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Proposal for valleytronic materials:Ferrovalley metal and valley gapless semiconductor

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Frontiers of physics 2024年第2期19卷 131-139页

作者： San-Dong Guo Yu-Ling tao Guangzhao Wang Shaobo Chen Dong Huang Yee Sin ang School of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology of Chongqing School of Electronic Information EngineeringYangtze Normal UniversityChongqing 408100China College of Electronic and Information Engineering Anshun UniversityAnshun 561000China Science Mathematics and Technology(SMT)Singapore University of Technology and Design(SUTD)8 Somapah RoadSingapore 487372Singapore

Valleytronic materials can provide new degrees of freedom to future electronic *** this work,the concepts of the ferrovalley metal(FVM)and valley gapless semiconductor(VGS)are proposed,which can be achieved in valleytronic bilayer systems by electric field *** valleytronic bilayer systems,the interaction between out-of-plane ferroelectricity and A-type antiferromagnetism can induce layer-polarized anomalous valley Hall(LP-AVH)*** K and−K valleys of FVM are both metallic,and electron and hole carriers simultaneously *** the extreme case,the FVM can become VGS by analogizing spin gapless semiconductor(SGS).Moreover,it is proposed that the valley splitting enhancement and valley polarization reversal can be achieved by electric field engineering in valleytronic bilayer *** the bilayer RuBr_(2.as an example,our proposal is confirmed by the first-principle *** FVM and VGS can be achieved in bilayer RuBr_(2)by applying electric *** appropriate electric field range,increasing electric field can enhance valley splitting,and the valley polarization can be reversed by flipping electric field *** effectively tune valley properties by electric field in bilayer systems,the parent monolayer should possess out-of-plane magnetization,and have large valley *** results shed light on the possible role of electric field in tuning valleytronic bilayer systems,and provide a way to design the ferrovalley-related material by electric field.

关键词： valleytronics electric field bilayer

Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina

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World Journal of Diabetes 2024年第3期15卷 519-529页

作者： Jian Tan ang Xiao Lin Yang Yu-Lin tao Yi Shao Qiong Zhou Department of Ophthalmology The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Diabetic retinopathy(DR)is a major ocular complication of diabetes mellitus,leading to visual *** pigment epithelium(RPE)injury is a key component of the outer blood retinal barrier,and its damage is an important indicator of *** for activated C kinase 1(RACK1)activates protein kinase C-ε(PKC-ε)to promote the generation of reactive oxygen species(ROS)in RPE cells,leading to ***,we hypothesize that the activation of RACK1 under hypoxic/high-glucose conditions may promote RPE cell apoptosis by modulating PKC-ε/ROS,thereby disrupting the barrier effect of the outer blood retinal barrier and contributing to the progression of *** To investigate the role and associated underlying mechanisms of RACK1 in the development of early *** In this study,Sprague-Dawley rats and adult RPE cell line-19(ARPE-19)cells were used as in vivo and in vitro models,respectively,to explore the role of RACK1 in mediating PKC-εin early ***,the impact of RACK1 on apoptosis and barrier function of RPE cells was also investigated in the former *** Streptozotocin-induced diabetic rats showed increased apoptosis and upregulated expression of RACK1 and PKC-εproteins in RPE cells following a prolonged ***,ARPE-19 cells exposed to high glucose and hypoxia displayed elevated mRNA and protein levels of RACK1 and PKC-ε,accompanied by an increases in ROS production,apoptosis rate,and monolayer ***,silencing RACK1 significantly downregulated the expression of PKC-εand ROS,reduced cell apoptosis and permeability,and protected barrier *** RACK1 plays a significant role in the development of early DR and might serve as a potential therapeutic target for DR by regulating RPE apoptosis and barrier function.

