检索结果-南通市图书馆

Proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease

引用

World Journal of Pediatrics 2024年第3期20卷 259-271页

作者： yi-long Wang Meng-ying Zhu Zhe-Feng Yuan Xiao-Yan Ren Xiao-Tong Guo yi Hua Lu Xu Cong-ying Zhao Li-Hua Jiang Xin Zhang Guo-Xia Sheng Pei-Fang Jiang Zheng-Yan Zhao Feng Gao Department of Neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Children's Hospital National Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhou 310052China

Background Myelin oligodendrocyte glycoprotein(MOG)antibody-associated disease(MOGAD)is an autoimmune demy-elinating disorder of the central nervous *** Extracted proteins from 34 cerebrospinal fluid(CSF)samples[patients with MOGAD(MOG group,n=12);healthy controls(HC group,n=12);patients with MOG seronegative and metagenomics next-generation sequencing-negative inflammatory neurological diseases(IND group,n=10)]were processed and subjected to label-free quantitative *** partial least squares-discriminant analysis(PLS-DA)and orthogonal PLS-DA(O-PLS-DA)models were also performed based on proteomics *** analysis of differentially expressed proteins(DEPs)was performed using Gene Ontology,InterPro,and Kyoto Encyclopedia Genes and *** enzyme-linked immunosorbent assay was used to determine the complement levels in serum from patients with *** Four hundred and twenty-nine DEPs(149 upregulated and 280 downregulated proteins)were identified in the MOG group compared to the HC group according to the P value and fold change(FC).Using the O-PLS-DA model,872 differentially abundant proteins were identified with variable importance projection(VIP)scores>*** proteins(gamma-glutamyl hydrolase,cathepsin F,interalpha-trypsin inhibitor heavy chain 5,latent transforming growth factor beta-binding protein 4 and leukocyte-associated immunoglobulin-like receptor 1)overlapping between the top 30 DEPs with top-ranked P value and FC and top 30 proteins in PLS-DA VIP lists were *** analysis revealed that the dysregulated proteins in the MOG group were primarily involved in complement and coagulation cascades,cell adhesion,axon guidance,and glycosphingolipid biosynthesis compared to the HC *** The proteomic alterations in CSF samples from children with MOGAD identified in the current study might provide opportunities for developing novel biomarker candidates.

关键词： Acute disseminated encephalomyelitis Cerebrospinal fluid Complement cascades Myelin oligodendrocyte glycoprotein-associated disease Proteomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Extensive carbon cycle between peatland and vegetation: Insights from high net primary productivity of the Middle Jurassic in northwestern China

引用

Journal of Palaeogeography 2024年第4期13卷 1016-1028页

作者： Yang-Yang Huang Hao Liang long-yi Shao Bin Yang Baruch Spiro Jia-Min Zhou Jing Lu Tan-Guang Fan State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources College of Geoscience and Surveying Engineering China University of Mining and Technology (Beijing) Research Institute of Exploration & Development PetroChina Tuha Oilfield Company Exploration Company PetroChina Tuha Oilfield Company Department of Earth Sciences Natural History Museum School of Marine Sciences University of Haifa

Peatlands have obvious carbon storage capacity and are crucial in mitigating global climate *** the end-product of peatlands,coals have preserved a large amount of palaeoenvironmental *** carbon accumulation rate and the net primary productivity （NPP） of coal-forming peatlands can be used as proxies for recovering palaeoenvironments.A super-thick coal seam （42°35'N,91°25'E） was developed in the Middle Jurassic Xishanyao Formation in the Shaerhu coalfield in the southern margin of the Tuha （Turpan-Hami） Basin,northwestern *** this study,we use the time series analysis to identify the periods of Milankovitch orbital cycles in the Gamma-ray curve of this super-thick （124.85 m） coal and then use the obtained cycle periods of 405 ka,173 ka,44 ka,37.6 ka,22.5 ka to calculate the timeframe of the coalforming peatlands which ranges from 2703.44 to 2975.11 *** that the carbon content of the coal seam is 78.32%and the carbon loss during the coalification is about 25.80%,the carbon accumulation rate of the targeted coal seam is estimated to be 58.47-64.34 g C/m2·a,and the NPP is estimated to be252.28-277.63 g C/m2·*** main palaeoenvironmental factors controlling the NPP of peatlands are CO2content,palaeolatitude and *** reduced NPP values of the palaeo-peatlands in the Shaerhu coalfield can be attributed to the mid-palaeolatitude and/or too low atmospheric *** a certain extent,the NPP of palaeo-peatlands reflects the changes in atmospheric CO2,which can further reveal the dynamic response of the global carbon cycle to climate ***,predicting the level of NPP in the Middle Jurassic and studying the final destination of carbon in the ecosystem are beneficial to understanding the coal-forming process and palaeoenvironment.

