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Spatio-temporal pattern analysis of single-trial EEG signals recorded during visual object recognition

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Science China(Information Sciences) 2011年第12期54卷 2519-2527页

作者： WANG ChangMing 1 , HU XiaoPing 3 , YAO Li 1,2., XIONG Shi 2.& ZHANG JiaCai 2.1 National Key laboratory of Cognitive neuroscience and Learning, Beijing Normal University, Beijing 100875, China 2.College of Information Science and Technology, Beijing Normal University, Beijing 100875, China 3 Biomedical Imaging Technology Center, Emory University/Georgia Institute of Technology, Atlanta 3032., USA 1. National Key laboratory of Cognitive neuroscience and Learning Beijing Normal University Beijing 100875 China3. Biomedical Imaging Technology Center Emory University/Georgia Institute of Technology Atlanta 30322 USA2. College of Information Science and Technology Beijing Normal University Beijing 100875 China

Object discrimination is a fundamental cognitive function for human brains. In this study, we utilized an analysis approach for single-trial electroencephalography (EEG) to analyze the spatio-temporal activation patterns of visual objects processing in human brains, and attempted to apply it to discriminate different visual objects. The spatial patterns were respectively extracted from scalp EEG and the reconstructed cortical sources, while the experiment participants were perceiving 4 different categories of visual objects (faces, buildings, cats and cars). By classifying the patterns extracted from single-trial EEG, the presented visual objects could be discriminated by a computer, and the classification accuracies may provide a quantitative index to evaluate the spatial differences of the brain activations related to different visual objects. Our results demonstrated that the spatial patterns on both the scalp and the sources levels resulted in higher classification accuracies than chance rate. We also examined the classification results using temporally non-overlapping time intervals of different event-related potential (ERP) components. The temporal changes of classification accuracies may reflect the temporal distribution of the discriminative information in the EEG responses. The present pattern extraction and classification methods may compose a computational model for single-trial EEG data analysis in investigations of the spatio-temporal activation patterns for object recognition. These spatio-temporal patterns in EEG may be useful to identifying the discriminative spatial areas and time stages to improve the accuracies and efficiencies of object discrimination. In addition, investigating and utilizing humans'cognitive mechanisms of object recognition may improve computers' processing efficiency of visual information.

关键词： EEG spatio-temporal pattern object recognition single-trial analysis visual information processing

Modeling and simulation of ion channels and action potentials in taste receptor cells

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Science China(Life Sciences) 2009年第11期52卷 1036-1047页

作者： CHEN PeiHua1, LIU Xiao-dong2. ZHANG Wei1, ZHOU Jun1, WANG Ping1, YANG Wei3 & LUO JianHong3 1Biosensor National Special laboratory, Key laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 31002., China 2.alcium Signals Lab, Department of Biomedical Engineering and {2., Johns Hopkins University, Baltimore, MD 2.2.5, USA 3Department of Neurobiology, Institute for {2., Zhejiang University School of Medicine, Hangzhou 310058, China 1. Biosensor National Special laboratory Key Laboratory of Biomedical Engineering of Ministry of Education Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China 2. Calcium Signals Lab Department of Biomedical Engineering and Neuroscience Johns Hopkins University Baltimore MD 21205 USA 3. Department of Neurobiology Institute for Neuroscience Zhejiang University School of Medicine Hangzhou 310058 China

Based on patch clamp data on the ionic currents of rat taste receptor cells, a mathematical model of mammalian taste receptor cells was constructed to simulate the action potentials of taste receptor cells and their corresponding ionic components, including voltage-gated Na+ currents and outward delayed rectifier K+ currents. Our simulations reproduced the action potentials of taste receptor cells in response to electrical stimuli or sour tastants. The kinetics of ion channels and their roles in action potentials of taste receptor cells were also analyzed. Our prototype model of single taste receptor cell and simulation results presented in this paper provide the basis for the further study of taste information processing in the gustatory system.

关键词： taste receptor cell action potential modeling and simulation Na+ channel delayed rectifier K+ channel

Attention and available long-term memory in an activation-based model

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Science China(Life Sciences) 2010年第6期53卷 743-752页

作者： LIU ZhaoMin1,GUO ChunYan2.3 & LUO Liang4 1 School of Sociology,China University of Political Science and Law,Beijing 102.49,China 2.Beijing Key laboratory of Learning and Cognition,Department of Psychology,Capital Normal University,Beijing 100048,China 3 Key laboratory of Mental Health,Chinese Academy of Sciences,Beijing 100101,China 4 State Key laboratory of Cognitive neuroscience and Learning,Beijing Normal University,Beijing 100875,China 1. School of Sociology China University of Political Science and Law Beijing 102249 China2. Beijing Key Laboratory of Learning and Cognition Department of Psychology Capital Normal University Beijing 100048 China3. Key Laboratory of Mental Health Chinese Academy of Sciences Beijing 100101 China4. State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing 100875 China

The influence of attention on memorizing related items and on available long-term memory (ALTM) was explored,showing that N400 of no-memory items was more negative than that of the memory *** results of the category comparison task indicated that information processing under attention-driven in WM determined the availability of related long-term memory,i.e.,specific content,which was formerly concerned or ignored,yielding different indirect semantic priming *** indicate that the orientation of conceptual attention leads the related representations of LTM to diverse activation patterns,supporting the activation-based model.

