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新管理主义下交叉学科组织管理的困境与出路

黑龙江高教研究 2024年第3期42卷 76-83页

作者：包开鑫浙江师范大学浙江金华321004

当前阶段交叉学科组织发展缓慢,组织管理处于探索期。优化组织管理,解决组织管理环境及其面临的管理难题,需要我们重新反思新管理主义式的交叉组织管理模式。新管理主义已经成为高校的一种治理模式。新管理主义主导下的市场化治理模式... 详细信息

当前阶段交叉学科组织发展缓慢,组织管理处于探索期。优化组织管理,解决组织管理环境及其面临的管理难题,需要我们重新反思新管理主义式的交叉组织管理模式。新管理主义已经成为高校的一种治理模式。新管理主义主导下的市场化治理模式并非完全适用于交叉学科组织,甚至阻碍学科交叉。交叉学科组织管理的困境主要体现在量化考核阻碍交叉学科研究成果的产出、结果导向妨碍交叉学科研究过程的尝试、择优配置滞碍交叉学科研究规模的扩大。交叉学科组织治理要摆脱新管理主义的束缚,更好地服务学科交叉的研究,可以采用考核评估指标多元化、组织管理制度灵活化、学术资源配置稳定化策略。

关键词：新管理主义高校内部治理交叉学科组织学科交叉

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家校命运共同体构建逻辑与实现路径

教学与管理 2024年第19期 1-6页

作者：王甲龙宝新陕西师范大学教育学部西安710062

构建家校命运共同体是对家校合作关系的最高级别的价值体认和精神追求。从新时代家校命运共同体的构建逻辑分析,家校命运共同体由指向家校能力共进的发展共同体、追求家校义利统一的利益共同体、实现家校情理共融的情感共同体、形成家... 详细信息

构建家校命运共同体是对家校合作关系的最高级别的价值体认和精神追求。从新时代家校命运共同体的构建逻辑分析,家校命运共同体由指向家校能力共进的发展共同体、追求家校义利统一的利益共同体、实现家校情理共融的情感共同体、形成家校权责共担的责任共同体构成。新时代家校命运共同体的建设需要通过坚持发展共赢,建立共勉共进的进阶机制来提升家校共育能力;凸显利益共生,达成共生共荣的价值共识来激发家校共育动力;重视情感共鸣,营造情理交融的情感氛围来增强家校共育活力;强化责任共担,夯实多元参与的责任主体来提高家校共育效力,进而推动家校命运共同体的健康发展。

关键词：家校命运共同体家校共育协同育人教育高质量发展

Targeting the chromatin structural changes of antitumor immunity

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Journal of Pharmaceutical Analysis 2024年第4期14卷 460-482页

作者： Nian-nian Li Deng-xing Lun Ningning Gong Gang Meng xin-ying Du He Wang Xiangxiang bao xin-yang Li Ji-wu Song Kewei Hu Lala Li Si-ying Li Wenbo Liu Wanping Zhu Yunlong Zhang Jikai Li Ting Yao Leming Mou Xiaoqing Han Furong Hao Yongcheng Hu Lin Liu Hongguang Zhu Yuyun Wu Bin Liu Weifang People's Hospital WeifangShandong261000China School of Life Sciences Nankai UniversityTianjin300071China Weifang Traditional Chinese Medicine Hospital WeifangShandong261000China Shaanxi Key Laboratory of Sericulture Ankang UniversityAnkangShaanxi725000China Guizhou Education University Guiyang550018China Guizhou Normal University Guiyang550025China School of Medical Imaging Weifang Medical UniversityWeifangShandong261053China Department of Bone and Soft Tissue Oncology Tianjin HospitalTianjin300299China xinqiao Hospital of Army Military Medical University Chongqing400038China Teda Institute of Biological Sciences&Biotechnology Nankai UniversityTianjin300457China

Epigenomic imbalance drives abnormal transcriptional processes,promoting the onset and progression of *** defective gene regulation generally affects carcinogenesis and tumor suppression networks,tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes,which may have significant implications for the development and application of epigenetic therapy,cancer immunotherapy,and their ***,we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes,DNA methylation,histone post-translational modification,and chromatin structure in tumor immunogenicity,and introduce these epigenetic research *** emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immuno-therapy through the complex interaction between cancer epigenetics and cancer immunology.