关键词： Xishanyao Formation Super-thick coal Milankovitch cycle Carbon accumulation rate Carbon cycle

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Combined gastroscopic and laparoscopic resection of gastric metastatic adenosquamous carcinoma from lung: A case report

引用

World Journal of Gastrointestinal Surgery 2024年第9期16卷 3065-3073页

作者： yin Lin yi-long Wu Dong-Dong Zou Xiao-long Luo Shi-Yan Zhang Department of Gastroenterology Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Proctology Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

BACKGROUND Primary lung cancer is the leading cause of cancer-related death *** metastatic sites include the brain,liver,bones,and adrenal ***,gastric metastases from lung cancer are *** case may be the first report of a combined gastroscopic and laparoscopic resection for gastric metasta-tic adenosquamous carcinoma(ASC).CASE SUMMARY We report a case of gastric metastasis from lung *** patient was a 61-year-old Han Chinese female who first attended our hospital complaining of a per-sistent cough,leading to the diagnosis of advanced-stage lung *** more than four years of chemotherapy,the patient began to experience epi-gastric *** was performed,and pathological examination of biopsy specimens confirmed that the gastric lesion was a metastasis from lung *** lesion was successfully resected by combined gastroscopy and *** examination of the resected gastric specimen revealed *** Gastric metastases from lung cancer are ***,histological and immunohistochemical staining are useful for diagnosing metastatic *** management may provide extended survival in appropriately selected patients.

关键词： Primary lung cancer Gastric metastasis Endoscopic submucosal dissection Laparoscopic surgery Adenosquamous carcinoma Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Experimental study on photodegradation and leaching of typical pesticides in greenhouse soil from Shouguang, Shandong Province, East China

引用

Ecological Processes 2024年第2期 32-47页

作者： Li-Ting Hua Rui-Lin Wu Cun-Lu Li Chao-Nan Wang yi-long Li Fu-Liu Xu MOE Laboratory for Earth Surface Processes College of Urban and Envi-ronmental Sciences Peking University Department of Ecology and Environment of Shanxi Province

Background Pesticide use contributes to national food security. The dissipation pathways and degradation mecha-nisms of pesticides have been widely studied and pesticide residues have remained a focus of public concern. How-ever, studies on the migration and transformation behaviors of pesticide residues in real-world greenhouse soils are insufficient. Therefore, in this study, we collected greenhouse soil from Shouguang, Shandong Province, and investi-gated the photodegradation and leaching of 17 common pesticides, which leave residues in the soil and are the most frequently used pesticides in Shouguang. The environmental behavior of pesticides in greenhouse soils will provide new information on pesticide residues in the real environment and provide a scientific basis for the prevention and control of pesticide pollution in greenhouse *** The photodegradation of trifloxystrobin followed a first-order kinetic equation, whereas those of emamec-tin benzoate, chlorantraniliprole, buprofezin, difenoconazole, pyraclostrobin, boscalid, tebuconazole, isoprothiolane, metalaxyl, and oxadixyl followed second-order kinetics. The half-lives of 17 pesticides under light and dark conditions ranged from 2.5–104(mean: 36.2) and 2.6–110(mean: 31.4) days, respectively. The half-lives of emamectin benzoate, pyraclostrobin, and metalaxyl in the light were 86.6%, 68.5%, and 94.5% of their half-lives in the dark, respectively. Chlorantraniliprole, metalaxyl, nitenpyram, diethofencarb, acetamiprid, carbendazim, and oxadixyl were leached to ≥ 90% in aqueous solution. Six pesticides, avermectin B1A, emamectin benzoate, trifloxystrobin, difenoconazole, pyraclostrobin, and buprofezin, were difficult to leach from aqueous *** The degradation rate of some pesticides was higher in the light environment than in the dark. The leaching potential of the leachable pesticides was nitenpyram ? metalaxyl > acetamiprid > carbendazim > diethofen-carb ≈ chlorantraniliprole > iso

