Variation of lifespan in multiple strains,and effects of dietary restriction and BmFoxO on lifespan in silkworm,Bombyx mori
作者单位：State Key Laboratory of Silkworm Genome BiologyCollege of BiotechnologySouthwest University Key Laboratory for Sericulture Functional Genomics and Biotechnology of Agricultural MinistryCollege of BiotechnologySouthwest University
会议名称：《中国蚕学会第十届青年学术研讨会》
会议日期：2019年
学科分类：090504[农学-特种经济动物饲养（含：蚕、蜂等）] 0905[农学-畜牧学] 09[农学]
关 键 词：BmFoxO Gerotarget dietary restriction experimental animal lifespan silkworm
摘 要：Established animal models have accelerated our understanding of the mechanisms involved in lifespan ***,more experimental animals are required to clarify the complex mechanisms behind the phenomena of aging and *** this study,we reported the variation of lifespan in nine distinct silkworm *** correlated significantly with BmFoxO gene expression in the representative silkworm strains tested（Xiafang,Dazao-N,and N4）.In general,the female silkworm was longer lived than the male of the same *** restriction extended the silkworm lifespan compared with that of silkworms fed ad *** expression of BmFoxO was significantly elevated in the dietary restriction group on day 3 of the 4th instar and day 3 of the 5th instar,suggesting that BmFoxO contributes to dietary restriction-mediated lifespan *** RNA interference and overexpression of the BmFoxO gene significantly shortened and extended the silkworm adulthood,*** conclusion,our findings suggest that the silkworm might serve as a promising experimental animal to explore the complex biological mechanisms of lifespan determination.