关键词： activation-based model attention available long-term memory event-related potentials

英语语音意识在汉语儿童英语单词阅读及拼写中的作用

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心理发展与教育 2011年第4期27卷 388-393页

作者：李蓓蕾陶沙董奇北京师范大学教育学部北京100875 北京师范大学认知神经科学与学习国家重点实验室北京100875

本研究考察了英语语音意识在小学汉语儿童英语单词读写学习中的作用。对189名小学儿童的研究表明:(1)一、二、五年级在首音和韵脚意识上差异显著;在音位意识上,一、二年级差异不显著,五年级显著高于其他两个年级;(2.各年级儿童的语音意... 详细信息

本研究考察了英语语音意识在小学汉语儿童英语单词读写学习中的作用。对189名小学儿童的研究表明:(1)一、二、五年级在首音和韵脚意识上差异显著;在音位意识上,一、二年级差异不显著,五年级显著高于其他两个年级;(2.各年级儿童的语音意识与其英语单词读写均存在显著相关;(3)控制英语口语词汇量后,一年级的首音意识显著解释其单词读写的变异,二年级的首音意识显著解释其单词拼写的变异,五年级的音位意识显著解释其单词读写的变异;(4)各年级的语音意识对单词拼写较之于阅读都具有更强的变异解释力。可见,小学汉语儿童的英语语音意识与其单词读写存在密切联系,语音意识与拼写的关系相对更为紧密;首音意识对早期读写发展具有重要意义,而音位意识在后期读写学习中的作用更为突出。

关键词：语音意识阅读拼写英语学习小学生

FGF13A represses transcription of rRNA genes as a nucleolar protein

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FGF13A represses transcription of rRNA genes as a nucleolar ...

Inconspicuous anchoring effects generated by false information

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Liu YANG~1,Lan BAO~2.Xu ZHANG~(1,*) 1 Institute of neuroscience and State Key laboratory of neuroscience 2.Institute of Biochemistry and Cell Biology and laboratory of Molecular Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,2.0031,China

Objective Fibroblast growth factors(FGFs) are among the first-indentified families of growth *** are polypeptides with diverse biological activities including cell proliferation,differentiation,migration and so *** their functions are much more evident in the nervous system than in *** FGFs have N-terminal signal peptides and can be secreted ***,FGF11 subfamily(FGFs 11-14) is a special *** FGFs lack signal peptides, remain intracellularly and function within cells in a receptor-independent manner,hereafter referred to as *** growth factor 13(FGF13) is a member of the intracellular FGF homologous factor subfamily(iFGFs) and highly expressed in nervous system,however its functions are still *** The subcellular localization of FGF13A was investigated by *** interaction between FGF13A and UBF1 was investigated by coimmunoprecipitation (co-IP) *** function of FGF13A on the neurite outgrowth of DRG neurons was investigated by electroporation and ***(1) The expression of FGF13A-EGFP in transfected ND7-2. cells or dissociated primary DRG neurons was highly enriched in the nucleolus of the two types of cells and colocalized with the nucleolus marker,fibrillarin and nucleolin.(2. Overexpression of FGF13A repressed rRNA transcription through interacting with upstream binding factor 1(UBF1),a RNA pol I transcription factor.(3) Overexpression of FGF13A significantly inhibited neurite outgrowm of dissociated DRG *** Nucleolus-localized FGF13A represses rRNA transcription and therefore inhibits DRG neurite outgrowth.

关键词： iFGF UBF1 ribosomal RNA transcription neurite outgrowth

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Progress in Natural Science:Materials International 2008年第11期18卷 1375-1382页

作者： Chen Qu~(a,b) Jun Wang~a Yuejia Luo~(a,c,*) a State Key laboratory of Cognitive neuroscience and Learning,Beijing Normal University,Beijing 100875,China b Center for studies of Psychological Application,South China Normal University Guangzhou,510631,China c Key laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China State Key laboratory of Cognitive neuroscience and Learning Beijing Normal University Beijing 100875 China Center for studies of Psychological Application South China Normal University Guangzhou 510631 China Key laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China

The impact of false information on numerical judgments was examined on young normal subjects by an event-related potential(ERP) *** imitate the judgments in real world,we ensured the subjects acknowledged of the target *** behavioral results found that both uncertain information and false information assimilated the final estimates:higher after higher anchors and lower after lower anchors;and false information caused a weaker anchoring bias than uncertain *** results provided further electro- physiological evidence for the mechanism of *** the early phrase,it was an accessibility-dominated process in which two kinds of anchors elicited an N300 component related to the accessibility of anchors *** knowledge relevant to targets joined the process in the late phrase,which caused a larger amplitude of late positive component(LPC)for implausible lower anchors than that for plausible higher *** analysis showed that medial frontal gyrus,whose activity was suggested to signal the need of adjust- ment,was more reliable to explain the LPC elicited by implausible lower ***,we suggest that accessibility is facilitated when the external anchor is consistent with the world knowledge,and adjustment is initiated when the external anchor is inconsistent.

