Fabrication of HCPT-phospholipid Complex loaded Alginate Microspheres for Hepatocellular Carcinoma by Arterial Chemoembolization
会议名称：《2009年中国药学大会暨第九届中国药师周》
会议日期：2009年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Microsphere Alginate Chitosan HCPT-phospholipid complex Artery Chemoembolization Interpenetrating Polymer Network Electrospray
摘 要：Because of a low disease-free survival rate, surgical resection for local control of the hepatocellular carcinoma （HCC） has not been satisfactory. However the effects of preoperative transcatheter arterial chemoembolization （TACE） on improving the disease-free survival of HCC after hepatectomy have been proved [1, 2]. Because of the good properties of biodegradation and biocompatibility, alginate microspheres are widely used in artery chemoembolization. Dry alginate microspheres can be easily stored and after absorbing of 0.9% sodium chloride solution it can be used directly in clinical treatment [3, 4]. In this study Ca-alginate microspheres, HCPT-phospholipid complex loaded alginate microspheres and microspheres coated with chitosan are prepared using electrospray technique. These microspheres have inerratic configuration and narrow diameter distribution. After loaded by HCPT-phospholipid complex and coated with chitosan, microspheres show significant change in swelling properties and drug release in comparison to those of Ca-alginate ones. Emphasis is placed on secondary cross-linked gels to introduce the interpenetrating polymer network （IPN） to adjust the swelling time [3, 4]. We have studied the swelling properties of the reformative alginate-impregnated microspheres with polyvinyl alcohol （PVA）, Polyvinylpyrrolidone （PVP）, poly ethylene oxide （PEO）, and poly ethylene glycol （PEG）. After secondary cross-linking in glutaraldehyde, microspheres with PVA IPN show significant change in the swelling time from 10 min to 60 min. In conclusion, electrospray is for an effective method to produce microspheres for Artery Chemoembolization. The appropriate and controllable swelling properties by adjusting electrospray parameters, formulas and IPN structures make it possible for the precise manipulation in artery chemoembolization.