关键词：

来源：

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

局部一致性主动学习的源域无关开集域自适应

引用

软件学报 2024年第4期35卷 1651-1666页

作者：王帆韩忠义苏皖尹义龙山东大学软件学院山东济南250101

无监督域自适应在解决训练集(源域)和测试集(目标域)分布不一致的问题上已经取得了一定的成功.在面向低能耗场景和开放动态任务环境时,在资源约束和开放类别出现的情况下,现有的无监督域自适应方法面临着严峻的挑战.源域无关开集域自适...

无监督域自适应在解决训练集(源域)和测试集(目标域)分布不一致的问题上已经取得了一定的成功.在面向低能耗场景和开放动态任务环境时,在资源约束和开放类别出现的情况下,现有的无监督域自适应方法面临着严峻的挑战.源域无关开集域自适应(SF-ODA)旨在将源域模型中的知识迁移到开放类出现的无标签目标域,从而在无源域数据资源的限制下辨别公共类和检测开放类.现有的源域无关开集域自适应的方法聚焦于设计准确检测开放类别的源域模型或增改模型的结构.但是,这些方法不仅需要额外的存储空间和训练开销,而且在严格的隐私保护场景下难以实现.提出了一个更加实际的场景:主动学习的源域无关开集域自适应(ASF-ODA),目标是基于一个普通训练的源域模型和少量专家标注的有价值的目标域样本来实现鲁棒的迁移.为了达成此目标,提出了局部一致性主动学习(LCAL)算法.首先,利用目标域中局部特征标签一致的特点,LCAL设计了一种新的主动选择方法:局部多样性选择,来挑选更有价值的阈值模糊样本来促进开放类和公共类分离.接着,LCAL基于信息熵初步筛选出潜在的公共类集合和开放类集合,并利用第一步得到的主动标注样本对这两个集合进行匹配纠正,得到两个对应的可信集合.最后,LCAL引入开集损失和信息最大化损失来进一步促使公共类和开放类分离,引入交叉熵损失来实现公共类的辨别.在Office-31、Office-Home和VisDA-C这3个公开的基准数据集上的大量实验表明:在少量有价值的目标域样本的帮助下,LCAL不仅显著优于现有的源域无关开集域自适应方法,还大幅度超过了现有的主动学习方法的表现,在某些迁移任务上可以提升20%.

关键词：资源约束开集识别源域无关域自适应开集域自适应主动学习

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

IMpower210:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer

引用

Chinese Journal of Cancer Research 2024年第2期36卷 103-113页

作者： yi-long Wu Shun Lu Gongyan Chen Jianxing He Jifeng Feng yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian Fang Amy Cai Lilian Bu Jane Shi Jinjing Xia Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People's Hospital&Guangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China Shanghai Lung Cancer Center Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Respiration Harbin Cancer HospitalHarbin Medical UniversityHarbin 150081China Department of Thoracic Oncology and Surgery the First Affliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Medical Oncology Zhejiang Cancer HospitalHangzhou 330022China Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Medical Oncology Shenzhen HospitalCancer Hospital of Chinese Academy of Medical SciencesShenzhen 518116China Department of Thoracic Oncology Beijing Cancer HospitalBeijing 100142China Product Development Shanghai Roche Pharmaceutical LtdShanghai 201203China

