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Science china Mathematics 2007年第8期50卷 1205-1216页

作者： Zai-hong WANG School of Mathematical Sciences,capital Nor.al university,beijing 10003.,{3. 1. School of Mathematical Sciences Capital Normal University Beijing 100037 China

In this p.p.r. we deal with the existence of unbounded or.its of the map.ing $$\left\{ \begin{gather.d} \theta _1 = \theta + 2n\p. + \fr.cp.{\r.o }\mu (\theta ) + o(\r.o ^{ - 1} ), \hfill \\ \r.o _1 = \r.o + c - \mu '(\theta ) + o(1), \r.o \to \infty \hfill \\ \end{gather.d} \r.ght.$$ , wher. n is a p.sitive integer. c is a constant and μ(θ) is a 2π-p.r.odic function. We p.ove that if c > 0 and μ(θ) ≠ 0, θ, ∈ [0, 2?], then ever. or.it of the given map.ing goes to infinity in the futur. for.ρ lar.e enough; if c r. or.it of the given map.ing goes to infinity in the p.st for.ρ lar.e enough. By using this r.sult, we p.ove that the equation x″+f(x)x′+ax +?bx ?+?(x)=p.t) has unbounded solutions p.ovided that a, b satisfy $1/\sqr. a + 1/\sqr. b = 2/n$ and ?(x) satisfies some limit conditions. At the same time, we obtain the existence of 2π-p.r.odic solutions of this equation.

关键词： Liénar. equations unbounded solutions p.r.odic solutions 3.C11 3.C25

Gr.wth induction of hep.tic stimulator.substance in hep.tocytes thr.ugh its r.gulation on EGF r.cep.or.

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Cell r.sear.h 1999年第1期9卷 37-49页

作者： AN WEI XIAO JUN LIU TIAN GUANG LEI JIE DAI GUO GUANG DU(Dep.r.ment of Cell Biology, capital university of medical Sciences, {3. 100054, china) 1Dep.r.ment of Cell Biology Capital University of Medical Sciences Beijing 100054 China 1Dep.r.ment of Cell Biology Capital University of Medical Sciences Beijing 100054 China 1Dep.r.ment of Cell Biology Capital University of Medical Sciences Beijing 100054 China 1Dep.r.ment of Cell Biology Capital University of Medical Sciences Beijing 100054 China 1Dep.r.ment of Cell Biology Capital University of Medical Sciences Beijing 100054 China

The cytosolic liver.sp.cific gr.wth factor.hep.tic stimulator.substance (HSS) has been shown to be able to amp.ify the r.t hep.tocyte p.olifer.tion r.sp.nded to EGF. In or.er.to get mor. insight into the mechanism, the r.gulator. effect of HSS on EGF-r.cep.or.EGF-r. and the r.cep.or.p.osp.or.lation at molecular.level was studied. HSS p.r.ially p.r.fied fr.m weanling r.t liver.was given to cultur.d hep.tocytes and its influence on EGF-r.sp.cific binding and inter.alization as well as mr.A exp.ession wer. investigated. The r.sults showed that p.eincubation of hep.tocytes with HSS could lead to an incr.ase in [125I]-EGF binding to its r.cep.or. and inhibit EGFinduced r.cep.or.down-r.gulation. Fur.her.or., the over.xp.ession of EGF-r.mr.A stimulated by HSS was seen dur.ng 2-12 h after.the incubation. Additionally, it was demonstr.ted with human hep.toma sMMC-7721 cells in Wester. blot that the EGF-r.exp.ession and the r.cep.or.autop.osp.or.lation wer. incr.ased with dose/timedep.ndency after.HSS tr.atment. These r.sults str.ngly suggest that the mechanism of HSS action on hep.tocyte gr.wth might be r.lated to its modulation on EGF-r.and r.cep.or.mediated signaling tr.nsduction.

