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Flavonoid extracts from chrysanthemum with appropriate anthocyanins turn blue when exposed to iron ions

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Horticultural Plant Journal 2024年第3期10卷 837-852页

作者： Yanfei Li Jiaying Wang Chenfei Lu Zhongman Wang Chengyan Deng Kang Gao jingjing Li Zhijun Fang Hao liu Yan Hong Silan Dai Beijing Key Laboratory of Ornamental Plants Germplasm Innovation&Molecular Breeding National Engineering Research Center for FloricultureBeijingLaboratory of Urban and Rural Ecological EnvironmentKey Laboratory for Genetics and Breeding of Forest Trees and Ornamental Plants of Ministry of EducationSchool of Landscape ArchitectureBeijing Forestry UniversityBeijing 100083China Beijing Greenland Maintenance and Management Service Center Beijing 102211China Beijing North Asia Landscape Co. Beijing 102211China

Although some species that accumulate only cyanidin(Cy)in nature can produce blue flowers through iron ions,there has been no evidence of blue chrysanthemums being generated in this *** study revealed that flavonoid extracts from the ray florets of the chrysanthemum cultivar‘Wandai Fengguang’turned blue when exposed to Fe^(3+).Samples that could turn blue were labeled as CB(Cy-determined blue flowers),while samples that did not turn blue were labeled as CN(Cy-determined non-blue flowers).After a series of experiments,a stable screening system was established using flavonoid extracts containing NaAc buffer at pH 5.5 and a total anthocyanin concentration(TAC)of 30 μmol·L^(-1.,and the addition of Fe^(3+)from 0 to 0.25 μmol·L^(-1.allowed for the selection of five CB samples from 39 chrysanthemum *** five CB samples exhibited flower color phenotypes that belonged to Cluster-I with redness(a*)values ranging from 29.03 to 45.99,yellowness(b*)values from-1..31.to 3.77,and brightness(L*)values from 29.07 to ***,the ratio of TAC to total luteolin concentration(TLC)was found to be a critical factor for distinguishing between CB and CN *** realize the desired blue hue in the flavonoid extracts with the participation of Fe^(3+),a TAC to TLC ratio of 2.25 and above is ***,the protoplasts and ray florets of CB samples that turned blue with the involvement of Fe^(2+)showed great potential for cultivating blue chrysanthemums through ferric-anthocyanin ***,this study reveals that blue flowers can be cultivated through the increase in the iron ion concentration,combined with the accumulation of Cy.

关键词： Chrysanthemum×morifolium Cyanidin Copigment Ferric-anthocyanin chelate Blue flower

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1.dendritic cell(cDC1.activation and tumor infiltration

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2804-2818页

作者： Fenglian He Zhongen Wu Chenglong liu Yuanyuan Zhu Yan Zhou Enming Tian Rina Rosin-Arbesfeld Dehua Yang Ming-Wei Wang Di Zhu Department of Pharmacology Minhang Hospitaland Key Laboratory of Smart Drug DeliveryShanghai Engineering Research Center of Immune TherapySchool of PharmacyFudan UniversityShanghai 201203China The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of Sciences(CAS)Shanghai 201203China Department of Microbiology and Immunology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources SanyaChina Department of Chemistry School of ScienceThe University of TokyoTokyoJapan Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education School of PharmacyHainan Medical UniversityHaikouChina Shandong Academy of Pharmaceutical Science JinanChina

Conventional type 1.dendritic cells(cDC1.are the essential antigen-presenting DC subset in antitumor *** B-cell lymphoma 9 and B-cell lymphoma 9-like(BCL9/BCL9L)inhibits tumor growth and boosts immune responses against ***,whether oncogenic BCL9/BCL9L impairs antigen presentation in tumors is still not completely ***,we show that targeting BCL9/BCL9L enhanced antigen presentation by stimulating cDC1.activation and infiltration into *** inhibition of BCL9/BCL9L with a novel inhibitor hsBCL9z96 or Bcl9/Bcl9l knockout mice markedly delayed tumor growth and promoted antitumor CD8^(+)T cell ***,targeting BCL9/BCL9L promoted antigen presentation in *** is due to the increase of cDC1.activation and tumor infiltration by the XCL1.XCR1.***,using single-cell transcriptomics analysis,we found that Bcl9/Bcl9l deficient cDC1.were superior to wild-type(WT)cDC1.at activation and antigen presentation via NF-κB/IRF1.***,we demonstrate that targeting BCL9/BCL9L plays a crucial role in cDC1.modulated antigen presentation of tumor-derived antigens,as well as CD8^(+)T cell activation and tumor *** BCL9/BCL9L to regulate cDC1.function and directly orchestrate a positive feedback loop necessary for optimal antitumor immunity could serve as a potential strategy to counter immune suppression and enhance cancer immunotherapy.

