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橡胶工业 1991年第9期38卷 531-532页

作者：谢威扬

海藻酸钠-壳聚糖微胶囊作为肠道内生化微反应器的研究

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高等学校化学学报 2004年第7期25卷 1381-1383页

作者：于炜婷雄鹰刘袖洞王为谢威扬马小军中国科学院大连化学物理研究所生物医学材料工程组大连116023

An intestinal bio-microreactor with potential application prospect as a drug delivery system was proposed and studied. It was designed to overcome the problems such as complexity of separation and purification, and subsequent high costs, which always exist in producing genetically engineered drugs. For example, the process of separation and purification can be omitted by oral administration of genetically engineered microbes entrapped in semi-permeable membrane of microcapsules. The microencapsulated cells can live, metabolize and secrete therapeutic proteins in intestinal tract. In this paper, Pichia pastoris GS115 was selected as the model microbe, alginate-chitosan (AC) microcapsules as the carrier, and the physicochemical performance of the intestinal bio-microreactor was studied. It was found that the encapsulation efficiency of living yeast cells during the preparation of microcapsules was about 80%. It was shown that all AC microcapsules with yeast cells were kept intact in simulated gastric solution and simulated intestinal solution, and the survival of microencapsulated cells in simulated gastrointestinal solutions was 200-times higher than that of free cells, which showed that AC microcapsules can protect the activity of yeast cells. Furthermore, when being orally administered in mice, AC microcapsules could go through stomach and adhere to the surface of small intestinal mucous membrane over 12 h. Therefore, it was concluded that AC microencapsulated yeast cells could be used as intestinal bio-microreactor to secret bio-drugs in vivo directly.

关键词：海藻酸钠壳聚糖微胶囊生化微反应器基因工程酵母菌

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醋酸酯淀粉高取代度的测定

应用化学 2003年第7期20卷 687-689页

作者：戴小敏左秀锦刘袖洞谢威扬马小军中国科学院大连化学物理研究所

The acid-alkali titration method of determination of degree of substitution(DS) for starch acetates has been improved by using acetone as solvent instead of ethanol. The saponification time could be reduced from 48 h or 72 h(using ethanol as solvent) to 1 h with acetone as solvent, and the RSD also decreased. The method has advantages of rapidity and high accuracy.

关键词：醋酸酯淀粉高取代度酸碱滴定法

醋酸酯淀粉的溶解性能、形貌与XRD结构分析

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化学研究与应用 2004年第1期16卷 61-62,65页

作者：戴小敏左秀锦刘袖洞马小军谢威扬中国科学院大连化学物理研究所辽宁大连116023 大连大学化学化工系辽宁大连116622

淀粉是一种多糖类天然高分子，来源广泛，价格低廉，可生物降解并且降解产物环境友好。但天然淀粉脂溶性差、颗粒大、稳定性差、加工成型及使用受限。当分子中的羟基被亲脂基团取代后，淀粉原有的氢键将被破坏而使其脂溶性增强，同时原... 详细信息

淀粉是一种多糖类天然高分子，来源广泛，价格低廉，可生物降解并且降解产物环境友好。但天然淀粉脂溶性差、颗粒大、稳定性差、加工成型及使用受限。当分子中的羟基被亲脂基团取代后，淀粉原有的氢键将被破坏而使其脂溶性增强，同时原有的结晶区被破坏而引起淀粉聚集状态变化、颗粒尺寸减小、热稳定性增强。

关键词：醋酸酯淀粉溶解性能形貌取代度结晶性聚集状态结构分析

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氯代苯酐的合成

化工进展 2001年第10期20卷 5-8页

作者：谢威扬大伟高连勋丁孟贤中国科学院长春应用化学研究所长春130022

介绍由邻二甲苯氯代 ,再经空气氧化及异构体分离合成氯代苯酐中试规模的合成路线。氧化中采用现行商品苯酐氧化的固定床催化剂催化氧化 ,并采用 45块理论塔板的分离塔分离得到纯度大于 98%的 3 氯代苯酐和 4

关键词：氯代苯酐催化氯化氯代邻二甲苯合成

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纤维蛋白原在微胶囊表面的吸附行为

化工学报 2009年第4期60卷 929-935页

作者：谢红国李晓霞林军章谢威扬马小军中国科学院大连化学物理研究所生物医用材料工程组辽宁大连116023 中国科学院研究生院北京100039

Alginate-chitosan-alginate (ACA) microcapsules have been widely studied as devices for the immuno-isolation and transplantation of living ***, long-term survival of the micro-encapsulated cell grafts and thus their potential clinical applications are hampered by the pericapsular fibrotic overgrowth induced by adsorbed *** this study, the adsorption behavior of plasma fibrinogen (Fgn) onto ACA microcapsules was studied by using the batch *** results showed that the equilibrium time for the adsorption was 24 *** adsorption of Fgn onto ACA microcapsules fitted very well with Freundlich isotherm, which was indicative of multilayer *** kinetic experimental data correlated well with the second-order kinetic model,indicating that chemical sorption was the rate-limiting *** effects of pH and ionic strength on the adsorption were also studied to interpret the mechanism of *** was found that the amount of adsorbed Fgn decreased with increasing pH in the range of 4.9—*** pH 7.4, the amount of adsorbed Fgn increased with increasing NaCl concentration, and then decreased with further increase in NaCl *** pH 6.0, the amount of adsorbed Fgn decreased with increasing NaCl concentration, indicating that electrostatic interaction was one of the main interactions between Fgn and ACA microcapsules and the positively charged chitosans which was not sufficiently neutralized on the surface of microcapsules induced the adsorption.