关键词： EGF r.cep.or hep.tic stimulator.substance hep.tocyte p.olifer.tion

Technical develop.ent of p.oteomics

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Chinese Science Bulletin 1999年第16期44卷 1441-1447页

作者： WAN Jinghong and HE Fuchu1.Chongqing medical university, Chongqing 400046, china 2. {3. Institute of r.diation medicine, {3. 100850, china Cor.esp.nding author Chongqing medical university Chongqing China beijing Institute of r.diation medicine Beijing China

p.oteome r.sear.h is an imp.r.ant comp.ementar.ty for.the genome r.sear.h, which uses quantitative p.otein-level measur.ments to char.cter.ze biological p.ocess. p.oteome techniques include two asp.cts. One is two-dimensional electr.p.or.sis, which is the unique technology to sep.r.te the comp.nents of p.oteome. The other.is identification of the

关键词： p.oteome two-dimensional electr.p.or.sis image analysis p.p.ide-mass finger.0}inting database.

p.r.Or.ANCE EVALUATION OF SEVEr.L FUSION Ap.r.ACHES FOr.CCD/SAr.IMAGES

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Chinese Geogr.p.ical Science 2003年第1期13卷 91-96页

作者： WANG Yan-li, CHEN Zhe(School of Automation Science and Electr.cal Engineer.ng, beijing university of Aer.nautics and Astr.nautics, beijing 100083.{3.) School of Automation Science and Electr.cal Engineer.ng， beijing university of Aer.nautics and Astr.nautics， beijing 100083.{3.

Sever.l image fusion ap.r.aches for.CCD/SAr.images ar. studied and the p.r.or.ance evaluation of these fusion ap.r.aches is comp.eted in this p.p.r. Fir.tly, the p.ep.ocessing of CCD/SAr.images befor. fusion is fulfilled. Then, the image fusion methods including linear.sup.r.0}sition, nonlinear.op.r.tor.method and multir.solution methods, of which the multir.solution methods include Lap.acian p.r.mid, r.tio p.r.mid, contr.st p.r.mid, gr.dient p.r.mid, mor.0}ological p.r.mid and discr.te wavelet tr.nsfor., ar. adop.ed to fuse two typ.s of images. Lastly, the four.p.r.or.ance measur.s, standar. deviation, entr.p., cr.ss entr.p. and sp.tial fr.quency, ar. calculated to comp.r. the fusion r.sults by differ.nt fusion ap.r.aches in this p.p.r. Exp.r.mental r.sults show that contr.st p.r.mid, mor.0}ology p.r.mid and discr.te wavelet tr.nsfor.ation in multir.solution ap.r.aches ar. mor. suitable for.CCD/SAr.image fusion than other.ones p.op.sed in this p.p.r.and the objective p.r.or.ance evaluation of CCD/SAr.image fusion ap.r.aches ar. effective.

关键词： image fusion p.r.or.ance evaluation CCD image SAr.image

Inter.er.n-alfa in the tr.atment of chr.nic hep.titis B

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Hep.tobiliar. & p.ncr.atic Diseases Inter.ational 2004年第3期3卷 337-340页

作者： Fu-Kui Zhang Liver.r.sear.h Center. beijing Fr.endship.Hosp.tal,capital university of {3. Sciences, beijing 100050 , china Liver.r.sear.h Center Beijing Friendship Hospital Capital University of Medical Sciences Beijing 100050 China. frankliver@***

BACKGr.UND: Inter.er.n-alfa has been used in the tr.at-ment of chr.nic hep.titis B for.mor. than 20 year. and hasits own advantages including a definite cour.e of ther.p.,no p.oduction of dr.g-r.sistant var.ants, and sustained effi-cacy. This r.view was to under.tand the r.le of inter.er.n-alfa ther.p. in chr.nic hep.titis *** r.SOUr.ES: An English-language liter.tur. sear.husing Medscap. and MEDLINE was p.r.or.ed and a totalof 48 ar.icles on the tr.atment of chr.nic hep.titis with in-ter.er.n-alfa or.p.gylated inter.er.n-alfa wer. ***: Inter.er.n-alfa ther.p. was associated with ahigher.HBV DNA inhibition r.te and HBeAg loss r.te com-p.r.d with contr.ls, and it may have long-ter. beneficialeffects in ter.s of HBV clear.nce, r.duction of hep.tocel-lular.car.inoma, and p.olongation of sur.ival. p.gylatedinter.er.n-alfa was mor. effective than conventional inter.fer.n-alfa in the tr.atment of chr.nic hep.titis B as well aschr.nic hep.titis C, and was also associated with gr.ater.ef-ficacy than conventional inter.er.n in difficult-to-tr.at ***: Inter.er.n-alfa is still r.gar.ed as one ofthe fir.t-line dr.gs for.the tr.atment of chr.nic hep.titis *** inter.er.n is a mor. p.omising ther.p. than con-ventional inter.er.n-alfa, esp.cially in p.tients with r.fr.c-tor. chr.nic hep.titis B.

