Parental renovascular hypertension-induced autonomic dysfunction in offspring is improved by prenatal or postnatal treatment with hydrogen sulfide
作者单位：Department of PhysiologyHebei Medical University Department of Laboratory DiagnosticsHebei Medical University Hebei Key Laboratory of Animal ScienceHebei Medical University Hebei Collaborative Innovation Center for Cardio-Cerebrovascular Disease Key Laboratory of Vascular Medicine of Hebei Province
会议名称：《2019年中国生理学会心血管生理学术研讨会》
会议日期：2019年
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
关 键 词：hypertension fetal programming autonomic nervous system baroreflex angiotensin Ⅱ RVLM NTS
摘 要：Increasing evidence indicates there is a strong association between parental health during pregnancy and cardiovascular diseases of adult ***,hydrogen sulfide(H S) has been demonstrated to be a powerful vasodilator of the placental vasculature and can improve intrauterine growth *** this study,we investigated whether parental hypertension induces autonomic dysfunction in adult offspring,and the HS mechanism underlying this autonomic dysfunction.2-kidney-1-clip method was employed to induce parental hypertension during pregnancy and lactation in rats,and their adult offspring in both sexes were then used to evaluate basal blood pressure(BP) and autonomic ***,either maternal hypertensive dams or their offspring after weaning were treated with HS to determine improving effects of HS on autonomic dysfunction in the *** systolic and diastolic BP was significantly increased in both male and female offspring of renovascular hypertensive dams when compared to that in offspring of normotensive *** offspring of renovascular hypertensive dams also exhibited blunted baroreflex sensitivity and increased sympathetic effect and sympathetic *** blotting analysis revealed downregulation of endogenous HS catalyzed enzyme and upregulation of angiotensin(Ang) Ⅱ/Ang Ⅱ type 1 receptor(AT1R)pathway in the nucleus tractus solitarius and rostral ventrolateral medulla,two hindbrain nuclei involved in BP and autonomic regulation,in these *** prenatal or postnatal treatment with HS improved the adverse *** results suggest that parental hypertension results in elevated BP and autonomic dysfunction in adult offspring through activation of Ang II/AT1R pathway and inhibition of endogenous H2 S production in the brain.