Metal-free C-C and C-N bonds formation:Regioselective Synthesis of 6-Nitroindole Derivatives from Enaminones and Nitroaromatic Compounds
作者单位：Key Laboratory of Organic Synthesis of Jiangsu ProvinceCollege of ChemistryChemical Engineering and Materials Science ＆ Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow University
会议名称：《中国化学会第十三届全国有机合成化学学术研讨会》
会议日期：2016年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：国家自然科学基金(no.21372174,21672157) 国家教育部博士点基金(2013201130004)资助项目
关 键 词：indoles metal-free enaminones nitroaromatic compounds
摘 要：The indoles are key structural component of molecules with interesting bioactive and pharmaceutical properties,and also original scaffolds in natural products,agrochemicals and organic materials.1-2 In this paper,a simple and practical Cs2 CO3-promoted method for the synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds has been *** C-C and C-N bonds formed in a highly regioselective manner under transition-metal free conditions.