接头蛋白RACK1在肝细胞中的缺失使小鼠抵抗爆发性肝炎（英文）
作者单位：军事医学研究院
会议名称：《第十四届全国免疫学学术大会》
会议日期：2021年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
关 键 词：RACK1 爆发性肝炎 S100A9 MDSCs
摘 要：Receptor for activated C kinase 1(RACK1),a multi-functional scaffold protein,is highly expressed in normal liver and has been implicated in liver physiology and *** the in vivo role of hepatic RACK1 in fulminant hepatitis(FH) remains ***,we report liver-specific RACK1 deficiency renders mice resistant to *** mechanism,RACK1 directly interacts with co-repressor histone deacetylase 1(HDAC1) and thereby stabilizes *** the absence of RACK1,HDAC1 is *** consequent enhanced expression of chemokine(C-X-C motif) ligand 1(CXCL1) and S100 calcium-binding protein A9(S100 A9) is associated with the accumulation of MDSCs under steady-state *** accumulated MDSCs enhance the activation of IκB kinase(IKK)/NF-κB pathway in hepatocytes through,at least partially,expressing large amount of S100 A9.