INHIBITION OF IN VITRO GROWTH OF PATHOGENS TO PROTECT HUMAN MUCOSAE BY PROBIOTICS
作者单位：Department of Food Science and Biotechnology National Chung Hsing University Department of Research and Development Glac Biotech. Co. Ltd.
会议名称：《第七届乳酸菌与健康国际研讨会暨第三届亚洲乳酸菌研讨会》
会议日期：2012年
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
关 键 词：Probiotics Antibacterial activity
摘 要：Abstract The mechanism underlying the antibacterial activity of probiotic strains inhibiting the growth of other microorganisms appears to be multifactorial and includes lowering of the pH,the production of organic acids and secretion of antibacterial *** modified agar overlay method in our study was used for the determination of the presence of antibacterial activity among the 12 strains of probiotics against common microbial pathogens in different regions of epithelial cells including Streptococcus pneumoniae,Escherichia coli HB101,Candida albicans and Gardnerella *** showed that Lactobacillus salivarius AP-32,*** CT-53,*** LPL28,*** ET-22,*** F-1,Bifidobacterium breve bv-77,*** RE-88 had high ability to inhibit *** growth with a inhibition zone above 3 *** the 12 strains,LPL28,ET-22,bv-77 and RE-88 possessed the higher inhibition with inhibition zones above 3.7 ***-32,CT-53,LPL28,ET-22,F-1,Enterococcus faecalis YM-73,bv-77 and RE-88 had high ability to inhibit *** HB101 growth and ET-22,bv-77,RE-88 possessed the higher inhibition with inhibition zones above4 ***-32,ET-22,LPL28 and F-1 high inhibited the growth of *** the 12 strains,LPL28 and F-1 possessed the higher inhibition with inhibition zones above 4 ***-32,*** CS-773,CT-53,LPL28,ET-22,F-1,*** CP-9,bv-77 and RE-88 showed high ability to inhibit *** *** the 12 strains,CT-53,CP-9 and bv-77 possessed the higher inhibition with inhibition zones above 3.6 *** the whole,the results indicated that AP-32,ET-22,LPL28 and F-1 had high capacity of inhibiting the growth of 4 different pathogens in vitro and perhaps were more capable to promote the mucosal barrier *** verified antibacterial activity of probiotics maybe could decrease the incidence of pathogen infection and supported the development of functional foods as a key to the improvement of health in the consuming public.