关键词： Diabetic retinopathy Receptor for activated C kinase 1 Protein kinase C-ε Adult retinal pigment epithelium cell line-19

Negative enthalpy alloys and local chemical ordering:a concept and route leading to synergy of strength and ductility

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National Science Review 2024年第4期11卷 172-184页

作者： Zibing An tao Yang Caijuan Shi Shengcheng Mao Lihua Wang ang Li Wei Li Xianmeng Xue Ming Sun Yifan Bai Yapeng He Fuzeng Ren Zhouguang Lu Ming Yan Yang Ren Chain-Tsuan Liu Ze Zhang Xiaodong Han Beijing Key Lab of Microstructure and Property of Advanced Materials College of Materials Science &Engineering Beijing University of Technology Department of Materials Science and Engineering City University of Hong Kong Key Laboratory of Partial Acceleration Physics& Technology Institute of High Energy PhysicsChinese Academy of Sciences Department of Materials Science &Engineering Southern University of Science and Technology Department of Physics City University of Hong Kong State Key Laboratory of Silicon Materials Department of Materials Science and Engineering Zhejiang University

Solid solutions are ubiquitous in metals and alloys. Local chemical ordering(LCO) is a fundamental sub-nano/nanoscale process that occurs in many solid solutions and can be used as a microstructure to optimize strength and ductility. However, the formation of LCO has not been fully elucidated, let alone how to provide efficient routes for designing LCO to achieve synergistic effects on both superb strength and ductility. Herein, we propose the formation and control of LCO in negative enthalpy alloys. With engineering negative enthalpy in solid solutions, genetic LCO components are formed in negative enthalpy refractory high-entropy alloys(RHEAs). In contrast to conventional ‘trial-and-error' approaches, the control of LCO by using engineering negative enthalpy in RHEAs is instructive and results in superior strength(1160 MPa) and uniform ductility(24.5%) under tension at ambient temperature, which are among the best reported so far. LCO can promote dislocation cross-slip, enhancing the interaction between dislocations and their accumulation at large tensile strains; sustainable strain hardening can thereby be attained to ensure high ductility of the alloy. This work paves the way for new research fields on negative enthalpy solid solutions and alloys for the synergy of strength and ductility as well as new functions.

关键词： negative enthalpy alloys local chemical ordering strength ductility dislocation

Deep learning framework for comprehensive molecular and prognostic stratifications of triple-negative breast cancer

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Fundamental Research 2024年第3期4卷 678-689页

作者： Shen Zhao Chao-Yang Yan Hong Lv Jing-Cheng Yang Chao You Zi-ang Li Ding Ma Yi Xiao Jia Hu Wen-tao Yang Yi-Zhou Jiang Jun Xu Zhi-Ming Shao Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Institute for AI in Medicine School of Artificial IntelligenceNanjing University of Information Science and TechnologyNanjing 210044China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China Greater Bay Area Institute of Precision Medicine Guangzhou 511466China Department of Radiology Fudan University Shanghai Cancer CenterShanghai 200032China

Triple-negative breast cancer(TNBC)is the most challenging breast cancer *** stratification and target therapy bring clinical benefit for TNBC patients,but it is difficult to implement comprehensive molecular testing in clinical ***,using our multi-omics TNBC cohort(N=425),a deep learning-based framework was devised and validated for comprehensive predictions of molecular features,subtypes and prognosis from pathological whole slide *** framework first incorporated a neural network to decompose the tissue on WSIs,followed by a second one which was trained based on certain tissue types for predicting different ***-omics molecular features were analyzed including somatic mutations,copy number alterations,germline mutations,biological pathway activities,metabolomics features and immunotherapy *** was shown that the molecular features with therapeutic implications can be predicted including the somatic PIK3CA mutation,germline BRCA2 mutation and PD-L1 protein expression(area under the curve[AUC]:0.78,0.79 and 0.74 respectively).The molecular subtypes of TNBC can be identified(AUC:0.84,0.85,0.93 and 0.73 for the basal-like immune-suppressed,immunomodulatory,luminal androgen receptor,and mesenchymal-like subtypes respectively)and their distinctive morphological patterns were revealed,which provided novel insights into the heterogeneity of TNBC.A neural network integrating image features and clinical covariates stratified patients into groups with different survival outcomes(log-rank Panges in patient *** potential clinical translation,we built a novel online platform,where we modularized and deployed our framework along with the validated *** can realize real-time one-stop prediction for new *** summary,using only pathological WSIs,our proposed framework

关键词： Triple-negative breast cancer Deep learning Digital pathology Patient stratification Online platform

