Glial gap-junction communication is involved in hippocampal damage and cognitive deficits following middle cerebral artery occlusion
会议名称：《中国神经科学学会第九届全国学术会议暨第五次会员代表大会》
会议日期：2011年
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
关 键 词：astrocyte gap junctional communication hippocampus ischemia
摘 要：正Stroke induced by middle cerebral artery occlusion（MCAO） is a common cause of adult disability leading to motor-sensory disturbances and cognitive *** is generally accepted that cognitive impairment in stroke patients caused by MCAO results from damage to the cerebral cortex rather than the hippocampus,because the middle cerebral artery does not supply blood to the *** we provide the first evidence that patients with exclusively unilateral MCAO show hippocampal damage characterized by an infarct size-independent atrophy and alterations in neuronal and glial metabolites in the ipsilateral hippocampus as assessed by MRI,in parallel with a significant decline in cognitive *** MCAO also induces delayed shrinkage and pyramidal neuronal death in the ipsilateral hippocampus and an impairment of hippocampal-dependent spatial *** glutamate and pyramidal neuronal intracellular calcium levels were significantly elevated and spreading depression waves were observed in the hippocampus which correlated with neuronal *** gap junctional communication （GJC） with carbenoxolone or down-regulation Cx43 significantly increased the survival of the pyramidal neurons in the ipsilateral hippocampus and improved behavioral ***,Cx43 heterozygous mice showed reduced shrinkage and metabolites abnormality in ipsilateral hippocampus after *** results suggest a significant role of astroglial GJC in MCAO-induced remote hippocampal damage and cognitive impairment.