检索结果-南通市图书馆

Neuroscience Bulletin 2019年第1期35卷 91-97页

作者： Jin Chen He Gu Robert D.Wurster Zixi Cheng Division of Neuroscience and Division of Metabolic and Cardiovascular Sciences Burnett School of Biomedical SciencesCollege of MedicineUniversity of Central FloridaOrlandoFL 32816USA Department of Cellular and Molecular Physiology Stritch School of MedicineLoyola UniversityMaywoodIL 60153USA

Excessive reactive oxygen species(ROS)(such as the superoxide radical) are commonly associated with cardiac autonomic dysfunctions. Though superoxide dismutase 1(SOD1) overexpression may protect against ROS damage to the autonomic nervous system, superoxide radical reduction may change normal physiological functions. Previously, we demonstrated that human SOD1(hSOD1) overexpression does not change baroreflex bradycardia and tachycardia but rather increases aortic depressor nerve activity in response to arterial pressure changes in C57 B6 SJL-Tg(SOD1)2 Gur/J mice. Since the baroreflex arc includes afferent, central, and efferent components, the objective of this study was to determine whether hSOD1 overexpression alters the central and vagal efferent mediation of heart rate(HR) responses. Our data indicate that SOD1 overexpression decreased the HR responses to vagal efferent nerve stimulation but did not change the HR responses to aortic depressor nerve(ADN)stimulation. Along with the previous study, we suggest that SOD1 overexpression preserves normal baroreflex function but may differentially alter the functions of the ADN, vagal efferents, and central components. While SOD1 overexpression likely enhanced ADN function and the central mediation of bradycardia, it decreased vagal efferent control of HR.

关键词： SOD1 Parasympathetic baroreflex

维普期刊数据库

Contribution of baroreflex Afferent Pathway to NPY-Mediated Regulation of Blood Pressure in Rats

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第4期36卷 396-406页

作者： Yang Liu Shu-Yang Zhao Yan Feng Jie Sun Xiao-Long Lu Qiu-Xin Yan Ying Li Zhuo Liu Lu-Qi Wang Xun Sun Shijun Li Guo-Fen Qiao Bai-Yan Li Department of Pharmacology State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular Medicine ResearchMinistry of EducationCollege of PharmacyHarbin Medical UniversityHarbin 150081China Department of Clinical Laboratory The First Affiliated Hospital of Dalian Medical UniversityDalian 116011China Department of Pharmacology College of PharmacyDalian Medical UniversityDalian 116044China Riley Heart Center Wells Center for Pediatric ResearchIndiana University School of MedicineIndianapolisIN 46202USA

Neuropeptide Y (NPY), a metabolism-related cardiovascular factor, plays a crucial role in blood pressure(BP) regulation via peripheral and central pathways. The expression of NPY receptors (Y1R/Y2R) specific to baroreflex afferents impacts on the sexually dimorphic neural control of circulation. This study was designed to investigate the expression profiles of NPY receptors in the nodose ganglion (NG) and nucleus tractus solitary (NTS) under hypertensive conditions. To this end, rats with hypertension induced by NG-nitro-L-arginine methylester (L-NAME) or high fructose drinking (HFD), and spontaneously hypertensive rats (SHRs) were used to explore the effects/mechanisms of NPY on BP using functional, molecular, and electrophysiological approaches. The data showed that BP was elevated along with baroreceptor sensitivity dysfunction in model rats;Y1R was up-or down-regulated in the NG or NTS of male and female HFD/L-NAME groups,while Y2R was only down-regulated in the HFD groups as well as in the NG of the male L-NAME group. In SHRs,Y1R and Y2R were both down-regulated in the NTS, and not in the NG. In addition to NPY-mediated energy homeostasis, leptin-melanocortin activation may be essential for metabolic disturbance-related hypertension. We found that leptin and a-melanocyte stimulating hormone (aMSH) receptors were aberrantly down-regulated in HFD rats. In addition, a-MSH concentrations were reduced and NPY concentrations were elevated in the serum and NTS at 60 and 90 min after acute leptin infusion. Electrophysiological recordings showed that the decay time-constant and area under the curve of excitatory post-synaptic currents were decreased by Y1R activation in A-types, whereas, both were increased by Y2R activation in Ah-or C-types. These results demonstrate that sex-and afferent-specific NPY receptor expression in the baroreflex afferent pathway is likely to be a novel target for the clinical management of metabolism-related and essential hypertension.

