School of Computer Science Chengdu University of Information TechnologyChengdu610225China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing210044China Key Laboratory of Spatial Data Mining and Information Sharing of Ministry of Education National and Local Joint Engineering Research Center of Satellite Geospatial Information TechnologyFuzhou UniversityFuzhou350108China

Monitoring and predicting highly localized weather events over a very short-term period,typically ranging from minutes to a few hours,are very important for decision makers and public *** these events usually relies on radar observations through monitoring and *** advanced high-resolution imaging and sounding observations from weather satellites,nowcasting can be enhanced by combining radar,satellite,and other data,while quantitative applications of those data for nowcasting are advanced through using machine learning *** applications include monitoring the location,impact area,intensity,water vapor,atmospheric instability,precipitation,physical properties,and optical properties of the severe storm at different stages(pre-convection,initiation,development,and decaying),identification of storm types(wind,snow,hail,etc.),and predicting the occurrence and evolution of the *** observations can provide information on the environmental characteristics in the preconvection stage and are very useful for situational awareness and storm *** paper provides an overview of recent progress on quantitative applications of satellite data in nowcasting and its challenges,and future perspectives are also addressed and discussed.

关键词： weather satellite quantitative applications nowcasting pre-convection

Micro/nano flow chemistry by Beyond Limits Manufacturing

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Chinese Chemical Letters 2024年第5期35卷 3-12页

作者： Peiwen Liu Fang Zhao Jing Zhang Yunpeng Bai Jinxing Ye bo Bao Xinggui Zhou Li Zhang Changlu Zhou Xinhai Yu Peng Zuo Jianye Xia Lian Cen Yangyang Yang Guoyue Shi lin Xu Weiping Zhu Yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering Shanghai Collaborative Innovation Center for BiomanufacturingEast China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China

In September 2018,we proposed the cutting-edge concept of“Beyond Limits Manufacturing”(BLM).BLM technology is based on the three-dimensional inner engraving or precise outer engraving of ultra-fast laser,to invent micro/nano scale flow chips or devices,which makes it possible for the microform,integration,economy,safety,high efficiency,green and intelligence of research,development and manufacturing process,so as to realize transformational manufacturing in the era of Industry *** this paper,we reviewed the representative results we made in the field of micro/nano flow chemistry during the implementation of the BLM major project(December 2019 to August 2023.,and discussed its application prospects in micro/nano flow chemistry.

关键词： Beyond Limits Manufacturing Flow chemistry Pharmaceutical manufacturing Microreactor

10-Million Atoms Simulation of First-Principle Package LS3.F

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Journal of Computer Science & Technology 2024年第1期39卷 45-62页

作者：严昱瑾李海波赵曈汪林望石林刘涛谭光明贾伟乐孙凝晖 State Key Laboratory of Processors Institute of Computing TechnologyChinese Academy of SciencesBeijing 100190 China University of Chinese Academy of Sciences Beijing 101408China Computing System Optimization Laboratory Huawei TechnologiesBeijing 100094China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China School of Materials Science and Engineering Yancheng Institute of TechnologyYancheng 224051China

The growing demand for semiconductor devices simulation poses a big challenge for large-scale electronic structure *** various methods,the linearly scaling three-dimensional fragment(LS3.F)method exhibits excellent scalability in large-scale *** on algorithmic and system-level optimizations,we propose a highly scalable and highly efficient implementation of LS3.F on a domestic heterogeneous supercomputer equipped with *** terms of algorithmic optimizations,the original all-band conjugate gradient algorithm is refined to achieve faster convergence,and mixed precision computing is adopted to increase overall *** terms of system-level optimiza-tions,the original two-layer parallel structure is replaced by a coarse-grained parallel *** strategies such as multi-stream,kernel fusion,and redundant computation removal are proposed to increase further utilization of the com-putational power provided by the heterogeneous *** a result,our optimized LS3.F can scale to a 10-million sili-con atoms system,attaining a peak performance of 3..8 PFLOPS(21.2% of the peak).All the improvements can be adapt-ed to the next-generation supercomputers for larger simulations.