一种基于自适应Kriging集成模型的结构可靠性分析方法

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中国机械工程 2024年第1期35卷 83-92页

作者：高进崔海冰樊涛李昂杜尊峰潍柴动力股份有限公司潍坊261061 内燃机可靠性国家重点实验室潍坊261061 天津大学建筑工程学院天津300354

基于Kriging模型的复杂结构可靠性分析结果高度依赖于Kriging模型的拟合精度,在构建Kriging模型的过程中,不同相关函数和回归函数的选择均会影响模型精度。为解决模型的不确定性对可靠性分析结果的影响,同时兼顾计算效率和精度,基于Krig... 详细信息

基于Kriging模型的复杂结构可靠性分析结果高度依赖于Kriging模型的拟合精度,在构建Kriging模型的过程中,不同相关函数和回归函数的选择均会影响模型精度。为解决模型的不确定性对可靠性分析结果的影响,同时兼顾计算效率和精度,基于Kriging模型和蒙特卡罗模拟(MCS)方法,提出了一种结合自适应集成策略和主动学习函数的结构可靠度计算方法。该方法考虑Kriging模型的建模不确定性,将多种Kriging模型组合,构建了一种综合考虑样本点贡献和样本点距离的主动学习函数,通过主动学习函数迭代更新集成Kriging模型直至满足收敛条件,最后通过构建的集成Kriging模型和MCS方法进行结构可靠性分析。数值算例和工程算例结果验证了所提方法的有效性,该方法与其他主要方法相比稳健性更好,在保证计算精度的同时,计算效率更高。

关键词：结构可靠性自适应集成策略 Kriging模型主动学习函数

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清乾隆年间南京随园的玻璃与空间的新尝试

建筑学报 2024年第6期 102-107页

作者：白颖陈涛姜春霖东南大学建筑学院南京210096 陆军工程大学国防工程学院南京210007

通过江南园林中使用玻璃的较早案例:乾隆年间建造的南京随园,分析性灵派文人袁枚的诗文和随园的图像,发现袁枚在随园中大量使用玻璃窗和玻璃镜,并利用玻璃的透明、色彩与反射性能,追求曲折、复杂、多重的空间,指出玻璃带来的新材质感受... 详细信息

通过江南园林中使用玻璃的较早案例:乾隆年间建造的南京随园,分析性灵派文人袁枚的诗文和随园的图像,发现袁枚在随园中大量使用玻璃窗和玻璃镜,并利用玻璃的透明、色彩与反射性能,追求曲折、复杂、多重的空间,指出玻璃带来的新材质感受和视觉观念促发了随园独特的空间设计,袁枚借玻璃开启了江南园林中材料与空间的新尝试.

关键词：随园玻璃材料空间

基于第一性原理研究杂质补偿对硅光电性能的影响

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物理学报 2024年第11期73卷 263-272页

作者：王秀宇王涛崔雨昂吴溪广润王洋天津大学微电子学院天津市成像与传感微电子技术重点实验室天津300072

通过磷(P)和硼(B)共掺杂在硅禁带中构建了P^(+)/B^(-)局域态能级,形成了具有杂质补偿结构的硅.采用基于密度泛函理论框架下的第一性原理研究了杂质补偿硅(n/p-Sic)的电子态密度、介电函数和折射率等光电性能.态密度研究表明,相同浓度P和... 详细信息

通过磷(P)和硼(B)共掺杂在硅禁带中构建了P^(+)/B^(-)局域态能级,形成了具有杂质补偿结构的硅.采用基于密度泛函理论框架下的第一性原理研究了杂质补偿硅(n/p-Sic)的电子态密度、介电函数和折射率等光电性能.态密度研究表明,相同浓度P和B掺杂(12.5%)的n-Si和p-Si被完全杂质补偿后,费米能级位于两相邻态密度峰构成的谷底,且态密度不为零.在介电函数和折射率研究中,发现n-Sic在掺杂比例C_(B)/C_(P0)=0.25时,在低能区具有最大的介电函数和最大折射率.此外,对比本征硅及其掺杂物的介电常数实部(Re),发现如下规律:在E> 4 eV的高能区,本征Si,n/p-Si和p-Sic的Re为负值;而在0.64 25时的Re为负值;这表明在此掺杂比例下n-Sic能在更低的能量下就能获得较好的金属性,从而揭示了其价带电子更易被低能量的长波长光激发.理论研究表明,n-Sic在掺杂比例C_(B)/C_(P0)=0.25时具有较好的光电性能,可能与n-Si被B杂质补偿后部分Si—Si键变成Si—B键的同时产生的Si悬挂键以及在Si禁带中形成的局域态能级有关.

