检索结果-南通市图书馆

Analysis of Extended Fisher-Kolmogorov Equation in 2D Utilizing the Generalized Finite Difference Method with Supplementary Nodes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第10期141卷 267-280页

作者： Bingrui ju Wenxiang sun Wenzhen Qu Yan Gu Key Laboratory of Road Construction Technology and Equipment of MOE Chang’an UniversityXi’an710018China School of Mathematics and Statistics Qingdao UniversityQingdao266071China

In this study,we propose an efficient numerical framework to attain the solution of the extended Fisher-Kolmogorov(EFK)*** temporal derivative in the EFK equation is approximated by utilizing the Crank-Nicolson *** temporal discretization,the generalized finite difference method(GFDM)with supplementary nodes is utilized to address the nonlinear boundary value problems at each time *** supplementary nodes are distributed along the boundary to match the number of boundary *** incorporating supplementary nodes,the resulting nonlinear algebraic equations can effectively satisfy the governing equation and boundary conditions of the EFK *** demonstrate the efficacy of our approach,we present three numerical examples showcasing its performance in solving this nonlinear problem.

关键词： Generalized finite difference method nonlinear extended Fisher-Kolmogorov equation Crank-Nicolson scheme

Distributed IRS-Aided DF Relaying Systems:Performance Analysis and Optimization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Communications 2024年第6期21卷 129-145页

作者： sun Qiang Qian Panpan Chen Xiaomin ju Jinjuan Wang jue Zhang Jiayi School of Information Science and Technology Nantong UniversityNantong 226019China Nantong Research Institute for Advanced Communication Technologies Nantong 226019China School of Electronic and Information Engineering Nantong Vocational UniversityNantong 226007China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China

Intelligent reflecting surface(IRS)is a newly emerged and promising paradigm to substantially improve the performance of wireless communications by constructing favorable communication channels via properly tuning massive reflecting *** paper considers a distributed IRS aided decode-and-forward(DF)relaying system over Nakagami-m fading *** on a tight approximation for the distribution of the received signalto-noise ratio(SNR),we first derive exact closed-form expressions of the outage probability,ergodic capacity,and energy efficiency for the considered ***,we propose the optimal IRS configuration considering the energy efficiency and pilot ***,we compare the performance between the distributed IRS-aided DF relaying and multi-IRS-only systems,and verify the analytical results by using monte carlo simulations.

关键词： configuration energy efficiency ergodic capacity intelligent reflecting surface IRS outage probability

Measuring drug similarity using drug–drug interactions

在线全文

学校读者我要写书评

暂无评论

Quantitative Biology 2024年第2期12卷 164-172页

作者： Ji Lv Guixia Liu Yuan ju Houhou Huang Ying sun College of Computer Science and Technology Jilin UniversityChangchunChina Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin UniversityChangchunChina Sichuan University Library Sichuan UniversityChengduChina College of Chemistry Jilin UniversityChangchunChina Department of Respiratory Medicine The First Hospital of Jilin UniversityChangchunChina

Combination therapy is a promising approach to address the challenge of antimicrobial resistance,and computational models have been proposed for predicting drug–drug *** existing models rely on drug similarity measures based on characteristics such as chemical structure and the mechanism of *** this study,we focus on the network structure itself and propose a drug similarity measure based on drug–drug interaction *** explore the potential applications of this measure by combining it with unsupervised learning and semi-supervised learning *** unsupervised learning,drugs can be grouped based on their interactions,leading to almost monochromatic group–group *** addition,drugs within the same group tend to have similar mechanisms of action(MoA).In semi-supervised learning,the similarity measure can be utilized to construct affinity matrices,enabling the prediction of unknown drug–drug *** method exceeds existing approaches in terms of ***,our experiments demonstrate the effectiveness and practicability of the proposed similarity *** the one hand,when combined with clustering algorithms,it can be used for functional annotation of compounds with unknown *** the other hand,when combined with semi-supervised graph learning,it enables the prediction of unknown drug–drug interactions.

