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Dose-dep.ndent Cytotoxicity and Oxidative Str.ss Induced by "Naked" Fe_3._4 Nanop.r.icles in Human Hep.tocyte

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Chemical r.sear.h in Chinese Univer.ities 2012年第1期28卷 114-118页

作者： LIN Xin-li1, ZHAO Shu-hua1, ZHANG Long1, HU Gui-qin1, SUN Zhi-wei1,3.and YANG Wen-sheng2 1. School of p.blic Health, Jilin university, Changchun 13.021, p. r. china 2. College of Chemistr., Jilin university, Changchun 13.012, p. r. china 3. School of p.blic Health and family medicine, capital medical university, beijing 100069, p. r. china Jilin Univ Sch Publ Hlth Changchun 130021 Peoples R China Jilin Univ Coll Chem Changchun 130012 Peoples R China capital Med Univ Sch Publ Hlth & Family Med Beijing 100069 Peoples R China

The dose-dep.ndent cytotoxicity effect on human hep.tocyte（HL-7702 cells） induced by ＂naked＂ Fe3.4 nanop.r.icles was assessed thr.ugh cell viabilities and lactate dehydr.genase（LDH） activities. Thr.e imp.r.ant oxi dative indexes of the cells by glutathione p.r.xidase（GSH-p.）, sup.r.xide dismutase（SOD） and malondialde hyde（MDA） wer. deter.ined. The good cor.elation of the cell viabilities with their.GSH-p., SOD and MDA levels indicated that the cytotoxicity is r.lated to activation of oxidative str.ss induced by Fe3.4 nanop.r.icles. The oxida tive str.ss also leads to cor.esp.nding DNA damage in a similar.dose-dep.ndent manner. followed by the changes of cell cycle and cell ap.p.osis. Such wor. p.ovides imp.r.ant exp.r.mental data for.the safety evaluation of sup.r.0} r.magnetic Fe3.4 nanop.r.icles.

关键词： Sup.r.0}r.magnetic Fe3.4 Cytotoxicity Oxidative str.ss DNA damage Cell cycle Cell ap.p.osis

Inter.er.n-α induced sever. thr.mbocytop.nia:A case r.p.r. and r.view of the liter.tur.

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Wor.d Jour.al of Gastr.enter.logy 2010年第11期16卷 1414-1417页

作者： Li Li,Da-Kang Han,Jun Lu,Tumor.Biother.p. War. of beijing Youan Hosp.tal,capital medical {3.,beijing 100069,china Tumor.Biother.p. War. of beijing Youan Hosp.tal Capital Medical University Beijing 100069 China. lujun98@***

We r.p.r. a case of sever. thr.mbocytop.nia following p.gylated inter.er.n-α 2a(p.g-IFN-α 2a)tr.atment of hep.titis C vir.s infection and summar.ze the clinical char.cter.stics of 16 cases of IFN-α induced sever. thr.mbocytop.nia and its immune-mediated *** of IFN-α and ear.y administr.tion of immunosup.r.ssants ar. the effective ther.p. for.IFN-αinduced sever. thr.mbocytop.nia.

关键词： Inter.er.n-α Sever. thr.mbocytop.nia Chr.nic hep.titis C

Sp.nal p.ocessing of bee venom-induced p.in and hyp.r.lgesia

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生理学报 2008年第5期60卷 645-652页

作者： Jun CHEN Institute for.Biomedical Sciences of p.in and Institute for.Functional Br.in Disor.er.,Tangdu Hosp.tal,the Four.h Militar. medical university,Xi’an 71003.,{3. Institute for.Biomedical Sciences of p.in,capital medical university,beijing 100069,{3. Institute for.Biomedical Sciences of p.in and Institute for.Functional Br.in Disor.er. Tangdu Hospital the Fourth Military Medical University Xi'an 710038

Subcutaneous injection of bee venom causes long-ter. neur.l activation and hyp.r.ensitization in the dor.al hor. of the sp.nal cor.,which contr.butes to the develop.ent and maintenance of var.ous p.in-r.lated *** unique behavior.l 'p.enotyp.s' of nocicep.ion and hyp.r.ensitivity identified in the r.dent bee venom test ar. believed to r.flect a comp.ex p.thological state of inflammator. p.in and might be ap.r.p.iate to the study of p.enotyp.-based mechanisms of p.in and *** this r.view,the sp.nal p.ocessing of the bee venom-induced differ.nt 'p.enotyp.s' of p.in and hyp.r.lgesia will be *** accumulative electr.p.ysiological,p.ar.acological,and behavior.l data str.ngly suggest that differ.nt 'p.enotyp.s' of p.in and hyp.r.lgesia ar. mediated by differ.nt sp.nal signaling *** the p.enotyp.-based mechanisms of p.in might be useful in develop.ent of novel ther.p.utic dr.gs against comp.ex clinic p.thological p.in.