关键词： single instruction multiple thread accelerator electronic structure high-performance computing linearly scaling three-dimensional fragment(LS3.F)

综合定年标准样品研制——以青藏高原伦坡拉盆地丁青湖组凝灰岩为例

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岩石学报 2024年第8期40卷 2306-2320页

作者：安洁吴林任荣刘博张志勇王楠王非郑波中国科学院地质与地球物理研究所岩石圈演化与环境演变全国重点实验室北京100029 中国科学院地球科学研究院北京100029 中国科学院大学地球与行星科学学院北京100049 中国石油勘探开发研究院北京100083 东北大学深部金属矿山安全开采教育部重点实验室东北大学资源与土木工程学院沈阳110819 中国科学院地球化学研究所矿床地球化学国家重点实验室贵阳550081 西南石油大学地球科学与技术学院成都610500

现今已有的(U-Th)/He、裂变径迹标准样品数量较少,仅有墨西哥的Durango磷灰石、美国的FCT锆石和缅甸的MK-1磷灰石,且多数是针对单定年方法的标样。为了研究青藏高原伦坡拉(LPL)盆地丁青湖组的凝灰岩能否成为多定年方法的标样,我们在凝... 详细信息

现今已有的(U-Th)/He、裂变径迹标准样品数量较少,仅有墨西哥的Durango磷灰石、美国的FCT锆石和缅甸的MK-1磷灰石,且多数是针对单定年方法的标样。为了研究青藏高原伦坡拉(LPL)盆地丁青湖组的凝灰岩能否成为多定年方法的标样,我们在凝灰岩中挑选合适的磷灰石和锆石颗粒进行多重年代学定年分析,获得了多个定年结果,并对其进行相互验证。其中,LPL磷灰石(U-Th)/He年龄为24.4±0.3.a(1s),加权平均方差(MSWD)为4.25;LPL的锆石(U-Th)/He年龄为19.2±0.5Ma(1s),其MSWD为2.5;LPL磷灰石裂变径迹年龄为22.8±0.8Ma, LPL磷灰石U-Pb年龄为16.3.13.9Ma, MSWD为0.29。将LPL磷灰石与Durango磷灰石、MK-1磷灰石对比后认为LPL磷灰石有两种来源,所以不适合作为(U-Th)/He年龄标样。将LPL锆石与FCT锆石、蓬莱锆石做比较后,可以看出LPL锆石年龄结果较好,精确度和准确度较高且年龄分散性较弱,是一个潜在的(U-Th)/He年龄标样。

关键词：标样磷灰石锆石 (U-Th)/He定年裂变径迹定年

肺金汤方结合穴位埋线治疗慢性咳嗽临床效果观察

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辽宁中医杂志 2024年第5期51卷 176-179页

作者：林景王妙林波琼海市中医院海南琼海571400

目的观察肺金汤方结合穴位埋线治疗慢性咳嗽临床效果。方法将该院内科收治的82例慢性咳嗽患者(2019年4月—2022年4月收治)纳入本次研究,根据患者治疗方法不同分为对照组(42例)与观察组(40例),对照组患者口服复方甲氧那明胶囊进行治疗,... 详细信息

目的观察肺金汤方结合穴位埋线治疗慢性咳嗽临床效果。方法将该院内科收治的82例慢性咳嗽患者(2019年4月—2022年4月收治)纳入本次研究,根据患者治疗方法不同分为对照组(42例)与观察组(40例),对照组患者口服复方甲氧那明胶囊进行治疗,观察组患者口服复方甲氧那明胶囊+肺金汤方结合穴位埋线治疗,数据比较:临床疗效、不良反应、患者中医症状总积分变化、咳嗽缓解时间与消失时间、肺功能指标变化。结果对照组与观察组患者治疗总有效率比较[78.57%(3./42)vs95.00%(3./40)],P0.05,治疗后各组患者中医症状总积分、PEF、FEV1、FEV1/FVC等指标均改善,观察组患者治疗后中医症状总积分、PEF、FEV1、FEV1/FVC等指标均优于对照组患者,P<0.05。结论肺金汤方结合穴位埋线治疗慢性咳嗽效果良好,且安全可靠。

关键词：慢性咳嗽肺金汤方穴位埋线疗效肺功能不良反应