关键词：微胶囊蛋白吸附纤维蛋白原

凝胶渗透色谱法研究壳聚糖生物材料酶降解过程的均匀性

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色谱 2006年第4期24卷 407-410页

作者：任东文衣洪福谢威扬马小军中国科学院大连化学物理研究所

壳聚糖是一种重要的生物医用材料,脱乙酰度是影响其生物降解性能的重要因素。运用凝胶渗透色谱研究了脱乙酰度及相对分子质量分布相似、而聚合单元N-乙酰氨基-D-葡萄糖和D-氨基葡萄糖分布不同的两种壳聚糖材料在溶菌酶作用下的降解过程... 详细信息

壳聚糖是一种重要的生物医用材料,脱乙酰度是影响其生物降解性能的重要因素。运用凝胶渗透色谱研究了脱乙酰度及相对分子质量分布相似、而聚合单元N-乙酰氨基-D-葡萄糖和D-氨基葡萄糖分布不同的两种壳聚糖材料在溶菌酶作用下的降解过程,分析检测了壳聚糖材料在降解过程中的重均相对分子质量、相对分子质量多分散性和相对分子质量分布的变化。发现聚合单元为随机分布的壳聚糖样品,其降解是均匀的;而聚合单元为段状分布的壳聚糖样品,其降解是非均匀的;表明其聚合单元的分布方式决定壳聚糖材料酶降解过程的均匀性。

关键词：凝胶渗透色谱法壳聚糖降解溶菌酶均匀性

多通道微胶囊制备系统规模化制备海藻酸钙微胶珠

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化工学报 2009年第1期60卷 204-210页

作者：朱静谢威扬于炜婷张英刘袖洞王为马小军中国科学院大连化学物理研究所辽宁大连116023 大连大学环境与化学工程学院辽宁大连116622

In this paper,calcium alginate gel beads were prepared through a homemade microcapsule preparation system with multi-nozzles under forced high-voltage electrostatic *** effect of operation parameters on the large-scale preparation of gel beads was *** results showed that the air pressure of feed was the decisive factor affecting the size and yield of gel beads,and the size distribution was dependent on several factors including the distribution of electric field,pulse potential,air pressure of feed,pulse frequency,pulse width and threshold *** gel beads with good sphericity,smooth surface and low dispersivity(CV<20%)can be prepared by adjusting and optimizing above *** is more important that the yield of gel beads by the microcapsule preparation system is 20—40 folds higher than the traditional electrostatic droplet generator,which makes it possible to realize the large-scale preparation of gel beads.

关键词：微胶囊制备系统高压静电海藻酸钠微胶珠规模化制备

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壳聚糖混合膜酶降解的FTIR分析

光谱学与光谱分析 2006年第10期26卷 1825-1828页

作者：任东文王一力包德才谢威扬马小军中国科学院大连化学物理研究所生物医学材料工程组中国科学院研究生院辽宁大连116023

生物可降解性是壳聚糖的重要性质之一,但利用傅里叶变换红外光谱(FTIR)研究降解过程中壳聚糖的变化则较少。文章制备了由高脱乙酰度壳聚糖(HDC)和中脱乙酰度壳聚糖(MDC)组成的混合膜。运用FTIR分析了壳聚糖混合膜组分变化对其红外谱图... 详细信息

生物可降解性是壳聚糖的重要性质之一,但利用傅里叶变换红外光谱(FTIR)研究降解过程中壳聚糖的变化则较少。文章制备了由高脱乙酰度壳聚糖(HDC)和中脱乙酰度壳聚糖(MDC)组成的混合膜。运用FTIR分析了壳聚糖混合膜组分变化对其红外谱图和脱乙酰度(DD)的影响,并研究了该混合膜在溶菌酶的降解作用下红外谱图和脱乙酰度的变化。发现壳聚糖混合膜材料的脱乙酰度与膜中MDC组分的比例呈线性关系;随降解的进行,混合膜的脱乙酰度增加。结果证实了溶菌酶对较低脱乙酰度壳聚糖的选择性降解作用,而且表明FTIR可用于分析壳聚糖混合膜降解过程中的化学变化。

关键词：壳聚糖膜溶菌酶降解红外光谱

铸膜液溶剂对醋酸酯型改性淀粉膜结构及性能的影响

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膜科学与技术 2005年第1期25卷 21-24页

作者：戴小敏左秀锦刘袖洞谢威扬马小军中国科学院大连化学物理研究所生物医用材料工程组

以醋酸酯型改性淀粉(简称醋酸酯淀粉)为原料,分别以二氯甲烷、三氯甲烷、丙酮和1,4-二氧六环为铸膜液溶剂,用浇铸法制备醋酸酯淀粉膜,并研究了铸膜液溶剂对膜致密性、膜结晶度、膜耐水性及膜在土壤中降解速率的影响.实验结果表明:铸膜... 详细信息

以醋酸酯型改性淀粉(简称醋酸酯淀粉)为原料,分别以二氯甲烷、三氯甲烷、丙酮和1,4-二氧六环为铸膜液溶剂,用浇铸法制备醋酸酯淀粉膜,并研究了铸膜液溶剂对膜致密性、膜结晶度、膜耐水性及膜在土壤中降解速率的影响.实验结果表明:铸膜液溶剂的挥发速度越慢,则膜的致密性越好,结晶度越高;醋酸酯淀粉膜在土壤中能降解,致密性好的膜耐水性能较好并且土壤降解速率较低.

关键词：铸膜液溶剂醋酸酯淀粉结晶度耐水性能二氯甲烷丙酮改性淀粉原料降解速率