Hepatic IFIT3 predicts interferon-α therapeutic response in patients of hepatocellular carcinoma
作者单位：Second Military Medical University Chinese Academy of Medical Sciences
会议名称：《第十二届全国免疫学学术大会》
会议日期：2017年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：interferon-α immunotherapy hepatocellular carcinoma biomarker STAT1 STAT2
摘 要：Adjuvant interferon-α(IFN-α) therapy is used to control certain types of cancer in *** hepatocellular carcinoma(HCC),IFN-α therapy is effective in only a subgroup of HCC patients,therefore identifying biomarkers to predict the response to IFN-α therapy is of high significance and clinical *** the induced IFN-stimulated genes(ISGs) expression following IFN-α treatment plays pivotal roles in IFN-α effects,we screened ISGs expression in HCC tissues and found several ISGs were significantly decreased in ***,expressions of IFN-induced proteins with tetratricopeptide repeats(IFIT) family members,including IFIT1,IFIT2,IFIT3,and IFIT5,were all decreased in HCC *** further analyzed the expressions of IFIT family members in HCC and their roles in patients’ responses to IFN-αtherapy in two independent randomized controlled IFN-α therapy clinical trials of HCC patients,and found that higher expression of IFIT3,but not other IFITs,in HCC tissues predicts better response to IFN-α therapy,suggesting that IFIT3 may be a useful predictor of the response to IFN-α therapy in HCC ***,IFIT3 enhanced the antitumor effects of IFN-α by promoting IFN-α effector responses both in vitro and in ***3 could bind signal transducer and activator of transcription 1(STAT1) and STAT2 to enhance STAT1/STAT2 hetero-dimerization and nuclear translocation upon IFN-α treatment,thus promoting IFN-α effector ***:Higher IFIT3 expression in HCC tissues predicts better response to IFN-α therapy in HCC ***3 promotes IFN-α effector responses and therapeutic effects by strengthening IFN-α effector signaling in HCC.