关键词： chr.nic hep.titis B inter.er.n p.gylated inter.er.n lamivudine

The p.incip.l Eigenvalue for.Jump.p.ocesses

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Acta Mathematica Sinica,English Ser.es 2000年第3期16卷 361-368页

作者： Mufa Chen Dep.r.ment of Mathematics,beijing Nor.al university,beijing 100875,p.r.{3. Dep.r.ment of Mathematics Beijing Normal University Beijing 100875 P. R. China

A var.ational for.ula for.the lower.bound of the p.incip.l eigenvalue of gener.l Mar.ov jump.p.ocesses is *** r.sult is comp.ete in the sense that the condition is fulfilled and the r.sulting bound is shar.0}for.Mar.ov... 详细信息

关键词： p.incip.l eigenvalue Jump.p.ocesses Var.ational for.ula for.Dir.chlet for.

A novel ar.er.al p.uch model of saccular.aneur.sm by concomitant elastase and collagenase digestion

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Jour.al of Zhejiang university-Science B(Biomedicine & Biotechnology) 2007年第10期8卷 697-703页

作者： YANG Xin-jian, LI Li, WU Zhong-xue (Dep.r.ment of Inter.entional Neur.r.diology, beijing Neur.sur.ical Institute, capital medical university, beijing 100050, {3.) Dep.r.ment of Inter.entional Neur.r.diology Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China

Backgr.und: An ideal aneur.sm model of cer.br.l aneur.sm is of gr.at imp.r.ance for.studying the p.thogenesis of the lesion and testing new techniques for.diagnosis and tr.atment. Sever.l models have been cr.ated in r.bbits and ar. now widely used in exp.r.mental studies; however. ever. model has cer.ain intr.nsic limitations. Her. we r.p.r. the develop.ent of a novel saccular.aneur.sm model in r.bbits using an ar.er.al p.uch that is subject to in vitr. p.e-digestion with combined elastase and collagenase. Methods: A segment of r.ght common car.tid ar.er. (CCA) was dissected out and tr.ated with elastase (60 U/ml, 20 min) followed by typ. I collagenase (1 mg/ml, 15 min) in vitr.. The gr.ft was anastomosed to an ar.er.al ar.h built with the left CCA and the r.maining r.ght CCA, while the other.end of the gr.ft was ligated. The dimension and tissue str.ctur. of the p.uch wer. analysed immediately, 2 or.8 weeks after.op.r.tion. Findings: Ten ter.inal aneur.sms wer. p.oduced. The gr.ss mor.p.ology of the aneur.sm r.sembles the human cer.br.l ter.inal aneur.sms. We have obser.ed the following p.thological changes: (1) gr.wth of the aneur.sm (mean diameter.incr.ased fr.m (2.0±0.1) to (3.2±0.3. mm at 2 weeks, p.lt;0.001, n=7~10); (2) thinning of the aneur.smal wall (the mean wall thickness decr.ased to 44% at 2 weeks), which was accomp.nied by significant losses of elastic fibr.s, collagen and the cellular.comp.nent; and (3. sp.ntaneous r.p.ur. (3.out of 9, one aneur.sm r.p.ur.d 24 h after.op.r.tion with the other.two at 2 and 4 weeks r.sp.ctively). Conclusion: This r.bbit ar.er.al p.uch model mimics human cer.br.l aneur.sms in r.lation to mor.0}ology and histology. In p.r.icular. this model exhibited an incr.ased tendency of sp.ntaneous r.p.ur..

关键词： Animal model Collagenase Elastase Intr.cr.nial aneur.sm

On States of Total Weighted Occup.tion Times for.Sup.r.iffusions

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Acta Mathematica Sinica,English Ser.es 2002年第1期18卷 69-78页

作者： r.N Yan Xia Center.for.Advanced Study. Tsinghua university. beijing 100084. p. r. china Center.for.Advanced Study Tsinghua University Beijing P. R. China

Sup.ose X is a sup.r.iffusion in r.d with gener.l br.nching mechanism ￠. and Y_(D) denotes the total weighted occup.tion time of X in a bounded smooth domain D. We discuss the conditions on ψ to guar.ntee that Y_(D) has absolutey continuous states. And for.p.r.icular.ψ(z) = z^(l+, 0p.ove that. in the case dr.sp.ct to the Lebesgue measur. in D. wher.as in the case d>2 + 2/B. it is singular. As we know the absolute continuity and singular.ty of Y_(D have not been discussed befor..

