检索结果-南通市图书馆

Prenatal amoxicillin exposure induces developmental toxicity in fetal mice and its characteristics

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第3期137卷 287-301页

作者： Yongguo dai Yu peng Wen Hu Yi Liu Hui Wang Department of Pharmacology Wuhan University School of Basic Medical SciencesWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan 430071China

Amoxicillin,a widely used antibiotic in human and veterinary pharmaceuticals,is now considered as an“emerging contaminant”because it exists widespreadly in the environment and brings a series of adverse ***,systematic studies about the developmental toxicity of amoxicillin are still *** explored the potential effects of amoxicillin exposure on pregnancy outcomes,maternal/fetal serum phenotypes,and fetal multiple organ development in mice,at different doses(75,150,300 mg/(kg·day))during late-pregnancy,or at a dose of 300 mg/(kg·day)during different stages(mid-/latepregnancy)and courses(single-/multi-course).Results showed that prenatal amoxicillin exposure(PAmE)had no significant infuence on the body weights of dams,but it could inhibit the physical development and reduce the survival rate of fetuses,especially during the ***,PAmE altered multiple maternal/fetal serum phenotypes,especially in *** multi-organ function results showed that PAmE inhibited testicular/adrenal steroid synthesis,long bone/cartilage and hippocampal development,and enhanced ovarian steroid synthesis and hepatic glycogenesis/lipogenesis,and the order of severity might be gonad(testis,ovary)>liver>*** analysis found that PAmE-induced multiorgan developmental and functional alterations had differences in stages,courses and fetal gender,and the most obvious changes might be in high-dose,late-pregnancy and multicourse,but there was no typical rule of a dose-response *** conclusion,this study confirmed that PAmE could cause abnormal development and multi-organ function alterations,which deepens our understanding of the risk of PAmE and provides an experimental basis for further exploration of the long-term harm.

关键词： Amoxicillin Prenatal exposure Fetal development Organ function Developmental toxicity

Micro-macro evolution of mechanical behaviors of thermally damaged rock:A state-of-the-art review

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2833-2853页

作者： Yunmin Wang Jun peng Linfei Wang Chuanhua Xu Bibo dai State Key Laboratory of Safety and Health for Metal Mines Sinosteel Maanshan General Institute of Mining Research Co.Ltd.Maanshan243000China

The influence of thermal damage on macroscopic and microscopic characteristics of different rocks has received much attention in the field of rock *** the rocks are subjected to thermal treatment,the change of macroscopic characteristics and evolution of micro-structure would be induced,ultimately resulting in different degrees of thermal damage in *** better understand the thermal damage mechanism of different rocks and its effect on the rock performance,this study reviews a large number of test results of rock specimens experiencing heating and cooling treatment in the ***,the variations of macroscopic behaviors,including physical parameters,mechanical parameters,thermal conductivity and permeability,are *** variations of mechanical parameters with thermal treatment variables(*** or the number of thermal cycles)are divided into four ***,several measuring methods for microstructure,such as polarizing microscopy,fluorescent method,scanning electron microscopy(SEM),X-ray computerized tomography(CT),acoustic emission(AE)and ultrasonic technique,are ***,the effect of thermal damage on the mechanical parameters of rocks in response to different thermal treatments,involving temperature magnitude,cooling method and thermal cycle,are ***,the limitations and prospects for the research of rock thermal damage are proposed.

关键词： Thermal damage Macroscopic characteristics Microstructure evolution Temperature magnitude Cooling method Thermal cycle

The tail risk safe haven property of China's energy futures against US market implied volatility

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Management Science and Engineering 2024年第2期9卷 271-291页

作者： Xingyu dai peng-Fei dai Qunwei Wang Zhi-Yi Ouyang College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing211106China Research Center for Soft Energy Science Nanjing University of Aeronautics and AstronauticsNanjing211106China School of Management Wuhan University of TechnologyWuhan430070China Research Institute of Digital Governance and Management Decision Innovation Wuhan University of TechnologyWuhan430070China Huafu Fund Management Co. Ltd.ShanghaiChina

This paper analyses the tail risk contagion of US market implied volatility(USIV)on China's energy futures(CEF)markets,exploring how to utilize operations in the CEF to achieve a safe *** CEF characteristics to simultaneously take both long-/short-positions and engage in long-/short-run investment horizons,this paper defines eight different CEF safe haven attributes to counteract the tail risk of extreme increases in *** trading data from March 27,2018,to October 30,2023,the empirical results show that,first,in the analysis of the entire sample period,China's coking coal futures can serve as a weak safe haven,aiding long-position investors in mitigating the tail risks associated with US gold and stock market implied *** coal futures also assist short-position investors in countering US stock market implied volatility tail ***,in the sub-period analysis,the safe haven attributes of CEF exhibit strong heterogeneity and asymmetry across different ***,the time span during which CEF exhibits a particular safe haven attribute does not persist for an extended period.