关键词： Antitumor immunity Chromatin structural Cancer epigenetics DNA methylation Histone modification Chemotherapy

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美联储言辞沟通与中国投资者情绪

金融论坛 2024年第4期 11-22页

作者：姚登宝葛新杰安徽大学经济学院合肥230601 北京大学经济学院北京100871

本文运用词典法和大语言模型测度美联储言辞沟通和中国投资者情绪,分析美联储言辞沟通对中国投资者情绪的影响效应。结果表明:美联储言辞沟通与中国投资者情绪保持显著的正向关联,消极词汇和强弱语气词汇对投资者情绪的影响程度相对更强... 详细信息

本文运用词典法和大语言模型测度美联储言辞沟通和中国投资者情绪,分析美联储言辞沟通对中国投资者情绪的影响效应。结果表明:美联储言辞沟通与中国投资者情绪保持显著的正向关联,消极词汇和强弱语气词汇对投资者情绪的影响程度相对更强;仅有消极词汇对投资者情绪的影响存在显著的欠反应偏差,大部分词汇均对投资者情绪具备预期效应且具有显著的异质性;美联储言辞沟通对中国投资者情绪的影响效应具有非对称性,正向变动的边际效应强于负向变动;消极词汇在短期能提高投资者情绪的日内波动,而长期影响逐渐消失。

关键词：美联储言辞沟通投资者情绪文本分析关联模式影响效应

Tough Hydrogen Bonding Crosslinked Poly (3-fluorothiophene) Network via Electrosynthesis for High-performance Electrochromic Supercapacitors

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Chinese Journal of Polymer Science 2024年第11期 1749-1757页

作者： Chun-Hui Du Yu-Hua Xu Hui Li Zhi-xin Wu Han-Jun Yang Xi-Mei Liu {1.-Yang Lu Guang-Ming Nie Ge Zhang Jiangxi Key Lab of Flexible Electronics Flexible Electronics Innovation InstituteJiangxi Science & Technology Normal University Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science MOEState Key Laboratory Base of Eco-chemical EngineeringCollege of Chemistry and Molecular EngineeringQingdao University of Science and Technology

As a type of bi-functional device,electrochromic supercapacitors （EC-SCs） have attracted extensive attention in diverse applications such as flexible ***,despite recent encouraging progress,rational design and development of high-performance EC-SC materials with desirable stability remain challenging for practical ***,we propose a fluorination strategy to develop high-performance EC-SC materials with tough hydrogen bonding cross-linked intermolecular polymer network by one-step electrosynthesis of *** electrosynthesized free-standing poly（3-fluorothiophene）(PFT) films simultaneously achieve high electrochromic performance （optical contrast 42%at 560 nm with reversible color changes between purple and blue）,and good capacitance property (290 F·g-1.1.A·g-1.,as well as outstanding cyclic stability （<2%reduction after 20000 cycles）.We further demonstrate the fabrication of PFT-based flexible electrochromic supercapacitor devices （FESDs）,and the resultant devices can be used to visually monitor the energy storage state in real-time and maintain outstanding stability under mechanical distortion like *** a tough fluorination hydrogen bonding cross-linking strategy may provide a new design concept for high-performance EC-SC materials and reliable FESDs toward practical applications.

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家庭生活圈使用模式及其差异特征研究——以上海市为例

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人文地理 2024年第2期39卷 64-71,123页

作者：翟宝昕朱玮西北大学城市与环境学院西安710127 同济大学建筑与城市规划学院上海200092

生活圈规划已成为精准配置公共资源、保证居民生活质量的重要手段。既有生活圈研究与规划实践多以个人角度出发,缺乏从家庭视角考察人们使用生活圈的规律。本文基于对上海市家庭的问卷调查,考察家庭日常活动类型、时距、频率和出行方式... 详细信息

生活圈规划已成为精准配置公共资源、保证居民生活质量的重要手段。既有生活圈研究与规划实践多以个人角度出发,缺乏从家庭视角考察人们使用生活圈的规律。本文基于对上海市家庭的问卷调查,考察家庭日常活动类型、时距、频率和出行方式等特征的基础上,构建含“社区生活圈—补充生活圈—过渡生活圈—通勤生活圈”的四级家庭生活圈体系,识别出四类典型家庭生活圈使用模式,并进一步探讨不同的生命阶段、职住关系、居住区位和社区生活圈设施环境家庭的使用模式的差异特征。本文丰富了家庭视角的生活圈研究,对指导生活圈规划具有重要参考价值。

关键词：家庭生活圈使用模式社区生活圈规划上海市

A charge-assisted hydrogen-bonded organic framework with polar porosities for selective separation of o-xylene from CHaromatic isomers

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Science China Chemistry 2024年

作者： baoqiu Yu Xu Ding {1.lei Huang Xiaolin Liu Hailong Wang Hui Wu Wei Zhou Zhijie Shang Yucheng Jin Xiao Wang {1. Xiao Zongbi bao Jianzhuang Jiang Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province School of Chemistry and Chemical EngineeringGuizhou University Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials Department of Chemistry and Chemical Engineering School of Chemistry and Biological Engineering University of Science and Technology Beijing Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang University Center for Neutron Research National Institute of Standards and Technology