关键词： Neuropeptide Y Hypertension Nucleus of the solitary tract Excitatory post-synaptic current baroreflex

维普期刊数据库

Anti-Hypertensive Action of Fenofibrate via UCP2 Upregulation Mediated by PPAR Activation in baroreflex Afferent Pathway

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2019年第1期35卷 15-24页

作者： Jian Guan Miao Zhao Chao He Xue Li Ying Li Jie Sun Wei Wang Ya-Li Cui Qing Zhang Bai-Yan Li Guo-Fen Qiao Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular Medicine ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China

Fenofibrate, an agonist for peroxisome proliferator-activated receptor alpha(PPAR-a), lowers blood pressure, but whether this action is mediated via baroreflex afferents has not been elucidated. In this study, the distribution of PPAR-a and PPAR-c was assessed in the nodose ganglion(NG) and the nucleus of the solitary tract(NTS). Hypertension induced by drinking high fructose(HFD) was reduced, along with complete restoration of impaired baroreceptor sensitivity, by chronic treatment with fenofibrate. The molecular data also showed that both PPAR-a and PPAR-c were dramatically up-regulated in the NG and NTS of the HFD group. Expression of the downstream signaling molecule of PPAR-a, the mitochondrial uncoupling protein 2(UCP2), was up-regulated in the baroreflex afferent pathway under similar experimental conditions, along with amelioration of reduced superoxide dismutase activity and increased superoxide in HFD *** results suggest that chronic treatment with fenofibrate plays a crucial role in the neural control of blood pressure by improving baroreflex afferent function due at least partially to PPAR-mediated up-regulation of UCP2 expression and reduction of oxidative stress.

关键词： Fenofibrate Peroxisome proliferator-activated receptor Mitochondrial uncoupling protein baroreflex afferent function Blood pressure regulation

维普期刊数据库

Blood pressure,baroreflex sensitivity,and end organ damage in hybrid offspring of spontaneously hypertensive rats and Spraque-Dawlev rats

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2005年第9期26卷 1049-1056页

作者： He-hui XIE~2 Fu-ming SHEN~2 Chao-yu MIAO Ding-feng SU~3 Department of Pharmacology,Second Military Medical University,Shanghai 200433,China DepartmentofPharmacology SecondMilitaryMedicalUniversityShanghai200433China

Aim:To investigate the blood pressure(BP),baroreflex sensitivity(BRS),andorgan damage in hybrids of spontaneously hypertensive rats and ***:Spontaneously hypertensive rats and Sprague-Dawley rats werecrossbred,and the F1hybrids were inbred randomly to produce an *** the age of 52 weeks,the F1and F2hybrids were tested to determine BP and BRSin a conscious *** examinations were carried out after BPrecording and BRS ***:BP and BRS were not different in F1and *** was inversely related to systolic BP(SBP)in male,female,or wholepopulations of ***,BRS values were one-third determined bySBP level(the determinant coefficient was 0.326).The indexes for left ventricularhypertrophy,aortic hypertrophy,and renal damage were all positively related toBP,and negatively related to *** multiple-regression analysis,left ventricularand aortic hypertrophy and glomerulosclerosis score were all most significantlyassociated with lower BRS and higher systolic *** contribution of BRS to leftventricular and aortic hypertrophy and glomerulosclerosis was greater than thatof ***:The present work with hybrid rats demonstrated quantita-tively that the BRS value was one-third determined by SBP *** BP leveland BRS value contributed greatly to the hypertensive organ ***,the contribution of BRS to the hypertensive organ damage was greater than thatof BP level in these rats.

关键词： baroreflex blood pressure end organ damage hypertension genetic hybridization

Blood pressure variability and baroreflex sensitivity are not different in spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2005年第8期26卷 959-962页

作者： Lin-shu ZHAN, Yun-feng GUAN, Ding-feng SU, Chao-yu MIAO~2 Department of Pharmacology, Second Military Medical University, Shanghai 200433, China Department of Pharmacology Second Military Medical University Shanghai 200433 China