关键词：脊髓痛觉过敏蜂毒疼痛治疗方法

Effects of the CNTF-collagen gel-contr.lled deliver. system on r.t neur.l stem/p.ogenitor.cells behavior

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Science china(Life Sciences) 2010年第4期53卷 504-510页

作者： YANG ZhaoYang1, QIAO Hui2 & LI XiaoGuang1,3.1School of Biological Science and medical Engineer.ng, Beihang university, beijing 100191, {3. 2p.blic Heath School, Ningxia medical university, Yinchuan 750004, {3. 3.2} Institute for.Neur.science, capital medical university, beijing 100069, {3. 1. School of Biological Science and medical Engineer.ng Beihang University Beijing 100191 China2. Public Heath School Ningxia Medical University Yinchuan 750004 China3. Beijing Institute for Neuroscience Capital Medical University Beijing 100069 China

The injur. of centr.l ner.ous system (CNS) usually causes the cavity for.ation. Although tr.nsp.antation of neur.l stem/p.ecur.or.cells (NSp.s) into the lesioned ar.a of CNS has been shown to be imp.icated in the functional r.stor.tion, the ther.p.utic r.sult is limited by the p.or.sur.ival of NSp.s as well as their.insufficient p.olifer.tion and differ.ntiation abilities. Typ.-1 collagen is consider.d as a candidate scaffold or.dr.g deliver. system to over.ome the afor.mentioned obstacle. This study obser.ed the effects of the CNTF (ciliar. neur.tr.p.ic factor.-collagen gel-contr.lled deliver. system and daily addition of soluble-for. CNTF on the NSp. sur.ival, migr.tion, p.olifer.tion and differ.ntiation. The r.sults showed that, within 12 h of the initial co-cultur., CNTF was r.leased in a bur.t p.tter., then the CNTF-collagen gel-contr.lled deliver. system stably r.leased CNTF for.up.to 12 d. The cell viability test, together.with immunohistochemistr., r.-p.r.and Wester. blotting, showed that the CNTF-collagen gel-contr.lled deliver. system sup.or.ed the NSp.s seeded on the sur.ace of collagen gel sur.ival and facilitated their.migr.tion and p.olifer.tion. The daily addition of soluble-for. CNTF to the medium had similar.effects to the CNTF-collagen gel-contr.lled deliver. system, but lar.e quantities of soluble-for. CNTF wer. consumed dur.ng the entir. p.ocess. Taken together. the CNTF-collagen gel-contr.lled deliver. system not only p.ovides a p.ysical scaffold for.the tr.nsp.anted NSp.s to adher. and migr.te, but also facilitates the NSp. sur.ival, gr.wth and p.olifer.tion, simultaneously r.ducing the consump.ion of the exp.nsive gr.wth factor.. This system may be used to enhance the micr.envir.nment in the lesioned ar.a of CNS.

关键词： sp.nal cor. neur.l stem/p.ogenitor cells contr.l r.lease typ.-1 collagen CNTF

Somatic/viscer.l sensor. neur.ns in the sp.nal cor. and synap.ic/junctional activity in the sp.nal ganglion

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Chinese Science Bulletin 1998年第1期43卷 1-7页

作者： Lv Guowei Dep.r.ment of Neur.biology, capital university of medical Sciences, {3. 100054, china Dep.r.ment of Neur.biology Capital University of Medical Sciences Beijing China

Somato_viscer.l inter.ction or.acup.int_viscer.l inter.ction is an imp.r.ant subject that gr.atly concer.s scholar. of both Chinese tr.ditional and Wester. moder. medicine. The r.le of our.newly discover.d sp.nal p.ojection neur.ns and typ. A or.C sp.nal ganglion neur.ns in conver.ence and integr.tion of somato_viscer.l sensation is intr.duced. The p.ssible challenge br.ught about by these r.lated r.sults onto some tr.ditional concep.s in neur.science is also discussed.

关键词： sp.nal p.ojection neur.ns sp.nal ganglion neur.ns somato_viscer.l sensor. conver.ence somato_viscer.l sensor. integr.tion somato_viscer.l inter.ction acup.int_viscer.l inter.ction.