关键词： immunity Targeting markedly

ZmCYP90D1.regulates maize internode development by modulating brassinosteroid-mediated cell division and growth

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The Crop Journal 2024年第1期12卷 58-67页

作者： Canran Sun Yang liu Guofang Li Yanle Chen Mengyuan Li Ruihua Yang Yongtian Qin Yongqiang Chen Jinpeng Cheng Jihua Tang Zhiyuan Fu Key Laboratory of Wheat and Maize Crops Science/Collaborative Innovation Center of Henan Grain Crops/College of Agronomy Henan Agricultural UniversityZhengzhou 450046HenanChina The Shennong Laboratory Zhengzhou 450002HenanChina Hebi Academy of Agricultural Sciences Hebi 458030HenanChina Yunnan Tang Jihua Expert Workstation/Zhaotong Academy of Agricultural Sciences Zhaotong 657000YunnanChina

Plant height(PH)is associated with lodging resistance and planting density,which is regulated by a complicated gene *** this study,we identified a spontaneous dwarfing mutation in maize,m30,with decreased internode number and length but increased internode diameter.A candidate gene,ZmCYP90D1.which encodes a member of the cytochrome P450 family,was isolated by map-based ***90D1.was constitutively expressed and showed highest expression in basal internodes,and its protein was targeted to the nucleus.A G-to-A substitution was identified to be the causal mutation,which resulted in a truncated protein in *** of function of ZmCYP90D1.changed expression of hormoneresponsive genes,in particular brassinosteroid(BR)-responsive genes which is mainly involved in cell cycle regulation and cell wall extension and modification in *** concentration of typhasterol(TY),a downstream intermediate of ZmCYP90D1.in the BR pathway,was reduced.A haplotype conferring dwarfing without reducing yield was ***90D1.was inferred to influence plant height and stalk diameter via hormone-mediated cell division and cell growth via the BR pathway.

关键词： Maize ZmCYP90D1 BR biosynthesis Dwarf plant

METTL1.promotes colorectal cancer cell proliferation by attenuating CHEK2-induced G1.S phase arrest

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Genes & Diseases 2024年第2期11卷 579-581页

作者： Houxiang Jiang Ying liu Huibin Song Jinquan Xia Ying Tian Luolin Wang Mingwei Li Zhenyu Xu Zhenglei Xu Chang Zou Department of Gastrointestinal Surgery The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)WuhuAnhui 241001China Anhui Province Clinical Research Center for Critical Respiratory Medicine WuhuAnhui 241001China Department of Clinical Medical Research Center The Second Clinical Medical College (Shenzhen People's Hospital) of Jinan UniversityThe First Affiliated Hospital of Southern University of Science and TechnologyShenzhenGuangdong 518020China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhouGuangdong 510632China School of Pharmacy Southwest Medical UniversityLuzhouSichuan 646000China Department of Gastroenterology Shenzhen People's Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China Precision Medicine Center The First Affiliated Hospital of Wannan Medical College(Yijishan Hospital of Wannan Medical College)WuhuAnhui 241001China School of Medicine Life and Health SciencesThe Chinese University of Hong KongShenzhenGuangdong 518172China

Colorectal carcinoma(CRC),the third most commonly diagnosed cancer,accounts for 9.7%of all newly diagnosed cancer cases and 9.4%of cancer-related deaths globally.1.Recent studies have demonstrated that post-transcriptional RNA modifications,such as N^(6)-methyladenosine,N^(5)-methylcytosine,and N^(7)-methylguanosine,play critical roles in the regulation of mRNA stability and translation,primary microRNA processing,and lncRNA-protein complex that contributes to the progression of human cancer.

