Glycolysis Enhanced and Mitochondrial Impairment in Childhood type 1 Narcolepsy
作者单位：Changzheng HospitalDepartment of Neurology the Chinese University of Hong KongFaculty of MedicineDepartment of Psychiatry Fudan UniversitySchool of Basic Medical SciencesElectron Microscopy Core Laboratory Centre de Recherche en Neurosciences de LyonUniversite Claude-Bernard Lyon
会议名称：《第八届中国睡眠医学论坛暨中国睡眠研究会睡眠障碍专业委员...》
会议日期：2019年
关 键 词：narcolepsy type 1 childhood metabolism lactate mitochondria obesity
摘 要：Objective:Obesity is common in childhood narcolepsy type 1（NT1）,but the mechanism is still *** study aims to determine the characteristics of the metabolic dysfunction in NT1 and to reveal the underline ***:A total of 82 Chinese patients diagnosed with NT1 were compared with 62 age,sex,and body mass index（BMI） matched healthy *** lactate before and after aerobic exercise,lactate dehydrogenase（LDH） and its isozymes were *** performed muscle biopsies on 6 NT1 patients and 5 controls by transmission electron microscopic（TEM） to investigate mitochondrial impairment in skeletal muscle ***:Compared to the controls,patients with NT1 showed significantly higher lactate levels at baseline and after exercise,accompanied with higher levels of total LDH,LDH3,LDH4 and ***-exercise lactate was demonstrated the best performance in differentiating NT1 with healthy *** investigations discover morphological mitochondria impairment,accumulation of glycogen granules,and lipidosis in NT1 ***:Increased pre-/post-exercise lactate indicates serial glycose and oxygen metabolic dysfunction in *** impairment of muscular cells produces lactate in serum and might be the mechanism of metabolic *** findings provide important information about the mechanisms underlying the major narcoleptic comorbidities in patients such as obesity and even lower activity.