关键词： China's energy futures Safe havenImplied volatility Multi-timescale analysis Cross-quantilogram model

Distribution of per-and polyfluoroalkyl substances in blood,serum,and urine of patients with liver cancer and associations with liver function biomarkers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第5期139卷 418-427页

作者： Cao dai Lin peng Yanjie Li Zhendong Li Da Chen Fei Wang Nan Lin Department of Hepatobiliary Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China School of Environment Guangdong Key Laboratory of Environmental Pollution and HealthJinan UniversityGuangzhou 510632China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China South China Institute of Environmental Sciences MEEGuangzhou 510655China

Studies have shown that per-and polyfluoroalkyl substances(PFASs)may be hepatotoxic in animals or ***,data on clinical epidemiology are very *** this study,21PFASs were determined in patients with liver diseases,with the highest median concentrations detected in the serum sample(26.7 ng/mL),followed by blood(10.7 ng/mL)and urine(5.02 ng/mL).Higher total PFAS concentrations were found in hepatocellular carcinoma(HCC)patients compared to non-HCC patients,with significant discrepancies in serum and blood ***,significant correlations were also found among PFAS concentrations and age,gender,body mass index(BMI),and liver function biomarkers *** example,PFAS concentrations are significantly higher in males than in females;Several serum PFASs concentrations increase with age and BMI,while the serum perfluorohexane sulfonic acid(PFHxS)concentrations are negatively correlated with *** addition,multiple regression models adjusted for age,gender and BMI found that increased serum perfluorobutane sulfonic acid(PFBS),perfluoroheptane sulfonic acid(PFHpS)and perfluorohexylphosphonic acid(PFHxPA)conentrations are correlated with elevated alkaline phosphatase(ALP),aspartate aminotransferase(AST),and alpha-fetoprotein(AFP)(p<0.05).Our results provide epidemiological support for the future study on the potential clinical hepatotoxicity of PFAS.

关键词： Per-and polyfluoroalkyl substances(PFASs) Liver cancer Serum Blood Urine Liver function biomarkers

Heat transfer enhanced inorganic phase change material compositing carbon nanotubes for battery thermal management and thermal runaway propagation mitigation

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第2期89卷 226-238,I0006页

作者： Xinyi dai Ping Ping Depeng Kong Xinzeng Gao Yue Zhang Gongquan Wang Rongqi peng Center for Offshore Engineering and Safety Technology China University of Petroleum(East China)Qingdao 266580ShandongChina College of Chemistry and Chemical Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina

Developing technologies that can be applied simultaneously in battery thermal management(BTM)and thermal runaway(TR)mitigation is significant to improving the safety of lithium-ion battery *** phase change material(PCM)with nonflammability has the potential to achieve this dual *** study proposed an encapsulated inorganic phase change material(EPCM)with a heat transfer enhancement for battery systems,where Na_(2)HPO_(4)·12._(2)O was used as the core PCM encapsulated by silica and the additive of carbon nanotube(CNT)was applied to enhance the thermal *** microstructure and thermal properties of the EPCM/CNT were analyzed by a series of characterization *** different incorporating methods of CNT were compared and the proper CNT adding amount was also *** preparation,the battery thermal management performance and TR propagation mitigation effects of EPCM/CNT were further investigated on the battery *** experimental results of thermal management tests showed that EPCM/CNT not only slowed down the temperature rising of the module but also improved the temperature uniformity during normal *** peak battery temperature decreased from 76℃to 61.2℃at 2 C discharge rate and the temperature difference was controlled below 3℃.Moreover,the results of TR propagation tests demonstrated that nonflammable EPCM/CNT with good heat absorption could work as a TR barrier,which exhibited effective mitigation on TR and TR *** trigger time of three cells was successfully delayed by 12.,474 and 551 s,respectively and the propagation intervals were greatly extended as well.

关键词： Inorganic phase change material Carbon nanotube Battery thermal management Thermal runaway propagation Fire resistance Encapsulation

A Multi-strategy Improved Snake Optimizer Assisted with Population Crowding Analysis for Engineering Design Problems

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第3期21卷 1567-1591页

作者： Lei peng Zhuoming Yuan Guangming dai Maocai Wang Jian Li Zhiming Song Xiaoyu Chen School of Computer Science China University of GeosciencesWuhan430074China Hubei Key Laboratory of Intelligent Geo-Information Processing China University of GeosciencesWuhan430074China China Astronautics Standards Institute Beijing100071China

Snake Optimizer(SO)is a novel Meta-heuristic Algorithm(MA)inspired by the mating behaviour of snakes,which has achieved success in global numerical optimization problems and practical engineering ***,it also has certain drawbacks for the exploration stage and the egg hatch process,resulting in slow convergence speed and inferior solution *** address the above issues,a novel multi-strategy improved SO(MISO)with the assistance of population crowding analysis is proposed in this *** the algorithm,a novel multi-strategy operator is designed for the exploration stage,which not only focuses on using the information of better performing individuals to improve the quality of solution,but also focuses on maintaining population *** boost the efficiency of the egg hatch process,the multi-strategy egg hatch process is proposed to regenerate individuals according to the results of the population crowding *** addition,a local search method is employed to further enhance the convergence speed and the local search *** is first compared with three sets of algorithms in the CEC2020 benchmark functions,including SO with its two recently discussed variants,ten advanced MAs,and six powerful CEC competition *** performance of MISO is then verified on five practical engineering design *** experimental results show that MISO provides a promising performance for the above optimization cases in terms of convergence speed and solution quality.

