Busulfan and cyclosphamide induce liver inflammation through NLRP3 activation in mice after hematopoietic stem cell transplantation
作者单位：Department of Hematology the Affiliated Hospital of Xuzhou Medical University
会议名称：《第十一届全国免疫学学术大会》
会议日期：2016年
学科分类：1002[医学-临床医学] 100215[医学-康复医学与理疗学] 10[医学]
关 键 词：Liver inflammation NLRP3 inflammasome busulfan cyclosphamide hematopoietic stem cell transplanta
摘 要：Aims:To evaluate the role of NLRP3 inflammasome on BU/CY-induced liver inflammation in mice after HSCT.Methods:HSCT mice model was established through infusion of 5 x 106 bone marrow mononuclear cells after conditioned with BU/CY.On day 7,14,21 and 28 after HSCT,mice were sacrificed for analysis of liver inflamma-