关键词： cancer colorectal globally

A pH/ROS dual-responsive system for effective chemoimmunotherapy against melanoma via remodeling tumor immune microenvironment

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2263-2280页

作者： Leilei Wang Shanshan He Rong liu Yuan Xue Yuan Quan Rongying Shi Xueying Yang Qing Lin Xun Sun Zhirong Zhang Ling Zhang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Chemotherapeutics can induce immunogenic cell death(ICD)in tumor cells,offering new possibilities for cancer ***,the efficiency of the immune response generated is insufficient due to the inhibitory nature of the tumor microenvironment(TME).Here,we developed a pH/reactive oxygen species(ROS)dual-response system to enhance chemoimmunotherapy for *** system productively accumulated in tumors by specific binding of phenylboronic acid(PBA)to sialic acids(SA).The nanoparticles(NPs)rapidly swelled and released quercetin(QUE)and doxorubicin(DOX)upon the stimulation of tumor microenvironment(TME).The in vitro and in vivo results consistently demonstrated that the NPs improved anti-tumor efficacy and prolonged survival of mice,significantly enhancing the effects of the *** study revealed DOX was an ICD inducer,stimulating immune responses and promoting maturation of dendritic cells(DCs).Additionally,QUE served as a TME regulator by inhibiting the cyclooxygenase-2(COX2)-prostaglandin E2(PGE2)axis,which influenced various immune cells,including increasing cytotoxic T cells(CLTs)infiltration,promoting M1.macrophage polarization,and reducing regulatory T cells(Tregs)*** combination synergistically facilitated chemoimmunotherapy efficacy by remodeling the immunosuppressive *** work presents a promising strategy to increase anti-tumor efficiency of chemotherapeutic agents.

关键词： Quercetin Nanoparticle Responsiveness Chemoimmunotherapy Tumor immune microenvironment

超高强Ti-1.Mo-2.7Nb-3Al-0.2Si钛合金的强化行为及模型

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Transactions of Nonferrous Metals Society of China 2024年第4期34卷 1136-1149页

作者：石晓辉张琪荆镇范智渊刘江林乔珺威太原理工大学材料科学与工程学院太原030024 太原理工大学机械与运载工程学院太原030024

基于XRD、OM、SEM和TEM分析,研究超高强Ti-1.Mo-2.7Nb-3Al-0.2Si钛合金的组织演变及强化行为。结果表明,位错强化和析出强化效应对该合金的屈服强度影响较大。冷轧+再结晶+冷轧+双时效组合工艺可获得1.1. MPa的最高屈服强度,这主要归因... 详细信息

基于XRD、OM、SEM和TEM分析,研究超高强Ti-1.Mo-2.7Nb-3Al-0.2Si钛合金的组织演变及强化行为。结果表明,位错强化和析出强化效应对该合金的屈服强度影响较大。冷轧+再结晶+冷轧+双时效组合工艺可获得1.1. MPa的最高屈服强度,这主要归因于显微组织中的高密度残存位错及密集而细小的次生α相。建立复合强化模型,其预测误差在1..6%以内。此外,研究发现次生α相体积分数的增加可以不断强化晶内区域,这使得沿晶断裂开始出现并逐渐占据整个断裂面。

关键词：强化模型超高强强化行为钛合金 Ti-1.Mo-2.7Nb-3Al-0.2Si

Abstraction for model checking multi-agent systems

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Frontiers of Computer Science 2011年第1期5卷 14-25页

作者： Conghua Zhou (1. chzhou@*** Bo Sun (1. Zhifeng liu (1. Jiangsu Univ Sch Comp Sci & Telecommun Engn Zhenjiang 212013 Peoples R China

Model checking multi-agent systems （MAS） always suffers from the state explosion problem. In this paper we focus on an abstraction technique which is one of the major methods for overcoming this problem. For a multi-agent system, we present a novel abstraction procedure which reduces the state space by collapsing the global states in the system. The abstraction is automatically computed according to the property to be verified. The resulting abstract system simulates the concrete system, while the universal temporal epistemic properties are preserved. Our abstraction is an over-approximation. If some universal temporal epistemic property is not satisfied, then we need to identify spurious counterexamples. We further show how to reduce complex counterexamples to simple structures, i.e., paths and loops, such that the counterexamples can be checked and the abstraction can be refined efficiently. Finally, we illustrate the abstraction technique with a card game.