Porous materials have been extensively explored to facilitate the development of energy-efficient separation processes towards handling industrial ***,a microporous charge-assisted hydrogen-bonded organic framework,HOF-35,was assembled from 2,3,5,6-tetrakis（4-carboxyphenyl）pyrazine with dimethylamine formed from the decomposition of N,N-dimethylformamide under solvothermal *** crystal X-ray diffraction （SCXRD） analysis reveals that HOF-35 was assembled from divalent H2L2-anions and dimethylammonium cations via hydrogen bonding *** single-crystal to single-crystal transformations were achieved through two-step solvent exchanges followed by a desolvent process,resulting in the activated sample HOF-35a with a Brunauer-Emmett-Teller surface area of 464 m2g-1.ccording to CO2sorption experiment at 1.6 *** particular,HOF-35a can selectively adsorb o-xylene over m-xylene,p-xylene,and ethylbenzene on the basis of multicomponent liquid-phase adsorption *** studies disclose the exact binding sites and multiple host-guest interactions of the four C8 molecules accommodated in this ***-differential scanning calorimetry analyses further estimate the highest adsorption enthalpy for o-xylene among these four C8 molecules,accounting for its preferential adsorption in the activated HOF from a thermodynamic ***-dependent liquid-phase adsorption experiments unveil the kinetic diffusion of C8 ***,the thermodynamic effect in combination with the kinetic diffusion process synergistically promotes the above-mentioned selective separation.

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Shape and diffusion instabilities of two non-spherical gas bubbles under ultrasonic conditions

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Chinese Physics B 2024年第1期33卷 715-721页

作者：包乌日汗王德鑫 College of Physics and Electronics Inner Mongolia Minzu UniversityTongliao 028043China

Ultrasonic cavitation involves dynamic oscillation processes induced by small bubbles in a liquid under the influence of ultrasonic waves. This study focuses on the investigation of shape and diffusion instabilities of two bubbles formed during cavitation. The derived equations for two non-spherical gas bubbles, based on perturbation theory and the Bernoulli equation, enable the analysis of their shape instability. Numerical simulations, utilizing the modified Keller–Miksis equation,are performed to examine the shape and diffusion instabilities. Three types of shape instabilities, namely, Rayleigh–Taylor,Rebound, and parametric instabilities, are observed. The results highlight the influence of initial radius, distance, and perturbation parameter on the shape and diffusion instabilities, as evidenced by the R_0–P_a phase diagram and the variation pattern of the equilibrium curve. This research contributes to the understanding of multiple bubble instability characteristics, which has important theoretical implications for future research in the field. Specifically, it underscores the significance of initial bubble parameters, driving pressure, and relative gas concentration in determining the shape and diffusive equilibrium instabilities of non-spherical bubbles.

关键词： non-spherical bubble shape instability diffusive instability

Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-1. by targeting viral spike and anti-inflammation

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Journal of Pharmaceutical Analysis 2024年第1期14卷 115-127页

作者： Yang Yi Wenzhe Li Kefang Liu Heng Xue Rong Yu Meng Zhang Yang-Oujie bao {1.yuan Lai Jingjing Fan Yuxi Huang Jing Wang Xiaomeng Shi Junhua Li Hongping Wei Kuanhui Xiang Linjie Li Rong Zhang {1. Zhao Xue Qiao Hang Yang Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing100191China Yunnan Baiyao International Medical Research Center Peking UniversityBeijing100191China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterPeking UniversityBeijing100191China Hubei Jiangxia Laboratory Wuhan430000China Shenzhen Children's Hospital ShenzhenGuangdong518036China

Currently,human health due to corona virus disease 201.(COVID-1.)pandemic has been seriously *** coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)spike(S)protein plays a crucial role in virus transmission and several S-based therapeutic approaches have been approved for the treatment of ***,the efficacy is compromised by the SARS-CoV-2 evolvement and *** we report the SARS-CoV-2 S protein receptor-binding domain(RBD)inhibitor licorice-saponin A3(A3)could widely inhibit RBD of SARS-CoV-2 variants,including Beta,Delta,and Omicron BA.1.XBB and ***,A3 could potently inhibit SARS-CoV-2 Omicron virus in Vero E6 cells,with EC50 of 1.01.μ*** mechanism was related to binding with Y453 of RBD determined by hydrogen-deuterium exchange mass spectrometry(HDX-MS)analysis combined with quantum mechanics/molecular mechanics(QM/MM)***,phosphoproteomics analysis and multi fluorescent immunohistochemistry(mIHC)respectively indicated that A3 also inhibits host inflammation by directly modulating the JNK and p38 mitogen-activated protein kinase(MAPK)pathways and rebalancing the corresponding immune *** work supports A3 as a promising broad-spectrum small molecule drug candidate for COVID-1..

关键词： COVID-1. Inflammation Licorice-saponin A3 Receptor-binding domain(RBD) SARS-CoV-2