SCP3 regulates cell competence to Nodal and BMP signals via dephosphorylating linker sites of R-Smads during germ layer induction of Xenopus embryos

作     者：Guanni Sun Zhirui Hu Zheying Min Xiaohua Yan Zhenpo Guan Hanxia Su Yu Fu Xiaopeng Ma Ye-Guang Chen Michael Q.Zhang Qinghua Tao Wei Wu 

作者单位：MOE Key Laboratory of Protein ScienceSchool of Life SciencesTsinghua University 

会议名称：《第二届全国发育生物学大会》

会议日期：2014年

学科分类：0905[农学-畜牧学] 09[农学] 090501[农学-动物遗传育种与繁殖] 

摘      要：Nodal/Activin and BMP signals,playing key roles in the pattern formation and germ layer induction,are activated significantly soon after the MBT in *** signals are regulated by not only the burst of ligands but also the competence—the ability of a cell to respond to the *** we found that among the known Smadl and Smad2 linker region phosphatases,only SCP3(small C-terminal domain phosphatase 3)is expressed asymmetrically along the animal-vegetal axis in Xenopus,reminiscent the localization of initially activated Smadl and *** Xenopus early