关键词： Snake optimizer Multi-strategy Population crowding analysis Engineering design problem

Evaluating genetic insights into ulcerative colitis and anxiety:Limitations and future directions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第37期30卷 4156-4159页

作者： Ying peng Xi-dai Long Department of Pathology The First Affiliated HospitalGuangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518000Guangdong ProvinceChina Department of Pathology The Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200000China

We reviewed the study by He et al,which investigates the genetic correlation between ulcerative colitis(UC)and anxiety using bidirectional Mendelian *** study reveals a genetic link between UC and anxiety,diverging from prior research associating higher anxiety with Crohn’s *** the study's use of large-scale genome-wide association studies data is commendable,it faces limitations such as single nucleotide polymorphism selection biases,lack of multiple testing corrections,and a reliance on European *** research should address these limitations,incorporate diverse populations,and explore psychotherapeutic interventions to improve UC management and patient outcomes.

关键词： Ulcerative colitis Anxiety Mendelian randomization Genome-wide association study Gut-brain axis Instrumental variables Genetic epidemiology Pleiotropy

Unveiling the protective role of biofilm formation on the photoaging of microplastics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Technological Sciences 2024年第10期67卷 3067-3078页

作者： ZHANG HaiYu LIU peng ZHANG JiaYu dai JiaMin ZHANG XinRui ZHANG ZiXuan JIA HanZhong Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China Ministry of AgricultureCollege of Natural Resources and EnvironmentNorthwest A&F University Key Laboratory of Organic Compound Pollution Control Engineering School of Environmental and Chemical EngineeringShanghai University

In natural water, microplastics（MPs） inevitably undergo microbial colonization to form biofilm, while the effect of biofilm formation on the photoaging of MPs remains unknown. This study systematically investigated the photoaging behavior of disposable box-derived polypropylene（PPMPs） and polystyrene（PSMPs） mediated by formed biofilm in water. After incubating in Weihe water samples for 105 d, the biofilm was validated to form in PPMPs and PSMPs, with higher formation in PSMPs. In particular, biofilm formation inhibited the photoaging of PPMPs and PSMPs, with an 11.1% and 50.6% decrease in photooxidation compared to their virgin counterparts after 20 d of ultraviolet（UV） irradiation. Moreover, the photoaging route of MPs such as the reaction priority of functional groups（e.g., C–H, C=O, and benzene ring） was altered, indicating the important role of biofilm formation in the photoaging process of MPs. The protective effect of the biofilm was mainly caused by the role of optical light filters that absorbed UV energy by sacrificing themselves. Also, as the main attacker on MPs, the production of reactive oxygen species（ROS, mainly1O2and ·OH） was inhibited by biofilm, which was mainly responsible for the decreased photoaging of MPs. This study revealed the important role of biofilm in the photoaging process of MPs and suggested a higher resistance of（micro）plastics in natural water than that in the laboratory using pure MPs, which contributed to a deeper understanding of the environmental fate and pollution of MPs.

关键词： microplastics biofilm photoaging physical shielding reactive oxygen species

From Digital Human Modeling to Human Digital Twin: Framework and Perspectives in Human Factors

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2024年第1期37卷 1-14页

作者： Qiqi He Li Li dai Li Tao peng Xiangying Zhang Yincheng Cai Xujun Zhang Renzhong Tang State Key Laboratory of Fluid Power Components and Mechatronic Systems Zhejiang UniversityHangzhou 310027China ZJU-Sunon Joint Research Center for Smart Furniture Zhejiang UniversityHangzhou 310027China PICO-Lab Bytedance Inc.Shanghai 200233China Sunon Technology Co. Ltd.Hangzhou 311215China

The human digital twin(HDT)emerges as a promising human-centric technology in Industry 5.0,but challenges remain in human modeling and *** human modeling(DHM)provides solutions for modeling and simulating human physical and cognitive aspects to support ergonomic ***,it has limitations in real-time data usage,personalized services,and timely *** emerging HDT concept offers new possibilities by integrating multi-source data and artificial intelligence for continuous monitoring and ***,this paper reviews the evolution from DHM to HDT and proposes a unified HDT framework from a human factors *** framework comprises the physical twin,the virtual twin,and the linkage between these *** virtual twin integrates human modeling and AI engines to enable model-data-hybrid-enabled *** can potentially upgrade traditional ergonomic methods to intelligent services through real-time analysis,timely feedback,and bidirectional ***,the future perspectives of HDT for industrial applications as well as technical and social challenges are *** general,this study outlines a human factors perspective on HDT for the first time,which is useful for cross-disciplinary research and human factors innovation to enhance the development of HDT in industry.

关键词： Human digital twin Digital human modeling Human factors Human-centric technology