TRERNA1 function as an enhancer of SNAI1 promotes gastric cancer metastasis by regulating EMT
作者单位：Department of Medical Genetics and Developmental BiologyMedical School of Southeast UniversityThe Key Laboratory of Developmental Genes and Human DiseasesMinistry of EducationSoutheast University School of Life ScienceBengbu Medical College The 3rd Affiliated Hospital of Harbin Medical University(Harbin Medical University Cancer Hospital) Department of PathophysiologyMedical School of Southeast University
会议名称：《2017中国长三角遗传学大会》
会议日期：2017年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the grants from National Natural Science Foundation of China(81672414 and 81472548) The project supported the Jiangsu Provincial Natural Science Foundation-Youth Foundation(BK20160667) supported by the Foundational Research Funds for the Central University(No.2242016k41034)
关 键 词：TRERNA1 SNAI1 Metastasis Gastric Cancer CDH1
摘 要：Long noncoding RNA(IncRNA) has been implicated in cancer,little is known about the role of IncRNAs as regulators of tumor *** present study,we demonstrate that IncRNA TRERNA1 acts like an enhancer of SNAI1 to promote the cell invasion and migration and contribute to metastasis of gastric cancer(GC).TRERNA1 is significantly unregulated in GCs and GC cell *** TRERNAl is positively correlated with lymph node metastasis of *** and ChIP assay revealed that TRERNA1 function as a scaffold to recruit EZH2 to epigenetic silence epithelial-mesenchymal transition marker CDHl by H3 K27 me3 of its promoter ***1 knockdown markedly reduced GC cell migration,invasion,tumorigenicity and *** of TRERNAl reduced cell metastasis of GCs in *** together,our findings indicated that TRERNA1 serve as a critical effector in gastric cancer progression by regulating CDH1 in transcription ***’s implied that TRERNA1/CDH1 is a new potential target for gastric cancer therapy.