Aim: To demonstrate and compare hemodynamic phenotypes of blood pressure (BP), blood pressure variability (BPV) and baroreflex sensitivity (BRS) in genetic hypertensive rats. Methods: BP was recorded continuously in conscious, freely moving rats using a computerized technique. BPV was expressed as the standarddeviation of beat-to-beat BP values during a 1-h period. BRS was determined by measuring the heart period prolongation in response to the elevation in BP pro-duced by an intravenous injection of phenylephrine. Results: Body weight and heart period were not different between spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHR-SP) at the age of 15 weeks. The BP level was markedly higher in SHR-SP than SHR, whereas there were no significant differences in BPV and BRS. Quantitatively, systolic, diastolic and mean BP were significantly elevated by 36.9%, 42.9% and 39.5%, respectively, in SHR-SP compared with SHR (P0.05). Conclusion: BPV and BRS were not changed in parallel with the BP alterations in SHR and SHR-SP.

关键词： blood pressure variability baroreflex hypertension genetics

Urotensin Ⅱ inhibits carotid sinus baroreflex in anesthetized male rats

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第2期28卷 216-220页

作者： Yu-ming WU Hong-mei XUE Lin XIAO Rui-rong HE~1 Department of Physiology Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,China Department of Physiology Institute of Basic Medicine Hebei Medical University Shijiazhuang China

Aim:To study the effects of urotensin Ⅱ(UⅡ)on the carotid sinus baroreflex(CSB).Methods:The functional curve of carotid sinus baroreflex was measuredby recording changes in arterial pressure in anesthetized male rats with perfusedisolated carotid ***:UⅡ at the concentration of 3 nmol/L had no effecton the CSB,while at the concentration of 30,300 and 3000 nmol/L inhibited theCSB,shifting the functional curve of the baroreflex upward and to the *** a marked decrease in peak slope and reflex decrease in blood *** of UⅡ were *** with verapamil(anantagonist of the L-type calcium channel,10 μmol/L)partially eliminated *** of UⅡ(300 nmol/L)on the *** with BIM-23127(3 μmol/L),an antagonist of human and rat UⅡ receptors,abolished the actions of UⅡ on *** with N~G-nitro-L-arginine methyl ester(L-NAME)100 μmol/L didnot affect the inhibitory effects of UⅡ(300 nmol/L)on the ***:These data suggest that UⅡ exerts an inhibitory action on the isolated *** action of UⅡ is predominantly mediated by the UⅡ receptors in vascular smoothmuscles,resulting in the opening of L-type calcium channels.

关键词： urotensin ]I carotid sinus baroreflex verapamil BIM-23127 L-NAME

Ketanserin improves cardiac performance after myocardial infarction in spontaneously hypertensive rats partially through restoration of baroreflex function

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国药理学通报 2015年第B11期31卷 185-186页

作者： YUJian-guang ZHANGEn-hui LIUAi-jun LIUJian-guo GAIGuo-jun SUDing-feng DepartmentofPharmacology SecondMilitaryMedicalUniversityShanghai200433

Aim baroreflex dysfunction is associated with a higher rate of sudden death after myocardial infarction （MI）. Ketanserin enhances baroreflex function in rats. The present work was designed to examine whether ketan- serin improves the post-MI cardiac function and to explore the possible mechanism involved. Methods Spontane- ously hypertensive rats （SHR） were treated with ketanserin （0.3 mg · kg^-1 · d^-l）. Two weeks later, blood pres- sure and baroreflex function were measured, followed by a ligation of the left coronary artery. The expressions of ve- sicular acetylcholine transporter （VAChT） and α7 nicotinic acetylcholine receptor （α7-nAChR） in ischemic myo- cardium, angiogenesis, cardiac function, and left ventricular （LV） remodeling were evaluated subsequently. Re- sults Ketanserin significantly improved baroreflex sensitivity （0.62 ± 0. 21 vs. 0.34 ± 0. 12 ms/mmHg, P 〈 0.01 ） and vagal tonic activity （ heart rate changes in response to atropine, 54.8 ± 16.2 vs. 37.6 ± 13.4 b. p. m. , P 〈 0.01 ） without affecting the blood pressure or basic heart rate in SHR. Treatment of SHR with ketanserin promi- nently improved cardiac function and alleviated LV remodeling, as reflected by increases in the ejection fraction, fractional shortening, and LV systolic pressure as well as decreases in LV internal diameter and LV relative weight. The capillary density, vascular endothelial growth factor expression, and blood flow in the ischemic myocardium were significantly higher in the ketanserin-treated group. In addition, ketanserin markedly increased the expression of VAChT and α7-nAChR in ischemic myocardium. Conclusion Ketanserin improved post-MI cardiac function and angiogenesis in ischemic myocardium. The findings provide a mechanistic basis for restoring baroreflex function using ketanserin in the treatment of MI.