关键词： model checking abstraction refinement,epistemic temporal logic

鄂尔多斯盆地东南部长7段页岩油气富集主控因素

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新疆石油地质 2024年第1期45卷 27-34页

作者：宋海强刘慧卿王敬斯尚华杨潇中国石油大学(北京)石油工程学院北京102249 陕西延长石油国际能源化工有限公司西安710061 西安石油大学地球科学与工程学院西安710065 陕西延长石油(集团)有限责任公司研究院西安710061

为明确鄂尔多斯盆地东南部长7段页岩油气富集主控因素,综合钻井、测井、岩心分析化验等资料,对研究区长7段页岩油气富集程度及其机理进行研究。页岩解析气量与烃源岩总有机碳含量呈正比,有机质含量控制页岩油气的总含量,有机质发育大量... 详细信息

为明确鄂尔多斯盆地东南部长7段页岩油气富集主控因素,综合钻井、测井、岩心分析化验等资料,对研究区长7段页岩油气富集程度及其机理进行研究。页岩解析气量与烃源岩总有机碳含量呈正比,有机质含量控制页岩油气的总含量,有机质发育大量孔隙,页岩油气以吸附态和游离态赋存于有机孔隙中。储集层孔隙结构和孔隙度影响页岩油气的含量及赋存状态,吸附油气主要赋存于微孔中,游离油气主要赋存于中孔和大孔中,但中孔中游离气含量高于大孔,而孔隙度越大,页岩中油气绝对含量越高。砂岩夹层和富有机质页岩的配置关系控制着页岩油气的富集部位,根据粉砂岩、细砂岩与页岩的关系,延长组长7段页岩油气可划分为近源和源内2类,源内又可分为砂岩与页岩互层型、页岩夹砂岩型和页岩型;下伏于富有机质页岩中的砂体和透镜状砂体油气含量最高,其次是上覆于富有机质页岩的砂体和呈舌状或指状与富有机质页岩接触的砂体。

关键词：鄂尔多斯盆地东南部延长组长7段烃源岩储集层页岩油气主控因素

Genomic selection of eight fruit traits in pear

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Horticultural Plant Journal 2024年第2期10卷 318-326页

作者： Manyi Sun Mingyue Zhang Satish Kumar Mengfan Qin Yueyuan liu Runze Wang Kaijie Qi Shaoling Zhang Wen{1. Chang Jiaming Li Jun Wu College of Horticulture State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationNanjing Agricultural UniversityNanjingJiangsu 210095China State Key Laboratory of Crop Biology College of Horticulture Science and EngineeringShandong Agricultural UniversityTai'anShandong 271018China The New Zealand Institute for Plant and Food Research Limited Private Bag 1401Havelock North 4157New Zealand Zhongshan Biological Breeding Laboratory NanjingJiangsu 210014China

Genomic selection (GS) has the potential to improve selection efficiency and shorten the breeding cycle in fruit tree breeding. In this study,we evaluated the effect of prediction methods, marker density and the training population (TP) size on pear GS for improving its performance and reducing cost. We evaluated GS under two scenarios:(1. five-fold cross-validation in an interspecific pear family;(2) independent validation. Based on the cross-validation scheme, the prediction accuracy (PA) of eight fruit traits varied between 0.33 (fruit core vertical diameter)and 0.65 (stone cell content). Except for single fruit weight, a slightly better prediction accuracy (PA) was observed for the five parametrical methods compared with the two non-parametrical methods. In our TP of 31. individuals, 2 000 single nucleotide polymorphism (SNP) markers were sufficient to make reasonably accurate predictions. PAs for different traits increased by 1..21.-46.98%when the TP size increased from 50to 1.0, but the increment was smaller (-4.1.%-33.91.) when the TP size increased from 200 to 250. For independent validation, the PAs ranged from 0.1. to 0.45 using rrBLUP method. In summary, our results showed that the TP size and SNP numbers had a greater impact on the PA than prediction methods. Furthermore, relatedness among the training and validation sets, and the complexity of traits should be considered when designing a TP to predict the test panel.

关键词： Pear Pyrus Prediction method TP size SNP marker number