High Iodine Repressing the Occurrence of Papillary Thyroid Carcinoma by Regulating miR-146b-5p
作者单位：Center for Endemic Disease ControlChinese Center for Disease Control and Prevention Harbin Medical University Department of Biochemistry and Molecular Biology Harbin Medical University Department of Clinical Oncology Harbin Medical University Cancer Hospital
会议名称：《中国生物化学与分子生物学会2016年全国学术会议》
会议日期：2016年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Natural Science Foundation of China(No.81273011)
关 键 词：High iodine MiR-146b-5p BRAFV600E mutation Smad4 TGFβ
摘 要：Background:High iodine inhibits papillary thyroid carcinoma cell proliferation associated with TGFβ pathwayactivation,although thyroid cancers are frequently refractory to TGFβ*** TGFβpathway is proved to be regulated by mi *** RNAs are small noncoding RNAs that inhibit target m RNA translation and have emerged as potent