关键词： drug similarity drug–drug interactions drug combinations synergy effect clustering semi-supervised learning

Protein Arginine Methyltransferase 1.Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

在线全文

学校读者我要写书评

暂无评论

Research 2024年第1期2023卷 637-649页

作者： Hyun-Kyung So Hyebeen Kim Jinwoo Lee Chang-Lim You Chae-Eun Yun Hyeon-ju Jeong Eun-ju Jin Yunju Jo Dongryeol Ryu Gyu-Un Bae Jong-sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1.Prmt1.in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1.in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1.mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1.deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1.inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1.ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1.is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

SIRT1.inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress in vitro and in vivo

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第7期17卷 1205-1216页

作者： Hui Cui Di sun Sheng Meng Tian-ju Ma Zi Ye Zhao-Hui Li Medical School of Chinese PLA Beijing 100089China Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China

AIM:To explore the effect of silent information regulator factor 2-related enzyme 1.SIRT1.on modulating apoptosis of human lens epithelial cells(HLECs)and alleviating lens opacification of rats through suppressing endoplasmic reticulum(ER)***:HLECs(SRA01.04)were treated with varying concentrations of tunicamycin(TM)for 24h,and the expression of SIRT1.and C/EBP homologous protein(CHOP)was assessed using real-time quantitative polymerase chain reaction(RT-PCR),Western blotting,and *** morphology and proliferation was evaluated using an inverted microscope and cell counting kit-8(CCK-8)assay,*** the SRA01.04 cell apoptosis model,which underwent siRNA transfection for SIRT1.knockdown and SRT1.20 treatment for its activation,the expression levels of SIRT1.CHOP,glucose regulated protein 78(GRP78),and activating transcription factor 4(ATF4)were *** potential reversal of SIRT1.knockdown effects by 4-phenyl butyric acid(4-PBA;an ER stress inhibitor)was *** vivo,age-related cataract(ARC)rat models were induced by sodium selenite injection,and the protective role of SIRT1.activated by SRT1.20 intraperitoneal injections,was evaluated through morphology observation,hematoxylin and eosin(H&E)staining,Western blotting,and ***:SIRT1.expression was downregulated in TMinduced SRA01.04 ***,in SRA01.04 cells,both cell apoptosis and CHOP expression increased with the rising doses of *** stress was stimulated by TM,as evidenced by the increased GRP78 and ATF4 in the SRA01.04 cell apoptosis *** of SIRT1.by siRNA knockdown increased ER stress activation,whereas SRT1.20 treatment had opposite results.4-PBA partly reverse the adverse effect of SIRT1.knockdown on *** vivo,SRT1.20 attenuated the lens opacification and weakened the ER stress activation in ARC rat ***:SIRT1.plays a protective role against TM-induced apoptosis in HLECs and slows the progression of cataract in

关键词： silent information regulator factor 2-related enzyme 1 endoplasmic reticulum stress apoptosis human lens epithelial cells cataract

Styrax japonicus functional genomics:an efficient virus induced gene silencing(VIGS)system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticultural Plant Journal 2024年第1期10卷 252-258页

作者： Gangyu sun Yiqian ju Cuiping Zhang Lulu Li Xinqiang Jiang Xiaoman Xie Yizeng Lu Kuiling Wang Wei Li College of Landscape Architecture and Forestry Qingdao Agricultural UniversityQingdaoShandong 266109China Shandong Provincial Center of Forest and Grass Germplasm Resources JinanShandong 250102China

VIGS(Virus-induced gene silencing),a method for posttranscriptional gene silencing,is an effective technique for investigating the activities of genes in *** there is no report for available VIGS system in Styrax japonicus,the application of a VIGS approach that results in a gene knockdown to study gene function is *** this study,we compared the characteristics that could affect the viability of VIGS in ***,including the acetosyringone(AS)concentration,the Agrobacterium’s optical density and the inoculation *** stable reference genes of *** were selected to validate the gene’s knockdown by quantitative *** a result,we successfully constructed 2 VIGS systems based on TRV virus:vacuum with AS concentration of 200μmol·L^(-1.and OD600of 0.5,and friction-osmosis with AS concentration of 200μmol·L^(-1.and OD600of 1.0,which silencing efficiency was 83.33%and 74.1.%,*** successfully applied VIGS method provides a rapid and effective reverse gene functional analysis approach in *** to identify unknown gene functions.

关键词： Styrax japonicus VIGS Reference gene

Clinical analysis of patients with deep sternal wound infection-induced sepsis:a retrospective cohort study

在线全文

学校读者我要写书评

暂无评论

Emergency and Critical Care Medicine 2024年第2期4卷 67-73页

作者： Bin Song Zhentian Cui Hongyan ju Yue sun Dandan Liu Guanggang Li Department of Critical Care 7th Medical Center of Chinese PLA General HospitalBeijingChina Department of Cardiac and Macrovascular Surgery 7th Medical Center of Chinese PLA General HospitalBeijingChina