关键词： Total weighted occup.tion time Sup.r.iffusion Absolutely continuous state Singular.states

Sur.ical tr.atment of p.r.al hyp.r.ension

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Hep.tobiliar. & p.ncr.atic Diseases Inter.ational 2002年第2期1卷 211-214页

作者： Yu Wang Fr.m the Dep.r.ment of Gener.l Sur.er., beijing Fr.endship.Hosp.tal, capital university of {3. Sciences, beijing 100050, china Dep.r.ment of Gener.l Sur.er. Beijing Friendship Hospital Capital University of Medical Sciences Beijing 100050 China. wy9952@***

p.r.al hyp.r.ension is a common disease with high mor.ality and ser.ous influence on the life quality of p.tients. At p.esent, shunt and disconnection ar. commonly used for.the tr.atment of p.r.al hyp.r.en- sion. In r.cent year., combined p.ocedur.s of shunt and disconnection have evoked the p.tential inter.st of sur.eons. Initial exp.r.mental studies and clinical obser.ations showed that the combined p.ocedur.s ar. ideal for.tr.ating p.r.al hyp.r.ension. Tr.nsju- gular.intr.hep.tic p.r.acaval shunt (TIp.) is a new minimally invasive technique in tr.ating p.r.al hy- p.r.ension. Some sur.eons have tr.ed to p.r.or. dis- connection under.lap.r.scop. with success. Liver.tr.nsp.antation will be the focus of p.r.al hyp.r.en- sion sur.er. in the futur..

关键词： p.r.al hyp.r.ension shunt disconnection tr.nsjugular.intr.hep.tic p.r.acaval shunt liver.tr.nsp.antation

r.tr.vir.s-mediated her.0}s simp.ex vir.s thymidine kinase gene ther.p. ap.r.ach for.hep.tocellular.car.inoma

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Cell r.sear.h 1999年第3期9卷 225-235页

作者： GAO DING CHENG WEI AN JIE DAI(Dcp.r.ment of Cell Biology, capital university of medicalSciences 100054 {3., china) 1Dep.r.ment of Cell Biology Capital University of Medical Sciences Beijing 100054 China 1Dep.r.ment of Cell Biology Capital University of Medical Sciences Beijing 100054 China 1Dep.r.ment of Cell Biology Capital University of Medical Sciences Beijing 100054 China

The ther.p.utic effect of her.0}s simp.ex vir.s thymi-dine kinase/ganciclovir.(HSV-tk/GCV) system on hep.-tocellular.car.inoma was studied in this exp.r.meflt. Thetk-containing r.tr.vir.l r.combinants wer. used to infecthep.toma cells (BEL-7402) and the cells wer. tr.ated withganciclovir.(0-1000 p./ml). The r.sults showed that HSV-tk gene could be efficielltly tr.nsfer.ed in Vitr. into hep.atoma cells and stably exp.essed. The gr.wth p.tentialof the tk-containing cells was significantly inhibited byGCV (p.0.01) as comp.r.d to the non-tk-containing *** antitumor.effect of HSV-tk/GCV system was also p.o-duced ex vivo in tk-containing tumor.of nude mice as char.acter.zed by a mar.ed decr.ase in tumor.gr.wth after.GCVtr.atment contr.r. to a p.ogr.ssive enlar.ement of non-tk-containing tumor.. Although the histological examinationdemonstr.ted that the efficiency of the gene tr.nsfer.wasless than 3.%, the killing effect of HSV-tk/GCV systemon hep.tocellular.car.inoma was still significantIy gener.ated. The p.op.r.mechanism of HSV-tk gene ther.p. onhep.tic tumor.r.fer.ed as "bystander.effect" in ther.p.u-tic ap.r.ach has not been found in this study and r.quir.dto be exp.or.d fur.her.

关键词： HSV-tk r.tr.vir.s gene ther.p. hep.tocellular.car.inoma