关键词： False anchors Anchoring effects Accessibility Adjustment ERP

HIF-1 can protect neprilysin from hypoxia impairment

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HIF-1 can protect neprilysin from hypoxia impairment

Fibroblast growth factor 7 acts as a modulator of nociception

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Miao SUN~1,Ling-Ling ZHU~2.Ming FAN~2.De-Hua CUI~(1,*) 1 neuroscience Research Institute and Department of Neurobiology,Key laboratory for neuroscience,Ministry of Education,Key laboratory for neuroscience,Ministry of Public Health,Peking University Health Science Center, Beijing 100191,China 2.Department of Brain Protection and Plasticity,Institute of Basic Medical Sciences,Beijing,100850,China

＜正＞Objective Pathogenesis of Alzheimer’s disease（AD）,which is characterized by accumulation of extracellular deposits of P-amyloid peptide（Abeta） in the brain,has recently been linked to vascular disorders such as hypoxia. Extracellular deposits of P-amyloid peptide are closely associated with the metabolic balance between Abeta production and clearance *** recent work reports that hypoxia will disturb this metabolic balance by increasing Abeta production,little is known about hypoxia and Abeta *** neprilysin（NEP） is a mainly Abeta degradation enzyme,we focused on the effect of hypoxia on *** The changes of neprilysin expression level under hypoxia condition are mainly conduct in SH-SY5Y cell line by real-time PCR,western blot and *** confirm relationship between HIF and neprilysin,HIF-1αplasmid and shRNAi are ***（1） Severe hypoxia can decrease neprilysin protein and enzyme activity immediately in SH-SY5Y cells（2. the endogenous HIF can transiently attenuate this effect.（3） Over-express HIF-1αcan increase neprilysin expression level under hypoxia condition.（4） HIF-1 can directly regulate neprilysin protein and activity *** HIF-1 may protect neprilysin from hypoxia impairment by directly regulation.

关键词： hypoxia neprilysin(NEP) Hypoxia Inducible Factor-1α(HIF-1α)

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Fibroblast growth factor 7 acts as a modulator of nociceptio...

Theoretical analysis of transcranial Hall-effect stimulation based on passive cable model

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hui LIU~1,Qing-Feng WU~1,Qiong WANG~2.Lan BAO~2.Xu ZHANG~1 1 Institute of neuroscience and State Key laboratory of neuroscience,2.Institute of Biochemistry and Cell Biology and laboratory of Molecular Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences, Shanghai 2.0031,China

＜正＞Fibroblast growth factor（FGF）7,which is also known as keratinocyte growth factor（KGF）,is a member of the FGF *** studies regard it as a locally acting epithelial mitogen that is produced by cells of mesenchymal origin and has an important role in protecting and repairing epithelial ***,its potential functions in the nervous system are poorly *** found that FGF7,together with its high-affinity receptor FGFR2.,was expressed in both dorsal root ganglion（DRG）and spinal cord ***7 mRNA was consistently increased in DRGs after peripheral nerve injury and transiently up-regulated after intraplantar injection of complete Freund’s *** injection of recombinant human FGF7 exacerbated the formalin-induced hyperalgesia, while application with either the antibodies against FGF7 or recombinant FGF R2.（Ⅲb）Fc chimera alleviated inflammatory nociceptive ***,behavior tests and wide-dynamic range neuron recordings of FGF7 knockout mice showed a defect in nociceptive *** together,these results suggest that FGF7 may contribute to inflammatory pain sensation and play an important role in nociceptive transmission.

关键词： fibroblast growth factor 7 inflammatory pain nociceptive transmission

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Chinese Physics B 2015年第12期24卷 373-378页

作者：袁毅李小俚 Institute of Electrical Engineering Yanshan University State Key laboratory of Cognitive neuroscience and Learning & IDG Mc Govern Institute for Brain Research Beijing Normal University Center for Collaboration and Innovation in Brain and Learning Sciences Beijing Normal University

Transcranial Hall-effect stimulation（THS） is a new stimulation method in which an ultrasonic wave in a static magnetic field generates an electric field in an area of interest such as in the brain to modulate neuronal activities. However, the biophysical basis of simulating the neurons remains unknown. To address this problem, we perform a theoretical analysis based on a passive cable model to investigate the THS mechanism of neurons. Nerve tissues are conductive; an ultrasonic wave can move ions embedded in the tissue in a static magnetic field to generate an electric field（due to Lorentz force）.In this study, a simulation model for an ultrasonically induced electric field in a static magnetic field is derived. Then,based on the passive cable model, the analytical solution for the voltage distribution in a nerve tissue is determined. The simulation results showthat THS can generate a voltage to stimulate neurons. Because the THS method possesses a higher spatial resolution and a deeper penetration depth, it shows promise as a tool for treating or rehabilitating neuropsychiatric disorders.

关键词： Hall-effect stimulation passive cable model neurons