Molecular game theory for a toxin-dominant food chain model
作者单位：Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan ProvinceKunming Institute of Zoology Key Laboratory of Bioactive Peptides of Yunnan ProvinceKunming Institute of Zoology Department of Biomedical EngineeringCenter for the Investigation of Membrane Excitability DiseasesWashington University in St Louis Key Laboratory of Medical NeurobiologyDepartment of Biophysics and Kidney Disease CenterFirst Affiliated HospitalInstitute of NeuroscienceNational Health Commission and Chinese Academy of Medical SciencesZhejiang University School of Medicine
会议名称：《第十四届生物毒素毒理学术大会暨第一届生物毒素——从生存...》
会议日期：2019年
学科分类：07[理学] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学]
关 键 词：Game Theory Sodium Channel Scorpion Amphibia Food Chain
摘 要：A general concept is established that animal toxins are used to subdue prey and deter predators,which act as the key drivers in natural food chains and ***,the predators of venomous animals may exploit feeding adaptation strategies to overcome the toxin burdens placed by their *** remains unknown about the genetic and molecular game process in the toxindominant food chain *** we show an evolutionary strategy in different trophic levels of scorpion-eating amphibians,scorpions,and insects,representing each predation relationship in this type of habitat,which is dominated by paralytic toxins of *** scorpion preying on insects,we found that the scorpion a-toxins irreversibly activate skeletal muscle sodium channel of their prey（insect,BgNaV1） through a membrane delivery mechanism and an efficient binding with the Asp/LysTyr motif of ***,in the predatory game between frogs and scorpions,with a single point mutation（Lys to Glu） in this motif of frog’s skeletal muscle sodium channel（fNaV1.4）,fNaV1.4 breaks this interaction and diminishes muscular toxicity to the frog,thus regularly preying on scorpions without showing ***,this molecular strategy has also been employed by some other scorpion-eating amphibians,especially *** contrast to these amphibians,the Asp/Lys-Tyr motifs are structurally and functionally conserved in other animals which do not prey on ***,our findings elucidate the protein-protein interacting mechanism of a toxin-dominant predator-prey system,implying the evolutionary game theory at molecular level.