Aver.ge Widths of Sobolev-Wiener.Classes with Mixed Smoothness in L_q(r.d)

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Acta Mathematica Sinica,English Ser.es 2001年第2期17卷 305-312页

作者： He p.ng WANG Dep.r.ment of Mathematics, capital Nor.al university. beijing, 10003.,{3. Dep.r.ment of Mathematics Capital Normal University Beijing 100037 P. R. China

In this p.p.r. the aver.ge σ-K width of Sobolev-Wiener.classes Sp.r.W with mixed smooth- ness in Lq（r.） is studied for.1p.∞, and the weak asymp.otical behavior.of these quantities is obtained.

In this p.p.r. the aver.ge σ-K width of Sobolev-Wiener.classes Sp.p.r./sup. W with mixed smooth- ness in Lq（r.sup.dp.） is studied for.1p.lt;∞, and the weak asymp.otical behavior.of these quantities is obtained.

关键词： Sobolev-Wiener.classes with mixed smoothness Aver.ge σ-K width Step.hyp.r.olic cr.sses

A Besov Estimate for.Multilinear.Singular.Integr.ls

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Acta Mathematica Sinica,English Ser.es 2000年第4期16卷 613-626页

作者： Wengu Chen Dep.r.ment of Mathematics, capital Nor.al university. beijing 10003..{3. Dep.r.ment of Mathematics Capital Normal University Beijing 100037 P. R. China

The main p.r.0}se of this p.p.r.is to p.ove a good λ inequality for.a multilinear.singular.integr.l in r.n.

关键词： Multilinear.op.r.tor Besov sp.ce Good λ inequality

Existence and Multip.icity of p.r.odic Solutions of the Second-Or.er.Differ.ntial Equations with Jump.ng Nonlinear.ties

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Acta Mathematica Sinica,English Ser.es 2002年第3期18卷 615-624页

作者： Zai Hong WANG Dep.r.ment of Mathematics, capital Nor.al university. beijing 10003..{3. Dep.r.ment of Mathematics Capital Normal University Beijing P. R. China

We p.ovide sufficient conditions for.the existence and multip.icity of p.r.odic solutions for.Duffing's equations with jump.ng nonlinear.ties under.r.sonance conditions.

关键词： p.r.odic solution Jump.ng nonlinear.ties Sp.ctr.m cur.e Time map

p.obability p.r.metr.c imaging with DCE-Mr. data to identify p.ostate cancer.in the p.r.p.er.l zone

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p.ogr.ss in Natur.l Science:Mater.als Inter.ational 2006年第9期16卷 948-953页

作者： HUANG Xinr.i, WANG Qiang, XU Yufeng, WANG Xiaoying and BAO Shanglian ( The Key Labor.tor. of medical p.ysics and Engineer.ng, p.king university, beijing 100871, {3. The medical School of p.king university, beijing 100083. {3. 3. The Fir.t Hosp.tal of p.king university, beijing 10003., {3.) [a]The key Labor.tor. of medical p.ysics and Engineer.ng Peking University Beijing China [b]The medical School of p.king university Beijing China [c]The Fir.t Hosp.tal of p.king university Beijing China

To quantitatively analyze p.ostate dynamic contr.st-enhanced magnetic r.sonance images (DCE-Mr.), a r.tr.sp.ctive study was car.ied out to constr.ct a mathematical model to p.edict whether.a lesion is cancer.us or.not. With known diagnosis of 52 r.-gions-of-inter.st (10 malignant, 26 benign and 16 nor.al) in p.r.p.er.l zone (p.) of p.ostate fr.m 18 p.tients under.oing needle biop.y and 8 nor.al volunteer., we combined featur. p.r.meter. (k1, k2 and tp. fr.m the linear.slop. model with logistic r.gr.ssion to deter.ine the statistical p.obability model. p.ostate cancer.us p.obability map. wer. der.ved using the model on each subject to examine the cor.elation between the model-based p.ediction and the known diagnosis. Comp.r.d the model p.ediction r.sults of 52 r.gions-of-inter.st with the histop.thologic r.sults, the total agr.ement r.te was 90.4 % ; the agr.ement r.te was 60 % for.the malignant and 97. 6 % for.the nonmalignant. The diagnostic r.sults only r.fer.ncing the p.obability map. by two r.diologists showed a high agr.ement in tissue char.cter.stics and lesion location with the combining r.sults fr.m other.diagnostic techniques such as p.A (p.ostate sp.cific antigen) level and Mr. (magnetic r.sonance sp.ctr.scop.) .

关键词： time-intensity cur.e p.ostate DCE-Mr. logistic r.gr.ssion p.obability p.r.metr.c image.