Objective: IMpower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab *** as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian ***: Key eligibility criteria for this phase Ⅲ, open-label, randomized study included age ≥18 years;histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system(7th edition);Eastern Cooperative Oncology Group performance status of 0 or 1;and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2:1 to receive either atezolizumab(1,200 mg) or docetaxel(75 mg/m^(2)). The primary study endpoint was overall survival(OS) in the intention-to-treat(ITT) population with wild-type epidermal growth factor receptor expression(ITT EGFR-WT) and in the overall ITT ***: Median OS in the ITT EGFR-WT population(n=467) was 12.3 [95% confidence interval(95% CI),10.3-13.8] months in the atezolizumab arm(n=312) and 9.9(95% CI, 7.8-13.9) months in the docetaxel arm[n=155;stratified hazard ratio(HR), 0.82;95% CI, 0.66-1.03]. Median OS in the overall ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab treatment and 11.1(95% CI, 8.4-14.2) months(n=377) with docetaxel treatment(n=188;stratified HR, 0.87;95% CI, 0.71-1.08). Grade 3/4 treatment-related adverse events(TRAEs) occurred in 18.4% of patients in the atezolizumab arm and 50.0% of patients in the docetaxel ***: IMpower210 did not meet its primary efficacy endpoint of OS in the ITT EGFR-WT or overall ITT populations. Atezolizumab was comparatively more tolerable than docetaxel, with a lower incidence of grade3/4 TRAEs.

关键词： Atezolizumab East Asia non-small cell lung cancer programmed death-ligand 1 inhibitors monoclonal antibody

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients:Hepatitis B virus infection and transaminases should be considered

引用

World Journal of Hepatology 2024年第7期16卷 1018-1028页

作者： Jia-Yao Huang Jian-Yun Peng Hai-yi long Xian Zhong Yu-Hua Xie Lu Yao Xiao-Yan Xie Man-Xia Lin Department of Medical Ultrasonics The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Liver condition is a crucial prognostic factor for patients with hepatocellular carcinoma(HCC),but a convenient and comprehensive method to assess liver condition is *** stiffness(LS)measured by two-dimensional shear wave elastography may help in assessing liver fibrosis and liver *** hepatitis B(CHB)is an important risk factor for HCC progression,but LS was found to be less reliable in assessing liver fibrosis following hepatitis viral *** hypothesize that the status of hepatitis virus infection would affect the accuracy of LS in assessing the liver *** To test the feasibility and impact factors of using LS to assess liver condition in patients with HCC and *** A total of 284 patients were retrospectively recruited and classified into two groups on the basis of serum CHB virus hepatitis B virus(HBV)-DNA levels[HBV-DNA≥100.00 IU/mL as Pos group(n=200)and100.00 IU/mL as Neg group(n=84)].Correlation analyses and receiver operating characteristic analyses were conducted to evaluate the relationship between LS and liver *** A significant correlation was found between LS and most of the parameters considered to have the ability to evaluate liver condition(P0.05).When alanine aminotransferase(ALT)concentrations were normal(≤40 U/L),LS was correlated with liver condition indices(P0.05),but the optimal cutoff of LS to identify a Child-Pugh score of 5 was higher in the Neg group(9.30 kPa)than the Pos group(7.40 kPa).When ALT levels were elevated(>40 U/L),the correlations between LS and liver condition indices were not significant(P>0.05).CONCLUSION LS was significantly correlated with most liver condition indices in patients with CHB and ***,these correlations varied according to differences in HBV-DNA and transaminase concentrations.

关键词： Liver function Liver stiffness Elastography Chronic hepatitis B Hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

指向深度学习的高中数学概念课问题链教学探索

引用

教学与管理 2024年第19期 35-39页

作者：张隆亿福建省永春第一中学福建泉州362601

探讨指向深度学习的高中数学概念课问题链的教学实践,首先阐述了深度学习在高中数学教学中的重要性,以及问题链作为一种教学策略的优势;其次对问题链在高中数学概念课的教学现状与挑战进行了梳理,并在此基础上,提出了指向深度学习的高...

