Stem cell differentiation directed by the scaffold stiffness at microscale comparable to cell stiffness
作者单位：School of BioengineeringChongqing University Material Measurement LaboratoryNational Institute of Standards and Technology Gaithersburg Department of ChemistryAmerican University Washington Material Measurement LaboratoryNational Institute of Standards and Technology
会议名称：《第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议》
会议日期：2018年
学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学]
基 金：NSFC11532004
摘 要：Objective This study is to demonstrate the biological efficacy of scaffolds used for regenerative medicine strongly correlates with its local (microscopic) stiffness. Methods This demonstration has been carried out through investigating the osteogenic potential of dental follicle stem cells (DFSCs) grown within fibrous scaffolds. Electrospinning process of blends containing PCL/SF/CNC (polycaprolactone/silk fibroin/cellulose nanocrystals) solutions was adopted to fabricate scaffolds composing of nanofibers mesh with various macro-