咨询与建议

看过本文的还看了

相关文献

该作者的其他文献

文献详情 >Ketamine modulates dopamine re... 收藏
Ketamine modulates dopamine release in mice striatum in vivo

Ketamine modulates dopamine release in mice striatum in vivo

作     者:Muhammad Younus Xiaoxuan Sun Li Zhou Mingli Li Suhua Sun Guoqing Chen Lun Wang Lili Yin Bo Zhou Yang Lu Feipeng Zhu Zhuan Zhou 

作者单位:State Key Laboratory of Biomembrane-Center for Life Sciences-McGovern Brain Research Institute Institute of Molecular Medicine Peking University 

会议名称:《中国神经科学学会第十二届全国学术会议》

会议日期:2017年

学科分类:1002[医学-临床医学] 100217[医学-麻醉学] 10[医学] 

关 键 词:ketamine dopamine release vesicle pool reuptake in vivo 

摘      要:Ketamine is known as a general anesthetic that administration of subanesthetic doses(R, S)-ketamine(2, 10, 50 mg/kg, i.p.) produces rapid onset antidepressant effects in humans with profound analgesic and hypnotic properties. It is also a popular addictive drug that targeting dopaminergic(DA) system. However, whether and how ketamine modulates DA functions is elusive. Here we determined the effect of ketamine on DA release using electrochemical carbon fiber electrode(CFE) in mouse striatum in vivo. DA release was evoked by electrical stimulation at MFB. Ketamine decreased the DA overflow, while the DA uptake and vesicle pool recycling were not changed. Ketamine effect on DA release was similar in anesthetic and awaking status. These results suggest that ketamine may exert its addictive role is probably independent on MFB-induced DA release in vivo.

读者评论 与其他读者分享你的观点

用户名:未登录
我的评分