探讨指向深度学习的高中数学概念课问题链的教学实践,首先阐述了深度学习在高中数学教学中的重要性,以及问题链作为一种教学策略的优势;其次对问题链在高中数学概念课的教学现状与挑战进行了梳理,并在此基础上,提出了指向深度学习的高中数学概念课问题链的教学策略,包括问题链的设计原则、实施步骤以及教师角色与教学技巧。

关键词：深度学习问题链设计高中数学数学概念课

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于前期降雨指数的SCS-CN模型在三峡库区改进与应用

引用

中国农村水利水电 2024年第8期 128-135页

作者：冉玲玲龙翼中国科学院、水利部成都山地灾害与环境研究所四川成都610299 中国科学院大学北京100049

径流是土壤流失的主要载体,准确预测径流量对于三峡库区土壤侵蚀预报和水库安全管理至关重要。为优化径流曲线数模型(SCS-CN)中土壤前期含水量核算方法,提高径流模拟准确性,研究通过引入前期降雨指数来表征土壤含水量,并基于实测的土壤...

径流是土壤流失的主要载体,准确预测径流量对于三峡库区土壤侵蚀预报和水库安全管理至关重要。为优化径流曲线数模型(SCS-CN)中土壤前期含水量核算方法,提高径流模拟准确性,研究通过引入前期降雨指数来表征土壤含水量,并基于实测的土壤饱和含水量设定上限阈值,对SCS-CN模型进行了改进,利用忠县水土保持监测站2019-2022年的场次降雨径流监测数据评估了模型准确性,并对改进前后模型在不同降雨类型和土地利用条件的适用性进行评价。结果表明,在两种初始模型和两种改进模型中,基于MSCS-CN改进的模型(M4)对于径流深的模拟精度更高,纳什效率系数(NSE)较原始SCS-CN模型(M1)提高了134%,尤其是在前期土壤含水量达饱和状态的情况下NSE提升至0.74,引入最大前期降雨指数(APImax)作为前期降雨指数上限值能减弱以往模型对高径流事件预测值的高估。此外,改进模型M4对三峡库区主要的产流性降雨类型(高雨强)以及主要的土地利用(耕地、果园)适用性良好,有效提高了小雨量产流事件和高侵蚀风险土地利用类型的径流模拟精度(雨型Ⅱ的NSE为0.66,耕地、果园NSE分别为0.69和0.75)。总体而言,改进模型M4提高了径流模拟精度,更适合三峡库区的产流机制、土地利用类型,能为三峡库区径流预测及水土流失防治工作提供参考。

关键词：径流前期降雨指数 SCS-CN模型

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

基于知识创新的创新型企业品牌竞争力培育机制研究

引用

情报探索 2024年第4期 9-15页

作者：隆毅福建师范大学图书馆福建福州350007

[目的/意义]基于知识创新分析创新型企业品牌竞争力培育机制,可以较完整地解析创新型企业品牌竞争力培育的本质。[方法/过程]通过对星网锐捷1998—2022年的品牌竞争力培育过程进行嵌套式多案例分析,尝试从品牌竞争力产生的源头、过程和...

[目的/意义]基于知识创新分析创新型企业品牌竞争力培育机制,可以较完整地解析创新型企业品牌竞争力培育的本质。[方法/过程]通过对星网锐捷1998—2022年的品牌竞争力培育过程进行嵌套式多案例分析,尝试从品牌竞争力产生的源头、过程和实现目标三方面探讨创新型企业品牌竞争力培育机制。[结果/结论]创新型企业品牌竞争力培育机制包括四个子机制,其中,知识创造机制提供源动力,知识产权转化机制用于创新最终实现,创新激励机制提供管理保障,反馈机制提供推动力。这四个机制彼此独立又相互联系,影响着品牌竞争力的成长。

关键词：创新型企业品牌竞争力培育机制知识创新

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：