Manganese-Catalyzed C-H Cyanation of Arenes with N-Cyano-N-(4-methoxy)phenyl-p-toluenesulfonamide
作者单位：State Key Laboratory of Fine ChemicalsDalian University of Technology 大连理工大学
会议名称：《中国化学会·第十六届全国有机合成化学学术研讨会》
会议日期：2019年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
关 键 词：arenes aromatic nitriles C-H activation cyanation manganese
摘 要：Aryl nitriles are important structural motifs present in various therapeutically significant natural products and marketed drugs. Moreover,nitriles can be easily transformed to a series of functional molecules,such as benzoic acid derivatives,aldehydes,amines,and ***,the development of convenient and efficient methods for the synthesis of aryl nitriles has attracted considerable *** group reported the manganese-catalyzed C-H cyanation reactions of some heterocycles including indoles,pyrroles,and thiophenes with ***,the manganese-catalyzed C-H cyanation reaction of arenes remains a *** our work,we developed a convenient and efficient method for the synthesis of aromatic nitriles through manganese-catalyzed C-H cyanation reactions of arenas with N-cyano-N-(4-methoxy);*** optimized C-H cyanation reaction was highly functional-group-tolerant,simple for synthetically useful aromatic nitriles with ample scope,and with mild reaction conditions.