关键词： ketanserin myocardial infarction baroreflex angiogenesis α7-nAChR

Spontaneous baroreflex Sensitivity in Normotensive African-American Men

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Molecular and Integrative Physiology 2019年第1期9卷 1-10页

作者： Peter L. Latchman Gregory J. Gates Robert Thiel Robert S. Axtell Weili Zhu Ally Morin-Viall Tianhong Yue Qin Yang Kenneth Gardner Ronald E. De Meersman Exercise Science Department Southern Connecticut State University New Haven CT USA Department of Pediatrics Albert Einstein College of Medicine Yeshiva University Bronx NY USA Capital University of Physical Education and Sports Beijing China G. C. Foster College of Physical Education and Sport Spanish Town Jamaica College of Medicine American University of Antigua Osbourn Antigua and Barbuda

Purpose: African-American men (AAM) have a greater risk of hypertension (HTN) than Caucasian men (CM). To reduce this risk, determining the differences in mechanisms involved in HTN and understanding the relationship between these mechanisms and factors affecting blood pressure (BP) in AAM and CM is necessary. One such mechanism is spontaneous baroreflex sensitivity (sBRS) and two factors are cardiorespiratory fitness (CRF) and arterial stiffness (AS). The aims of this study were to determine, firstly, whether there are differences in sBRS between young, normotensive AAM and CM, and secondly, to determine if CRF and AS are significant predictors of sBRS in young, normotensive AAM and CM. Methods: Twenty-three normotensive AAM and 36 CM were recruited from Southern Connecticut State University. Measures included anthropometric, sBRS (alpha-index), and CRF (maximal oxygen consumption [VO2max]), as well as AS (carotid-femoral pulse wave velocity [Cf-PWV]). Independent t-tests were used to determine differences between groups and multiple regression analysis was used to determine how much of the variation in sBRS was explained by CRF and AS. Results: The sBRS was significantly lower in AAM (10.3 ± 3.8 ms/mmHg) vs. CM (13.3 ± 5.7 ms/ mmHg), P = 0.03. CRF and AS were not significant predictors of sBRS in AAM (P = 0.25) and CM (P = 0.30). There was no relationship between, sBRS, CRF and AS;CRF was significantly reduced in AAM vs. CM (45.1 ± 6.3 vs. 52.1 ± 7.5 mL·kg?1·min?1, P ≤ 0.001). Conclusions: Young normotensive AAM demonstrated significantly lower sBRS vs. CM, irrespective of having fair CRF and normal BP. CRF and AS are not significant predictors of sBRS in young, normotensive AAM and CM. The attenuation in sBRS in AAM did not result in AAM having higher BP versus CM. This finding underscores the need for more detailed examination of the role of sBRS in the etiology of HTN in AAM.

关键词： African-American Men Spontaneous baroreflex Sensitivity Cardiorespiratory Fitness Arterial Stiffness Hypertension

The Effect of baroreflex Function on Blood Pressure Variability

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Clinical Medicine 2013年第9期4卷 378-383页

作者： Xiufang Wei Xinhui Fang Lina Ren Yanyan Meng Zixin Zhang Yongquan Wang Guoxian Qi Department of Cardiology The First Affiliated Hospital China Medical University Shenyang China.

Objective: The aim of this study was to assess the relationship of blood pressure variability (BPV) and heart rate variability (HRV) to investigate the effect of baroreflex function on blood pressure variability. Methods: This study consisted of 111 subjects, including 32 normotensives and 79 hypertensives. All the subjects were given two concurrent tests: 24-hour Holter ECG and ambulatory blood pressure monitoring. According to standard deviation of normal-to-normal sinus RR intervals (SDNN) derived from the Holter ECG, the hypertensives were divided into two groups: an HRV normal group with SDNN > 100 ms and an HRV abnormal group with

关键词： Blood Pressure Variability Heart Rate Variability baroreflex Function Hypertension

Central modulation of chronic intermittent hypobaric hypoxia on the baroreflex sympathetic out-come in renovascular hypertension rats

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Central modulation of chronic intermittent hypobaric hypoxia...