关键词：第一性原理态密度杂质补偿硅光学性质

砂土压缩变形传感光缆耦合试验分析与预测模型研究

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岩土力学 2024年第5期45卷 1570-1582页

作者：许时昂张平松程刚吴海波张涛安徽理工大学地球与环境学院安徽淮南232001 合肥综合性国家科学中心能源研究院(安徽省能源实验室) 安徽合肥230051 华北科技学院计算机学院北京101601 合肥工业大学机械工程学院安徽合肥230009

灾害监测、预测是地质与岩土工程领域一项极为重要的任务。分布式光纤传感技术凭借其连续、实时、抗干扰、稳定性好等优点在长距离、长周期、高隐蔽性、强突发性的灾害监测中发挥了显著的作用。然而,针对不同工程问题,评价与解决传感光... 详细信息

灾害监测、预测是地质与岩土工程领域一项极为重要的任务。分布式光纤传感技术凭借其连续、实时、抗干扰、稳定性好等优点在长距离、长周期、高隐蔽性、强突发性的灾害监测中发挥了显著的作用。然而,针对不同工程问题,评价与解决传感光缆与被测岩土体协调变形问题,是精细化分析岩土体变形分布与研究演化规律的关键所在。利用自主研制的三维主动变形可控围压光缆-砂土耦合试验装置,探究了0~4.0MPa围压条件下金属基索传感光缆与粗砂介质压缩变形的协调性问题。试验结果表明:低围压条件下金属基索传感光缆与砂土压缩变形协调性较差,变形表现为非线性变化特征;随着围压增大,传感光缆与砂土耦合效果提高,变形呈现线性变化特征,当围压达到1.6MPa后,两者协调变形一致性明显提高,其形变由非线性向线性转变。基于上述变形特性,提出了一种围压曲面投影数值模型,采用非扭结边界条件的样条插值算法对非试验数据实际位移进行预测,结果表明该模型具有较好的可靠性。试验研究认为金属基索光缆用于高围压条件下砂土变形测试具有更高的准确性,研究内容可以为分布式光纤传感测试技术用于深部地层变形监测提供科学的参考依据。

关键词：分布式光纤岩土变形应变传递协调变形数值模型

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Fe-金属有机框架玻璃的形成过程与机理

硅酸盐学报 2024年第8期52卷 2553-2558页

作者：刘鑫宇郭超慧陶海征乔昂武汉理工大学硅酸盐建筑材料国家重点实验室武汉430070 中山市武汉理工大学先进工程技术研究院广东中山528400

不同的中心金属离子能够赋予金属有机框架材料(MOFs)不同的性能,众多Fe基MOF材料具有优异的电、磁性能。但由于Fe元素存在变价,且Fe—N配位键难以形成,可熔融成玻Fe-MOF材料鲜有报道。使用无溶剂法成功制备Fe_(3)(C_(3)H_(2)N_(2))_6(C_... 详细信息

不同的中心金属离子能够赋予金属有机框架材料(MOFs)不同的性能,众多Fe基MOF材料具有优异的电、磁性能。但由于Fe元素存在变价,且Fe—N配位键难以形成,可熔融成玻Fe-MOF材料鲜有报道。使用无溶剂法成功制备Fe_(3)(C_(3)H_(2)N_(2))_6(C_(3)H_(4)N_(2))_(2)晶体,命名为FCIR,即Fe-MOF晶体,并且利用熔融淬冷法制成了Fe-MOF玻璃,并探究该Fe-MOF晶体在加热过程中的形态和结构演变,以及其玻璃态形成的机理。结果表明:相较于以Zn为中心离子的可熔融MOF材料,Fe离子对晶体加热过程中的熔融过程和结构演变会产生较大影响;FCIR晶体熔融淬冷后发生近程序结构变化,即由晶态时Fe离子与咪唑的6配位八面体脱去2个单配位咪唑转变为玻璃态的4配位四面体。

关键词：金属有机框架玻璃形成熔融结构变化