Background:This study aimed to summarize the clinical characteristics of patients with deep sternal wound infection-induced sepsis after median sternotomy and improve the treatment outcomes of infection-related ***:A retrospective cohort study was conducted on 21.patients with deep sternal wound infection-induced sepsis after median sternotomy who were admitted to the Department of Critical *** clinical manifestations,laboratory test results,infection control,and organ and nutritional support of the patients were summarized,and the follow-up data were ***:The primary symptoms of deep sternal wound infection-induced sepsis included dyspnea,high fever,chills,and altered state of *** test results revealed increased inflammatory markers and decreased oxygenation *** and liver function injury were observed in 8 and 4 patients,respectively;1. and 1. patients demonstrated elevated D-dimer and N-terminal Pro B type natriuretic peptide levels,*** the 8 patients whose wound secretions tested positive for bacteria,Acinetobacter baumannii and Staphylococcus aureus infections were present in 6 and 2 patients,*** of the 6 patients whose blood cultures tested positive for bacteria demonstrated Candida albicans *** patients received ventilator-assisted ventilation and 2 patients received renal replacement *** all the 21.patients,1. were cured,2 died,and 2 were ***:Postmedian sternotomy sepsis attributed to a deep sternal wound infection usually results from a preexisting *** most prominent clinical manifestation is dyspnea,which is sometimes accompanied by the impairment of organ *** prevention,proper nutrition support,and maintenance of healthy organ function are the cornerstones for successful treatment outcomes.

关键词： Clinical analysis Deep sternal wound infection Sepsis

A bacterial protein Rhp-PSP inhibits plant viral proliferation through endoribonuclease activity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第6期23卷 1967-1978页

作者： Lijie Chen Qianze Peng Xiaohua Du Weixing Zhang ju’e Cheng Shu’e sun Deyong Zhang Pin Su Yong Liu Longping Branch College of BiologyHunan UniversityChangsha 410082China State Key Laboratory of Hybrid Rice/Institute of Plant Protection Hunan Academy of Agricultural SciencesChangsha 410125China

Plant virus causes massive crop losses ***,there is currently no effective measure to control plant viral ***,we identify an antiviral protein Rhp-PSP,produced by the bacterial Rhodopseudomonas palustris strain *** this study,we discover that the antiviral activity of Rhp-PSP relies on its endoribonuclease *** the arginine(R)residue at position 1.9 onto alanine(A)abolishs its endoribonuclease activity on coat protein(CP)RNA of tobacco mosaic virus(TMV),consequentially,compromises the antiviral activity of *** investigation demonstrates that,the mutant Rhp-PSP^(R1.9A)is unable to form the homotrimer as the wild type,indicating the importance of quaternary junction for the endoribonuclease *** of Rhp-PSP in Nicotiana benthamiana significantly enhances the resistance against TMV of seedlings,while expression of Rhp-PSP^(R1.9A)did not,confirming that endoribonuclease activity is responsible for the antiviral activity of *** addition,foliar spray of Rhp-PSP solution on tomato and pepper plants significantly reduces the disease index of viral diseases,indicating that Rhp-PSP shows potential to develop antiviral agent in practice.

关键词： Rhodopseudomonas palustris Rhp-PSP tobacco mosaic virus endoribonuclease antiviral activity

TransCell:In Silico Characterization of Genomic Landscape and Cellular Responses by Deep Transfer Learning

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2024年第2期22卷 157-170页

作者： Shan-ju Yeh Shreya Paithankar Ruoqiao Chen Jing Xing Mengying sun Ke Liu Jiayu Zhou Bin Chen Department of Pediatrics and Human Development Michigan State UniversityGrand RapidsMI 49503USA Department of Pharmacology and Toxicology Michigan State UniversityGrand RapidsMI 49503USA Department of Computer Science and Engineering Michigan State UniversityEast LansingMI 48824USA

Gene expression profiling of new or modified cell lines becomes routine today;however,obtaining comprehensive molecular characterization and cellular responses for a variety of cell lines,including those derived from underrepresented groups,is not trivial when resources are *** gene expression to predict other measurements has been actively explored;however,systematic investigation of its predictive power in various measurements has not been well ***,we evaluated commonly used machine learning methods and presented TransCell,a two-step deep transfer learning framework that utilized the knowledge derived from pan-cancer tumor samples to predict molecular features and *** these models,TransCell had the best performance in predicting metabolite,gene effect score(or genetic dependency),and drug sensitivity,and had comparable performance in predicting mutation,copy number variation,and protein ***,TransCell improved the performance by over 50%in drug sensitivity prediction and achieved a correlation of 0.7 in gene effect score ***,predicted drug sensitivities revealed potential repurposing candidates for new 1.0 pediatric cancer cell lines,and predicted gene effect scores reflected BRAF resistance in melanoma cell ***,we investigated the predictive power of gene expression in six molecular measurement types and developed a web portal(http://***/transcell/)that enables the prediction of 352,000 genomic and cellular response features solely from gene expression profiles.

关键词： Genomics Transcriptomics Cancer dependency Drug repurposing Transfer learning